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1. 发明申请

US20100021548A1 USE OF MICROPARTICLES WITH ADSORBED ANTIGEN TO STIMULATE IMMUNE RESPONSES 审中-公开
标题翻译：使用微生物与吸附抗原刺激免疫应答
公开(公告)号：US20100021548A1
公开(公告)日：2010-01-28
申请号：US12573903
申请日：2009-10-06
申请人： Derek O'Hagan , Gary Van Nest , Gary S. Ott , John Barackman , Jina Kazzaz
发明人： Derek O'Hagan , Gary Van Nest , Gary S. Ott , John Barackman , Jina Kazzaz
IPC分类号： A61K9/14 , A61K39/21 , A61K39/29 , A61K39/145
CPC分类号： A61K39/245 , A61K9/1647 , A61K9/167 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/39 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , C12N2710/16634 , C12N2740/16234 , C12N2760/16134 , Y02A50/396
摘要： The use of poly(lactide) or poly(lactide-co-glycolide) microparticles with adsorbed antigen is disclosed. The microparticles are useful for enhancing CTL responses to a selected antigen.
摘要翻译：公开了使用具有吸附抗原的聚（丙交酯）或聚（丙交酯 - 共 - 乙交酯）微粒。微粒可用于增强对所选抗原的CTL应答。

2. 发明授权

US07597908B2 Use of microparticles with adsorbed antigen to stimulate immune responses 失效
标题翻译：使用具有吸附抗原的微粒刺激免疫应答
公开(公告)号：US07597908B2
公开(公告)日：2009-10-06
申请号：US10189104
申请日：2002-07-03
申请人： Derek O'Hagan , Gary Van Nest , Gary S. Ott , John Barackman , Jina Kazzaz
发明人： Derek O'Hagan , Gary Van Nest , Gary S. Ott , John Barackman , Jina Kazzaz
IPC分类号： A61K9/18
CPC分类号： A61K39/245 , A61K9/1647 , A61K9/167 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/39 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , C12N2710/16634 , C12N2740/16234 , C12N2760/16134 , Y02A50/396
摘要： The use of poly(lactide) or poly(lactide-co-glycolide) microparticles with adsorbed antigen is disclosed. The microparticles are useful for enhancing CTL responses to a selected antigen.
摘要翻译：公开了使用具有吸附抗原的聚（丙交酯）或聚（丙交酯 - 共 - 乙交酯）微粒。微粒可用于增强对所选抗原的CTL应答。

3. 发明授权

US08734832B2 Microemulsions with adsorbed macromolecules and microparticles 有权
公开(公告)号：US08734832B2
公开(公告)日：2014-05-27
申请号：US13621174
申请日：2012-09-15
申请人： Derek O'Hagan , Gary S. Ott , John Donnelly , Jina Kazzaz , Mildred Ugozzoli , Manmohan Singh , John Barackman
发明人： Derek O'Hagan , Gary S. Ott , John Donnelly , Jina Kazzaz , Mildred Ugozzoli , Manmohan Singh , John Barackman
IPC分类号： A61F2/02 , A61K9/14 , A61K9/50
CPC分类号： A61K39/39 , A61K9/1075 , A61K9/167 , A61K39/0208 , A61K39/21 , A61K39/245 , A61K39/29 , Y02A50/411 , Y02A50/471
摘要： Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and methods of increasing a Th1 immune response in a host animal by administering to the animal an immunogenic composition of the microparticles, and/or microemulsions of the invention, are also provided.

4. 发明申请

US20130195898A1 MICROEMULSIONS WITH ADSORBED MACROMOLECULES AND MICROPARTICLES 有权
公开(公告)号：US20130195898A1
公开(公告)日：2013-08-01
申请号：US13621174
申请日：2012-09-15
申请人： Derek O'Hagan , Gary S. Ott , John Donnelly , Jina Kazzaz , Mildred Ugozzoli , Manmohan Singh , John Barackman
发明人： Derek O'Hagan , Gary S. Ott , John Donnelly , Jina Kazzaz , Mildred Ugozzoli , Manmohan Singh , John Barackman
IPC分类号： A61K39/39
CPC分类号： A61K39/39 , A61K9/1075 , A61K9/167 , A61K39/0208 , A61K39/21 , A61K39/245 , A61K39/29 , Y02A50/411 , Y02A50/471
摘要： Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and methods of increasing a Th1 immune response in a host animal by administering to the animal an immunogenic composition of the microparticles, and/or microemulsions of the invention, are also provided.

5. 发明申请

US20130195923A1 MICROEMULSIONS WITH ADSORBED MACROMOLECULES AND MICROPARTICLES 有权
标题翻译：具有吸附的大分子和微阵列的微乳液
公开(公告)号：US20130195923A1
公开(公告)日：2013-08-01
申请号：US13618020
申请日：2012-09-14
申请人： Derek O'Hagan , Gary S. Ott , John Donnelly , Jina Kazzaz , Mildred Ugozzoli , Manmohan Singh , John Barackman
发明人： Derek O'Hagan , Gary S. Ott , John Donnelly , Jina Kazzaz , Mildred Ugozzoli , Manmohan Singh , John Barackman
IPC分类号： A61K9/107 , A61K39/39 , A61K39/245 , A61K39/02 , A61K39/21 , A61K39/29
CPC分类号： A61K39/39 , A61K9/1075 , A61K9/167 , A61K39/0208 , A61K39/21 , A61K39/245 , A61K39/29 , Y02A50/411 , Y02A50/471
摘要： Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and methods of increasing a Th1 immune response in a host animal by administering to the animal an immunogenic composition of the microparticles, and/or microemulsions of the invention, are also provided.
摘要翻译：公开了具有吸附剂表面的微粒，制备这种微粒的方法及其用途。微粒包含聚（α-羟基酸），多羟基丁酸，聚己内酯，聚原酸酯，聚酐等聚合物，并使用阳离子，阴离子或非离子型洗涤剂形成。微粒的表面有效吸附生物活性大分子，如DNA，多肽，抗原和佐剂。还提供了具有可代谢油和乳化剂的油滴乳液的组合物。还提供了具有免疫刺激量的抗原物质的免疫原性组合物和免疫刺激量的佐剂组合物。刺激免疫应答的方法，免疫宿主动物免受病毒，细菌或寄生虫感染的方法，以及通过向动物施用微粒的免疫原性组合物和/或增加宿主动物的Th1免疫应答的方法还提供了本发明的微乳液。

6. 发明授权

US08309139B2 Microemulsions with adsorbed macromolecules and microparticles 有权
标题翻译：具有吸附的大分子和微粒的微乳液
公开(公告)号：US08309139B2
公开(公告)日：2012-11-13
申请号：US11406144
申请日：2006-04-18
申请人： Derek O'Hagan , Gary S. Ott , John Donnelly , Jina Kazzaz , Mildred Ugozzoli , Manmohan Singh , John Barackman
发明人： Derek O'Hagan , Gary S. Ott , John Donnelly , Jina Kazzaz , Mildred Ugozzoli , Manmohan Singh , John Barackman
IPC分类号： A61K9/50 , A61K9/14
CPC分类号： A61K39/39 , A61K9/1075 , A61K9/167 , A61K39/0208 , A61K39/21 , A61K39/245 , A61K39/29 , Y02A50/411 , Y02A50/471
摘要： Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and methods of increasing a Th1 immune response in a host animal by administering to the animal an immunogenic composition of the microparticles, and/or microemulsions of the invention, are also provided.
摘要翻译：公开了具有吸附剂表面的微粒，制备这种微粒的方法及其用途。微粒包含聚（α-羟基酸），多羟基丁酸，聚己内酯，聚原酸酯，聚酐等聚合物，并使用阳离子，阴离子或非离子型洗涤剂形成。微粒的表面有效吸附生物活性大分子，如DNA，多肽，抗原和佐剂。还提供了具有可代谢油和乳化剂的油滴乳液的组合物。还提供了具有免疫刺激量的抗原物质的免疫原性组合物和免疫刺激量的佐剂组合物。刺激免疫应答的方法，免疫宿主动物免受病毒，细菌或寄生虫感染的方法，以及通过向动物施用微粒的免疫原性组合物和/或增加宿主动物的Th1免疫应答的方法还提供了本发明的微乳液。

7. 发明授权

US08206749B1 Microemulsions with adsorbed macromolecules and microparticles 有权
公开(公告)号：US08206749B1
公开(公告)日：2012-06-26
申请号：US09914279
申请日：2000-02-09
申请人： Derek O'Hagan , Gary S. Ott , John Donnelly , Jina Kazzaz , Mildred Ugozzoli , Manmohan Singh , John Barackman
发明人： Derek O'Hagan , Gary S. Ott , John Donnelly , Jina Kazzaz , Mildred Ugozzoli , Manmohan Singh , John Barackman
IPC分类号： A61K9/50
CPC分类号： A61K39/39 , A61K9/1075 , A61K9/167 , A61K39/0208 , A61K39/21 , A61K39/245 , A61K39/29 , Y02A50/411 , Y02A50/471
摘要： Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and methods of increasing a Th1 immune response in a host animal by administering to the animal an immunogenic composition of the microparticles, and/or microemulsions of the invention, are also provided.

8. 发明授权

US08771747B2 Microemulsions with adsorbed macromolecules and microparticles 有权
标题翻译：具有吸附的大分子和微粒的微乳液
公开(公告)号：US08771747B2
公开(公告)日：2014-07-08
申请号：US13618020
申请日：2012-09-14
申请人： Derek O'Hagan , Gary S. Ott , John Donnelly , Jina Kazzaz , Mildred Ugozzoli , Manmohan Singh , John Barackman
发明人： Derek O'Hagan , Gary S. Ott , John Donnelly , Jina Kazzaz , Mildred Ugozzoli , Manmohan Singh , John Barackman
IPC分类号： A61K9/50 , A61K39/39 , A61K39/21 , A61K9/107 , A61K39/29 , A61K39/02 , A61K39/245 , A61K9/16
CPC分类号： A61K39/39 , A61K9/1075 , A61K9/167 , A61K39/0208 , A61K39/21 , A61K39/245 , A61K39/29 , Y02A50/411 , Y02A50/471
摘要： Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and methods of increasing a Th1 immune response in a host animal by administering to the animal an immunogenic composition of the microparticles, and/or microemulsions of the invention, are also provided.
摘要翻译：公开了具有吸附剂表面的微粒，制备这种微粒的方法及其用途。微粒包含聚（α-羟基酸），多羟基丁酸，聚己内酯，聚原酸酯，聚酐等聚合物，并使用阳离子，阴离子或非离子型洗涤剂形成。微粒的表面有效吸附生物活性大分子，如DNA，多肽，抗原和佐剂。还提供了具有可代谢油和乳化剂的油滴乳液的组合物。还提供了具有免疫刺激量的抗原物质的免疫原性组合物和免疫刺激量的佐剂组合物。刺激免疫应答的方法，免疫宿主动物免受病毒，细菌或寄生虫感染的方法，以及通过向动物施用微粒的免疫原性组合物和/或增加宿主动物的Th1免疫应答的方法还提供了本发明的微乳液。

9. 发明申请

US20070116709A1 Microemulsions with adsorbed macromolecules and microparticles 有权
标题翻译：具有吸附的大分子和微粒的微乳液
公开(公告)号：US20070116709A1
公开(公告)日：2007-05-24
申请号：US11406144
申请日：2006-04-18
申请人： Derek O'Hagan , Gary Ott , John Donnelly , Jina Kazzaz , Mildred Ugozzoli , Manmohan Singh , John Barackman
发明人： Derek O'Hagan , Gary Ott , John Donnelly , Jina Kazzaz , Mildred Ugozzoli , Manmohan Singh , John Barackman
IPC分类号： A61K39/00 , A61K39/12 , A61K39/21 , A61K39/145
CPC分类号： A61K39/39 , A61K9/1075 , A61K9/167 , A61K39/0208 , A61K39/21 , A61K39/245 , A61K39/29 , Y02A50/411 , Y02A50/471
摘要： Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and methods of increasing a Th1 immune response in a host animal by administering to the animal an immunogenic composition of the microparticles, and/or microemulsions of the invention, are also provided.
摘要翻译：公开了具有吸附剂表面的微粒，制备这种微粒的方法及其用途。微粒包含聚（α-羟基酸），多羟基丁酸，聚己内酯，聚原酸酯，聚酐等聚合物，并使用阳离子，阴离子或非离子型洗涤剂形成。微粒的表面有效吸附生物活性大分子，如DNA，多肽，抗原和佐剂。还提供了具有可代谢油和乳化剂的油滴乳液的组合物。还提供了具有免疫刺激量的抗原物质的免疫原性组合物和免疫刺激量的佐剂组合物。刺激免疫应答的方法，免疫宿主动物免受病毒，细菌或寄生虫感染的方法，以及通过向动物施用微粒的免疫原性组合物和/或增加宿主动物的Th1免疫应答的方法还提供了本发明的微乳液。

10. 发明申请

US20050208143A1 Microparticles with adsorbent surfaces, methods of making same, and uses thereof 审中-公开
公开(公告)号：US20050208143A1
公开(公告)日：2005-09-22
申请号：US11113861
申请日：2005-04-25
申请人： Derek O' Hagan , Manmohan Singh , Gary Ott , John Barackman , Jina Kazzaz
发明人： Derek O' Hagan , Manmohan Singh , Gary Ott , John Barackman , Jina Kazzaz
IPC分类号： A61K9/00 , A61K9/16 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/245 , A61K39/39 , A61K48/00 , A61K9/14 , A61K39/38
CPC分类号： A61K39/245 , A61K9/1647 , A61K9/167 , A61K39/12 , A61K39/21 , A61K39/39 , A61K2039/53 , A61K2039/543 , A61K2039/545 , A61K2039/55505 , A61K2039/55555 , A61K2039/55561 , C12N2740/16111 , C12N2740/16134 , C12N2740/16234 , C12N2770/24211 , C12N2770/24234
摘要： Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants.

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