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1. 发明授权

US5430151A Trifluoromethyl-containing pseudopeptides active against retroviruses 失效
标题翻译：对逆转录病毒有活性的含三氟甲基的伪肽
公开(公告)号：US5430151A
公开(公告)日：1995-07-04
申请号：US920216
申请日：1992-07-24
申请人： Dieter Habich , Wolfgang Roben , Jutta Hansen , Arnold Paessens
发明人： Dieter Habich , Wolfgang Roben , Jutta Hansen , Arnold Paessens
IPC分类号： A61K31/16 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/435 , A61K31/4427 , A61K31/445 , A61K31/47 , A61K31/535 , A61K31/5375 , A61K31/66 , A61K38/00 , A61P31/12 , A61P31/18 , C07C237/22 , C07C271/22 , C07C317/44 , C07D207/08 , C07D209/42 , C07D211/18 , C07D215/12 , C07D217/14 , C07D295/16 , C07D295/18 , C07D401/12 , C07F9/40 , C07F9/572 , C07F9/59 , C07F9/62 , C07K5/06 , C07K5/08 , C07K5/083 , C07D211/06 , C07D207/04
CPC分类号： C07D207/08 , C07C317/44 , C07D211/18 , C07D217/14 , C07K5/06191 , C07K5/081 , C07K5/0827 , A61K38/00
摘要： The present invention relates to new trifluoromethyl-containing pseudopeptides of the general formula (I) ##STR1## in which W, A, B, D, E, R.sub.1, R.sub.2 and R.sub.3 have the meaning as outlined of their making and use as pharmaceuticals.
摘要翻译：本发明涉及通式（I）的新的含三氟甲基的伪肽，其中W，A，B，D，E，R 1，R 2和R 3具有其制备和使用概述的含义作为药物。

2. 发明授权

US5492918A Use of substituted chromans, some of which are known, as medicaments, new active compounds and processes for their preparation 失效
标题翻译：取代的苯并二氢吡喃酮（其中一些已知的）用作药物，新的活性化合物及其制备方法
公开(公告)号：US5492918A
公开(公告)日：1996-02-20
申请号：US251986
申请日：1994-06-01
申请人： Hanno Wild , Wolfgang Bender , Dieter Habich , Hans-Georg Heine , Siegfried Raddatz , Wolfgang Roben , Jutta Hansen , Arnold Paessens
发明人： Hanno Wild , Wolfgang Bender , Dieter Habich , Hans-Georg Heine , Siegfried Raddatz , Wolfgang Roben , Jutta Hansen , Arnold Paessens
IPC分类号： A61K31/443 , A61K31/445 , A61P31/12 , C07D405/06 , C07D405/14
CPC分类号： C07D405/06 , C07D405/14
摘要： The present invention relates to the use of substituted chromans of the general formula (I) ##STR1## in which the substituents have the meaning indicated in the description, for the production of medicaments, in particular as HIV protease-inhibiting agents, new active compounds and processes for their preparation.
摘要翻译：本发明涉及通式（I）的取代苯并二氢吡喃的用途，其中取代基具有说明书中指出的含义，用于生产药物，特别是作为HIV蛋白酶抑制剂，新的活性化合物及其制备方法。

3. 发明授权

US5739127A 2,4'-bridged bis-2,4-diaminoquinazolines 失效
标题翻译： 2,4'-桥连双-2,4-二氨基喹唑啉
公开(公告)号：US5739127A
公开(公告)日：1998-04-14
申请号：US745591
申请日：1996-11-08
申请人： Rudolf Schohe-Loop , Peter-Rudolf Seidel , William Bullock , Gabriele Handke , Achim Feurer , Wolfgang Roben , Georg Terstappen , Joachim Schuhmacher , Franz-Josef van der Staay , Bernard Schmidt , Richard J. Fanelli , Jane C. Chisholm , Richard T. McCarthy
发明人： Rudolf Schohe-Loop , Peter-Rudolf Seidel , William Bullock , Gabriele Handke , Achim Feurer , Wolfgang Roben , Georg Terstappen , Joachim Schuhmacher , Franz-Josef van der Staay , Bernard Schmidt , Richard J. Fanelli , Jane C. Chisholm , Richard T. McCarthy
IPC分类号： C07D239/95 , C07D401/14 , C07D403/14 , C07D471/04 , C07D403/02 , A61K31/505 , A61K31/535
CPC分类号： C07D401/14 , C07D239/95 , C07D403/14 , C07D471/04
摘要： The present invention provides 2,4'-bridged bis-2,4-diaminoquinazolines of the general formula (I): ##STR1## in which the indicated substituents are as defined in the description. The invention also provides a process for the preparation of the compounds of the formula (I), drugs containing said compounds and processes for the preparation of drugs containing said compounds.
摘要翻译：本发明提供了通式（I）的2,4'-桥连双-2,4-二氨基喹唑啉：ts如说明书中所定义。本发明还提供了制备式（I）化合物，含有所述化合物的药物和制备含有所述化合物的药物的方法。

4. 发明授权

US4916120A Parasiticidal avermectin derivatives 失效
标题翻译：杀虫剂阿维菌素衍生物
公开(公告)号：US4916120A
公开(公告)日：1990-04-10
申请号：US230221
申请日：1988-08-01
申请人： Wolfgang Roben , Stendel Wilhelm , Peter Andrews
发明人： Wolfgang Roben , Stendel Wilhelm , Peter Andrews
IPC分类号： C07D493/22 , A61K31/365 , A61P33/00 , C07H17/08 , C07H19/01
CPC分类号： C07H19/01
摘要： Parasiticidally active avermectin derivatives of the formula ##STR1## in which R.sup.1 stands for hydrogen, OH, C.sub.1-5 -alkanoyloxy, .alpha.-L-oleandrosyloxy, .alpha.-L-oleandrosyl-.alpha.-L-oleandrosyloxy, 4'-C.sub.1-5 -alkanoyl-.alpha.-oleandrosyloxy or 4"-C.sub.1-5 -alkanoyl-.alpha.-L-oleandrosyl-.alpha.-L-oleandrosyloxy,R.sup.2 stands for hydrogen, OH, C.sub.1-5 -alkanoyloxy, or R.sup.2 stands for hydrogen when there is a double bond between C22 and C23,R.sup.3 stands for straight-chain or branched alkyl or alkenyl, andR.sup.4 stands for hydrogen, OH, C.sub.1-5 -alkanoyloxy, heterocyclylcarbonyloxy, or the bond between the C atoms C22 and C23 is a single or a double bond and the double bond of the cyclohexene ring can be between the C atoms C3 and C4 or between the C atoms C4 and C5.
摘要翻译：其中R1代表氢，OH，C1-5-烷酰氧基，α--L-烯丙基氧基，α-L-胆烷酰基-α-胆碱硫代酰氧基，4'-C1-5的分子式活性阿维菌素衍生物 - 烷酰基-α-链烷氧基或4'-“C 1 -C 5 - 烷酰基-α-L-胆烷酰基-α-胆碱酰氧基，R2代表氢，OH，C1-5-烷酰氧基，或当R2代表氢 C22和C23之间的双键，R3表示直链或支链烷基或烯基，R4表示氢，OH，C1-5-烷酰氧基，杂环基羰基氧基，或C原子之间的键C22和C23是单或双键并且环己烯环的双键可以在C原子C3和C4之间或C原子C4和C5之间。

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