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1. 发明授权

US09517263B2 Benzonaphthyridine-containing vaccines 有权
标题翻译：含有苯并萘啶的疫苗
公开(公告)号：US09517263B2
公开(公告)日：2016-12-13
申请号：US13377511
申请日：2010-06-10
申请人： Derek O'Hagan , Manmohan Singh , Siddhartha Jain , Sushma Kommareddy
发明人： Derek O'Hagan , Manmohan Singh , Siddhartha Jain , Sushma Kommareddy
IPC分类号： A61K39/02 , C07D471/00 , A61K39/39 , A61K39/00 , A61K39/12
CPC分类号： A61K39/39 , A61K2039/55511 , A61K2039/6093
摘要： The invention provides, inter alia, immunogenic compositions that comprise (a) a first antigen, (b) polymeric particles and (c) a benzonaphthyridine compound, which compositions elicits an immune response when administered to a vertebrate subject. The invention also provides, inter alia, methods of producing immunogenic compositions and methods for using immunogenic compositions (e.g., for treatment), among other benefits.
摘要翻译：本发明尤其提供了免疫原性组合物，其包含（a）第一抗原，（b）聚合物颗粒和（c）苯并萘啶化合物，该组合物在施用于脊椎动物受试者时引起免疫应答。本发明尤其提供产生免疫原性组合物的方法和使用免疫原性组合物（例如用于治疗）的方法以及其它益处。

2. 再颁专利

USRE45137E1 Adjuvanted meningococcus compositions 有权
标题翻译：佐剂脑膜炎球菌组成
公开(公告)号：USRE45137E1
公开(公告)日：2014-09-16
申请号：US13587840
申请日：2012-08-16
申请人： Derek O'Hagan , Nicholas Valiante
发明人： Derek O'Hagan , Nicholas Valiante
IPC分类号： A61K39/02 , A61K39/00 , A61K39/116 , A61K39/095 , A61K38/00 , C07K14/00
摘要： A combination of CpG oligonucleotides and polymer microparticles is an extremely effective adjuvant for Neisserial antigens. The invention therefore provides a composition comprising: (a) a Neisserial antigen; (b) a CpG oligonucleotide; and (c) a biodegradable polymer microparticle.
摘要翻译： CpG寡核苷酸和聚合物微粒的组合是奈瑟氏球菌抗原非常有效的佐剂。因此，本发明提供一种组合物，其包含：（a）奈维菌素抗原; （b）CpG寡核苷酸; 和（c）可生物降解的聚合物微粒。

3. 发明授权

US08541023B2 Immunogenic compositions containing phospholipid 有权
标题翻译：含有磷脂的免疫原性组合物
公开(公告)号：US08541023B2
公开(公告)日：2013-09-24
申请号：US13270107
申请日：2011-10-10
申请人： Derek O'Hagan
发明人： Derek O'Hagan
IPC分类号： A61K39/00 , A61K39/38 , A61K38/00 , A61K39/02 , A61K45/00 , A61K47/00 , A61K9/48 , A61K9/14 , A61K9/16
CPC分类号： A61K47/26 , A61K9/0019 , A61K9/10 , A61K9/1075 , A61K9/1676 , A61K9/19 , A61K9/5031 , A61K39/095 , A61K39/12 , A61K39/21 , A61K39/39 , A61K47/06 , A61K2039/545 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/6093 , A61K2039/622 , C12N2740/16234
摘要： Immunogenic compositions containing phospholipid adjuvants, including microparticle and emulsion compositions. According to one aspect of the invention, an immunogenic microparticle composition is provided comprising: water; a polymer microparticle; an antigen adsorbed to the microparticle; and a phospholipid compound, e.g., a synthetic phospholipid compound comprising: (i) one or more phosphoryl groups independently selected from a phosphato group and a phosphodiester group; (ii) a plurality of linear alkane groups. According to another aspect of the invention an immunogenic emulsion composition is provided that comprises: water; a metabolizable oil; an emulsifying agent; an antigen; and a phospholipid compound, e.g., a synthetic phospholipid compound like that above. The emulsion composition is an oil-in-water emulsion having oil and aqueous phases, in which the oil phase is in the form of oil droplets, substantially all of which are less than 1 micron in diameter.
摘要翻译：含有磷脂佐剂的免疫原性组合物，包括微粒和乳剂组合物。根据本发明的一个方面，提供免疫原性微粒组合物，其包含：水; 聚合物微粒; 吸附在微粒上的抗原; 和磷脂化合物，例如合成磷脂化合物，其包含：（i）一个或多个独立地选自磷酸酯基和磷酸二酯基团的磷酰基; （ii）多个直链烷烃基团。根据本发明的另一方面，提供免疫原性乳剂组合物，其包含：水; 代谢油; 乳化剂; 抗原; 和磷脂化合物，例如如上所述的合成磷脂化合物。乳液组合物是具有油相和水相的水包油乳液，其中油相是油滴形式，其基本上都小于1微米直径。

4. 发明申请

US20120263753A1 BENZONAPHTHYRIDINE-CONTAINING VACCINES 有权
标题翻译：含有苯并噻嗪的疫苗
公开(公告)号：US20120263753A1
公开(公告)日：2012-10-18
申请号：US13377511
申请日：2010-06-10
申请人： Derek O'Hagan , Manmohan Singh , Siddhartha Jain , Sushma Kommareddy
发明人： Derek O'Hagan , Manmohan Singh , Siddhartha Jain , Sushma Kommareddy
IPC分类号： A61K39/39 , A61P37/04 , A61K39/02 , A61K39/00 , A61K39/12
CPC分类号： A61K39/39 , A61K2039/55511 , A61K2039/6093
摘要： The invention provides, inter alia, immunogenic compositions that comprise (a) a first antigen, (b) polymeric particles and (c) a benzonaphthyridine compound, which compositions elicits an immune response when administered to a vertebrate subject. The invention also provides, inter alia, methods of producing immunogenic compositions and methods for using immunogenic compositions (e.g., for treatment), among other benefits.
摘要翻译：本发明尤其提供了免疫原性组合物，其包含（a）第一抗原，（b）聚合物颗粒和（c）苯并萘啶化合物，该组合物在施用于脊椎动物受试者时引起免疫应答。本发明尤其提供产生免疫原性组合物的方法和使用免疫原性组合物（例如用于治疗）的方法以及其它益处。

5. 发明申请

US20120171244A1 MUCOSAL BOOSTING FOLLOWING PARENTERAL PRIMING 审中-公开
标题翻译：在下面的MUCOSAL升级
公开(公告)号：US20120171244A1
公开(公告)日：2012-07-05
申请号：US13366296
申请日：2012-02-04
申请人： Derek O'Hagan
发明人： Derek O'Hagan
IPC分类号： A61K39/00 , A61K39/095 , A61K39/102 , A61K39/09 , A61P31/04 , A61P31/12 , A61K39/21 , A61K39/12 , A61K39/29 , A61K39/155 , A61K39/145 , A61K39/245 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P31/22 , A61P35/00 , A61P37/04
CPC分类号： A61K39/385 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/1647 , A61K39/00 , A61K39/0011 , A61K39/092 , A61K39/095 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/54 , A61K2039/541 , A61K2039/545 , A61K2039/55555 , A61K2039/55561 , A61K2039/57 , A61K2039/6093 , C12N2740/16134 , Y02A50/464
摘要： Mucosal immunization using one or more antigens following parenteral administration of the same or different antigens is described.
摘要翻译：描述了肠胃外给予相同或不同抗原后使用一种或多种抗原的粘膜免疫。

6. 发明授权

US08206749B1 Microemulsions with adsorbed macromolecules and microparticles 有权
公开(公告)号：US08206749B1
公开(公告)日：2012-06-26
申请号：US09914279
申请日：2000-02-09
申请人： Derek O'Hagan , Gary S. Ott , John Donnelly , Jina Kazzaz , Mildred Ugozzoli , Manmohan Singh , John Barackman
发明人： Derek O'Hagan , Gary S. Ott , John Donnelly , Jina Kazzaz , Mildred Ugozzoli , Manmohan Singh , John Barackman
IPC分类号： A61K9/50
CPC分类号： A61K39/39 , A61K9/1075 , A61K9/167 , A61K39/0208 , A61K39/21 , A61K39/245 , A61K39/29 , Y02A50/411 , Y02A50/471
摘要： Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and methods of increasing a Th1 immune response in a host animal by administering to the animal an immunogenic composition of the microparticles, and/or microemulsions of the invention, are also provided.

7. 发明申请

US20110150923A1 MUCOSAL MENINGOCOCCAL VACCINES 审中-公开
标题翻译：粘膜肉芽孢杆菌疫苗
公开(公告)号：US20110150923A1
公开(公告)日：2011-06-23
申请号：US13036007
申请日：2011-02-28
申请人： Giuseppe Del Giudice , Barbara Baudner , Derek O'Hagan
发明人： Giuseppe Del Giudice , Barbara Baudner , Derek O'Hagan
IPC分类号： A61K39/095 , A61K39/108 , A61P31/04 , A61K39/295
CPC分类号： A61K39/095 , A61K2039/543 , A61K2039/55544 , A61K2039/55583 , A61K2039/6037
摘要： The invention provides immunogenic compositions for mucosal delivery comprising capsular saccharides from at least two of serogroups A, C, W135 and Y of N. meningitidis. It is preferred that the capsular saccharides in the compositions of the invention are conjugated to carrier protein(s) and/or are oligosaccharides. Conjugated oligosaccharide antigens are particularly preferred. The invention also provides immunogenic compositions comprising (a) a capsular saccharide antigen from serogroup C of N. meningitidis, and (b) a chitosan adjuvant. The composition preferably comprises (c) one or more further antigens and/or (d) one or more further adjuvants. The compositions are particularly suitable for mucosal delivery, including intranasal delivery. The use of chitosan and/or detoxified ADP-ribosylating toxin adjuvants enhances anti-meningococcal mucosal immune responses and can shift the Th1/Th2 bias of the responses.
摘要翻译：本发明提供用于粘膜递送的免疫原性组合物，其包含来自脑膜炎奈瑟菌脑膜炎的血清群A，C，W135和Y的至少两个的荚膜糖。本发明组合物中的荚膜糖优选与载体蛋白结合，和/或是寡糖。共轭寡糖抗原是特别优选的。本发明还提供免疫原性组合物，其包含（a）来自脑膜炎奈瑟氏球菌的血清群C的荚膜糖抗原和（b）壳聚糖佐剂。组合物优选包含（c）一种或多种另外的抗原和/或（d）一种或多种另外的佐剂。组合物特别适用于粘膜递送，包括鼻内递送。使用壳聚糖和/或解毒的ADP-核糖基化毒素佐剂增强了抗脑膜炎球菌粘膜免疫应答，并且可以改变反应的Th1 / Th2偏差。

8. 发明申请

US20110052716A1 Adjuvant Comprising Aluminum, Oligonucleotide and Polycation 有权
标题翻译：佐剂包括铝，寡核苷酸和聚阳离子
公开(公告)号：US20110052716A1
公开(公告)日：2011-03-03
申请号：US12870708
申请日：2010-08-27
申请人： Michele Pallaoro , Derek O'Hagan , Rino Rappuoli
发明人： Michele Pallaoro , Derek O'Hagan , Rino Rappuoli
IPC分类号： A61K39/39 , A61K9/14 , A61P37/04 , A61P31/04
CPC分类号： A61K39/39 , A61K39/0002 , A61K39/0258 , A61K39/085 , A61K39/092 , A61K39/095 , A61K39/155 , A61K2039/55505 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , C12N2760/18534 , Y02A50/474
摘要： An immunological adjuvant comprises an aluminium salt, an immunostimulatory oligonucleotide and a polycationic polymer, wherein the oligonucleotide and the polymer ideally associate with each other to form a complex. The adjuvant can be included in a composition with an immunogen e.g. to elicit an immune response that protects against a bacterial disease or a fungal disease.
摘要翻译：免疫佐剂包括铝盐，免疫刺激寡核苷酸和聚阳离子聚合物，其中寡核苷酸和聚合物理想地相互结合以形成络合物。佐剂可以包括在具有免疫原的组合物中。以引发免疫应答，防止细菌性疾病或真菌性疾病。

9. 发明申请

US20110038900A1 NANOPARTICLES FOR USE IN PHARMACEUTICAL COMPOSITIONS 有权
标题翻译：用于药物组合物的纳米颗粒
公开(公告)号：US20110038900A1
公开(公告)日：2011-02-17
申请号：US12990110
申请日：2009-04-28
申请人： Aravind Chakrapani , Manmohan Singh , Derek O'Hagan
发明人： Aravind Chakrapani , Manmohan Singh , Derek O'Hagan
IPC分类号： A61K39/00 , A61K9/00 , A61P37/00 , B82Y40/00 , B82Y5/00
CPC分类号： A61K39/095 , A61K2039/55555 , A61K2039/62 , C08J3/14 , C08J2300/16 , C08J2367/04
摘要： In various aspects of the present invention, nanoparticle compositions are provided which comprise (a) nanoparticles comprising at least one biodegradable polymer and (b) at least one pharmaceutical associated with the nanoparticles. In other aspects of the present invention, methods of forming nanoparticles compositions are provided, which comprise contacting a first liquid that comprises one or more biodegradable polymers dissolved in a first solvent with a second liquid that comprises a second solvent which is miscible with the first solvent while being a non-solvent for the one or more biodegradable polymers, such that nanoparticles are formed.
摘要翻译：在本发明的各个方面，提供纳米颗粒组合物，其包含（a）包含至少一种生物可降解聚合物的纳米颗粒和（b）至少一种与纳米颗粒相关的药物。在本发明的其他方面，提供了形成纳米颗粒组合物的方法，其包括将包含溶解在第一溶剂中的一种或多种可生物降解的聚合物的第一液体与包含与第一溶剂混溶的第二溶剂的第二液体接触同时作为一种或多种可生物降解的聚合物的非溶剂，使得形成纳米颗粒。

10. 发明授权

US07838015B2 Adjuvanted meningococcus compositions 有权
标题翻译：佐剂脑膜炎球菌组成
公开(公告)号：US07838015B2
公开(公告)日：2010-11-23
申请号：US10264802
申请日：2002-10-03
申请人： Derek O'Hagan , Nicholas Valiante
发明人： Derek O'Hagan , Nicholas Valiante
IPC分类号： A61K39/02 , A61K39/00 , A61K39/116 , A61K39/095 , A61K38/00 , C07K14/00
CPC分类号： A61K39/095 , A61K9/0019 , A61K9/0043 , A61K9/5031 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/622 , Y10S530/825
摘要： A combination of CpG oligonucleotides and polymer microparticles is an extremely effective adjuvant for Neisserial antigens. The invention therefore provides a composition comprising: (a) a Neisserial antigen; (b) a CpG oligonucleotide; and (c) a biodegradable polymer microparticle.
摘要翻译： CpG寡核苷酸和聚合物微粒的组合是奈瑟氏球菌抗原非常有效的佐剂。因此，本发明提供一种组合物，其包含：（a）奈维菌素抗原; （b）CpG寡核苷酸; 和（c）可生物降解的聚合物微粒。

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