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1. 发明授权

US09636422B2 Method for detecting a brain region with neurodegenerative change 有权
公开(公告)号：US09636422B2
公开(公告)日：2017-05-02
申请号：US12219609
申请日：2008-07-24
申请人： Thorsten Feiweier , Diana Martin , Günther Platsch , Sebastian Schmidt , Kristin Schmiedehausen , Michael Szimtenings
发明人： Thorsten Feiweier , Diana Martin , Günther Platsch , Sebastian Schmidt , Kristin Schmiedehausen , Michael Szimtenings
IPC分类号： A61K49/00 , A61B6/03 , A61B6/00 , A61B5/00
CPC分类号： A61K49/0004 , A61B5/4064 , A61B5/4088 , A61B6/037 , A61B6/5247
摘要： A computerized method is disclosed for detecting a brain region with neurodegenerative change and also a brain region with vascular change in the brain of a patient and also an imaging arrangement suitable for this. In at least one embodiment, the method includes recording a first data record of the brain via positron emission tomography and a second data record of the brain via magnetic resonance imaging; reconstructing a PET image from the first data record and an MRI image from the second data record; identifying evidence for a brain region with vascular change in the MRI image; segmenting the MRI image into gray matter and white matter; identifying a brain region with neurodegenerative change in the PET image; and superposing the PET image and the segmented MRI image to determine whether the brain region with neurodegenerative change is present in gray matter or in white matter, the recording of the first data record and the second data record being carried out in quick succession without repositioning the patient or is even carried out simultaneously.

2. 发明授权

US08467845B2 Method for data acquisition and/or data evaluation during a functional brain examination with the aid of a combined magnetic resonance/PET unit 有权
标题翻译：借助于组合磁共振/ PET单元在功能性脑部检查期间进行数据采集和/或数据评估的方法
公开(公告)号：US08467845B2
公开(公告)日：2013-06-18
申请号：US12153487
申请日：2008-05-20
申请人： Diana Martin , Thorsten Feiweier , Günther Platsch , Kristin Schmiedehausen , Sebastian Schmidt , Michael Szimtenings
发明人： Diana Martin , Thorsten Feiweier , Günther Platsch , Kristin Schmiedehausen , Sebastian Schmidt , Michael Szimtenings
IPC分类号： A61B5/05
CPC分类号： G01R33/481 , A61B6/501 , A61B6/5247 , A61B2090/364 , G01R33/4806
摘要： A method is disclosed for data acquisition and/or data evaluation during a functional brain examination with the aid of a combined magnetic resonance/PET unit. In at least one embodiment, functional image data of the brain are acquired in at least two activity states with the aid of both modalities. Further, magnetic resonance image data and PET image data are acquired within time windows determined by the activity states, the acquisition mode and/or the image data being synchronized as a function of a timing of stimulations determining the activity states.
摘要翻译：公开了一种借助于组合磁共振/ PET单元在功能性脑部检查期间进行数据采集和/或数据评估的方法。在至少一个实施例中，借助于两种模式在至少两个活动状态中获取大脑的功能图像数据。此外，在由活动状态确定的时间窗内获取磁共振图像数据和PET图像数据，获取模式和/或图像数据作为确定活动状态的刺激的定时的函数被同步。

3. 发明授权

US08452378B2 Method for determining attenuation values for PET data of a patient 有权
标题翻译：确定患者PET数据衰减值的方法
公开(公告)号：US08452378B2
公开(公告)日：2013-05-28
申请号：US12232522
申请日：2008-09-18
申请人： Diana Martin , Günther Platsch , Martin Requardt , Sebastian Schmidt , Kristin Schmiedehausen , Michael Szimtenings
发明人： Diana Martin , Günther Platsch , Martin Requardt , Sebastian Schmidt , Kristin Schmiedehausen , Michael Szimtenings
IPC分类号： A61B5/05
CPC分类号： G01T1/1603 , A61B6/037 , A61B6/4494 , G01T7/005 , G06F19/00 , G06Q50/22 , G06Q50/24
摘要： A method is disclosed for determining attenuation values for PET data of a patient. In at least one embodiment, the method includes detecting at least one accessory of a magnetic resonance imaging scanner and detecting the position and/or alignment of the accessory by way of an imaging measuring method; comparing the detected accessory with data from a database; and assigning an attenuation map, which is contained in the database, to attenuation values of the detected accessory and adapting the attenuation map to the detected position and/or alignment of the accessory.
摘要翻译：公开了一种用于确定患者PET数据的衰减值的方法。在至少一个实施例中，该方法包括检测磁共振成像扫描仪的至少一个附件，并通过成像测量方法检测附件的位置和/或对准; 将检测到的附件与来自数据库的数据进行比较; 以及将包含在所述数据库中的衰减图分配给所检测到的附件的衰减值，并将所述衰减图适配到所述检测到的位置和/或所述附件的对准。

4. 发明申请

US20090018431A1 Method and apparatus for imaging functional processes in the brain 审中-公开
标题翻译：用于成像脑功能过程的方法和装置
公开(公告)号：US20090018431A1
公开(公告)日：2009-01-15
申请号：US12216293
申请日：2008-07-02
申请人： Thorsten Feiweier , Diana Martin , Gunther Platsch , Sebastian Schmidt , Kristin Schmiedehausen , Michael Szimtenings
发明人： Thorsten Feiweier , Diana Martin , Gunther Platsch , Sebastian Schmidt , Kristin Schmiedehausen , Michael Szimtenings
IPC分类号： A61B5/05
CPC分类号： G01R33/481 , A61B5/0035 , A61B5/04008 , A61B5/4094 , A61B6/037 , A61B6/501 , A61B6/5247
摘要： A method and an apparatus are disclosed for imaging functional processes in the brain. In order to be able to correlate the results of MEG examinations with anatomical information and metabolic data, a positron emission tomography measurement is recorded in at least one embodiment by at least one radiation detector, a magnetic resonance imaging measurement is recorded by a coil and a radio-frequency antenna device and a magnetoencephalography measurement is recorded by a plurality of magnetic field sensors, the positron emission tomography measurement and the magnetic resonance imaging measurement being substantially undertaken at the same time, so that the records of the positron emission tomography measurement and the magnetic resonance tomography measurement are isocentric. In at least one embodiment, an evaluation apparatus is provided for carrying out a spatial correlation between the magnetoencephalography measurement and the magnetic resonance imaging measurement, so that registration between the magnetoencephalography measurement and the positron emission tomography measurement results.
摘要翻译：公开了一种用于成像脑中的功能过程的方法和装置。为了能够将MEG检查的结果与解剖信息和代谢数据相关联，在至少一个实施例中通过至少一个辐射检测器记录正电子发射断层摄影测量，磁共振成像测量由线圈和射频天线装置和脑磁图测量由多个磁场传感器记录，正电子发射断层摄影测量和磁共振成像测量基本上同时进行，使得正电子发射断层摄影测量和磁共振断层扫描测量是同中心的。在至少一个实施例中，提供了一种用于执行脑磁图测量和磁共振成像测量之间的空间相关性的评估装置，从而导致脑磁图测量与正电子发射断层摄影测量之间的配准。

5. 发明申请

US20090005678A1 Method for determining and displaying an access corridor to a target area in the brain of a patient 审中-公开
标题翻译：用于确定和显示到患者脑中的目标区域的通道走廊的方法
公开(公告)号：US20090005678A1
公开(公告)日：2009-01-01
申请号：US12213745
申请日：2008-06-24
申请人： Kristin Schmiedehausen , Gunther Platsch , Thorsten Feiweier , Diana Martin , Sebastian Schmidt , Michael Szimtenings
发明人： Kristin Schmiedehausen , Gunther Platsch , Thorsten Feiweier , Diana Martin , Sebastian Schmidt , Michael Szimtenings
IPC分类号： A61B6/03
CPC分类号： A61B6/501 , A61B6/037 , A61B6/507 , A61B34/10 , A61B90/36 , A61B2090/364 , A61B2090/374
摘要： A computer-implemented method is disclosed for determining and displaying an access corridor to a target area in the brain of a patient, as well as an imaging arrangement suited to this. In at least one embodiment, the method includes a) generating a first image of the brain via positron emission tomography, b) discriminating the target area relative to its surroundings via electronic image processing, c) generating a second image of the brain via magnetic resonance imaging while acquiring at least one anatomical structure, d) generating a third image of the brain via an imaging method displaying physiological processes for identifying at least one functional area of the brain that must not be injured in any circumstances, e) determining an access corridor to the target area while omitting the at least one functional area of the brain, and f) generating and displaying a fourth image of the brain in which the target area, the at least one functional area of the brain, the at least one anatomical structure and the access corridor are displayed, wherein steps a) to d) are carried out, one after another in quick succession, in a single frame of reference without repositioning the patient, or are even carried out simultaneously.
摘要翻译：公开了一种计算机实现的方法，用于确定和显示患者脑中的目标区域的通道走廊以及适合于此的成像装置。在至少一个实施例中，该方法包括：a）通过正电子发射断层摄影术产生脑的第一图像，b）通过电子图像处理区分相对于其周围的目标区域，c）通过磁共振产生大脑的第二图像成像，同时获取至少一个解剖结构，d）通过显示生理过程的成像方法产生大脑的第三图像，用于识别在任何情况下不得受伤的脑的至少一个功能区域，e）确定通路走廊到目标区域，同时省略脑的至少一个功能区域，以及f）产生和显示脑的第四图像，其中目标区域，脑的至少一个功能区域，至少一个解剖结构并且显示进入通道，其中步骤a）至d）在一个单独的参考框架中以快速连续的方式相继地执行而不重新定位或者甚至同时进行。

6. 发明申请

US20090030304A1 Method for detecting a brain region with neurodegenerative change 有权
标题翻译：用于检测具有神经变性变化的脑区域的方法
公开(公告)号：US20090030304A1
公开(公告)日：2009-01-29
申请号：US12219609
申请日：2008-07-24
申请人： Thorsten Feiweier , Diana Martin , Gunther Platsch , Sebastian Schmidt , Kristin Schmiedehausen , Michael Szimtenings
发明人： Thorsten Feiweier , Diana Martin , Gunther Platsch , Sebastian Schmidt , Kristin Schmiedehausen , Michael Szimtenings
IPC分类号： A61B5/055
CPC分类号： A61K49/0004 , A61B5/4064 , A61B5/4088 , A61B6/037 , A61B6/5247
摘要： A computerized method is disclosed for detecting a brain region with neurodegenerative change and also a brain region with vascular change in the brain of a patient and also an imaging arrangement suitable for this. In at least one embodiment, the method includes recording a first data record of the brain via positron emission tomography and a second data record of the brain via magnetic resonance imaging; reconstructing a PET image from the first data record and an MRI image from the second data record; identifying evidence for a brain region with vascular change in the MRI image; segmenting the MRI image into gray matter and white matter; identifying a brain region with neurodegenerative change in the PET image; and superposing the PET image and the segmented MRI image to determine whether the brain region with neurodegenerative change is present in gray matter or in white matter, the recording of the first data record and the second data record being carried out in quick succession without repositioning the patient or is even carried out simultaneously.
摘要翻译：公开了一种用于检测具有神经变性变化的脑区域以及患者脑部血管变化的脑区域的计算机化方法，以及适合于此的成像装置。在至少一个实施例中，该方法包括通过正电子发射断层摄影和脑的第二数据记录经由磁共振成像记录脑的第一数据记录; 从第一数据记录重建PET图像和从第二数据记录重建MRI图像; 识别MRI图像中具有血管变化的脑区域的证据; 将MRI图像分割成灰质和白质; 识别PET图像中具有神经变性变化的脑区域; 并叠加PET图像和分割的MRI图像，以确定具有神经变性变化的脑区域是否存在于灰质物质或白质中，第一数据记录和第二数据记录的记录被快速连续进行而不重新定位病人或甚至同时进行。

7. 发明申请

US20090048507A1 Method and apparatus for imaging functional and electrical activities of the brain 审中-公开
标题翻译：用于成像大脑功能和电活动的方法和装置
公开(公告)号：US20090048507A1
公开(公告)日：2009-02-19
申请号：US12222210
申请日：2008-08-05
申请人： Thorsten Feiweier , Diana Martin , Gunther Platsch , Sebastian Schmidt , Kristin Schmiedehausen , Michael Szimtenings
发明人： Thorsten Feiweier , Diana Martin , Gunther Platsch , Sebastian Schmidt , Kristin Schmiedehausen , Michael Szimtenings
IPC分类号： A61B5/055 , A61B5/0476 , G01V3/00 , A61B6/00
CPC分类号： A61B6/037 , A61B5/0402 , A61B5/0476 , A61B5/4094 , A61B6/032 , A61B6/501 , A61B6/5247 , G06T7/30
摘要： A method and an apparatus for imaging functional and electrical activities of the brain are disclosed. In order to allow improved relative positional determination of the epileptogenic focus with reference to the EEG electrodes, a positron emission tomography measurement using at least one radiation detector, and a magnetic resonance imaging measurement using at least one coil for generating a basic magnetic field, at least one gradient coil and a radio-frequency antenna device are undertaken in at least one embodiment. In addition, in at least one embodiment an electroencephalography measurement using a plurality of electrodes for acquiring spatial and temporal changes of the electrical activities of the brain and a computed tomography measurement using at least one x-ray source and at least one x-ray detector are carried out. By way of an evaluation apparatus in at least one embodiment, a spatial correlation between the computed tomography measurement and the magnetic resonance imaging measurement is undertaken, so as to result in registration between the electroencephalography measurement and the positron emission tomography measurement.
摘要翻译：公开了一种用于成像大脑的功能和电活动的方法和装置。为了允许参考EEG电极改进癫痫发生焦点的相对位置确定，使用至少一个辐射检测器的正电子发射断层摄影测量和使用至少一个线圈产生基本磁场的磁共振成像测量，在至少一个实施例中进行至少一个梯度线圈和射频天线装置。另外，在至少一个实施例中，使用多个电极获取脑的电活动的空间和时间变化以及使用至少一个X射线源和至少一个X射线检测器的计算机断层摄影测量的脑电图测量被执行。通过至少一个实施例中的评估装置，进行计算机断层摄影测量和磁共振成像测量之间的空间相关性，以便导致脑电图测量与正电子发射断层摄影测量之间的对准。

8. 发明申请

US20080290281A1 Method for data acquisition and/or data evaluation during a functional brains examination with the aid of a combined magnetic resonance/PET unit 有权
标题翻译：借助于组合磁共振/ PET单元在功能性大脑检查期间进行数据采集和/或数据评估的方法
公开(公告)号：US20080290281A1
公开(公告)日：2008-11-27
申请号：US12153487
申请日：2008-05-20
申请人： Diana Martin , Thorsten Feiweier , Gunther Platsch , Kristin Schmiedehausen , Sebastian Schmidt , Michael Szimtenings
发明人： Diana Martin , Thorsten Feiweier , Gunther Platsch , Kristin Schmiedehausen , Sebastian Schmidt , Michael Szimtenings
IPC分类号： G01T1/164
CPC分类号： G01R33/481 , A61B6/501 , A61B6/5247 , A61B2090/364 , G01R33/4806
摘要： A method is disclosed for data acquisition and/or data evaluation during a functional brain examination with the aid of a combined magnetic resonance/PET unit. In at least one embodiment, functional image data of the brain are acquired in at least two activity states with the aid of both modalities. Further, magnetic resonance image data and PET image data are acquired within time windows determined by the activity states, the acquisition mode and/or the image data being synchronized as a function of a timing of stimulations determining the activity states.
摘要翻译：公开了一种借助于组合磁共振/ PET单元在功能性脑部检查期间进行数据采集和/或数据评估的方法。在至少一个实施例中，借助于两种模式在至少两个活动状态中获取大脑的功能图像数据。此外，在由活动状态确定的时间窗内获取磁共振图像数据和PET图像数据，获取模式和/或图像数据作为确定活动状态的刺激的定时的函数被同步。

9. 发明申请

US20090105583A1 Method for determining attenuation values for pet data of a patient 有权
标题翻译：用于确定患者宠物数据的衰减值的方法
公开(公告)号：US20090105583A1
公开(公告)日：2009-04-23
申请号：US12232522
申请日：2008-09-18
申请人： Diana Martin , Gunther Platsch , Martin Requardt , Sebastian Schmidt , Kristin Schmiedehausen , Michael Szimtenings
发明人： Diana Martin , Gunther Platsch , Martin Requardt , Sebastian Schmidt , Kristin Schmiedehausen , Michael Szimtenings
IPC分类号： A61B5/055 , A61G7/00 , G06Q50/00
CPC分类号： G01T1/1603 , A61B6/037 , A61B6/4494 , G01T7/005 , G06F19/00 , G06Q50/22 , G06Q50/24
摘要： A method is disclosed for determining attenuation values for PET data of a patient. In at least one embodiment, the method includes detecting at least one accessory of a magnetic resonance imaging scanner and detecting the position and/or alignment of the accessory by way of an imaging measuring method; comparing the detected accessory with data from a database; and assigning an attenuation map, which is contained in the database, to attenuation values of the detected accessory and adapting the attenuation map to the detected position and/or alignment of the accessory.
摘要翻译：公开了一种用于确定患者PET数据的衰减值的方法。在至少一个实施例中，该方法包括检测磁共振成像扫描仪的至少一个附件，并通过成像测量方法检测附件的位置和/或对准; 将检测到的附件与来自数据库的数据进行比较; 以及将包含在所述数据库中的衰减图分配给所检测到的附件的衰减值，并将所述衰减图适配到所述检测到的位置和/或所述附件的对准。

10. 发明申请

US20090027052A1 Method for acquiring measured data 审中-公开
标题翻译：获取测量数据的方法
公开(公告)号：US20090027052A1
公开(公告)日：2009-01-29
申请号：US12213233
申请日：2008-06-17
申请人： Jurgen Kampmeier , Gunther Platsch , Martin Requardt , Stefan Roll , Sebastian Schmidt , Kristin Schmiedehausen , Michael Szimtenings
发明人： Jurgen Kampmeier , Gunther Platsch , Martin Requardt , Stefan Roll , Sebastian Schmidt , Kristin Schmiedehausen , Michael Szimtenings
IPC分类号： G01R33/483 , A61B5/055
CPC分类号： A61B6/037 , A61B5/055 , A61B6/5247 , A61B90/36 , A61B2090/364 , A61B2090/374
摘要： A PET examination which acquires a data record of the body of a patient is carried out during at least one embodiment of a method for acquiring measured data. On the basis of the measured values of the data record, at least one region of interest in the body of the patient is determined, in which at least one examination of at least one embodiment of a method is carried out.
摘要翻译：在获取测量数据的方法的至少一个实施例中，进行获取患者身体的数据记录的PET检查。基于数据记录的测量值，确定患者身体中的至少一个感兴趣区域，其中对方法的至少一个实施例的至少一次检查被执行。

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