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1. 发明授权

US5345070A Radio frequency tubing sealer 失效
标题翻译：射频管封口机
公开(公告)号：US5345070A
公开(公告)日：1994-09-06
申请号：US21507
申请日：1993-02-23
申请人： Dennis J. Hlavinka , Frank Corbin, III , Robert L. White
发明人： Dennis J. Hlavinka , Frank Corbin, III , Robert L. White
IPC分类号： A61M5/14 , B29C57/10 , B29C65/00 , B29C65/04 , B29C65/74 , B29L23/00 , B65B51/10 , H05B6/62
CPC分类号： B29C65/04 , B29C65/743 , B29C66/1122 , B29C66/4312 , B29C66/73921 , B29C66/8122 , B29C66/81263 , B29C66/81422 , B29C66/8187 , B29C66/8322 , B29C66/857 , B29C66/8614 , B29C57/10 , B29C66/71 , B29C66/81871 , B29L2023/007 , B29L2031/753 , Y10S128/24 , Y10S604/905
摘要： An insulating sleeve retains heat in the plastic of a flexible plastic medical tube when the plastic of the medical tube is dielectrically heated by a radio frequency tubing sealer. The heat retained by the insulating sleeve permits additional melting of the plastic of the medical tube after a seal has been formed. The additional melting results in forming an easily tearable web between the segments of the medical tube in the same operation as the sealing operation. The medical tube is selectively sealed without forming the easily tearable web by using the radio frequency tubing sealer without the insulating sleeve.
摘要翻译：当医疗管的塑料被射频管密封器介电加热时，绝缘套管在柔性塑料医疗管的塑料中保持热量。在形成密封件之后，由绝缘套管保留的热量允许医用管的塑料的额外熔化。在与密封操作相同的操作中，额外的熔化导致在医疗管的段之间形成容易撕裂的网。通过使用没有绝缘套筒的射频管封口机，医疗管被选择性地密封，而不形成易撕层。

2. 发明授权

US5520218A Medical tubing set for the use with an improved radio frequency tubing sealer 失效
标题翻译：医疗油管套装用于改进的射频管封口机
公开(公告)号：US5520218A
公开(公告)日：1996-05-28
申请号：US257653
申请日：1994-06-09
申请人： Dennis J. Hlavinka , Frank Corbin, III , Robert L. White
发明人： Dennis J. Hlavinka , Frank Corbin, III , Robert L. White
IPC分类号： A61M5/14 , B29C57/10 , B29C65/00 , B29C65/04 , B29C65/74 , B29L23/00 , B65B51/10 , F16L55/10
CPC分类号： B29C65/04 , B29C65/743 , B29C66/1122 , B29C66/4312 , B29C66/73921 , B29C66/8122 , B29C66/81263 , B29C66/81422 , B29C66/8187 , B29C66/8322 , B29C66/857 , B29C66/8614 , B29C57/10 , B29C66/71 , B29C66/81871 , B29L2023/007 , B29L2031/753 , Y10S128/24 , Y10S604/905
摘要： A tubing set includes at least one fluid conveying tube. The fluid conveying tube has a predetermined outside diameter, and is formed of a material adapted to be dielectrically heated at a sealing location. The insulating sleeve has an inside dimension at least as large as the outside diameter of the fluid conveying tube. The tubular insulating sleeve is positioned in a substantially coaxial relationship with the fluid conveying tube at the sealing location, and has a wall with thickness which insulates the fluid conveying tube to permit sealing the fluid conveying tube, and forming a thin, easily tearable web, by the application of the radio frequency dielectric heating.
摘要翻译：管组包括至少一个流体输送管。流体输送管具有预定的外径，并且由适于在密封位置进行介电加热的材料形成。绝缘套筒具有至少与流体输送管的外径一样大的内部尺寸。管状绝缘套管在密封位置处与流体输送管基本上同轴的关系定位，并且具有厚度的壁，该壁具有使流体输送管绝缘以允许密封流体输送管，并且形成薄的易撕层的腹板，通过应用射频电介质加热。

3. 发明申请

US20110220290A1 Heat Weld Tubing Connectors 审中-公开
标题翻译：热焊管连接器
公开(公告)号：US20110220290A1
公开(公告)日：2011-09-15
申请号：US13114170
申请日：2011-05-24
申请人： Dennis J. Hlavinka , Keith Manica , Frank Corbin, III , Terrence M. Cussen
发明人： Dennis J. Hlavinka , Keith Manica , Frank Corbin, III , Terrence M. Cussen
IPC分类号： B29C65/02
CPC分类号： F16L47/02 , A61M39/143 , A61M39/146 , A61M39/18 , B29C65/2046 , B29C65/2076 , B29C66/0042 , B29C66/00441 , B29C66/1122 , B29C66/1142 , B29C66/5221 , B29C66/71 , B29C66/712 , B29C66/73116 , B29C66/73921 , B29C66/80 , B29C66/8122 , B29C66/81821 , B29C66/8432 , B29C66/857 , B29K2021/003 , B29K2023/00 , B29K2027/06 , B29K2101/12 , B29K2827/18 , B29C65/00 , B29K2909/02 , B29K2867/00 , B29K2905/02 , B29K2905/10
摘要： The present invention provides thermoplastic tubes, thermoplastic melting plates, thermoplastic tube connecting apparatus, and methods for using the same.
摘要翻译：本发明提供热塑性管，热塑性熔融板，热塑性管连接装置及其使用方法。

4. 发明授权

US07582049B2 Fluid separation devices, systems and/or methods using a centrifuge and roller pump 失效
标题翻译：流体分离装置，使用离心机和滚子泵的系统和/或方法
公开(公告)号：US07582049B2
公开(公告)日：2009-09-01
申请号：US11307451
申请日：2006-02-08
申请人： Dennis J. Hlavinka , William G Palsulich , Thomas J. Felt , Frank Corbin, III
发明人： Dennis J. Hlavinka , William G Palsulich , Thomas J. Felt , Frank Corbin, III
IPC分类号： B04B5/02
CPC分类号： A61M1/0209 , A61M1/3693 , B04B5/0428
摘要： A centrifugal fluid separation system is disclosed for centrifugally separating a composite fluid into components thereof. This centrifugal separation system includes at least a centrifugal rotor which has a composite fluid containment area, a fluid flow channel/tubing and at least one separated component collection area defined therein. A composite fluid to be separated is delivered to the fluid containment area where under centrifugal forces the composite fluid is separated into components and then from which a component travels through an outlet channel to a respective separated component fluids flowing therethrough. A centrally disposed pump is also provided to move the separated component(s) to the collection area(s). Optical sensing of the interface of the separated fluid components may be used with a clamp to stop flow. A disposable bag and tubing system is also disclosed for use with reusable rotor devices.
摘要翻译：公开了用于将复合流体离心分离成其组分的离心流体分离系统。该离心分离系统至少包括离心转子，其具有复合流体容纳区域，流体流动通道/管道和限定在其中的至少一个分离的部件收集区域。要分离的复合流体被输送到流体容纳区域，在离心力作用下，复合流体被分离成组分，然后组分通过出口通道行进到流过其中的各自分离的组分流体。还提供了一个集中设置的泵以将分离的部件移动到收集区域。分离的流体组分的界面的光学感测可以与夹具一起使用以阻止流动。还公开了一次性袋和管道系统，用于可重复使用的转子装置。

5. 发明授权

US4246121A Fluid flow transfer device with formed-in-place manifold gasket and method of making same 失效
标题翻译：具有形成在位的歧管垫片的流体流动传送装置及其制造方法
公开(公告)号：US4246121A
公开(公告)日：1981-01-20
申请号：US961618
申请日：1978-11-17
申请人： Frank Corbin, III , Dennis J. Hlavinka
发明人： Frank Corbin, III , Dennis J. Hlavinka
IPC分类号： B01D31/00
CPC分类号： B01D63/14 , B01D2313/04
摘要： A fluid flow transfer device having a pleated membrane bonded at its tips to the interior of a housing and a method of making the same wherein a fluid manifold is provided by forming a channel portion in the housing interior, applying a gasket material around the channel portion, and placing the membrane tips against the adhesive to provide a formed-in-place gasket prior to potting of the membrane tips to the housing interior with a potting material.
摘要翻译：一种流体流动传递装置，具有在其顶端处连接到壳体内部的褶皱膜及其制造方法，其中通过在壳体内部形成通道部分来提供流体歧管，在通道部分周围施加垫圈材料，并且将膜尖端抵靠粘合剂，以在用封装材料将膜尖端灌封到壳体内部之前提供形成就位的垫圈。

6. 发明授权

US07033512B2 Fluid separation devices, systems and/or methods using a centrifuge and roller pump 失效
公开(公告)号：US07033512B2
公开(公告)日：2006-04-25
申请号：US10413890
申请日：2003-04-14
申请人： Dennis J. Hlavinka , William G. Palsulich , Thomas J. Felt , Frank Corbin, III
发明人： Dennis J. Hlavinka , William G. Palsulich , Thomas J. Felt , Frank Corbin, III
IPC分类号： C02F1/38
CPC分类号： A61M1/0209 , A61M1/3693 , B04B5/0428
摘要： A centrifugal fluid separation system is disclosed for centrifugally separating a composite fluid into components thereof. This centrifugal separation system includes at least a centrifugal rotor which has a composite fluid containment area, a fluid flow channel/tubing and at least one separated component collection area defined therein. A composite fluid to be separated is delivered to the fluid containment area where under centrifugal forces the composite fluid is separated into components and then from which a component travels through an outlet channel to a respective separated component fluids flowing therethrough. A centrally disposed pump is also provided to move the separated component(s) to the collection area(s). Optical sensing of the interface of the separated fluid components may be used with a clamp to stop flow. A disposable bag and tubing system is also disclosed for use with reusable rotor devices.

7. 发明授权

US07964048B2 Heat weld tubing connectors 有权
标题翻译：热焊管连接器
公开(公告)号：US07964048B2
公开(公告)日：2011-06-21
申请号：US11772337
申请日：2007-07-02
申请人： Dennis J. Hlavinka , Keith Manica , Frank Corbin, III , Terrence M. Cussen
发明人： Dennis J. Hlavinka , Keith Manica , Frank Corbin, III , Terrence M. Cussen
IPC分类号： B29C65/18
CPC分类号： F16L47/02 , A61M39/143 , A61M39/146 , A61M39/18 , B29C65/2046 , B29C65/2076 , B29C66/0042 , B29C66/00441 , B29C66/1122 , B29C66/1142 , B29C66/5221 , B29C66/71 , B29C66/712 , B29C66/73116 , B29C66/73921 , B29C66/80 , B29C66/8122 , B29C66/81821 , B29C66/8432 , B29C66/857 , B29K2021/003 , B29K2023/00 , B29K2027/06 , B29K2101/12 , B29K2827/18 , B29C65/00 , B29K2909/02 , B29K2867/00 , B29K2905/02 , B29K2905/10
摘要： The present invention provides thermoplastic tubes, thermoplastic melting plates, thermoplastic tube connecting apparatus, and methods for using the same.
摘要翻译：本发明提供热塑性管，热塑性熔融板，热塑性管连接装置及其使用方法。

8. 发明授权

US08123713B2 System and method for collecting plasma protein fractions from separated blood components 有权
$System and method for collecting plasma protein fractions from separated blood components$
标题翻译：用于从分离的血液成分收集血浆蛋白质级分的系统和方法
公开(公告)号：US08123713B2
公开(公告)日：2012-02-28
申请号：US12429266
申请日：2009-04-24
申请人： Thomas J. Felt , Frank Corbin, III , Steven Gage Urdahl
发明人： Thomas J. Felt , Frank Corbin, III , Steven Gage Urdahl
IPC分类号： A61M37/00 , C02F1/44
CPC分类号： A61M1/36 , A61M1/3496 , A61M1/3696 , A61M1/38 , A61M2202/0415 , A61M2202/07 , A61M2205/12
摘要： Method and apparatus for separating plasma from blood in a separation vessel and further separator the separated plasma into desired plasma proteins in a plasma separator fluidly connected to the separation vessel to receive the separated plasma.
摘要翻译：用于在分离容器中从血液中分离血浆的方法和装置，并且将分离的血浆进一步将流体连接到分离容器的血浆分离器中的所需血浆蛋白分离，以接收分离的血浆。

9. 发明授权

US06231537B1 Extracorporeal blood processing methods and apparatus 失效
公开(公告)号：US06231537B1
公开(公告)日：2001-05-15
申请号：US09010077
申请日：1998-01-21
申请人： Brian M. Holmes , Jeffrey J. Blakeslee , Marlene Adele Bainbridge , Frank Corbin, III
发明人： Brian M. Holmes , Jeffrey J. Blakeslee , Marlene Adele Bainbridge , Frank Corbin, III
IPC分类号： A61M3700
CPC分类号： B04B5/0442 , A61M1/3624 , A61M1/3639 , A61M1/3641 , A61M1/3652 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2205/123 , A61M2205/125 , A61M2205/128 , A61M2205/14 , A61M2205/505 , B04B9/08 , B04B2005/045
摘要： An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.

10. 发明授权

US07497944B2 Blood component processing system, apparatus, and method 有权
标题翻译：血液成分处理系统，装置和方法
公开(公告)号：US07497944B2
公开(公告)日：2009-03-03
申请号：US11727550
申请日：2007-03-27
申请人： Niclas Högberg , Emanuel Hällgren , Peter Pihlstedt , Brian M. Holmes , Lars Persson , Lars Strandberg , Geert Van Waeg , Frank Corbin, III
发明人： Niclas Högberg , Emanuel Hällgren , Peter Pihlstedt , Brian M. Holmes , Lars Persson , Lars Strandberg , Geert Van Waeg , Frank Corbin, III
IPC分类号： B01D21/30 , B04B5/02 , B04B5/04
CPC分类号： B04B13/00 , A61M1/0209 , A61M1/0218 , A61M1/025 , A61M1/26 , A61M1/262 , A61M1/3633 , A61M1/3639 , A61M1/3641 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M2205/331 , B04B5/0428 , B04B5/0442 , B04B2005/045 , B04B2005/0478 , B04B2013/006
摘要： A system and method are used in connection with processing of blood components. The processing of blood components may involve centrifugal separation and/or filtering of the blood components. In some examples, at least some blood components are centrifugally separated in a chamber and then filtered via a filter rotating along with a centrifuge rotor, wherein the filter is located closer than the chamber to an axis of rotation of the rotor. The filter may include a porous filtration medium configured to filter leukocytes, platelets, and/or red blood cells. Some examples include a pressure sensor sensing pressure of pumped blood components. The sensed pressure may be used in connection with controlling the pumping of the blood products and/or in connection with determining the location of an interface associated with the blood products. Other uses of the sensed pressure are also possible.
摘要翻译：与血液成分的处理有关的系统和方法。血液成分的处理可能涉及血液成分的离心分离和/或过滤。在一些实例中，至少一些血液成分在室中离心分离，然后通过与离心机转子一起旋转的过滤器过滤，其中过滤器位于比转筒更靠近转动轴的位置。过滤器可以包括被配置为过滤白细胞，血小板和/或红细胞的多孔过滤介质。一些示例包括感测泵送的血液成分的压力的压力传感器。感测到的压力可以与控制血液制品的泵送和/或与确定与血液制品相关联的界面的位置的结合一起使用。感测压力的其他用途也是可能的。

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