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1. 发明公开

EP2942068A1 REGULATION OF BONE GROWTH USING ZEOLITE IN COMBINATION WITH BONE GRAFT SUBSTITUTES 审中-公开
标题翻译：日本食品科技大学学院麻省理工学院KOCHENSPANERSÄTZEN
公开(公告)号：EP2942068A1
公开(公告)日：2015-11-11
申请号：EP15163787.3
申请日：2010-03-30
申请人： Difusion Technologies Inc.
发明人： Johns, Derrick , Geck, Matthew , Whang, Peter , Hafiz, Jami
IPC分类号： A61L27/02 , A61L27/54 , A61L27/44
CPC分类号： A61L27/446 , A61L27/025 , A61L27/54 , A61L2300/414 , A61L2430/02
摘要： Medical implants such as bone graft substitutes that include one or more cations are delivered in a local environment to promote osteogenesis. Zeolite loaded with a metal cation in combination with an implant such as a bone graft substitute can be used as an implant in the body to regulate protein transcription and translation. Also disclosed are methods of promoting osteogenesis in a patient in need thereof, methods for modulating bone formation and mineralization by implanting in a patient a medical implant comprising ion-exchangeable cations, and methods of regulating BMP gene expression in bone cells in a patient by controlling the delivery of certain cations through ionexchange via a zeolite incorporated in a bone substitute implanted in a patient so that BMP gene expression can be upregulated or downregulated appropriately.
摘要翻译：包括一种或多种阳离子在内的医用植入物例如骨移植物替代物在局部环境中递送以促进成骨。负载金属阳离子与植入物如骨移植物替代物组合的沸石可以用作体内的植入物以调节蛋白质转录和翻译。还公开了在有需要的患者中促进成骨的方法，通过在患者中植入包含可离子交换阳离子的医疗植入物来调节骨形成和矿化的方法，以及通过控制来调节患者骨细胞中BMP基因表达的方法通过离子交换通过掺入植入患者的骨替代物中的沸石递送某些阳离子，使得BMP基因表达可以适当地上调或下调。

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