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1. 发明授权

US5492896A Pseudopeptides having an antiviral action 失效
标题翻译：具有抗病毒作用的假肽
公开(公告)号：US5492896A
公开(公告)日：1996-02-20
申请号：US196939
申请日：1994-02-15
申请人： Dieter Habich , Michael Matzke , Klaus Frobel , Thomas Henkel , Hartwig Muller , Karl-Heinz Weber , Jurgen Reefschlager , Gert Streissle , Jutta Hansen , Rainer Neumann , Arnold Paessens
发明人： Dieter Habich , Michael Matzke , Klaus Frobel , Thomas Henkel , Hartwig Muller , Karl-Heinz Weber , Jurgen Reefschlager , Gert Streissle , Jutta Hansen , Rainer Neumann , Arnold Paessens
IPC分类号： A61K38/00 , A61P31/12 , C07K1/02 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/072 , C07K5/08 , C07K5/09 , C07K14/81 , C07K5/00 , C07K7/00 , C07K17/00
CPC分类号： C07K5/0817 , C07K5/0217 , C07K5/06095 , A61K38/00
摘要： The invention relates to new pseudopeptides having an antiviral action, oft he general formula (I) ##STR1## with the meanings given in the description for the substituents, to a process for their preparation and to their use as antiviral agents, in particular against cytomegaloviruses.
摘要翻译：本发明涉及具有抗病毒作用的新的假肽，其通式（I）为取代基，其制备方法及其作为抗病毒剂，特别是针对巨细胞病毒的用途。

2. 发明授权

US5532368A Xanthine derivatives with adenosine-antagonistic activity 失效
标题翻译：黄嘌呤衍生物具有腺苷拮抗活性
公开(公告)号：US5532368A
公开(公告)日：1996-07-02
申请号：US97478
申请日：1993-07-27
申请人： Ulrike Kufner-Muhl , Karl-Heinz Weber , Gerhard Walther , Werner Stransky , Helmut Ensinger , Gunter Schingnitz , Franz J. Kuhn , Erich Lehr
发明人： Ulrike Kufner-Muhl , Karl-Heinz Weber , Gerhard Walther , Werner Stransky , Helmut Ensinger , Gunter Schingnitz , Franz J. Kuhn , Erich Lehr
IPC分类号： C07D473/06 , A61K31/495 , A61K31/52 , A61K31/522 , A61P9/00 , A61P11/08 , A61P25/00 , A61P25/02 , C07D473/08 , C07D519/00 , C07H19/04 , C07D473/04
CPC分类号： C07D473/08 , C07D473/06
摘要： Xanthines of the formula I ##STR1## wherein R.sub.1 is a C.sub.1 -C.sub.4 alkyl group:R.sub.2 is a C.sub.1 -C.sub.4 alkyl group;R.sub.3 tetrahydropyran-4-yl or 1,3-dithiolan or;R.sub.3 represents one of the groups of formula ##STR2## and pharmaceutically acceptable acid addition salts thereof. These are adenosine antagonists, capable of acting as cholinomimetics, useful for the treatment of CNS disorders such as senile dementia and Alzheimer's disease.
摘要翻译：式I的黄嘌呤其中R 1是C 1 -C 4烷基：R 2是C 1 -C 4烷基; R3四氢吡喃-4-基或1,3-二硫戊环或; R 3代表式为其中一组式的化合物及其药学上可接受的酸加成盐。这些是能够作为胆碱模拟物的腺苷拮抗剂，可用于治疗CNS疾病如老年痴呆和阿尔茨海默病。

3. 发明授权

US5185442A New diazepines substituted in the 6-position, processes for their preparation and their use as pharmaceutical compositions 失效
标题翻译：在六位置取代新的重氮化合物，其制备方法及其作为药物组合物的用途
公开(公告)号：US5185442A
公开(公告)日：1993-02-09
申请号：US821514
申请日：1992-01-15
申请人： Karl-Heinz Weber , Werner Stransky , Ulrike Kuefner-Muehl , Hubert Heuer , Franz Birke , Wolf-Dietrich Bechtel
发明人： Karl-Heinz Weber , Werner Stransky , Ulrike Kuefner-Muehl , Hubert Heuer , Franz Birke , Wolf-Dietrich Bechtel
IPC分类号： A61K31/55 , A61P1/00 , A61P1/04 , A61P7/02 , A61P9/00 , A61P11/00 , A61P13/02 , A61P15/00 , A61P17/00 , A61P29/00 , A61P37/08 , C07D495/04 , C07D495/14
CPC分类号： C07D495/04 , C07D495/14
摘要： The invention relates to new diazephines of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined herein, processes for preparing them and their use as pharmaceutical compositions useful for treating PAF-induced disease.
摘要翻译：本发明涉及式（Ⅰ）所示的新的二氮嘧啶，其中R 1，R 2和R 3如本文所定义，其制备方法及其作为可用于治疗PAF诱导的疾病的药物组合物的用途。

4. 发明授权

US5082839A Thieno-triazolo-1,4-diazepino-2-carboxylic acid amides 失效
标题翻译：噻二唑-1,4-二氮杂环戊烷-2-羧酸
公开(公告)号：US5082839A
公开(公告)日：1992-01-21
申请号：US539416
申请日：1990-06-15
申请人： Karl-Heinz Weber , Albrecht Harreus , Jorge Casals-Stenzel , Gojko Muacevic , Wolfgang Troger , Gerhard Walther
发明人： Karl-Heinz Weber , Albrecht Harreus , Jorge Casals-Stenzel , Gojko Muacevic , Wolfgang Troger , Gerhard Walther
IPC分类号： A61K31/55 , A61K31/5517 , A61P7/02 , A61P9/02 , A61P11/08 , A61P29/00 , A61P37/00 , A61P37/08 , C07C235/40 , C07D243/00 , C07D249/08 , C07D333/00 , C07D333/36 , C07D495/00 , C07D495/04 , C07D495/14
CPC分类号： C07D495/04 , C07D333/36 , C07D495/14
摘要： The invention relates to new thieno-triazolo-1,4-diazepino-2-carboxylic acid amides of formula I ##STR1## wherein R.sub.1 represents hydrogen, a C.sub.1-C.sub.4 straight-chained or branched alkyl which can optionally be substituted by halogen, preferably C1 or Br, or by hydroxy, cyclopropyl, C.sub.1 -C.sub.3 alkoxy, preferably methoxy, or halogen, preferably chlorine or bromine;R.sub.2 and R.sub.3, each independently, represent hydrogen, a C.sub.1 -C.sub.4 straight-chained or branched alkyl, C.sub.1 -C.sub.4 hydroxyalkyl or the two groups R.sub.2 and R.sub.3 together with the nitrogen atom represent a 5-, 6- or 7-membered ring which optionally contains a nitrogen, oxygen or sulfur atom as a further heteroatom, the second nitrogen atom optionally being substituted by a C.sub.1 -C.sub.4 alkyl, preferably a methyl group;R.sub.4 represents alpha-pyridyl or a phenyl in which the phenyl ring can be substituted preferably in the 2-position, by methyl, halogen, preferably chlorine or bromine, nitro or trifluoromethyl;n represents one of the numbers 0, 1, 2, 3, 4, 5, 6, 7 or 8; and novel intermediates therefor.The compounds of formula I are useful in the treatment of pathological conditions and diseases in which platelet activating factor is implicated.

5. 发明授权

US4870697A Two-way communication system for winning machines in underground mining 失效
标题翻译：地下采矿机器双向通信系统
公开(公告)号：US4870697A
公开(公告)日：1989-09-26
申请号：US85772
申请日：1987-08-17
申请人： Karl-Heinz Weber
发明人： Karl-Heinz Weber
IPC分类号： E21C35/24 , G08C17/00 , G08C25/04
CPC分类号： E21C35/24 , G08C17/00 , G08C25/04 , G08C2201/50
摘要： A two-way communication system for transmitting command signals to and receiving operating data from a winning machine utilized in underground mining operations. The system includes a send-receive facility positioned remote from the winning machine for transmitting command information to the winning machine. A receiving means is positioned at the winning machine for receiving signals sent by the send-receive facility, and a transmitting means is positioned at the winning machine for transmitting signals corresponding to operating data of the winning machine. The send-receive facility receives the information transmitted by the transmitting means, and a separable memory is separably attached to the send-receive facility for storing such operating data and the command information. Because the memory is separable, the memory may be removed to allow the data contained therein to be analyzed at a remote location.
摘要翻译：一种双向通信系统，用于向地下采矿作业中使用的获胜机器发送命令信号并接收操作数据。该系统包括远离获胜机器的发送接收设备，用于将命令信息发送到获胜机器。接收装置位于获胜机器处，用于接收由发送接收设备发送的信号，并且发送装置位于获胜机器处，用于发送与获胜机器的操作数据相对应的信号。发送接收设备接收由发送装置发送的信息，并且可分离存储器可分离地附接到用于存储这种操作数据和命令信息的发送接收设施。因为存储器是可分离的，所以可以移除存储器以允许其中包含的数据在远程位置被分析。

6. 发明授权

US4762832A Morpholine containing pyrrolidinones pharmaceutical compositions and use 失效
标题翻译：含吡咯烷酮的吗啉药物组合物及用途
公开(公告)号：US4762832A
公开(公告)日：1988-08-09
申请号：US943532
申请日：1986-12-18
申请人： Karl-Heinz Weber , Claus Schneider , Gerhard Walther , Dieter Hinzen , Franz J. Kuhn , Erich Lehr , Helmut Ensinger , Wolfgang Troger
发明人： Karl-Heinz Weber , Claus Schneider , Gerhard Walther , Dieter Hinzen , Franz J. Kuhn , Erich Lehr , Helmut Ensinger , Wolfgang Troger
IPC分类号： A61K31/40 , A61K31/4015 , A61K31/4427 , A61K31/445 , A61K31/495 , A61K31/535 , A61P25/00 , A61P25/28 , C07D207/26 , C07D401/12 , C07D413/12 , C07D451/02 , C07D487/08
CPC分类号： C07D207/26 , C07D401/12 , C07D413/12 , C07D451/02
摘要： The invention relates to new substituted pyrrolidinones of general formula ##STR1## wherein R.sub.1 represents a phenyl group which may be mono- or di-substituted by methyl, methoxy, fluorine, chlorine, bromine or trifluoromethyl, or a pyridyl group;R.sub.2 represents hydrogen or a straight-chained or branched alkyl group with 1-4 carbon atoms;R.sub.3 represents a straight-chained or branched alkyl group with 1-3 carbon atoms, a hydroxyalkyl group with 2-3 carbon atoms, a phenyl group which can be mono- or di-substituted by chlorine, bromine, methyl or methoxy, a cyclohexyl group or a dialkylamino alkyl group, where in each alkyl group can contain from 1-3 carbon atoms;R.sub.4 represents hydrogen or a straight-chained or branched alkyl group with 1-3 carbon atoms; orR.sub.3 and R.sub.4 together with the nitrogen atom represents a piperidine, morpholine or piperazine ring, while the ring may be substituted by 1 or 2 methyl groups and the piperazine ring at the nitrogen atom in 4-position may also carry a phenyl, chlorophenyl or benzyl group, or they may represent the nortropanyl group, processes for preparing them and pharmaceutical compositions.The new compounds have proved effective in animal trails in alleviating or remedying conditions or restricted cerebral performance.
摘要翻译：本发明涉及通式为（I）的新的取代的吡咯烷酮，其中R 1表示可被甲基，甲氧基，氟，氯，溴或三氟甲基或吡啶基单取代或二取代的苯基; R 2表示氢或具有1-4个碳原子的直链或支链烷基; R3表示具有1-3个碳原子的直链或支链烷基，具有2-3个碳原子的羟烷基，可被氯，溴，甲基或甲氧基单取代或二取代的苯基，环己基基团或二烷基氨基烷基，其中在每个烷基中可以含有1-3个碳原子; R4表示氢或具有1-3个碳原子的直链或支链烷基; 或R 3和R 4与氮原子一起代表哌啶，吗啉或哌嗪环，而环可以被1或2个甲基取代，4-位氮原子上的哌嗪环也可以带有苯基，氯苯基或或它们可以代表异丙基丙基，其制备方法和药物组合物。新化合物已被证明在减轻或补救病症或限制性脑部表现方面在动物踪迹中是有效的。

7. 发明授权

US4622319A Methods of using PAF-antagonistic diazepines 失效
标题翻译：使用PAF拮抗二氮杂的方法
公开(公告)号：US4622319A
公开(公告)日：1986-11-11
申请号：US782631
申请日：1985-10-01
申请人： Jorge Casals-Stenzel , Karl-Heinz Weber , Gerhard Walther , Albrecht Harreus , Gojko Muacevic
发明人： Jorge Casals-Stenzel , Karl-Heinz Weber , Gerhard Walther , Albrecht Harreus , Gojko Muacevic
IPC分类号： C07D495/04 , A61K31/00 , A61K31/55 , A61P7/02 , A61P11/08 , A61P43/00 , C07D243/00 , C07D243/12 , C07D401/04 , C07D471/04
CPC分类号： A61K31/55
摘要： The invention discloses a method of treating an individual having a disorder responsive to PAF-antagonist activity by treating the individual with a compound of formula I or II ##STR1## wherein A is an anellated and optionally substituted benzene or 5- or 6-membered heterocyclic ring; R.sub.5 and Z are each independently hydrogen or an optionally substituted C.sub.1 -C.sub.8 alkyl, alkenyl or alkynyl; R.sub.6 is an optionally substituted phenyl, or is thienyl or is .alpha.-pyridyl; Y is CO, CS or CH.sub.2 ; and nontoxic, pharmaceutically acceptable acid addition salts thereof.
摘要翻译：本发明公开了一种通过用式I或II化合物或其药学上可接受的盐或其药物可接受的方法治疗患有对PAF拮抗剂活性的病症的个体的方法。取代的苯或5-或6-元杂环; R 5和Z各自独立地为氢或任选取代的C 1 -C 8烷基，烯基或炔基; R6是任选取代的苯基，或是噻吩基或是α-吡啶基; Y是CO，CS或CH2; 和无毒的药学上可接受的酸加成盐。

8. 发明授权

US4482559A 4-Phenyl-4,5,6,7-tetrahydro-thieno [2,3-c]pyridines, compositions and use 失效
标题翻译： 4-苯基-4,5,6,7-四氢 - 噻吩并[2,3-c]吡啶，组合物和用途
公开(公告)号：US4482559A
公开(公告)日：1984-11-13
申请号：US466100
申请日：1983-02-14
申请人： Claus Schneider , Gerhard Walther , Karl-Heinz Weber , Wolf D. Bechtel , Karin Boke-Kuhn
发明人： Claus Schneider , Gerhard Walther , Karl-Heinz Weber , Wolf D. Bechtel , Karin Boke-Kuhn
IPC分类号： A61K31/435 , A61P25/24 , A61P25/26 , C07D495/04 , A61K31/44
CPC分类号： C07D495/04
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is amino, acetylamino, hydroxymethyl, methoxymethyl or ##STR2## R.sub.2 and R.sub.3, which may be identical to or different from each other, are each hydrogen, fluorine, chlorine, bromine, trifluoromethyl, hydroxyl, methoxy, methyl or ethyl;R.sub.4 is straight or branched alkyl of 1 to 3 carbon atoms; andR.sub.5 and R.sub.6, which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 4 carbon atoms or, together with each other and the nitrogen atom to which they are attached, form a 5-, 6- or 7-membered heterocyclic ring where, in the case of a 6-membered ring, a --CH.sub.2 -group in the ring may be replaced by an oxygen atom, and non-toxic, pharmacologically acceptable salts thereof. The compounds as well as their salts are useful as antidepressants.
摘要翻译：其中R 1是氨基，乙酰氨基，羟甲基，甲氧基甲基或者R 2和R 3的式（I）化合物可以相同或不同，分别是氢，氟，氯，溴，三氟甲基，羟基，甲氧基，甲基或乙基; R4是1〜3个碳原子的直链或支链烷基; 和可以相同或不同的R 5和R 6各自为氢或1至4个碳原子的烷基，或彼此连接并与它们相连的氮原子形成5-，6- 或7-元杂环，其中在6元环的情况下，环中的-CH 2 - 基可被氧原子取代，及其无毒的药学上可接受的盐。化合物及其盐可用作抗抑郁药。

9. 发明授权

US4313931A Fused dibenzo imidazolo compounds, compositions and use 失效
标题翻译：稠合二苯并咪唑化合物，组合物和用途
公开(公告)号：US4313931A
公开(公告)日：1982-02-02
申请号：US236818
申请日：1981-02-23
申请人： Gerhard Walther , Claus S. Schneider , Karl-Heinz Weber , Armin Fugner
发明人： Gerhard Walther , Claus S. Schneider , Karl-Heinz Weber , Armin Fugner
IPC分类号： A61K31/5365 , A61K31/542 , A61K31/55 , A61P7/02 , A61P11/06 , A61P17/00 , A61P27/02 , A61P31/16 , A61P37/08 , A61P43/00 , C07D223/20 , C07D267/20 , C07D281/16 , C07D487/04 , C07D498/04 , C07D513/04 , A61K31/535 , A61K31/415
CPC分类号： C07D487/04 , C07D223/20 , C07D267/20 , C07D281/16 , C07D513/04 , Y10S514/826 , Y10S514/849 , Y10S514/912
摘要： This invention relates to a compound of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, and R.sub.4, which may be the same or different, each represent a hydrogen or halogen atom or an alkyl or alkoxy group of from 1 to 6 carbon atoms;R.sub.5 and R.sub.6, which may be the same or different, each represent a hydrogen atom, an alkyl group of from 1 to 6 carbon atoms, or an alkenyl group of from 3 to 6 carbon atoms, or R.sub.5 and R.sub.6 together with the nitrogen atom to which they are attached represent a pyrrolidino, piperidino, or morpholino group; andX represents oxygen, sulfur, or a methylene group,or a non-toxic, pharmacologically acceptable acid addition salt thereof, or a racemate, enantiomer, or mixture of enantiomers thereof. The compounds of Formula I are useful in pharmaceutical compositions for treating bronchial asthma and allergic bronchitis.
摘要翻译：本发明涉及式（I）的化合物，其中R 1，R 2，R 3和R 4可以相同或不同，分别表示氢或卤素原子或烷基或烷氧基， 6个碳原子; R 5和R 6可以相同或不同，分别表示氢原子，1〜6个碳原子的烷基或3〜6个碳原子的链烯基，或者R5和R6与氮原子一起它们所连接的表示吡咯烷基，哌啶子基或吗啉基; X表示氧，硫或亚甲基，或其无毒的药学上可接受的酸加成盐，或其外消旋物，对映异构体或其对映异构体的混合物。式I的化合物可用于治疗支气管哮喘和过敏性支气管炎的药物组合物。

10. 发明授权

US5688802A Bornyl xanthine derivatives with adenosine-antagonistic activity 失效
标题翻译：具有腺苷拮抗作用的牛磺酸黄嘌呤衍生物
公开(公告)号：US5688802A
公开(公告)日：1997-11-18
申请号：US663417
申请日：1996-06-14
申请人： Ulrike Kufner-Muhl , Karl-Heinz Weber , Gerhard Walther , Werner Stransky , Helmut Ensinger , Gunter Schingnitz , Franz Josef Kuhn , Erich Lehr
发明人： Ulrike Kufner-Muhl , Karl-Heinz Weber , Gerhard Walther , Werner Stransky , Helmut Ensinger , Gunter Schingnitz , Franz Josef Kuhn , Erich Lehr
IPC分类号： C07D473/06 , A61K31/495 , A61K31/52 , A61K31/522 , A61P9/00 , A61P11/08 , A61P25/00 , A61P25/02 , C07D473/08 , C07D519/00 , C07H19/04
CPC分类号： C07D473/08 , C07D473/06
摘要： The invention relates to new xanthine derivatives of general formula I, processes for preparing them and their use as pharmaceutical compositions.
摘要翻译：本发明涉及通式I的新型黄嘌呤衍生物，其制备方法及其作为药物组合物的用途。

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