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1. 发明申请

US20080009829A1 Balloon catheter having a branched distal section with secured branches 审中-公开
标题翻译：气球导管具有带有固定分支的分支远端部分
公开(公告)号：US20080009829A1
公开(公告)日：2008-01-10
申请号：US11830104
申请日：2007-07-30
申请人： Diem Ta , Caroline WU , Brenna Hearn , Daniel Cox , Leonard Barbod , Jessie Delgado , Stephen Pacetti , Thomas Hatten , David Wrolstad , Kenneth Armstrong , Darrin Kent
发明人： Diem Ta , Caroline WU , Brenna Hearn , Daniel Cox , Leonard Barbod , Jessie Delgado , Stephen Pacetti , Thomas Hatten , David Wrolstad , Kenneth Armstrong , Darrin Kent
IPC分类号： A61M31/00 , A61F2/06
CPC分类号： A61F2/856 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2002/067 , A61F2002/91525 , A61F2002/91575 , A61F2250/006
摘要： An improved stent design and stent delivery catheter assembly for repairing a main vessel and a side branch vessel forming a bifurcation. The stent includes rings aligned along a common longitudinal axis and connected by links, where the stent has one or more portals for aligning with and partially expanding into the opening to the side branch vessel. The stent is implanted at a bifurcation so that the main stent section is in the main vessel, and the portal section covers at least a portion of the opening to the side branch vessel. A second stent can be implanted in the side branch vessel and abut the expanded central section to provide full coverage of the bifurcated area in the main vessel and the side branch vessel. Radiopaque markers on the stent and on the tip of the delivery catheter assist in aligning the portal section with the opening to the side branch vessel.
摘要翻译：改进的支架设计和支架输送导管组件，用于修复形成分叉的主血管和侧分支血管。支架包括沿着共同的纵向轴线对齐并且通过连接件连接的环，其中支架具有用于与侧分支容器的开口对准并部分地扩张的一个或多个门户。将支架植入分叉处，使得主支架部分在主容器中，并且入口部分覆盖至侧分支容器的开口的至少一部分。第二支架可以植入侧支血管并且邻接扩张的中心部分以提供主血管和侧支血管中的分叉区域的全面覆盖。在支架上和输送导管的尖端上的不透射线的标记有助于将门静脉部分与侧支血管的开口对准。

2. 发明授权

US09242005B1 Pro-healing agent formulation compositions, methods and treatments 有权
标题翻译：预愈合剂配方组合物，方法和治疗
公开(公告)号：US09242005B1
公开(公告)日：2016-01-26
申请号：US11507860
申请日：2006-08-21
申请人： Syed Hossainy , Florian Niklas Ludwig , Stephen Pacetti , Paul Consigny , Fozan El-Nounou , Thierry Glauser , Jessica DesNoyer
发明人： Syed Hossainy , Florian Niklas Ludwig , Stephen Pacetti , Paul Consigny , Fozan El-Nounou , Thierry Glauser , Jessica DesNoyer
IPC分类号： A61M31/00 , A61K47/42 , A61K47/48 , A61M5/178
CPC分类号： A61K47/42 , A61K9/0019 , A61K9/1075 , A61K9/127 , A61K9/1273 , A61M5/178 , A61M25/104 , A61M31/00 , A61M2025/0087 , A61M2025/105 , A61M2025/1052
摘要： Pro-healing agent formulation compositions, methods and treatments for enhancing vascular healing are disclosed herein. In some embodiments, a pro-healing agent is encapsulated, suspended, disposed within or loaded into a biodegradable carrier for sustained-release delivery to a denuded or damaged endothelium treatment area in a blood vessel. In some applications, the pro-healing agent can accelerate re-endothelialization of a denuded vascular region. In some applications, the pro-healing agent can assist in the regaining of endothelium functionality. The formulation can be delivered by a delivery assembly such as an infusion catheter, a porous balloon catheter, a needle injection catheter, a double balloon catheter or the like.
摘要翻译：本文公开了用于增强血管愈合的预愈合剂制剂组合物，方法和治疗。在一些实施方案中，将前修复剂包封，悬浮，置于生物降解载体内或装载到可生物降解的载体中，以缓释递送至血管内的裸露或损伤的内皮治疗区域。在一些应用中，预愈合剂可以加速裸露的血管区域的再内皮化。在一些应用中，前修复剂可以帮助恢复内皮功能。制剂可以通过输送组件例如输注导管，多孔气囊导管，针注射导管，双气囊导管等来递送。

3. 发明授权

US08658749B2 Methods for manufacturing amino acid mimetic copolymers and use of same 失效
标题翻译：制备氨基酸模拟共聚物的方法及其用途
公开(公告)号：US08658749B2
公开(公告)日：2014-02-25
申请号：US12575720
申请日：2009-10-08
申请人： Stephen Pacetti
发明人： Stephen Pacetti
IPC分类号： C08F220/48 , C08F220/06 , C08F118/02 , C08F20/70
CPC分类号： A61L27/54 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00 , C08L27/18
摘要： Biocompatible polymers are manufactured to include an ammo acid mimetic monomer and one or more hydrophobic acrylate monomers. The amino acid mimetic monomers are selected to mimic the side chain of the amino acids asparagine or glutamine. The amino acid mimetic monomer can be a methacryloyl or acryloyl derivative of 2-hydroxyacetamide, 3-hydroxypropionamide, alaninamide, lactamide, or glycinamide. These amide functional groups offer the advantage of moderate hydrophilicity with little chemical reactivity. The amino acid mimetic monomer can be copolymerized with one or more hydrophobic acrylate monomers to obtain desired coating properties.
摘要翻译：制备生物相容性聚合物以包含氨基酸模拟单体和一种或多种疏水性丙烯酸酯单体。选择氨基酸模拟单体以模拟氨基酸天冬酰胺或谷氨酰胺的侧链。氨基酸模拟单体可以是2-羟基乙酰胺，3-羟基丙酰胺，丙烯酰胺，乳酰胺或甘氨酰胺的甲基丙烯酰基或丙烯酰基衍生物。这些酰胺官能团具有中等的亲水性，几乎没有化学反应性的优点。氨基酸模拟单体可以与一种或多种疏水丙烯酸酯单体共聚以获得所需的涂料性质。

4. 发明申请

US20130013055A1 RADIOPAQUE INTRALUMINAL STENT 有权
标题翻译：放射性胸腔镜
公开(公告)号：US20130013055A1
公开(公告)日：2013-01-10
申请号：US13618602
申请日：2012-09-14
申请人： Stephen Pacetti , Pamela A. Kramer
发明人： Stephen Pacetti , Pamela A. Kramer
IPC分类号： A61F2/86
CPC分类号： A61L31/18 , A61F2/91 , A61F2/92 , A61L31/022
摘要： The present invention includes a radiopaque stent comprising a cylindrical main body. The tubular main body comprises a cobalt chromium alloy that comprises cobalt, chromium and one or more radiopaque materials.
摘要翻译：本发明包括一种包括圆柱形主体的不透射线支架。管状主体包括钴铬合金，其包括钴，铬和一种或多种不透射线材料。

5. 发明授权

US08071705B2 Amino acid mimetic copolymers and medical devices coated with the copolymers 有权
公开(公告)号：US08071705B2
公开(公告)日：2011-12-06
申请号：US13045464
申请日：2011-03-10
申请人： Stephen Pacetti
发明人： Stephen Pacetti
IPC分类号： C08F120/58
CPC分类号： A61L27/54 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00 , C08L27/18
摘要： Biocompatible polymers are manufactured to include an amino acid mimetic monomer and one or more hydrophobic acrylate monomers. The amino acid mimetic monomers are selected to mimic the side chain of the amino acids asparagine or glutamine. The amino acid mimetic monomer can be a methacryloyl or acryloyl derivative of 2-hydroxyacetamide, 3-hydroxypropionamide, alaninamide, lactamide, or glycinamide. These amide functional groups offer the advantage of moderate hydrophilicity with little chemical reactivity. The amino acid mimetic monomer can be copolymerized with one or more hydrophobic acrylate monomers to obtain desired coating properties.

6. 发明申请

US20110143014A1 COATINGS WITH TUNABLE MOLECULAR ARCHITECTURE FOR DRUG-COATED BALLOON 有权
标题翻译：用于涂覆气囊的可分子结构涂层
公开(公告)号：US20110143014A1
公开(公告)日：2011-06-16
申请号：US12636079
申请日：2009-12-11
申请人： John Stankus , Mikael Trollsas , Syed Hossainy , Stephen Pacetti , Michael Ngo
发明人： John Stankus , Mikael Trollsas , Syed Hossainy , Stephen Pacetti , Michael Ngo
IPC分类号： B05D7/00
CPC分类号： A61L29/085 , A61F2/958 , A61F2250/0067 , A61L29/16 , A61L2300/204 , A61L2300/416 , A61L2300/606 , A61L2420/02 , A61L2420/06 , A61M25/10 , A61M25/1029 , A61M2025/1031 , A61M2025/105
摘要： A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first therapeutic agent and a first excipient, and can include a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable.
摘要翻译：提供药物递送球囊，具有外表面的气囊和设置在球囊表面的至少一段长度上的可调涂层。可调涂层包括第一治疗剂和第一赋形剂，并且可以包括第二治疗剂和第二赋形剂。第一和第二治疗剂在球囊膨胀期间具有不同的溶解速率，因此提供可调谐的涂层。

7. 发明申请

US20100183798A1 METHODS FOR MANUFACTURING AMINO ACID MIMETIC COPOLYMERS AND USE OF SAME 有权
标题翻译：制备氨基酸类共聚物的方法及其用途
公开(公告)号：US20100183798A1
公开(公告)日：2010-07-22
申请号：US12575744
申请日：2009-10-08
申请人： Stephen Pacetti
发明人： Stephen Pacetti
IPC分类号： B05D1/00
CPC分类号： A61L27/54 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00 , C08L27/18
摘要： A method of using a biocompatible polymer is used. Biocompatible polymers are manufactured to include an ammo acid mimetic monomer and one or more hydrophobic acrylate monomers. The amino acid mimetic monomers are selected to mimic the side chain of the amino acids asparagine or glutamine. The amino acid mimetic monomer can be a methacryloyl or acryloyl derivative of 2-hydroxyacetamide, 3-hydroxypropionamide, alaninamide, lactamide, or glycinamide. These amide functional groups offer the advantage of moderate hydrophilicity with little chemical reactivity. The amino acid mimetic monomer can be copolymerized with one or more hydrophobic acrylate monomers to obtain desired coating properties.
摘要翻译：使用使用生物相容性聚合物的方法。制备生物相容性聚合物以包含氨基酸模拟单体和一种或多种疏水性丙烯酸酯单体。选择氨基酸模拟单体以模拟氨基酸天冬酰胺或谷氨酰胺的侧链。氨基酸模拟单体可以是2-羟基乙酰胺，3-羟基丙酰胺，丙烯酰胺，乳酰胺或甘氨酰胺的甲基丙烯酰基或丙烯酰基衍生物。这些酰胺官能团具有中等的亲水性，几乎没有化学反应性的优点。氨基酸模拟单体可以与一种或多种疏水丙烯酸酯单体共聚以获得所需的涂料性质。

8. 发明申请

US20080286372A1 THERAPEUTIC COMPOSITIONS FOR TARGETED VESSEL DELIVERY 有权
标题翻译：针对目的港运输的治疗组合物
公开(公告)号：US20080286372A1
公开(公告)日：2008-11-20
申请号：US11749385
申请日：2007-05-16
申请人： Stephen Pacetti , Syed Faiyaz Ahmed Hossainy , Florian Niklas Ludwig
发明人： Stephen Pacetti , Syed Faiyaz Ahmed Hossainy , Florian Niklas Ludwig
IPC分类号： A61K9/51 , A61K31/4353 , A61K31/56 , A61K35/00 , A61P9/00 , A61K38/02 , A61K38/16
CPC分类号： A61K9/0019 , A61K9/127 , A61K9/16 , A61K9/1694 , A61K9/51 , A61K47/6915 , A61K47/6925
摘要： Methods for treating a vascular disease by delivering therapeutic compositions with enhanced endothelium targeting are disclosed.
摘要翻译：公开了通过递送具有增强的内皮靶向的治疗组合物治疗血管疾病的方法。

9. 发明申请

US20080147178A1 ZWITTERIONIC COPOLYMERS, METHOD OF MAKING AND USE ON MEDICAL DEVICES 有权
标题翻译： ZWITTERICIC共聚物，制备和使用医疗设备的方法
公开(公告)号：US20080147178A1
公开(公告)日：2008-06-19
申请号：US11942693
申请日：2007-11-19
申请人： Stephen Pacetti , Wouter Roorda
发明人： Stephen Pacetti , Wouter Roorda
IPC分类号： A61F2/82 , A61M25/10 , A61K47/32 , C08F218/02 , A61B17/00
CPC分类号： A61L27/54 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00 , C08L27/18
摘要： Biocompatible copolymers are manufactured to include a zwitterionic monomer and an alkoxy acrylate monomer. The alkoxy acrylate monomer can be a 2-methoxyethyl methacrylate (MOEMA) or a 2-methoxyethyl methacrylate (EOEMA). Alternatively, the alkoxy acrylate can be 2-methoxyethyl acrylate (MOEA) or 2-ethoxyethyl acrylate (EOEA). The alkoxy acrylate monomers advantageously give the zwitterionic copolymers greater ductility, strength, and toughness while maintaining a desired amount of hydrophilicity. The improved toughness allows the zwitterionic copolymers to be processed without cross-linking, which improves the elongation properties of the zwitterionic copolymer, and reduces the risk of cracking during use.
摘要翻译：制造生物相容性共聚物以包括两性离子单体和烷氧基丙烯酸酯单体。烷氧基丙烯酸酯单体可以是甲基丙烯酸2-甲氧基乙酯（MOEMA）或甲基丙烯酸2-甲氧基乙酯（EOEMA）。或者，烷氧基丙烯酸酯可以是丙烯酸2-甲氧基乙酯（MOEA）或丙烯酸2-乙氧基乙酯（EOEA）。烷氧基丙烯酸酯单体有利地使两性离子共聚物具有更高的延展性，强度和韧性，同时保持所需量的亲水性。改进的韧性使得两性离子共聚物在不交联的情况下进行加工，这提高了两性离子共聚物的伸长性能，并降低了使用过程中的开裂风险。

10. 发明申请

US20080139746A1 COPOLYMERS HAVING ZWITTERIONIC MOIETIES AND DIHYDROXYPHENYL MOIETIES AND MEDICAL DEVICES COATED WITH THE COPOLYMERS 有权
标题翻译：具有ZWITTERICIC MOITIES和二羟基苯基酯的共聚物和用共聚物涂覆的医疗装置
公开(公告)号：US20080139746A1
公开(公告)日：2008-06-12
申请号：US11942695
申请日：2007-11-19
申请人： Stephen Pacetti
发明人： Stephen Pacetti
IPC分类号： C08L33/12 , C08G61/00 , C08L33/08
CPC分类号： A61L27/54 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00 , C08L27/18
摘要： Copolymers are manufactured to include a zwitterionic monomer (e.g., methacryloyloxyethyl phosphorylcholine monomer), a dihydroxyphenyl derivatized monomer, and optionally one or more additional monomers. The dihydroxyphenyl derivatized monomer gives the copolymers excellent adhesion properties. Optional monomers include a cationic amino monomer, a hydrocarbon monomer, and/or a hydrophilic monomer. The copolymers are biocompatible and can be used with medical devices.
摘要翻译：制备共聚物以包括两性离子单体（例如，甲基丙烯酰氧基乙基磷酸胆碱单体），二羟基苯基衍生的单体和任选的一种或多种另外的单体。二羟基苯基衍生的单体使共聚物具有优异的粘合性能。任选的单体包括阳离子氨基单体，烃单体和/或亲水单体。共聚物是生物相容的并且可以与医疗装置一起使用。

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