专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100104551A1 METHOD FOR PROLONGING ACTIVITY OF AUTODEGRADABLE ENZYMES AND COMPOSITIONS THEREOF 审中-公开
标题翻译：用于增强可自由可扩链酶活性的方法及其组合物
公开(公告)号：US20100104551A1
公开(公告)日：2010-04-29
申请号：US12603988
申请日：2009-10-22
申请人： Dharmendra M. Jani , Kai Kwok , Gregory L. McIntire , Bruce A. Pfeffer , Afshin Shafiee , Ruiwen Shi , Srini Venkatesh , Hongna Wang , Yan Huang , Stephen R. Davio
发明人： Dharmendra M. Jani , Kai Kwok , Gregory L. McIntire , Bruce A. Pfeffer , Afshin Shafiee , Ruiwen Shi , Srini Venkatesh , Hongna Wang , Yan Huang , Stephen R. Davio
IPC分类号： A61K38/48 , A61P27/02
CPC分类号： C12N9/50 , A61K31/198 , C12N9/6435 , C12N9/96 , C12Y304/21007
摘要： A composition of a long-acting enzyme comprises the enzyme in a formulation comprising a buffer and an additive selected from the group consisting of tranexamic acid, ε-aminocaproic acid, and analogs of L-lysine other than tranexamic acid and ε-aminocaproic acid, combinations thereof, and mixtures thereof. The composition can further comprise another additive selected from the group consisting of L-lysine, L-arginine, L-ornithine (or its pharmaceutically acceptable salts; e.g., L-ornithine hydrochloride), γ-aminobutyric acid, 5-aminovaleric acid, 7-aminoheptanoic acid, glycylglycine, triglycine, N-α-acetyl-L-arginine, betaine, sarcosine, gelatin, HSA, streptokinase, tPA, uPA, non-ionic surfactants, glycerin, D-sorbitol, combinations thereof, and mixtures thereof. A method for prolonging the activity of an autodegradable enzyme comprises storing the enzyme after manufacture at a low pH, and reconstituting the acidified enzyme before use with a solution containing at least one of such additives. The method is useful to provide enzyme for wide use, which otherwise would lose activity upon long storage. In one embodiment the method is applicable to provide enzyme for inducing controlled posterior vitreous detachment.
摘要翻译：长效酶的组合物包含在包含缓冲液和添加剂的制剂中的酶，所述缓冲剂和添加剂选自氨甲环酸，氨基己酸和除了氨甲环酸以外的L-赖氨酸和β-氨基己酸酸，其组合，及其混合物。所述组合物可以进一步包含选自L-赖氨酸，L-精氨酸，L-鸟氨酸（或其药学上可接受的盐，例如L-鸟氨酸盐酸盐），γ-氨基丁酸，5-氨基戊酸，7 氨基庚酸，甘氨酰甘氨酸，三甘氨酸，N-α-乙酰基-L-精氨酸，甜菜碱，肌氨酸，明胶，HSA，链激酶，tPA，uPA，非离子表面活性剂，甘油，D-山梨糖醇，其组合及其混合物。用于延长自动降解酶的活性的方法包括在低pH下制备后储存酶，并且在使用前将酸化酶与含有至少一种这样的添加剂的溶液重新组合。该方法对于提供广泛使用的酶是有用的，否则将在长期储存时失去活性。在一个实施方案中，该方法适用于提供用于诱导受控的后玻璃体脱离的酶。

2. 发明申请

US20100036387A1 Viscoelastic Composition for Surgical Procedures 审中-公开
标题翻译：用于外科手术的粘弹性组合物
公开(公告)号：US20100036387A1
公开(公告)日：2010-02-11
申请号：US12581242
申请日：2009-10-19
申请人： Claudio Bucolo , Melina G. Cro , Adriana L.A. Maltese , Dharmendra M. Jani
发明人： Claudio Bucolo , Melina G. Cro , Adriana L.A. Maltese , Dharmendra M. Jani
IPC分类号： A61F9/007 , A61K31/7016
CPC分类号： A61L31/042 , A61L31/10 , A61L31/143 , A61L2430/16
摘要： A method of protecting tissue from trauma during a surgical procedure, the method comprising the step of coating at least a portion of the tissue with a viscoelastic composition comprising: a mixture of hyaluronic acid and/or salts thereof and hydroxypropyl methylcellulose, wherein the concentration of hyaluronic acid and/or salts thereof is a minimum of about 0.1% w/v and a maximum of about 6% w/v and the concentration of hydroxypropyl methylcellulose is a minimum of about 0.05% w/v and a maximum of about 5% w/v, based upon the total volume of the viscoelastic composition; tris[hydroxymethyl]aminomethane at a maximum of about 50 mM and a minimum of about 0.1 mM based upon the total weight of the viscoelastic composition; and a hexahydric alcohol.
摘要翻译：一种在外科手术过程中保护组织免受创伤的方法，所述方法包括用粘弹性组合物涂覆组织的至少一部分的步骤，所述粘弹性组合物包含：透明质酸和/或其盐和羟丙基甲基纤维素的混合物，其中透明质酸和/或其盐的最小值为约0.1％w / v，最大约6％w / v，羟丙基甲基纤维素的浓度为最小约0.05％w / v，最多约5％ w / v，基于粘弹性组合物的总体积; 基于粘弹性组合物的总重量，最大约50mM的三羟甲基氨基甲烷和最小约0.1mM的三[羟甲基]氨基甲烷; 和六元醇。

3. 发明授权

US06364934B1 Method of making ocular devices 有权
标题翻译：制造眼睛装置的方法
公开(公告)号：US06364934B1
公开(公告)日：2002-04-02
申请号：US09628974
申请日：2000-07-31
申请人： Mahendra Nandu , Dharmendra M. Jani
发明人： Mahendra Nandu , Dharmendra M. Jani
IPC分类号： B01D1900
CPC分类号： G02B1/043 , B01D19/0031 , B29B7/84 , B29D11/00038 , B29K2105/0002 , B29K2995/0092 , B29K2995/0093
摘要： A method of decreasing the amount of cosmetic defects in contact lenses made from hydrophilic and hydrophobic monomers. By filtering the monomer mixture with a filter, the hydrophilic and hydrophobic components are finely dispersed throughout the mixture. Dissolved gases contained within the mixture are also finely dispersed. Contact lenses produced from this method have improved optical quality.
摘要翻译：一种减少由亲水和疏水单体制成的隐形眼镜中的美容缺陷的量的方法。通过用过滤器过滤单体混合物，亲水和疏水组分精细地分散在整个混合物中。包含在混合物中的溶解气体也被细分散。由该方法生产的隐形眼镜具有改善的光学质量。

4. 发明申请

US20080152669A1 Method of Stimulating the Production of Mucin in the Eye of a Patient 审中-公开
标题翻译：刺激患者眼中粘蛋白生产的方法
公开(公告)号：US20080152669A1
公开(公告)日：2008-06-26
申请号：US11943906
申请日：2007-11-21
申请人： Dharmendra M. Jani
发明人： Dharmendra M. Jani
IPC分类号： A61K36/02 , A61P27/02
CPC分类号： A61K31/734 , A61K9/0048
摘要： The present invention includes a method of treating a patient comprising mucin deficiency comprising administering to an eye of a patient suffering from mucin deficiency, a composition comprising alginate in an amount effective to increase production of mucin in the mucin deficient patient.
摘要翻译：本发明包括治疗包含粘蛋白缺乏症的患者的方法，其包括向患有粘蛋白缺乏症的患者的眼睛施用包含藻酸盐的组合物，其量有效地增加粘蛋白缺乏患者中粘蛋白的产生。

5. 发明申请

US20080147021A1 DRUG DELIVERY DEVICES 审中-公开
标题翻译：药物递送装置
公开(公告)号：US20080147021A1
公开(公告)日：2008-06-19
申请号：US11611503
申请日：2006-12-15
申请人： Dharmendra M. Jani
发明人： Dharmendra M. Jani
IPC分类号： A61M37/00
CPC分类号： A61F9/0017 , A61K9/0051 , A61K9/70
摘要： A drug delivery device that is suitable for delivery of a therapeutic agent to limited access regions of the eye is provided. Preferred devices of the invention are minimally invasive, refillable and may be easily fixed to the treatment area.
摘要翻译：提供了适合于将治疗剂递送到眼睛的有限进入区域的药物递送装置。本发明的优选装置是微创的，可再填充的并且可以容易地固定到治疗区域。

6. 发明申请

US20080280853A1 COMPOSITIONS FOR REDUCING, AMELIORATING, TREATING, OR PREVENTING CONDITION OF DRY EYE AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：用于减少，调理，治疗或预防干眼症状的组合物及其制备和使用方法
公开(公告)号：US20080280853A1
公开(公告)日：2008-11-13
申请号：US12114878
申请日：2008-05-05
申请人： Erning Xia , Dharmendra M. Jani
发明人： Erning Xia , Dharmendra M. Jani
IPC分类号： A61K31/715 , A61P27/02
CPC分类号： A61K9/0048 , A61K47/26 , A61K47/36
摘要： Compositions for relief, treatment, or prevention of a condition of dry eye comprise alginate, at least a polyol, and a pharmaceutically acceptable carrier, wherein the compositions have pH in the range from about 5 to about 7.5. In some embodiment, the compositions can further include a chelating agent, a buffering system or agent, an organic acid, or combinations thereof.
摘要翻译：用于缓解，治疗或预防干眼症状的组合物包括藻酸盐，至少多元醇和药学上可接受的载体，其中所述组合物的pH在约5至约7.5的范围内。在一些实施方案中，组合物可进一步包括螯合剂，缓冲系统或试剂，有机酸或其组合。

7. 发明申请

US20080161266A1 Ophthalmic Alginate Composition Related Methods of Manufacture and Methods of Use 审中-公开
标题翻译：眼海藻酸盐组合物相关制造方法和使用方法
公开(公告)号：US20080161266A1
公开(公告)日：2008-07-03
申请号：US11961447
申请日：2007-12-20
申请人： Dharmendra M. Jani , Stephen E. Maier
发明人： Dharmendra M. Jani , Stephen E. Maier
IPC分类号： A61K31/717 , A61P27/02 , A61K47/36 , A61K31/155 , A61K47/10
CPC分类号： A61L12/141 , A61K9/0048 , A61K31/155 , A61K31/717 , A61K36/03 , A61L12/142 , A61L12/143 , A61L12/145
摘要： The present invention is directed to an ophthalmic composition comprising alginate having a minimum of about 0% and a maximum of about 50% guluronic units bound to an adjacent guluronic unit as a percentage of the total number of monomeric units in the alginate. The composition further includes a cationic antimicrobial agent. The alginate set forth above forms less deactivating complexes with cationic antimicrobial agent, and thus, the composition has improved preservative efficacy.
摘要翻译：本发明涉及一种眼用组合物，其包含藻酸盐，其具有与藻酸盐中单体单元总数的百分比具有最小约0％和最多约50％的古罗糖醛酸单元的相邻古罗糖醛单元。组合物还包含阳离子抗微生物剂。上述藻酸盐与阳离子抗微生物剂形成更少的失活复合物，因此，该组合物具有改善的防腐功效。

8. 发明申请

US20080153908A1 Method of Treating Mucin Deficiency with an Active Pharmaceutical and Related Composition 审中-公开
标题翻译：用活性药物及相关组合物处理粘蛋白缺乏症的方法
公开(公告)号：US20080153908A1
公开(公告)日：2008-06-26
申请号：US11933496
申请日：2007-11-01
申请人： Dharmendra M. Jani
发明人： Dharmendra M. Jani
IPC分类号： A61K31/19 , A61P27/02
CPC分类号： A61K31/19 , A61K9/0048
摘要： The present invention includes a method of treating a patient suffering from mucin deficiency comprising administering to an eye of a patient suffering from mucin deficiency, a composition comprising an active pharmaceutical selected from the group consisting of acetate, propionate or butyrate in their salt or acid forms and combinations thereof, wherein the active pharmaceutical is present in an amount effective to increase production of mucin in the eye of the mucin deficient patient.
摘要翻译：本发明包括治疗患有粘蛋白缺乏症的患者的方法，其包括向患有粘蛋白缺乏症的患者的眼睛施用包含其盐或酸形式的选自乙酸盐，丙酸盐或丁酸盐的活性药物的组合物及其组合，其中活性药物以有效增加粘蛋白缺乏患者眼睛中粘蛋白产生的量存在。

9. 发明申请

US20080153776A1 Method of Treating Inflammation of the Eye 有权
标题翻译：治疗眼睛炎症的方法
公开(公告)号：US20080153776A1
公开(公告)日：2008-06-26
申请号：US11955418
申请日：2007-12-13
申请人： Erning Xia , Dharmendra M. Jani
发明人： Erning Xia , Dharmendra M. Jani
IPC分类号： A61K31/7016 , A61P29/00 , A61K31/715 , A61P27/14
CPC分类号： A61K31/7016 , A61K9/0048 , A61K31/715 , A61K36/03 , Y10S514/914
摘要： The present invention includes a method of treating inflammation of the eye comprising administering to an eye of a patient suffering from inflammation of the eye, a composition comprising an aqueous solution of alginate having a minimum of about 50% mannuronate residues based upon the total number of saccharide monomeric units.
摘要翻译：本发明包括治疗眼睛炎症的方法，包括向患有眼睛炎症的患者的眼睛施用包含至少约50％甘露糖醛酸残基的藻酸盐水溶液的组合物，糖单体单位。

10. 发明授权

US08337553B2 Optical material and method for modifying the refractive index 有权
$Optical material and method for modifying the refractive index$
标题翻译：用于改变折射率的光学材料和方法
公开(公告)号：US08337553B2
公开(公告)日：2012-12-25
申请号：US12846950
申请日：2010-07-30
申请人： Wayne H. Knox , Li Ding , Jay F. Kunzler , Dharmendra M. Jani , Candido D. Pinto
发明人： Wayne H. Knox , Li Ding , Jay F. Kunzler , Dharmendra M. Jani , Candido D. Pinto
IPC分类号： A61F2/16 , G02C7/02
CPC分类号： A61F2/14 , A61B18/20 , A61F2/142 , A61F2/1451 , A61F2/147 , A61F2/16 , A61F9/008 , A61L27/16 , A61L27/18 , A61L27/52 , B29D11/00355 , B29D11/00461 , B29D11/023 , B29K2083/00 , B29K2105/0061 , C08J7/12 , C08J7/123 , C08J2333/14 , C08J2339/06 , C08J2383/04 , G02B1/041 , G02C7/022 , G02C2202/12 , G02C2202/14
摘要： The invention is directed to an optical device comprising refractive optical structures, wherein the refractive structures are characterized by a change in refractive index, exhibit little or no scattering loss, and exhibit no significant differences in the Raman spectrum with respect to the non-irradiated optical, polymeric material.
摘要翻译：本发明涉及一种包括折射光学结构的光学装置，其中折射结构的特征在于折射率的变化，显示很少或没有散射损耗，并且在拉曼光谱方面相对于未照射的光学器件没有显着差异，聚合材料。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式