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1. 发明申请

US20050169989A1 Generally linear effervescent oral fentanyl dosage form and methods of administering 有权
标题翻译：一般线性泡腾口服芬太尼剂型及给药方法
公开(公告)号：US20050169989A1
公开(公告)日：2005-08-04
申请号：US11026132
申请日：2004-12-30
申请人： Derek Moe , Vikas Agarwal , Walid Habib
发明人： Derek Moe , Vikas Agarwal , Walid Habib
IPC分类号： A61K9/00 , A61K9/20 , A61K9/46 , A61K31/445
CPC分类号： A61K31/445 , A61K9/0007 , A61K9/006 , A61K9/205
摘要： Fentanyl containing dosage forms and methods using same are described. These dosage forms include substantially less fentanyl by weight than know oral formulation and have advantages in terms of cost and side effects. These dosage forms are intended for oral administration of fentanyl across the oral mucosa.
摘要翻译：描述了含有芬太尼的剂型及使用它们的方法。这些剂型包括比已知口服制剂重量少的芬太尼，并且在成本和副作用方面具有优势。这些剂型旨在口服口服粘膜上的芬太尼。

2. 发明授权

US07862832B2 Generally linear effervescent oral fentanyl dosage form and methods of administering 有权
标题翻译：一般线性泡腾口服芬太尼剂型及给药方法
公开(公告)号：US07862832B2
公开(公告)日：2011-01-04
申请号：US11026132
申请日：2004-12-30
申请人： Derek Moe , Vikas Agarwal , Walid Habib
发明人： Derek Moe , Vikas Agarwal , Walid Habib
IPC分类号： A61K9/20 , A61K9/46
CPC分类号： A61K31/445 , A61K9/0007 , A61K9/006 , A61K9/205
摘要： Fentanyl containing dosage forms and methods using same are described. These dosage forms include substantially less fentanyl by weight than know oral formulation and have advantages in terms of cost and side effects. These dosage forms are intended for oral administration of fentanyl across the oral mucosa.
摘要翻译：描述了含有芬太尼的剂型及使用它们的方法。这些剂型包括比已知口服制剂重量少的芬太尼，并且在成本和副作用方面具有优势。这些剂型旨在口服口服粘膜上的芬太尼。

3. 发明申请

US20050142198A1 Effervescent oral fentanyl dosage form and methods of administering fentanyl 有权
标题翻译：泡腾口服芬太尼剂型及施用芬太尼的方法
公开(公告)号：US20050142198A1
公开(公告)日：2005-06-30
申请号：US11027353
申请日：2004-12-30
申请人： Derek Moe , Vikas Agarwal , Walid Habib
发明人： Derek Moe , Vikas Agarwal , Walid Habib
IPC分类号： A61K9/00 , A61K9/20 , A61K9/46 , A61K31/445 , A61K9/70
CPC分类号： A61K31/445 , A61K9/0007 , A61K9/006 , A61K9/205
摘要： Fentanyl-containing dosage forms and methods using same are described. These dosage forms include substantially less fentanyl by weight than known oral formulation and have advantages in terms of reduced cost and reduced side effects. These dosage forms are intended for oral administration of fentanyl across the oral mucosa.
摘要翻译：描述了含有芬太尼的剂型及使用它们的方法。这些剂型包括比已知口服制剂重量少的芬太尼，并且在降低成本和减少副作用方面具有优点。这些剂型旨在口服口服粘膜上的芬太尼。

4. 发明授权

US07858121B2 Effervescent oral fentanyl dosage form and methods of administering fentanyl 有权
标题翻译：泡腾口服芬太尼剂型及施用芬太尼的方法
公开(公告)号：US07858121B2
公开(公告)日：2010-12-28
申请号：US11027353
申请日：2004-12-30
申请人： Derek Moe , Vikas Agarwal , Walid Habib
发明人： Derek Moe , Vikas Agarwal , Walid Habib
IPC分类号： A61K9/20 , A61K9/46
CPC分类号： A61K31/445 , A61K9/0007 , A61K9/006 , A61K9/205
摘要： Fentanyl-containing dosage forms and methods using same are described. These dosage forms include substantially less fentanyl by weight than known oral formulation and have advantages in terms of reduced cost and reduced side effects. These dosage forms are intended for oral administration of fentanyl across the oral mucosa.
摘要翻译：描述了含有芬太尼的剂型及使用它们的方法。这些剂型包括比已知口服制剂重量少的芬太尼，并且在降低成本和减少副作用方面具有优点。这些剂型旨在口服口服粘膜上的芬太尼。

5. 发明申请

US20070036853A1 Generally linear effervescent oral fentanyl dosage form and methods of administering 审中-公开
标题翻译：一般线性泡腾口服芬太尼剂型及给药方法
公开(公告)号：US20070036853A1
公开(公告)日：2007-02-15
申请号：US11521796
申请日：2006-09-15
申请人： Vikas Agarwal , Walid Habib , Derek Moe
发明人： Vikas Agarwal , Walid Habib , Derek Moe
IPC分类号： A61K9/46 , A61K31/445
CPC分类号： A61K9/0007 , A61K9/006 , A61K9/205 , A61K31/445
摘要： Fentanyl containing dosage forms and methods using same are described. These dosage forms include substantially less fentanyl by weight than know oral formulation and have advantages in terms of cost and side effects. These dosage forms are intended for oral administration of fentanyl across the oral mucosa.
摘要翻译：描述了含有芬太尼的剂型及使用它们的方法。这些剂型包括比已知口服制剂重量少的芬太尼，并且在成本和副作用方面具有优势。这些剂型旨在口服口服粘膜上的芬太尼。

6. 发明申请

US20110073518A1 Generally Linear Effervescent Oral Fentanyl Dosage Form and Methods of Administering 有权
标题翻译：一般线性泡腾口服芬太尼剂量形式和给药方法
公开(公告)号：US20110073518A1
公开(公告)日：2011-03-31
申请号：US12955229
申请日：2010-11-29
申请人： Derek Moe , Vikas Agarwal , Walid Habib
发明人： Derek Moe , Vikas Agarwal , Walid Habib
IPC分类号： A61K31/4468 , A61P29/00 , B65D83/04
CPC分类号： A61K31/445 , A61K9/0007 , A61K9/006 , A61K9/205
摘要： Fentanyl containing dosage forms and methods using same are described. These dosage forms include substantially less fentanyl by weight than know oral formulation and have advantages in terms of cost and side effects. These dosage forms are intended for oral administration of fentanyl across the oral mucosa.
摘要翻译：描述了含有芬太尼的剂型及使用它们的方法。这些剂型包括比已知口服制剂重量少的芬太尼，并且在成本和副作用方面具有优势。这些剂型旨在口服口服粘膜上的芬太尼。

7. 发明申请

US20050142197A1 Generally linear effervescent oral fentanyl dosage form and methods of administering 审中-公开
公开(公告)号：US20050142197A1
公开(公告)日：2005-06-30
申请号：US11026327
申请日：2004-12-30
申请人： Derek Moe , Vikas Agarwal , Walid Habib
发明人： Derek Moe , Vikas Agarwal , Walid Habib
IPC分类号： A61K9/00 , A61K9/20 , A61K9/46 , A61K31/445 , A61K9/70
CPC分类号： A61K31/445 , A61K9/0007 , A61K9/006 , A61K9/205
摘要： Fentanyl containing dosage forms and methods using same are described. These dosage forms include substantially less fentanyl by weight than know oral formulation and have advantages in terms of cost and side effects. These dosage forms are intended for oral administration of fentanyl across the oral mucosa.

8. 发明申请

US20060147516A1 Taste masking system for alprazolam 审中-公开
标题翻译：阿普唑仑的口味遮蔽系统
公开(公告)号：US20060147516A1
公开(公告)日：2006-07-06
申请号：US11325038
申请日：2006-01-04
申请人： Walid Habib , Derek Moe
发明人： Walid Habib , Derek Moe
IPC分类号： A61K9/48 , A61K9/20
CPC分类号： A61K9/14 , A61K9/0056 , A61K9/2081 , A61K9/5026 , A61K9/5078 , A61K31/5517 , A61K47/10 , A61K47/36
摘要： The present invention relates to taste masking system, taste masked formulations, dosage forms made from those formulations and methods of making those formulations that involve dissolving or dispersing a pH dependant polymer and alprazolam in a solvent, granulating using that material or forming layers over a solid support therewith. This can be followed with the use of an overcoating layer.
摘要翻译：本发明涉及味道掩蔽系统，掩味制剂，由这些制剂制成的剂型和制备涉及将pH依赖性聚合物和阿普唑仑溶解或分散在溶剂中的制剂的方法，使用该材料制粒或在固体上形成层支持。可以使用外涂层。

9. 发明申请

US20080069891A1 Abuse resistant drug formulation 审中-公开
标题翻译：滥用药物制剂
公开(公告)号：US20080069891A1
公开(公告)日：2008-03-20
申请号：US11900851
申请日：2007-09-13
申请人： Walid Habib , Ehab Hamed , Derek Moe
发明人： Walid Habib , Ehab Hamed , Derek Moe
IPC分类号： A61K9/16 , A61K47/14 , A61K47/30 , A61P25/04 , A61K47/36 , A61K47/38
CPC分类号： A61K9/2095 , A61K9/1652 , A61K9/1694 , A61K9/2081 , A61K9/5047 , A61K31/485
摘要： A pharmaceutical composition may include a granulate which may include at least one active pharmaceutical ingredient susceptible to abuse by an individual mixed with at least two materials, a first material that is substantially water insoluble and at least partially alcohol soluble and a second material that is substantially alcohol insoluble and at least partially water soluble, wherein the active pharmaceutical ingredient and the two materials are granulated in the presence of water and alcohol. The composition may also include a coating on the granulate exhibiting crush resistance which may have a material that is deposited on the granulate using an alcohol based solvent. The composition further comprises a second particle comprising a fat/wax. The present invention also includes a coated granulate, various dosage forms of the composition, as well as methods of production and tableting.
摘要翻译：药物组合物可以包括颗粒，其可以包括至少一种易受由与至少两种材料混合的个体滥用的活性药物成分，基本上不溶于水且至少部分醇溶性的第一种物质，醇不溶和至少部分水溶性，其中活性药物成分和两种物质在水和醇存在下造粒。该组合物还可以包括具有抗压溃性的颗粒上的涂层，其可以具有使用醇基溶剂沉积在颗粒上的材料。组合物还包含包含脂肪/蜡的第二颗粒。本发明还包括涂覆的颗粒，组合物的各种剂型，以及生产和压片的方法。

10. 发明申请

US20110200681A1 Abuse Resistant Drug Formulation 审中-公开
标题翻译：滥用药物配方
公开(公告)号：US20110200681A1
公开(公告)日：2011-08-18
申请号：US13095434
申请日：2011-04-27
申请人： Walid Habib , Ehab Hamed , Derek Moe , Carrie Kraling , Lisa Hillman
发明人： Walid Habib , Ehab Hamed , Derek Moe , Carrie Kraling , Lisa Hillman
IPC分类号： A61K9/50 , A61K9/52 , A61K31/485 , A61P25/04 , A61P25/36
CPC分类号： A61K9/2095 , A61K9/1652 , A61K9/1694 , A61K9/2081 , A61K9/5047 , A61K31/485
摘要： A pharmaceutical composition may include a granulate which may include at least one active pharmaceutical ingredient susceptible to abuse by an individual mixed with at least two materials, a first material that is substantially water insoluble and at least partially alcohol soluble and a second material that is substantially alcohol insoluble and at least partially water soluble, wherein the active pharmaceutical ingredient and the two materials are granulated in the presence of water and alcohol. The composition may also include a coating on the granulate exhibiting crush resistance which may have a material that is deposited on the granulate using an alcohol based solvent. The composition further comprises a second particle comprising a fat/wax. The present invention also includes a coated granulate, various dosage forms of the composition, as well as methods of production and tableting.
摘要翻译：药物组合物可以包括颗粒，其可以包括至少一种易受由与至少两种材料混合的个体滥用的活性药物成分，基本上不溶于水且至少部分醇溶性的第一种物质，醇不溶和至少部分水溶性，其中活性药物成分和两种物质在水和醇存在下造粒。该组合物还可以包括具有抗压溃性的颗粒上的涂层，其可以具有使用醇基溶剂沉积在颗粒上的材料。组合物还包含包含脂肪/蜡的第二颗粒。本发明还包括涂覆的颗粒，组合物的各种剂型，以及生产和压片的方法。

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