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1. 发明授权

US4300835A Attenuator for stray light produced in monochromators 失效
标题翻译：在单色仪中产生的杂散光的衰减器
公开(公告)号：US4300835A
公开(公告)日：1981-11-17
申请号：US146728
申请日：1980-05-02
申请人： Dieter Schiemann , Wolfgang Witte
发明人： Dieter Schiemann , Wolfgang Witte
IPC分类号： G01J3/18
CPC分类号： G01J3/02 , G01J3/0262 , G01J3/18
摘要： Stray light produced in a monochromator by the diffuse reflection of the incoming light beam specularly reflected from the surface of the diffraction grating is practically eliminated by interposing a black glass "absorbent-reflector" in the path of the specularly reflected beam. The small percentage of radiation that is not absorbed by the absorbing glass is reflected to an opposite blackened wall which diffuse reflects an extremely small percentage of the beam back to the absorbent-reflector where a very negligible part is returned to the grating surface and eventually to the monochromator exit slit.
摘要翻译：通过在衍射光栅表面镜面反射的入射光束的漫反射产生的杂散光实际上通过在镜面反射光束的路径中插入黑色玻璃“吸收反射器”来消除。不被吸收玻璃吸收的较小百分比的辐射被反射到相对的黑化壁，其漫反射反射非常小百分比的光束到吸收反射器，其中非常可忽略的部分返回到光栅表面，并且最终到单色仪出口狭缝。

2. 发明授权

US4563090A Grating spectrometer 失效
标题翻译：光栅光谱仪
公开(公告)号：US4563090A
公开(公告)日：1986-01-07
申请号：US502991
申请日：1983-06-10
申请人： Wolfgang Witte
发明人： Wolfgang Witte
IPC分类号： G01J3/30 , G01J3/28 , G01J3/18
CPC分类号： G01J3/28
摘要： In a grating spectrometer a signal spectrum is measured repeatedly while inserting different filters. The number of the filters and measurements correspond to the number of the occurring grating orders not suppressed. The signal spectra and the transmission characteristics of the filters are stored. A system of equations is achieved, from which a computer calculates the signal partial spectra associated with the individual grating orders. A total spectrum is composed from these signal partial spectra. Separation of the higher grating orders need not be effected optically, for example by cut-off filters.
摘要翻译：在光栅光谱仪中，在插入不同的滤光片时重复测量信号光谱。滤波器和测量的数量对应于未被抑制的出现的光栅顺序的数量。存储滤波器的信号频谱和传输特性。实现了一种方程组，计算机计算与各个光栅顺序相关联的信号分光谱。总谱由这些信号部分谱组成。较高光栅级数的分离不需要光学地进行，例如通过截止滤光器。

3. 发明授权

US06124290A Polycyclic phthalazine compounds and their use 失效
标题翻译：多环酞嗪化合物及其用途
公开(公告)号：US06124290A
公开(公告)日：2000-09-26
申请号：US242295
申请日：2000-01-28
申请人： Lothar Heinisch , Ute Moellmann , Wolfgang Witte , Christiane Cuny , Ernst Roemer , Walter Werner , Udo Graefe
发明人： Lothar Heinisch , Ute Moellmann , Wolfgang Witte , Christiane Cuny , Ernst Roemer , Walter Werner , Udo Graefe
IPC分类号： C07D307/32 , A61K31/50 , A61K31/502 , A61P31/04 , C07D237/26 , C07D237/32 , A61K31/435
CPC分类号： C07D237/26
摘要： Polycyclic phthalazines, in particular 2-substituted maduraphthalazines (10,12,15,16-tetrahydroxy-8-methoxy-11-methyl-1,9,14-trioxo-1,2,6,7,9,14-hexahydronaphthaceno-1,2-g-phthalazines), of formula I and their use against gram-positive bacterial strains, particularly against multi-resistant staphylococci (MRSA) and against glycopeptide-resistant, for example vancomycin-resistant, enterococci. The polycyclic phthalazines are thus suitable for preparing anti-bacterially effective pharmaceutical compositions. In formula I, R.sup.1 is carboxyalkyl or carboxyaryl, and R.sup.2 and R.sup.3 represent H or acyl (for example CO-alkyl or COO-alkyl), with R.sup.1 being different from optionally substituted carboxyphenyl when R.sup.3 represents C.sub.1-8 alkanoyl. The invention also relates to salts, amides and esters of compounds of formula I.
摘要翻译： PCT No.PCT / FI96 / 03632 Sec。 371日期2000年1月28日 102（e）日期2000年1月28日PCT 1997年7月9日PCT公布。公开号WO98 / 07706 日期1998年2月26日多环酞嗪，特别是2-取代的马卡波肼（10,12,15,16-四羟基-8-甲氧基-11-甲基-1,9,14-三氧杂-1,2,6,7,9 ，14-六氢萘并-1,2- -g-酞嗪），以及它们对革兰氏阳性细菌菌株，特别是针对多重耐药葡萄球菌（MRSA）和抗糖肽抗性（例如万古霉素抗性肠球菌）的用途。因此，多环酞嗪适于制备抗细菌有效的药物组合物。在式I中，R 1是羧基烷基或羧基芳基，R 2和R 3表示H或酰基（例如CO-烷基或COO-烷基），当R 3表示C 1-8烷酰基时，R 1不同于任选取代的羧基苯基。本发明还涉及式I化合物的盐，酰胺和酯。

4. 发明授权

US4575243A Monochromator 失效
标题翻译：单色器
公开(公告)号：US4575243A
公开(公告)日：1986-03-11
申请号：US502990
申请日：1983-06-10
申请人： Wolfgang Witte
发明人： Wolfgang Witte
IPC分类号： G01J3/12 , G01J3/18
CPC分类号： G01J3/18 , G01J3/0208 , G01J3/0229
摘要： A monochromator comprises a first and a second concave grating. An entrance slit is imaged by the concave grating in the plane as a spectrum. A disc comprises a spiral slot. A section of the slot forms an intermediate slit periodically sweeping transversely across the spectrum. A concave mirror images the fanning point of the concave grating. Thereby the fanned beams are recombined to a single beam. An exit slit is located in an image plane in which an image of the entrance slit is generated. The spectrum can be scanned quickly and cyclically without the gratings having to be rotated. There is also the effect of a double monochromator. Another embodiment comprises two concave mirrors to generate the image.
摘要翻译：单色器包括第一和第二凹光栅。入射狭缝通过平面内的凹形光栅作为光谱成像。盘包括螺旋槽。槽的一部分形成横向横穿光谱周期扫描的中间狭缝。凹面镜成像凹面光栅的扇形点。因此，扇形光束被重新组合成单个光束。出口狭缝位于其中产生入口狭缝的图像的图像平面中。可以快速和周期地扫描光谱，而不必旋转光栅。还有一个双色仪的效果。另一个实施例包括两个凹面镜以产生图像。

5. 发明授权

US4453826A Double monochromator 失效
标题翻译：双色单色仪
公开(公告)号：US4453826A
公开(公告)日：1984-06-12
申请号：US346443
申请日：1982-02-08
申请人： Wolfgang Witte
发明人： Wolfgang Witte
IPC分类号： G01J3/18
CPC分类号： G01J3/18
摘要： A pre-monochromator having a grating monochromator includes an unsymmetrically ruled concave diffraction grating, by means of which a light source is directly imaged upon an exit slit. The diffraction grating is unsymmetrical with respect to the distribution of the grating constants such that the image distance remains substantially constant during the rotation of the diffraction grating.
摘要翻译：具有光栅单色仪的预单色仪包括不对称刻槽的凹面衍射光栅，通过该光栅将光源直接成像在出射狭缝上。衍射光栅相对于光栅常数的分布是不对称的，使得在衍射光栅的旋转期间图像距离保持基本恒定。

6. 发明申请

US20080280775A1 Determination of Antibiotic Resistance in Staphylococcus Aureus 审中-公开
标题翻译：金黄色葡萄球菌耐药性测定
公开(公告)号：US20080280775A1
公开(公告)日：2008-11-13
申请号：US11908660
申请日：2006-03-08
申请人： Christiane Kettlitz , Birgit Stromenger , Guido Werner , Wolfgang Witte
发明人： Christiane Kettlitz , Birgit Stromenger , Guido Werner , Wolfgang Witte
IPC分类号： C40B30/04 , C40B40/08
CPC分类号： C12Q1/689 , C12Q1/6837 , C12Q2600/156 , C12Q2600/16 , C12Q2600/166
摘要： The present invention relates to the detection of antibiotic resistance determinants in Staphylococcus aureus. The present invention discloses a micro-array for the detection of antibiotic resistance determinants and mutations in Staphylococcus aureus, a method for the detection of the determinants and mutations, and a kit.
摘要翻译：本发明涉及金黄色葡萄球菌中抗生素抗性决定簇的检测。本发明公开了用于检测金黄色葡萄球菌中抗生素抗性决定簇和突变的微阵列，检测决定簇和突变的方法以及试剂盒。

7. 发明申请

US20070059714A1 Detection of presence and antibiotic susceptibility of enterococci 审中-公开
标题翻译：检测肠球菌的存在和抗生素敏感性
公开(公告)号：US20070059714A1
公开(公告)日：2007-03-15
申请号：US11224393
申请日：2005-09-12
申请人： Birgit Strommenger , Christiane Kettlitz , Ulrich Nubel , Guido Werner , Ingo Klare , Wolfgang Witte
发明人： Birgit Strommenger , Christiane Kettlitz , Ulrich Nubel , Guido Werner , Ingo Klare , Wolfgang Witte
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/689 , C12Q1/6837 , C12Q2600/156 , C12Q2600/16 , C12Q2600/166
摘要： The present invention relates in general to the detection of antibiotic resistance genes in Enterococci. The present invention discloses a micro-array for the detection of the presence of bacteria of the genus Enterococcus and antibiotic resistance genes in said organism, a method for the detection of said genes and a kit. This micro-array concept offers the rapid sensitive and specific identification of antibiotic resistance profiles.
摘要翻译：本发明一般涉及肠球菌抗生素抗性基因的检测。本发明公开了一种用于检测肠球菌属细菌和所述生物体中抗生素抗性基因的存在的微阵列，检测所述基因的方法和试剂盒。这种微阵列概念提供了抗生素抗性谱的快速敏感和特异性鉴定。

8. 发明申请

US20060210998A1 Determination of antibiotic resistance in staphylococcus aureus 审中-公开
标题翻译：测定金黄色葡萄球菌中抗生素耐药性
公开(公告)号：US20060210998A1
公开(公告)日：2006-09-21
申请号：US11083787
申请日：2005-03-18
申请人： Christiane Kettlitz , Birgit Stromenger , Guido Werner , Wolfgang Witte
发明人： Christiane Kettlitz , Birgit Stromenger , Guido Werner , Wolfgang Witte
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/689 , C12Q2600/156 , C12Q2600/166
摘要： The present invention relates to the detection of antibiotic resistance determinants in Staphylococcus aureus. The present invention discloses a micro-array for the detection of antibiotic resistance determinants and mutations in said organism, a method for the detection of said determinants and mutations and a kit.
摘要翻译：本发明涉及金黄色葡萄球菌中抗生素抗性决定簇的检测。本发明公开了用于检测所述生物体中抗生素抗性决定簇和突变的微阵列，检测所述决定簇和突变的方法和试剂盒。

9. 发明授权

US4267572A Apparatus for determining the concentration of the components of a sample 失效
标题翻译：用于确定样品组分浓度的装置
公开(公告)号：US4267572A
公开(公告)日：1981-05-12
申请号：US26710
申请日：1979-04-03
申请人： Wolfgang Witte
发明人： Wolfgang Witte
IPC分类号： G01J3/28 , G06F17/00 , G06F15/20
CPC分类号： G01J3/28
摘要： Apparatus for determining the concentration of the various components of a sample, which includes a spectrophotometer for receiving a sample to be analyzed and performing extinctions of the sample at a plurality of preselected wavelengths to form a sample spectrum; memory devices for storing a standard spectra of each of the individual components; circuitry for weighting the sample spectrum at different wavelengths in conformity with each of the standard spectra and providing estimated values of the concentrations of the components from the sample spectra thus weighted; circuitry for reconstructing the sample spectrum as a linear combination of the estimated values of the concentrations and the standard spectra; a subtractor for forming a difference spectrum from the sample spectrum and the reconstructed sample spectrum; circuitry for weighting the difference spectrum at different wavelengths in conformity with each of the standard spectra and providing corrective values of the concentrations of the components from the difference spectrum thus weighted, and means for reconstructing the difference spectrum as a linear combination from the corrective values of the concentrations and the standard spectra; a subtractor for forming a second difference spectrum from the first difference spectrum and the reconstructed difference spectrum; updating means for correcting the estimated values by the corrective values, and a readout device for reading out the corrected values of the concentrations of the components.
摘要翻译：用于确定样品的各种组分的浓度的装置，其包括用于接收待分析样品的分光光度计，并以多个预选波长执行样品的消光以形成样品光谱; 用于存储每个单独部件的标准光谱的存储器件; 用于根据每个标准光谱对不同波长的样品光谱进行加权的电路，并从如此加权的样品光谱提供组分浓度的估计值; 用于将样品光谱重建为浓度和标准光谱的估计值的线性组合的电路; 用于从样本谱和重建的样本谱形成差分谱的减法器; 电路，用于根据每个标准光谱对不同波长的差分光谱进行加权，并从如此加权的差分光谱中提供分量的浓度的校正值，以及用于从差分光谱重建差分谱作为线性组合的装置，浓度和标准光谱; 用于从所述第一差分谱和所述重建的差谱形成第二差分谱的减法器; 用于通过校正值校正估计值的更新装置，以及读出组件浓度校正值的读出装置。

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