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1. 发明授权

US5938623A Guide wire with adjustable stiffness 失效
标题翻译：导丝可调刚度
公开(公告)号：US5938623A
公开(公告)日：1999-08-17
申请号：US780687
申请日：1997-01-08
申请人： Dignah B. Quiachon , Robert A. Guziak , Dennis L. Brooks , Deepak R. Gandhi , Mir A. Imran , Roger J. Guidi
发明人： Dignah B. Quiachon , Robert A. Guziak , Dennis L. Brooks , Deepak R. Gandhi , Mir A. Imran , Roger J. Guidi
IPC分类号： A61M25/00 , A61M25/09 , H04L7/00 , H04L25/14 , A61B5/00
CPC分类号： H04L7/0008 , A61M25/09 , H04L25/14 , A61M2025/0063 , A61M2025/09133 , A61M2025/0915 , A61M2025/09158 , A61M25/0054
摘要： Guide wire for use in a medical procedure and for use with a power supply comprising a solid core wire having proximal and distal extremities. The proximal extremity has a predetermined diameter. At least a portion of the distal extremity has a reduced size with respect to the predetermined diameter. A flexible coil is secured to the distal extremity of the core wire and extends over the portion of the core wire having a reduced size. An actuator member is disposed proximal of the coil and extends along the core wire. Electrical conductors extend from the proximal extremity of the core wire to the actuator member for supplying heat to the actuator member. The actuator member is formed of a temperature activated metal alloy having a Young's modulus of 4.times.10.sup.6 to 14.times.10.sup.6 psi which increases in stiffness when heat is supplied thereto to increase the stiffness of the guide wire proximally of the coil.
摘要翻译：导线，用于医疗程序并用于电源，包括具有近端和远端的实心芯线。近端具有预定的直径。远端末端的至少一部分相对于预定直径具有减小的尺寸。柔性线圈固定到芯线的远端，并且在具有减小尺寸的芯线的部分上延伸。致动器构件设置在线圈的近侧并且沿着芯线延伸。电导体从芯线的近端延伸到致动器构件，以向致动器构件供热。致动器构件由具有4×10 6至14×10 6 psi的杨氏模量的温度活化金属合金形成，当向其供应热量时，刚度增加，从而增加导线在线圈近侧的刚度。

2. 发明授权

US5697380A Guide wire having distal extremity with adjustable support characteristic and method 失效
标题翻译：导丝具有远端，具有可调支撑特性和方法
公开(公告)号：US5697380A
公开(公告)日：1997-12-16
申请号：US585885
申请日：1996-01-11
申请人： Dignah B. Quiachon , Deepak R. Gandhi , Dennis L. Brooks , Mir A. Imran , Roger J. Guidi
发明人： Dignah B. Quiachon , Deepak R. Gandhi , Dennis L. Brooks , Mir A. Imran , Roger J. Guidi
IPC分类号： A61F11/00 , A61M25/00 , A61M25/09 , A61M29/00
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/0915 , A61M2025/09158 , A61M2025/09175
摘要： A guide wire having a distal extremity with an adjustable support characteristic comprising a core wire having proximal and distal extremities. The distal extremity has a reduced cross sectional area which is more flexible than the proximal extremity. A tip secured to the distal extremity of the core wire. A sleeve of superelastic material is disposed coaxially on the distal extremity of the core wire. The sleeve is annealed so that it is relatively flexible at a temperature ranging from 20.degree. to 40.degree. C. and becomes progressively stiffer as temperature increases. The core wire conducts electrical energy to the superelastic sleeve to supply heat to the sleeve and extends from the proximal extremity of the core wire to the sleeve to cause the sleeve to become stiffer to thereby increase the stiffness of the distal extremity of the guide wire. A guide wire is provided having a distal extremity with an adjustable support characteristic which varies from a floppy characteristic to a stiff characteristic.
摘要翻译：一种具有远端的引导线，其具有可调节的支撑特征，包括具有近端和远端的芯线。远端具有减小的横截面积，其比近端更灵活。尖端固定在芯线的远端。超弹性材料的套筒同轴地设置在芯线的远端上。套管退火，使其在20°至40°C的温度范围内具有相对的柔韧性，随着温度升高而逐渐变硬。芯线将电能传导到超弹性套管以向套管供热并且从芯线的近端延伸到套筒以使套筒变得更硬，从而增加导丝的远端的刚度。提供导丝，其具有远端，具有可调整的支撑特性，其从软盘特性变为刚性特征。

3. 发明授权

US6039743A Guide wire having distal extremity with adjustable support characteristic and method 失效
标题翻译：导丝具有远端，具有可调支撑特性和方法
公开(公告)号：US6039743A
公开(公告)日：2000-03-21
申请号：US902772
申请日：1997-07-30
申请人： Dignah B. Quiachon , Deepak R. Gandhi , Dennis L. Brooks , Mir A. Imran , Roger J. Guidi
发明人： Dignah B. Quiachon , Deepak R. Gandhi , Dennis L. Brooks , Mir A. Imran , Roger J. Guidi
IPC分类号： A61F11/00 , A61M25/00 , A61M25/09 , A61M29/00
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/0915 , A61M2025/09158 , A61M2025/09175
摘要： A guide wire having a distal extremity with an adjustable support characteristic including a core wire having proximal and distal extremities. The distal extremity has a reduced cross sectional area which is more flexible than the proximal extremity. A tip is secured to the distal extremity of the core wire. A sleeve of superelastic material is disposed coaxially on the distal extremity of the core wire. The sleeve is annealed so that it is relatively flexible at a temperature ranging from 20.degree. to 40.degree. C. and becomes progressively stiffer as temperature increases. The core wire conducts electrical energy to the superelastic sleeve to supply heat to the sleeve and extends from the proximal extremity of the core wire to the sleeve to cause the sleeve to become stiffer to thereby increase the stiffness of the distal extremity of the guide wire. A guide wire is provided having a distal extremity with an adjustable support characteristic which varies from a floppy characteristic to a stiff characteristic.
摘要翻译：一种具有远端的引导线，其具有可调节的支撑特征，包括具有近端和远端的芯线。远端具有减小的横截面积，其比近端更灵活。尖端被固定到芯线的远端。超弹性材料的套筒同轴地设置在芯线的远端上。套管退火，使其在20°至40°C的温度范围内具有相对的柔韧性，随着温度升高而逐渐变硬。芯线将电能传导到超弹性套管以向套管供热并且从芯线的近端延伸到套筒以使套筒变得更硬，从而增加导丝的远端的刚度。提供导丝，其具有远端，具有可调整的支撑特性，其从软盘特性变为刚性特征。

4. 发明授权

US5542434A Guide wire with deflectable tip and method 失效
标题翻译：导线带有偏转尖端和方法
公开(公告)号：US5542434A
公开(公告)日：1996-08-06
申请号：US331216
申请日：1994-10-28
申请人： Mir A. Imran , Deepak R. Gandhi , Henry Bourang , Dignah B. Quiachon , Andrew Y. Chow
发明人： Mir A. Imran , Deepak R. Gandhi , Henry Bourang , Dignah B. Quiachon , Andrew Y. Chow
IPC分类号： A61M25/00 , A61M25/01 , A61M25/09 , H04L7/00 , A61B5/00
CPC分类号： A61M25/0144 , A61M25/0158 , A61M25/09 , H04L7/0008 , A61M2025/0063 , A61M2025/0915 , A61M25/0054
摘要： Guide wire for use in a medical procedure and for use with the power supply comprising a flexible elongate tubular member having proximal and distal extremities and having a bore extending from the proximal extremity to the distal extremity. A core wire extends through the bore of the flexible elongate tubular member. A coil assembly is mounted on the distal extremity of the flexible elongate member and has a distal extremity. A rounded tip is formed on the distal extremity. An actuator member has at least a portion thereof disposed in the coil assembly and has proximal and distal extremities. The proximal extremity of the actuator member is secured to the distal extremity of the flexible elongate tubular member. The distal extremity of the actuator member is secured to the rounded tip. The actuator member has a portion thereof formed of a shape memory material and incorporating a shape member therein. A heater is disposed in the vicinity of said portion of the actuator member for heating said portion to cause it to assume the predetermined shape memory. Electrical conductors are connected to the heater and extending to the proximal extremity of the flexible elongate tubular member and are adapted to be connected to the power supply to supply energy to the heater.
摘要翻译：用于医疗过程和与电源一起使用的导线，包括具有近端和远端的柔性细长管状构件，并且具有从近端至远端延伸的孔。芯线延伸穿过柔性细长管状构件的孔。线圈组件安装在柔性细长构件的远端上并且具有远端。在远端上形成圆形尖端。致动器构件具有设置在线圈组件中的至少一部分，并且具有近端和远端。致动器构件的近端被固定到柔性细长管状构件的远端。致动器构件的远端被固定到圆形尖端。致动器构件的一部分由形状记忆材料形成并且在其中结合有形状构件。加热器设置在致动器构件的所述部分附近，用于加热所述部分以使其呈现预定形状记忆。电导体连接到加热器并延伸到柔性细长管状构件的近端，并且适于连接到电源以向加热器供应能量。

5. 发明授权

US5813997A Guide wire with deflectable tip and method 失效
公开(公告)号：US5813997A
公开(公告)日：1998-09-29
申请号：US690749
申请日：1996-08-01
申请人： Mir A. Imran , Deepak R. Gandhi , Henry Bourang , Dignah B. Quiachon , Andrew Y. Chow
发明人： Mir A. Imran , Deepak R. Gandhi , Henry Bourang , Dignah B. Quiachon , Andrew Y. Chow
IPC分类号： A61M25/00 , A61M25/01 , A61M25/09 , H04L7/00 , A61B5/00
CPC分类号： A61M25/0144 , A61M25/0158 , A61M25/09 , H04L7/0008 , A61M2025/0063 , A61M2025/0915 , A61M25/0054
摘要： Guide wire for use in a medical procedure and for use with the power supply comprising a flexible elongate tubular member having proximal and distal extremities and having a bore extending from the proximal extremity to the distal extremity. A core wire extends through the bore of the flexible elongate tubular member. A coil assembly is mounted on the distal extremity of the flexible elongate member and has a distal extremity. A rounded tip is formed on the distal extremity. An actuator member has at least a portion thereof disposed in the coil assembly and has proximal and distal extremities. The proximal extremity of the actuator member is secured to the distal extremity of the flexible elongate tubular member. The distal extremity of the actuator member is secured to the rounded tip. The actuator member has a portion thereof formed of a shape memory material and incorporating a shape member therein. A heater is disposed in the vicinity of said portion of the actuator member for heating said portion to cause it to assume the predetermined shape memory. Electrical conductors are connected to the heater and extending to the proximal extremity of the flexible elongate tubular member and are adapted to be connected to the power supply to supply energy to the heater.

6. 发明授权

US5779688A Low profile balloon-on-a-wire catheter with shapeable and/or deflectable tip and method 失效
标题翻译：薄型气球在线导管，具有可塑和/或可偏转的尖端和方法
公开(公告)号：US5779688A
公开(公告)日：1998-07-14
申请号：US504927
申请日：1995-07-20
申请人： Mir A. Imran , Cecily M. Hillsman , Deepak R. Gandhi , Dennis L. Brooks
发明人： Mir A. Imran , Cecily M. Hillsman , Deepak R. Gandhi , Dennis L. Brooks
IPC分类号： A61M25/00 , A61M25/01 , A61M29/02
CPC分类号： A61M25/0158 , A61M25/0097 , A61M25/104 , A61M2025/0186 , A61M2025/1079 , A61M2025/1093
摘要： A low profile, balloon-on-a-wire catheter comprising a flexible elongate tubular member having proximal and distal extremities. A balloon inflation-deflation lumen extends from the proximal extremity to the distal extremity. An inflatable balloon is carried by the distal extremity of the flexible elongate tubular member. The flexible elongate tubular member carries means which establishes communication between the lumen and the interior of the inflatable balloon. A removable inflation device is removably secured to the proximal extremity of the flexible elongate tubular member for supplying an inflation fluid to the lumen for inflating and deflating the balloon. The removable inflation device forms a high pressure seal with the proximal extremity of the flexible elongate tubular member. The removable inflation device is free of obstructions so that another balloon catheter can be advanced over the proximal extremity of the flexible elongate tubular member which serves as a stand-alone guide wire. The distal extremity of the catheter is formed so that it is mechanically shapeable or can be electrically deflectable to facilitate steering of the distal extremity.
摘要翻译：一种薄型气球在线导管，其包括具有近端和远端的柔性细长管状构件。气球充气 - 通气腔从近端延伸到远端。可膨胀气囊由柔性细长管状构件的远端承载。柔性细长管状构件承载建立管腔和可充气气囊内部之间的连通的装置。可移除的充气装置可移除地固定到柔性细长管状构件的近端，用于向腔内供应充气流体以使气囊膨胀和放气。可移除的充气装置与柔性细长管状构件的近端形成高压密封。可移除的充气装置没有障碍物，使得另一个气囊导管可以在用作独立导丝的柔性细长管状构件的近端上前进。导管的远端被形成为使得其可机械地成形或可以电可偏转以便于远端的转向。

7. 发明授权

US5666968A Flexible guide wire with extension capability and guide wire extension for use therewith 失效
标题翻译：具有延伸能力的柔性导丝和与其一起使用的导丝延伸
公开(公告)号：US5666968A
公开(公告)日：1997-09-16
申请号：US405882
申请日：1995-03-17
申请人： Mir A. Imran , Dennis L. Brooks , Deepak R. Gandhi
发明人： Mir A. Imran , Dennis L. Brooks , Deepak R. Gandhi
IPC分类号： A61M25/01 , A61M25/09 , A61B5/00
CPC分类号： A61M25/01 , A61M25/0905
摘要： A guide wire with extension capability for use in a medical procedure having a guide wire and a guide wire extension. The guide wire comprises a flexible elongate cylindrical member having proximal and distal extremities. A portion of the distal extremity is formed of a material having high torquability and high pushability. The guide wire extension comprises a flexible elongate cylindrical member formed of a shape memory material. A major portion of the flexible elongate cylindrical member of the guide wire extension has a shape memory in the form of a coil so that when it is free it will assume a shape memory coil. A junction is formed between the proximal extremity of the guide wire and the distal extremity of the guide wire extension for connection of the guide wire extension to the guide wire.
摘要翻译：具有延伸能力的导丝，用于具有导丝和导丝延伸的医疗过程中。导丝包括具有近端和远端的柔性细长圆筒形构件。远端的一部分由具有高扭矩和高推力性的材料形成。导丝延伸部包括由形状记忆材料形成的柔性细长圆柱形构件。导丝延伸件的柔性细长圆柱形构件的主要部分具有线圈形式的形状记忆，使得当其自由时，其将呈现形状记忆线圈。在引导线的近端和导丝延伸部的远端之间形成有接头，用于将导丝延伸部与导丝连接。

8. 发明授权

US5520645A Low profile angioplasty catheter and/or guide wire and method 失效
标题翻译：低剖面血管成形术导管和/或导丝及方法
公开(公告)号：US5520645A
公开(公告)日：1996-05-28
申请号：US331217
申请日：1994-10-28
申请人： Mir A. Imran , Deepak R. Gandhi , Dennis L. Brooks
发明人： Mir A. Imran , Deepak R. Gandhi , Dennis L. Brooks
IPC分类号： A61M25/00 , A61M25/01 , A61M29/02 , A61M37/00
CPC分类号： A61M25/0158 , A61M25/0097 , A61M25/104 , A61M2025/0186 , A61M2025/1079 , A61M2025/1093
摘要： A low profile balloon-on-a-wire catheter having a flexible elongate tubular member with proximal and distal extremities and with a lumen extending from the proximal extremity to the distal extremity. An inflatable balloon is mounted on the distal extremity of the flexible elongate tubular member. Communication is established between the lumen and the interior of the inflatable balloon. An inflation fitting is removably secured to the proximal extremity of the flexible elongate tubular member for supplying an inflation fluid to the lumen for inflating and deflating the balloon. The inflation fitting when removed provides a proximal extremity on the catheter which is free of obstructions so that another balloon catheter can be advanced over the proximal extremity of the flexible elongate tubular member.
摘要翻译：一种低剖面气球在线导管，其具有柔性细长管状构件，其具有近端和远端，并且具有从近端至远端延伸的内腔。可膨胀气囊安装在柔性细长管状构件的远端上。在可充气气囊的内腔和内部之间建立通信。膨胀配件可移除地固定到柔性细长管状构件的近端，用于将充气流体供应到管腔以使气囊膨胀和放气。当去除时的充气接头提供导管上的近端，其没有障碍物，使得另一气囊导管可以在柔性细长管状构件的近端延伸越过。

9. 发明申请

US20090099415A1 Endoscopic Instrument System for Implanting a Device in the Stomach 审中-公开
标题翻译：用于在胃中植入装置的内窥镜仪器系统
公开(公告)号：US20090099415A1
公开(公告)日：2009-04-16
申请号：US12340565
申请日：2008-12-19
申请人： Mir A. Imran , Olivier K. Colliou , Ted W. Layman , Deepak R. Gandhi , Sharon L. Lake
发明人： Mir A. Imran , Olivier K. Colliou , Ted W. Layman , Deepak R. Gandhi , Sharon L. Lake
IPC分类号： A61B1/018
CPC分类号： A61B5/6882 , A61B5/4238 , A61B17/3421 , A61B17/3478 , A61B2017/00004 , A61B2017/00017 , A61B2017/00026 , A61B2017/00084 , A61B2017/00477 , A61B2017/306 , A61B2017/3488 , A61F5/0003 , A61M25/02 , A61M2025/0233 , A61M2025/028 , A61N1/0509 , A61N1/0517 , A61N1/36007 , A61N1/372 , G01N27/126
摘要： An endoscopic delivery system is provided to deliver a functional device through the esophagus and into the stomach where it is attached the stomach wall. The endoscopic instruments attach or remove the attachment devices and functional devices from the stomach and may be used to assist in determining the optimal attachment location.
摘要翻译：提供内窥镜递送系统以将功能装置通过食道递送到胃中，在胃中其附着胃壁。内窥镜器械将附接装置和功能装置从胃附接或移除，并且可以用于帮助确定最佳的附接位置。

10. 发明授权

US07120498B2 Method and device for securing a functional device to a stomach 有权
标题翻译：用于将功能装置固定到胃的方法和装置
公开(公告)号：US07120498B2
公开(公告)日：2006-10-10
申请号：US10691880
申请日：2003-10-23
申请人： Mir A. Imran , Olivier K. Colliou , Ted W. Layman , Deepak R. Gandhi , Sharon L. Lake
发明人： Mir A. Imran , Olivier K. Colliou , Ted W. Layman , Deepak R. Gandhi , Sharon L. Lake
IPC分类号： A61N1/18
CPC分类号： A61B5/6882 , A61B5/4238 , A61B17/3421 , A61B17/3478 , A61B2017/00004 , A61B2017/00017 , A61B2017/00026 , A61B2017/00084 , A61B2017/00477 , A61B2017/306 , A61B2017/3488 , A61F5/0003 , A61M25/02 , A61M2025/0233 , A61M2025/028 , A61N1/0509 , A61N1/0517 , A61N1/36007 , A61N1/372 , G01N27/126 , G06F19/00
摘要： A device, system and method for diagnosing and treating gastric disorders is provided. A functional device resides within the patient's stomach and is secured to the stomach wall by an attachment device. The functional device may be a sensor for sensing various parameters of the stomach or stomach environment, or may be a therapeutic delivery device. The functional device in one embodiment provides a device, system and method for gastric electrical stimulation where stimulating electrodes are secured to the wall of the stomach by the attachment device or otherwise. A preferred device includes: at least one stimulating electrode in electrical contact with the stomach wall; an electronics unit containing the electronic circuitry of the device; and an attachment mechanism for attaching the device to the stomach wall. The functional devices may be programmed to respond to sensed information or signals. An endoscopic delivery system delivers the functional device through the esophagus and into the stomach where it is attached the stomach wall. The endoscopic instruments attach or remove the attachment devices and functional devices from the stomach and may be used to assist in determining the optimal attachment location.
摘要翻译：提供了用于诊断和治疗胃疾病的装置，系统和方法。功能装置位于患者的胃内，并通过附接装置固定到胃壁。功能装置可以是用于感测胃或胃环境的各种参数的传感器，或者可以是治疗递送装置。在一个实施例中的功能装置提供了用于胃电刺激的装置，系统和方法，其中刺激电极通过附接装置或其它方式固定到胃壁。优选的装置包括：与胃壁电接触的至少一个刺激电极; 包含该装置的电子电路的电子单元; 以及用于将装置附接到胃壁的附接机构。功能设备可以被编程为响应感测的信息或信号。内窥镜递送系统通过食管将功能装置输送到胃中，在胃附着胃壁。内窥镜器械将附接装置和功能装置从胃附接或移除，并且可以用于帮助确定最佳的附接位置。

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