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    • 3. 发明授权
    • Diagnostic composition for the detection of leukocytes and chromogens
useful therein
    • 用于检测其中有用的白细胞和色原体的诊断组合物
    • US4296202A
    • 1981-10-20
    • US63211
    • 1979-08-02
    • Dieter BergerFranz BraunGunter FreyWerner GuthleinManfred Kuhr
    • Dieter BergerFranz BraunGunter FreyWerner GuthleinManfred Kuhr
    • C09B43/20C09B43/18C09B43/28G01N33/50
    • C09B43/18G01N33/5094
    • Novel diagnostic composition for the detection of leukocytes in body fluids, comprising an absorbent carrier impregnated with a buffer substance and a chromgen, wherein the chromogen is an azo dyestuff ester of the formulaA--N.dbd.N--B(OR).sub.nwhereinA is a five- or six-membered heterocyclic radical of up to 2 hetero ring atoms selected from nitrogen, sulfur and oxygen, and wherein the heterocyclic ring may be substituted with at least one member of the group selected from halogen, lower alkyl and lower alkoxy; orA is phenyl substituted by at least one member of the group selected from lower alkyl, lower alkoxy, nitro, sulphanato and acylamino;B is benzene, naphthalene or quinolone, optionally substituted with one or two radicals selected from sulphanato, lower alkoxy and lower alkoxypoly-alkyleneoxy;R is a carboxylic acid residue or an amino acid or peptide residue having a nitrogen protective group; andn is 1 or 2.
    • 用于检测体液中白细胞的新型诊断组合物,其包含浸渍有缓冲物质和染色剂的吸收剂载体,其中所述色原是式AN = NB(OR)n的偶氮染料酯,其中A是五或 多至2个选自氮,硫和氧的杂环原子的六元杂环基,其中杂环可以被选自卤素,低级烷基和低级烷氧基中的至少一个基团取代; 或A是被选自低级烷基,低级烷氧基,硝基,磺酰基和酰氨基中的至少一个基团取代的苯基; B是苯,萘或喹诺酮,任选地被一个或两个选自磺酰基,低级烷氧基和低级烷氧基聚 - 亚烷氧基的基团取代; R是具有氮保护基团的羧酸残基或氨基酸或肽残基; n为1或2。
    • 4. 发明授权
    • Diagnostic agents for the detection of proteolytic enzymes
    • 用于检测蛋白水解酶的诊断剂
    • US4278763A
    • 1981-07-14
    • US99180
    • 1979-11-30
    • Dieter BergerFranz BraunWerner GuthleinManfred KuhrWolfgang Werner
    • Dieter BergerFranz BraunWerner GuthleinManfred KuhrWolfgang Werner
    • C07D209/36C07D209/12C07D333/64C07K1/113C07K5/04C07K7/06C12Q1/37G01N33/48G01N33/50C12Q1/38
    • C12Q1/37C12Q2334/50
    • The present invention provides a diagnostic agent for the detection of proteolytic enzymes, comprising an absorbent carrier, a film layer, a powder mixture, a lyophilisate, a solution or a reagent tablet, containing at least one chromogen and an appropriate buffer substance, wherein the chromogen used is an indoxyl- and/or thioindoxyl-amino acid ester and/or peptide ester of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which can be the same or different, are hydrogen or halogen atoms, lower alkyl, lower alkoxy, aryl, aralkyl, aralkoxy, hydroxyl, carboxy, carboxy lower alkoxy, aralkoxycarbonyl, aralkyloxycarbonyl lower alkoxy, nitro or lower acylamino radicals, whereby two adjacent substituents can also represent an optionally halogenated fused benzene ring, X is a sulphur atom or an imino group optionally substituted by a lower alkyl, aryl, aralkyl or acyl radical, A is an amino acid or peptide residue and B is a nitrogen protective group conventional in peptide chemistry or derived therefrom.The present invention also provides new compounds of the above-given general formula and processes for the preparation thereof.Furthermore, the present invention is concerned with the use of the compounds of the above-given general formula for the production of diagnostic agents for the detection of proteolytic enzymes.
    • 本发明提供了用于检测蛋白水解酶的诊断剂,其包含含有至少一种色原体和适当的缓冲物质的吸收剂载体,膜层,粉末混合物,冻干物,溶液或试剂片剂,其中 使用的色原是通式为:其中R 1,R 2,R 3和R 4可以相同或不同,为氢或卤素原子的通式如下的吲哚氧基和/或硫代吲哚氧基 - 氨基酸酯和/或肽酯: 低级烷基,低级烷氧基,芳基,芳烷基,芳烷氧基,羟基,羧基,羧基低级烷氧基,芳烷氧基羰基,芳烷氧基羰基低级烷氧基,硝基或低级酰基氨基,其中两个相邻的取代基也可以表示任选卤代的稠合苯环,X是硫 原子或任选被低级烷基,芳基,芳烷基或酰基取代的亚氨基,A是氨基酸或肽残基,B是肽化学中常规的氮保护基或 从其衍生。 本发明还提供了上述给出的通式的新化合物及其制备方法。 此外,本发明涉及上述给出的通式的化合物用于产生用于检测蛋白水解酶的诊断剂的用途。
    • 6. 发明授权
    • Elastic muslin bandage
    • 弹力棉布绷带
    • US4236550A
    • 1980-12-02
    • US874158
    • 1978-02-01
    • Franz BraunEwald Schafer
    • Franz BraunEwald Schafer
    • D03D15/08
    • D03D15/08
    • The invention relates to an elastic muslin bandage with in part elastic and non-elastic threads and with non-elastic weft threads which can be used elastically and as a fixing dressing having a high elastic behavior, permits an easy application to conical extremities and joints, is conductive to moisture and heat so that no moisture and heat chambers form, and in which slipping of the individual bandage layers is prevented, whereby the bandage is constructed in such a way that in the warp the web has textured polyfilic polyamide threads of thickness Td 70/13/2 or a lighter or heavier titre varying therefrom as the elastic element and threads of 17 tex staple fibre and/or bleached cotton of size Nm 60 or the like as the rigid element in a ratio 1:1, 1:2, 1:3, 2:1, 2:2, 2:3, 2:4 or the like, and in the case of a ratio of 1:1 in a number of 59 textured polyfilic polyamide fibres and 58 staple fibres based on the web width of 10 cm, and in the weft threads of 17 tex bleached cotton and/or staple fibre or a blended yarn of cotton/staple fibre of size Nm 60 or the like in a number of 68 threads per 10 cm and/or in the case of a ratio of 1:2, 39 textured polyfilic polyamide fibres and 78 staple fibres and/or bleached cotton fibres or blended yarn filaments of cotton/staple fibre and/or in the case of a ratio of 1:3, 29 textured polyfilic polyamide fibres and 88 staple fibre and/or bleached cotton threads or blended yarn filaments of cotton/staple fibre based on a web width of 10 cm.
    • 本发明涉及一种具有部分弹性和非弹性线的弹性棉布绷带和可弹性使用的非弹性纬纱,并且作为具有高弹性性能的定影敷料,可以容易地应用于圆锥形末端和接头, 对湿气和热量具有导电性,使得不形成湿气和热室,并且其中防止单个绷带层的滑动,由此绷带以这样的方式构造,使得在经纱中,幅材具有纹理的厚度为Td的多层聚酰胺线 70/13/2或更轻或更重的滴定剂作为刚性元件的比例为1:1,1:2的弹性元件和17tex短纤维和/或尺寸为Nm 60等的漂白棉的弹性元件和线 ,1:3,2:1,2:2,2:3,2:4等,并且在59个织构的多聚聚酰胺纤维和58个短纤维的数量比为1:1的情况下,基于 腹板宽度为10厘米,17纬纱的纬纱和/或 短纤维或尺寸为Nm 60等的棉/短纤维的混合纱线,每十厘米数68根线,和/或比例为1:2,39织构的多聚聚酰胺纤维和78短纤维 和/或漂白的棉纤维或棉/短纤维的混纺纱线长丝和/或在比例为1:3,29织构的多聚酰胺纤维和88短纤维和/或漂白棉线或棉花混纺纱线的情况下 /基于幅宽为10cm的短纤维。
    • 7. 发明授权
    • Electrostatic coating guns
    • 静电喷枪
    • US4171098A
    • 1979-10-16
    • US788592
    • 1977-04-18
    • Franz Braun
    • Franz Braun
    • B05B5/053H01B19/00H01F27/02H01G4/38B05B5/02
    • H01F27/022B05B5/0531H01B19/00H01G4/385
    • Electrostatic coating guns are described wherein a conduit for coating material extends from a handle part, and a high-tension electrostatic generator, constructed as a block or unit, may be replaceably mounted on the handle part. The high-tension generator consists of an electrostatic cascade device wholly embedded in an insulating moulded composition and arranged to apply full high tension to the muzzle end of the gun, this high tension decreasing towards the handle part. The conduit may be a bore moulded in the insulating composition, or it may be a rigid tube, on which the bore in the generator is a sliding fit, or on which the generator may be clamped. In another alternative, the generator is detachably located in the handle part.
    • 描述了静电涂覆枪,其中用于涂覆材料的导管从手柄部分延伸,并且构造为块或单元的高压静电发生器可以可替换地安装在手柄部分上。 高压发生器由完全嵌入绝缘模制组合物中的静电级联装置组成,并且被布置成向喷枪的枪口端施加全高的张力,这种高张力朝向手柄部分减小。 导管可以是在绝缘组合物中模制的孔,或者其可以是刚性管,发生器中的孔可滑动配合在其上,或者发生器可夹在其上。 在另一替代方案中,发电机可拆卸地位于手柄部分中。