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1. 发明申请

US20110077289A1 METHOD OF TREATING PNEUMOCONIOSIS WITH OLIGODEOXYNUCLEOTIDES 有权
标题翻译：用寡核苷酸处理肺炎的方法
公开(公告)号：US20110077289A1
公开(公告)日：2011-03-31
申请号：US12993809
申请日：2009-05-20
申请人： Dennis M. Klinman , Takashi Sato
发明人： Dennis M. Klinman , Takashi Sato
IPC分类号： A61K31/7088 , A61P11/00 , A61P31/00 , A61P29/00 , A61P11/10 , A61P11/08 , A61P43/00
CPC分类号： A61K31/7088
摘要： Methods are disclosed for treating, preventing or reducing the risk of developing occupational lung diseases, such as pneumoconiosis. In several embodiments, the methods include administering a therapeutically effective amount of the suppressive ODN to a subject having or at risk of developing a pneumoconiosis, thereby treating or inhibiting the pneumoconiosis. In several examples, thee subject can have or be at risk of developing silicosis, asbestosis or berryliosis. The method can include selecting a subject exposed to, or at risk of exposure to, inorganic particles, including, but not limited to silica, asbestos, berrylium, coal dust, or bauxite.
摘要翻译：公开了治疗，预防或降低发展职业性肺部疾病如肺尘埃沉着病的风险的方法。在几个实施方案中，所述方法包括向具有或具有发生肺尘埃沉着病风险的受试者施用治疗有效量的抑制性ODN，从而治疗或抑制肺尘埃沉着病。在几个例子中，您的受试者可能有或有发生矽肺，石棉沉滞症或bellyliosis的风险。该方法可以包括选择暴露于或有暴露于无机颗粒的风险的对象，包括但不限于二氧化硅，石棉，铍，煤粉或铝土矿。

2. 发明授权

US08222225B2 Method of treating pneumoconiosis with oligodeoxynucleotides 有权
标题翻译：用寡脱氧核苷酸治疗肺尘埃沉着病的方法
公开(公告)号：US08222225B2
公开(公告)日：2012-07-17
申请号：US12993809
申请日：2009-05-20
申请人： Dennis M. Klinman , Takashi Sato
发明人： Dennis M. Klinman , Takashi Sato
IPC分类号： A61K48/00 , C12N5/00 , C12N15/00 , A01N63/00
CPC分类号： A61K31/7088
摘要： Methods are disclosed for treating, preventing or reducing the risk of developing occupational lung diseases, such as pneumoconiosis. In several embodiments, the methods include administering a therapeutically effective amount of the suppressive ODN to a subject having or at risk of developing a pneumoconiosis, thereby treating or inhibiting the pneumoconiosis. In several examples, thee subject can have or be at risk of developing silicosis, asbestosis or berryliosis. The method can include selecting a subject exposed to, or at risk of exposure to, inorganic particles, including, but not limited to silica, asbestos, berrylium, coal dust, or bauxite.
摘要翻译：公开了治疗，预防或降低发展职业性肺部疾病如肺尘埃沉着病的风险的方法。在几个实施方案中，所述方法包括向具有或具有发生肺尘埃沉着病风险的受试者施用治疗有效量的抑制性ODN，从而治疗或抑制肺尘埃沉着病。在几个例子中，您的受试者可能有或有发生矽肺，石棉沉滞症或bellyliosis的风险。该方法可以包括选择暴露于或有暴露于无机颗粒的风险的对象，包括但不限于二氧化硅，石棉，铍，煤粉或铝土矿。

3. 发明申请

US20090099122A1 USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE EPITHELIAL CELL GROWTH 有权
标题翻译：使用CpG寡糖氧化酶诱导上皮细胞生长
公开(公告)号：US20090099122A1
公开(公告)日：2009-04-16
申请号：US12205756
申请日：2008-09-05
申请人： Dennis M. Klinman , Takashi Sato
发明人： Dennis M. Klinman , Takashi Sato
IPC分类号： A61K31/711 , C12N5/02 , A61P17/02
CPC分类号： A61K31/711
摘要： This disclosure provides a method of inducing epithelial cell growth. The method includes administering an effective amount of a K-type CpG oligonucleotide, thereby inducing epithelial cell growth. The epithelial cell can be in vivo or in vitro. Methods are also provided for inducing wound healing in a subject. The methods include administering to the subject a therapeutically effective amount of at least on K-type CpG ODN.
摘要翻译：本公开提供了诱导上皮细胞生长的方法。该方法包括施用有效量的K型CpG寡核苷酸，从而诱导上皮细胞生长。上皮细胞可以在体内或体外。还提供了用于在受试者中诱导伤口愈合的方法。所述方法包括向受试者施用治疗有效量的至少一种K型CpG ODN。

4. 发明授权

US08466116B2 Use of CpG oligodeoxynucleotides to induce epithelial cell growth 有权
标题翻译：使用CpG寡脱氧核苷酸诱导上皮细胞生长
公开(公告)号：US08466116B2
公开(公告)日：2013-06-18
申请号：US12205756
申请日：2008-09-05
申请人： Dennis M. Klinman , Takashi Sato
发明人： Dennis M. Klinman , Takashi Sato
IPC分类号： A61K39/00 , A61K39/38 , A61K45/00 , A61K47/00 , A61K48/00 , A01N43/04 , C07H21/02
CPC分类号： A61K31/711
摘要： This disclosure provides a method of inducing epithelial cell growth. The method includes administering an effective amount of a K-type CpG oligonucleotide, thereby inducing epithelial cell growth. The epithelial cell can be in vivo or in vitro. Methods are also provided for inducing wound healing in a subject. The methods include administering to the subject a therapeutically effective amount of at least one K-type CpG ODN.
摘要翻译：本公开提供了诱导上皮细胞生长的方法。该方法包括施用有效量的K型CpG寡核苷酸，从而诱导上皮细胞生长。上皮细胞可以在体内或体外。还提供了用于在受试者中诱导伤口愈合的方法。所述方法包括向受试者施用治疗有效量的至少一种K型CpG ODN。

5. 发明授权

US08697666B2 Anti-cancer oligodeoxynucleotides 有权
标题翻译：抗癌寡脱氧核苷酸
公开(公告)号：US08697666B2
公开(公告)日：2014-04-15
申请号：US13243841
申请日：2011-09-23
申请人： Dennis M. Klinman , Hidekazu Ikeuchi
发明人： Dennis M. Klinman , Hidekazu Ikeuchi
IPC分类号： C12N15/113 , C07H21/04
CPC分类号： A61K31/7088
摘要： It is disclosed herein that suppressive OD Ns are of use for preventing or delaying the formation of a tumor, reducing the risk of developing a tumor, treating a tumor, preventing conversion of a benign to a malignant lesion, or preventing metastasis. In some embodiments, methods are disclosed herein for treating, preventing or reducing the risk of developing a tumor, such as esophageal, gastrointestinal, liver, lung, skin and colon tumors or a mesothelioma. Generally, the methods disclosed herein include selecting a subject for treatment and administering to the subject a therapeutically effective amount of one or more suppressive ODN. In some examples, additional agents can also be administered to the subject of interest.
摘要翻译：本文公开了抑制性OD Ns用于预防或延缓肿瘤的形成，降低发展肿瘤的风险，治疗肿瘤，预防良性转化为恶性病变或预防转移的风险。在一些实施方案中，本文公开了用于治疗，预防或降低发展肿瘤如食道，胃肠，肝，肺，皮肤和结肠肿瘤或间皮瘤的风险的方法。通常，本文公开的方法包括选择受试者以治疗和给予受试者治疗有效量的一种或多种抑制性ODN。在一些实例中，还可以向感兴趣的受试者施用另外的药剂。

6. 发明申请

US20110110883A1 METHODS OF ALTERING AN IMMUNE RESPONSE INDUCED BY CPG OLIGODEOXYNUCLEOTIDES 有权
标题翻译：改变CPG寡糖氧化酶诱导的免疫反应的方法
公开(公告)号：US20110110883A1
公开(公告)日：2011-05-12
申请号：US13005488
申请日：2011-01-12
申请人： Dennis M. Klinman , Mayda Gursel , Ihsan Gursel
发明人： Dennis M. Klinman , Mayda Gursel , Ihsan Gursel
IPC分类号： A61K31/7088 , A61K38/19 , A61K38/21 , A61K39/00 , A61P37/04 , A61P31/04 , A61P31/12 , A61P31/10 , A61P31/00 , A61P35/00
CPC分类号： C12N15/117 , C12N15/111 , C12N2310/17 , C12N2320/50
摘要： It is disclosed herein that agents that affect the activity and/or expression of CXCL16 can be used to alter the uptake of D-type CpG oligodeoxynucleotides (D ODNs). Methods of inducing an immune response are disclosed that include administering agents that increase the activity and/or expression of CXCL16 and a D ODN. Methods of decreasing an immune response to a CpG ODN are also disclosed. These methods include administering an agent that decreases the activity and/or expression of CXCL16. Compositions including one or more D-type ODNs and an agent that modulates that activity and/or expression of CXCL16 are provided.
摘要翻译：本文公开了影响CXCL16的活性和/或表达的药剂可用于改变D型CpG寡脱氧核苷酸（D ODN）的摄取。公开了诱导免疫应答的方法，其包括增加CXCL16和DODN的活性和/或表达的施用试剂。还公开了降低对CpG ODN的免疫应答的方法。这些方法包括施用降低CXCL16的活性和/或表达的试剂。提供包含一种或多种D型ODN的组合物和调节CXCL16的活性和/或表达的试剂。

7. 发明授权

US07354909B2 Method for rapid generation of mature dendritic cells 有权
标题翻译：快速生成成熟树突细胞的方法
公开(公告)号：US07354909B2
公开(公告)日：2008-04-08
申请号：US10486755
申请日：2002-08-13
申请人： Dennis M. Klinman , Mayda Gursel , Daniela Verthelyi
发明人： Dennis M. Klinman , Mayda Gursel , Daniela Verthelyi
IPC分类号： A61K31/70
CPC分类号： C12N5/0639 , A61K39/39 , A61K2039/5158 , A61K2039/55561 , C12N2501/056
摘要： Novel methods for rapidly generating dendritic cells are disclosed herein. The methods include contacting a dendritic cell precursor with a D ODN to generate a mature dendritic cell. In one specific, non/limiting example, the method includes contacting the dendritic cell precursor or the mature dendritic cell with an antigen. The methods are of use both in vitro and in vivo.
摘要翻译：本文公开了用于快速产生树突状细胞的新方法。所述方法包括使树状细胞前体与D ODN接触以产生成熟树突细胞。在一个具体的非限制性实例中，该方法包括使树突细胞前体或成熟树突状细胞与抗原接触。该方法在体外和体内都是有用的。

8. 发明授权

US08895521B2 Methods and compositions for the treatment of uveitis 有权
标题翻译：用于治疗葡萄膜炎的方法和组合物
公开(公告)号：US08895521B2
公开(公告)日：2014-11-25
申请号：US11579518
申请日：2005-05-05
申请人： Dennis M. Klinman , Igal Gery , Chiaki Fujimoto
发明人： Dennis M. Klinman , Igal Gery , Chiaki Fujimoto
IPC分类号： C12N15/113 , C07H21/04 , A61K31/7088 , C12N15/117 , A61K45/06
CPC分类号： C12N15/117 , A61K31/7088 , A61K45/06 , C12N2310/151 , C12N2310/17 , C12N2310/18 , C12N2310/315 , A61K2300/00
摘要： Pharmaceutical compositions are disclosed that are of use for the treatment of uveitis. These compositions include a suppressive oligonucleotide. These compositions including an immunosuppressive oligonucleotide can be used for the treatment of uveitis, including anterior, posterior, and diffuse uveitis.
摘要翻译：公开了用于治疗葡萄膜炎的药物组合物。这些组合物包括抑制性寡核苷酸。包括免疫抑制性寡核苷酸的这些组合物可用于治疗葡萄膜炎，包括前，后和弥漫性葡萄膜炎。

9. 发明授权

US08263091B2 Method of treating and preventing infections in immunocompromised subjects with immunostimulatory CpG oligonucleotides 有权
标题翻译：用免疫刺激性CpG寡核苷酸治疗和预防免疫受损受试者感染的方法
公开(公告)号：US08263091B2
公开(公告)日：2012-09-11
申请号：US10666022
申请日：2003-09-17
申请人： Dennis M. Klinman , Daniela Verthelyi
发明人： Dennis M. Klinman , Daniela Verthelyi
IPC分类号： A61K31/70
CPC分类号： C07K16/082 , A61K31/7115 , A61K31/7125 , A61K39/39 , A61K2039/55561 , Y02A50/41 , Y02A50/492
摘要： A method is disclosed herein for increasing an immune response to an opportunistic infection in an immunocompromised subject. In one embodiment, the subject is infected with a lentivirus. The method includes increasing an immune response to a pathogen using D oligodeoxynucleotides including a CpG motif.
摘要翻译：本文公开了一种在免疫受损受试者中增加对机会性感染的免疫应答的方法。在一个实施方案中，受试者被慢病毒感染。该方法包括使用包含CpG基序的D寡脱氧核苷酸增加对病原体的免疫应答。

10. 发明授权

US08043622B2 Method of treating inflammatory lung disease with suppressors of CpG oligonucleotides 有权
标题翻译：用CpG寡核苷酸抑制剂治疗炎症性肺病的方法
公开(公告)号：US08043622B2
公开(公告)日：2011-10-25
申请号：US10682130
申请日：2003-10-07
申请人： Dennis M. Klinman , Hiroshi Yamada
发明人： Dennis M. Klinman , Hiroshi Yamada
IPC分类号： A61K39/38 , C07H19/00 , C07H21/00
CPC分类号： C12N15/117 , C12N2310/151
摘要： The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for inhibiting or treating inflammatory lung disease by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
摘要翻译：本公开涉及抑制免疫应答的寡脱氧核苷酸。公开了通过施用治疗有效量的抑制性寡脱氧核苷酸来抑制或治疗炎症性肺病的方法。

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