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1. 发明授权

US4848402A Rotary slide valve for hydraulic auxiliary power steerings 失效
标题翻译：液压辅助动力转向旋转滑阀
公开(公告)号：US4848402A
公开(公告)日：1989-07-18
申请号：US946710
申请日：1986-12-04
申请人： Dieter Elser , Helmut Hetzel , Manfred Keller
发明人： Dieter Elser , Helmut Hetzel , Manfred Keller
IPC分类号： B62D5/083 , F16K11/085 , F16K47/04
CPC分类号： B62D5/083 , F16K47/045 , Y10T137/86654 , Y10T137/86662
摘要： A rotary valve assembly having a valve sleeve and a rotary valve core are provided with flow control grooves having control edges distributed over the peripheries for regulation of pressurized fluid. Such pressure regulation occurs at the control edges forming sets of three gaps in each rotational direction of the steering control valve. One of such gaps forms a relatively deep return flow passage that is fully opened in the neutral position of the valve assembly and two throttle gaps on opposite sides thereof that are relatively shallow for restricted return flow. Rotational displacement of the valve core initially effects pressure regulation through the intermediate deep gap within a low pressure range. Continued rotation of the rotary valve core effects pressure regulation within a high pressure range by return flow through the other gaps conducting restricted flow, to both continue pressure regulation within the high pressure range and suppress hissing noises developed in response to entry of pressurized fluid.
摘要翻译： PCT No.PCT / EP86 / 00181 Sec。一九八六年十二月四日 102（e）日期1986年12月4日PCT提交1986年3月26日PCT公布。出版物WO86 / 06228 PCT 日本1986年10月23日。具有阀套和旋转阀芯的旋转阀组件设置有流量控制槽，其具有分布在周边上的控制边缘，用于调节加压流体。这种压力调节发生在控制边缘，在转向控制阀的每个旋转方向上形成三组间隙。这种间隙之一形成相对较深的回流通道，其在阀组件的中间位置处完全打开，并且在其相对侧上的两个节气门间隙对于受限回流而相对较浅。阀芯的旋转位移最初通过中间深度间隙在低压范围内实现压力调节。旋转阀芯的继续旋转通过返回流动通过其它间隙进行限制流动来在高压范围内实现压力调节，以在高压范围内继续压力调节，并且抑制响应加压流体进入而产生的嘶嘶声。

2. 发明授权

US4029124A Power steering control valve 失效
标题翻译：动力转向控制阀
公开(公告)号：US4029124A
公开(公告)日：1977-06-14
申请号：US576147
申请日：1975-05-09
申请人： Manfred Keller , Dieter Elser
发明人： Manfred Keller , Dieter Elser
IPC分类号： B62D5/08 , F15B13/14
CPC分类号： B62D5/08 , Y10T137/87177
摘要： There is disclosed a control valve arrangement for power steering systems having a servomotor piston which carries a piston valve constructed with a pair of reaction chambers having relief valves and communicating with each other in such a manner as to provide variable resistance against the manual force being applied to a steering wheel which actuates the piston valve. The purpose of thus effecting an automatically varying force is to impart to the vehicle driver a simulated sense of mechanical steering, i.e., simulated road resistance feel, but with a decreasing requirement of force expenditure during vehicle parking operations, or during low speed driving. The construction permits the use of simple parts in a very compact arrangement in which either reaction chamber imparts road resistance feel by being subjected only to servopump inlet pressure while the other is subjected to exhaust pressure. The unbalance of force acts on the piston valve in a direction opposite the manually impressed force. However, both reaction chambers have relief valves, biased closed, but exposed upstream to inlet pressure. Should that pressure exceed a certain limit, the reaction chamber under exhaust pressure will have an inlet pressure feed mixing with exhaust pressure to effect a force opposing the road resistance force of the other reaction chamber. Thus, manual steering effort during parking or driving at slow speeds is decreased even though servomotor pressure may increase.
摘要翻译：公开了一种用于动力转向系统的动力转向系统，该动力转向系统具有伺服电机活塞，该伺服电机活塞承载由具有安全阀的一对反应室构成的活塞阀，并且以相对于施加的手动力提供可变阻力的方式彼此连通到致动活塞阀的方向盘。因此，实现自动变化的力的目的是赋予车辆驾驶员模拟的机械转向感，即模拟道路阻力感，但是在车辆驻车操作期间或在低速行驶期间对力消耗的要求降低。该结构允许以非常紧凑的布置使用简单部件，其中任一反应室通过仅受到伺服泵入口压力而另一个受到排气压力而施加阻力感。力的不平衡作用在与手动加压力相反的方向上的活塞阀上。然而，两个反应室都具有泄压阀，偏压闭合，但在上游暴露于入口压力。如果该压力超过一定限度，则在排气压力下的反应室将具有与排气压力混合的入口压力进料，以产生与另一个反应室的道路阻力相反的力。因此，即使伺服电动机的压力可能增加，在停车或慢速驾驶时的手动转向力降低。

3. 发明申请

US20090232744A1 Macrolide compositions having improved taste and stability 审中-公开
标题翻译：具有改善的味道和稳定性的大环内酯组合物
公开(公告)号：US20090232744A1
公开(公告)日：2009-09-17
申请号：US12380378
申请日：2009-02-26
申请人： Manfred Keller , Evy Corbanie
发明人： Manfred Keller , Evy Corbanie
IPC分类号： A61K9/12 , A61K31/7048 , A61K31/7028
CPC分类号： A61K9/0078 , A61K31/7028 , A61K31/7048 , A61K47/12
摘要： The invention provides an aqueous pharmaceutical composition for administration as an aerosol to the respiratory tract, nose or oropharyngeal region comprising (i) a macrolide having a poor taste and poor chemical stability in aqueous solution; (ii) at least one salt selected from the group consisting of sodium gluconate, sodium aspartate, sodium acetate, sodium lactate, sodium succinate, sodium maleate, magnesium gluconate, magnesium aspartate, magnesium citrate, magnesium acetate, magnesium lactate, magnesium succinate, and magnesium maleate; or mixtures thereof and (iii) a taste-masking agent different from said salt; wherein (a) the concentration of said macrolide in the composition is in the range of about 0.25 wt.-% to about 15 wt.-%; (b) the molar ratio of said macrolide:said salt is in the range from about 1:0.5 to about 1:100; (c) the pH of the composition is in the range of about 3 to 9; and (d) the osmolality of the composition is in the range of about 150 mOsmol/kg to about 1500 mOsmol/kg. The invention further provides a method of generating an aerosol, preferably by means of a nebuliser, which uses such an aqueous pharmaceutical composition. The macrolide may be used alone or in combination with other drugs. The composition is suitable to treat inflammatory disorders and/or infections of the respiratory tract. It has an improved taste and stability.
摘要翻译：本发明提供一种用于作为气溶胶施用于呼吸道，鼻或口咽区域的水性药物组合物，其包含（i）具有差的味道和在水溶液中的化学稳定性差的大环内酯类; （ii）至少一种选自葡萄糖酸钠，天冬氨酸钠，乙酸钠，乳酸钠，琥珀酸钠，马来酸钠，葡糖酸镁，天冬氨酸镁，柠檬酸镁，乙酸镁，乳酸镁，琥珀酸镁和马来酸镁或其混合物和（iii）不同于所述盐的掩味剂; 其中（a）所述大环内酯在组合物中的浓度在约0.25重量％至约15重量％的范围内; （b）所述大环内酯：所述盐的摩尔比在约1:0.5至约1:100的范围内; （c）组合物的pH在约3至9的范围内; 和（d）组合物的重量摩尔渗透压浓度在约150mOsmol / kg至约1500mOsmol / kg的范围内。本发明还提供了一种产生气雾剂的方法，优选通过使用这种水性药物组合物的雾化器。大环内酯可以单独使用或与其他药物组合使用。该组合物适用于治疗炎症性疾病和/或呼吸道感染。它具有改善的味道和稳定性。

4. 发明申请

US20090025713A1 Nebulised Antibiotics for Inhalation Therapy 审中-公开
标题翻译：用于吸入治疗的雾化抗生素
公开(公告)号：US20090025713A1
公开(公告)日：2009-01-29
申请号：US12223735
申请日：2007-02-08
申请人： Manfred Keller , Aslihan Akkar
发明人： Manfred Keller , Aslihan Akkar
IPC分类号： A61K9/12 , A61K47/38 , A61K47/36 , A61K47/40 , A61P11/00
CPC分类号： A61K9/0078 , A61K9/0043 , A61K31/4709 , A61K31/496 , A61K31/535 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/6951 , B82Y5/00 , Y02A50/473 , Y02A50/478
摘要： The present invention provides pharmaceutical aerosols which are useful for the prevention or treatment of infectious diseases of the airways, such as the lungs, the bronchi, or the sinunasal cavities. The aerosols comprise an active agent selected from the group of quinolone antibiotics. Also disclosed are liquid and solid compositions suitable for being converted into the aerosols, and kits comprising such compositions.
摘要翻译：本发明提供了可用于预防或治疗气道如肺，支气管或鼻腔的传染病的药用气溶胶。气溶胶包含选自喹诺酮类抗生素的活性剂。还公开了适于转化成气溶胶的液体和固体组合物，以及包含这种组合物的试剂盒。

5. 发明授权

US07173712B2 Method and device for increasing the long-term operational reliability of a fiber optic interferometer 有权
标题翻译：提高光纤干涉仪长期运行可靠性的方法和装置
公开(公告)号：US07173712B2
公开(公告)日：2007-02-06
申请号：US10485579
申请日：2002-07-26
申请人： Manfred Keller
发明人： Manfred Keller
IPC分类号： G01C19/72
CPC分类号： G01C19/721
摘要： A method for increasing the long-term operational reliability of a fiber optic interferometer. Noise in a detector output signal is set to a desired value by correcting the detector light power. Detector light power is corrected by varying a light source current of a light source of the interferometer. A change in the light source power results. It is thereby possible to increase both the reliability and useful life of the interferometer.
摘要翻译：一种提高光纤干涉仪长期运行可靠性的方法。通过校正检测器光功率将检测器输出信号中的噪声设置为期望值。通过改变干涉仪的光源的光源电流来校正检测器光功率。导致光源功率的变化。从而可以提高干涉仪的可靠性和使用寿命。

6. 发明申请

US20050244339A1 Pharmaceutical aerosol composition 有权
标题翻译：药物气溶胶组成
公开(公告)号：US20050244339A1
公开(公告)日：2005-11-03
申请号：US11106999
申请日：2005-04-14
申请人： Jurgen Jauernig , Frank-Christophe Lintz , Manfred Keller , Ingo Friedrich
发明人： Jurgen Jauernig , Frank-Christophe Lintz , Manfred Keller , Ingo Friedrich
IPC分类号： A61K9/00 , A61K9/107 , A61K9/127 , A61K9/19 , A61L9/04
CPC分类号： A61K9/1075 , A61K9/0078 , A61K9/127 , A61K9/19
摘要： Sterile compositions for administration as aerosols are described. They contain an active agent which is poorly water-soluble, a non-ionic surfactant acomponent and a phospholipid component. The compositions are suitable for oral or nasal inhalation, but also for topical or oromucosal administration. They are particulary useful for the efficient pulmonary administration of poorly soluble corticosteroids and can be aerosolized with common nebulizers.
摘要翻译：描述了作为气溶胶施用的无菌组合物。它们含有水溶性差的活性剂，非离子表面活性剂组分和磷脂组分。所述组合物适用于口服或鼻吸入，也适用于局部或粘膜粘膜给药。它们对于有效的肺部给药难溶性皮质类固醇是特别有用的，并且可以用普通喷雾器进行雾化。

7. 发明授权

US06475467B1 Medicinal aerosol formulations 有权
标题翻译：药用气雾剂
公开(公告)号：US06475467B1
公开(公告)日：2002-11-05
申请号：US09744798
申请日：2001-04-20
申请人： Manfred Keller , Kurt Herzog , Rudi Müller-Walz , Holger Kraus
发明人： Manfred Keller , Kurt Herzog , Rudi Müller-Walz , Holger Kraus
IPC分类号： A61K912
CPC分类号： A61K9/008 , A61K9/124 , A61K47/22
摘要： The use of solid, pharmaceutically acceptable salts of cromoglycic acid and/or nedocromil as carriers in a therapeutically and prophylactically inefficacious amount in suspension aerosol formulations of pharmaceutical active compounds improves the dispersion properties, increases the chemical and physical stability of moisture-sensitive active compounds, makes possible a more accurate dosage, in particular even of low-dose active compounds, and as a rule permits the abandonment of surface-active agents.
摘要翻译：在治疗和预防无效量的药物活性化合物的悬浮气雾剂制剂中使用色甘酸和/或奈多罗米的固体药学上可接受的盐作为载体改善了分散性能，提高了湿敏性活性化合物的化学和物理稳定性，使得可能更准确的剂量，特别是甚至低剂量活性化合物，并且通常允许放弃表面活性剂。

8. 发明授权

US4973227A Method of producing a vacuum 失效
标题翻译：制造真空的方法
公开(公告)号：US4973227A
公开(公告)日：1990-11-27
申请号：US367025
申请日：1989-06-16
申请人： Otto Bernauer , Clemens Halene , Manfred Keller
发明人： Otto Bernauer , Clemens Halene , Manfred Keller
IPC分类号： B01J3/00 , C01B3/00 , F04B37/02
CPC分类号： F04B37/02
摘要： A method of producing a vacuum in a volume of a hollow body which has at least one outlet opening for the gaseous atmosphere present therein, the method includes the following steps: introducing at least about 3 g/dm.sup.3 of evacuation volume of a metal hydride into the hollow body so as to take up less than about 5% of the volume 3. The metal hydride comprises a hydride forming alloy of the formulaTi(V.sub.1-a-b Fe.sub.a Al.sub.b).sub.xy Mn.sub.z,wherein1
摘要翻译：一种在具有至少一个气体气氛出口的中空体的体积中产生真空的方法，该方法包括以下步骤：将至少约3g / dm 3的金属氢化物排空体积引入空心体以便占据体积3的小于约5％。金属氢化物包括式Ti（V1-ab FeaAlb）xyMnz的氢化物形成合金，其中1 = = 0 0 z 。将金属氢化物加热到使氢化物中释放大量气态氢的温度，进行加热步骤，使中空体的加热温度不超过约500℃。用从氢化物释放的气态氢冲洗体积，从而在释放之前更换体积中存在的气体气氛; 关闭中空体的出口; 冷却空心体; 并用氢化物形成合金吸收气态氢。

9. 发明授权

US4707606A Proportional counter for detecting surface contaminations 失效
标题翻译：用于检测表面污染物的比例计数器
公开(公告)号：US4707606A
公开(公告)日：1987-11-17
申请号：US658114
申请日：1984-10-05
申请人： Manfred Keller
发明人： Manfred Keller
IPC分类号： H01J47/00 , H01J47/06 , G01T1/18
CPC分类号： H01J47/06 , H01J47/002
摘要： Proportional counters for the detection and measurement of radioactive surface contaminations are provided with at least two flat window faces enclosing an angle and being formed by a thin foil spread or stretched by a framework including thin rods arranged along the inner edges of contacting window faces, to which rods the foil may be adhered. A perforated lattice or grid cage serves in particular to protect the thin window against any contact, the cage provides for a spacing of about double rod thickness between the framework and the controlled surface. Preferred is a polygonal and in particular hexagonal lattice whose grid wires or strips do not lie in the main scanning direction. Particularly convenient for checking pipelines are, for example, cylindrical measuring probes comprising window foils extending over and perhaps adhered to a circularly arranged frame of thin rods.
摘要翻译：用于检测和测量放射性表面污染物的比例计数器设置有至少两个平坦的窗口面，其包围一角度，并且由薄片展开形成，薄的薄片由包括沿着接触窗面的内边缘布置的细棒的框架延伸或拉伸，哪个棒可以粘附。穿孔格栅或格栅笼特别用于保护薄窗不受任何接触，保持架在框架和受控表面之间提供约双重杆厚度的间隔。优选的是多边形，特别是其网格线或条不位于主扫描方向的六边形格子。检查管道特别方便的是例如圆柱形测量探针，其包括延伸并可能粘附到圆形的细棒框架上的窗口箔。

10. 发明授权

US4506157A Thermoluminescence dosimeter taking account of tissue depth of dose 失效
标题翻译：考虑组织深度剂量的热释光剂量计
公开(公告)号：US4506157A
公开(公告)日：1985-03-19
申请号：US336611
申请日：1982-01-04
申请人： Manfred Keller
发明人： Manfred Keller
IPC分类号： G01T1/11 , G01T1/00
CPC分类号： G01T1/11
摘要： Three dosimeter disks of a thickness increasing towards the base piece which is to lie against the skin are used, with a covering of .beta. ray window for thermoluminescence dosimetry. In order to provide dosimetry referred to a 70 um depth of living tissue, corresponding to a weight of material per unit area of 7 mg/cm.sup.2, it is found that the thermoluminescent dosimeter (TLD) disk, which is next to the .beta. window, should have a weight per unit area in the range from 15 to 30 mg/cm.sup.2. A three-disk dosimeter should have TLD disks of increasing weight per unit area in the ratio 1:3:7 or, at any rate, the weight of the middle disk should be in the range from 30 to 90 mg/cm.sup.2, and the third disk should have a weight of at least 90 mg/cm.sup.2. TLD's are conventionally made of LiF crystals embedded in PTFE.
摘要翻译：使用三个剂量计盘，其厚度朝着贴在皮肤上的基片上增加，并具有用于热发光剂量测定法的β射线窗口的覆盖物。为了提供称为70μm深度的生物体组织的剂量测定，对应于每单位面积的材料的重量为7mg / cm 2，发现在β窗口旁边的热发光剂量计（TLD）盘，每单位面积的重量应在15至30mg / cm2的范围内。三盘剂量计应该具有以1:3:7的比例增加每单位面积重量的TLD盘，或者无论如何，中盘的重量应在30至90mg / cm2的范围内，并且第三盘应该具有至少90mg / cm 2的重量。 TLD通常由嵌入PTFE的LiF晶体制成。

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