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    • 1. 发明申请
    • DUCKBILL CATHETER RELEASE MECHANISM
    • DUCKILLER CATHETER发布机制
    • US20070038188A1
    • 2007-02-15
    • US11161554
    • 2005-08-08
    • Dennis BialeckiDavid GoralAlan KingSean AlbertThomas Sutton
    • Dennis BialeckiDavid GoralAlan KingSean AlbertThomas Sutton
    • A61M5/178
    • A61M25/0618A61M5/3273A61M2005/325
    • A needle guard includes a clip with a canting wall to grip the needle shaft and a distal wall to block the tip thereof, wherein the canting and distal walls may be interconnected by an angled strut, a spring member, such as a leaf spring, may have a portion extending past an edge of the strut to bias the clip to grip the needle shaft, and the distal wall may be or include a stylus and have an L-shape to define a lip to help block the needle tip. The clip may have a depending heel to help pivot the clip about a ledge to grip the needle shaft. A needle support may be provided to limit flexure of the needle which might otherwise allow the needle to come loose from the clip. Arrangements for limiting rotation of the needle hub and needle guard housing are provided, as is a protective shroud to reduce the risk of inadvertent activation of the needle guard. Further, the needle guard may be used with a catheter assembly. Also provided is an improved duckbill release mechanism.
    • 针护罩包括具有倾斜壁以夹持针轴的夹子和用于阻挡其尖端的远侧壁,其中倾斜和远侧壁可以通过成角度的支柱,弹簧构件(例如板簧)相互连接, 具有延伸穿过支柱的边缘的部分以偏置夹子以夹持针轴,并且远侧壁可以是或包括触针并且具有L形以限定唇缘以帮助阻止针尖。 夹子可以具有悬垂的鞋跟,以帮助夹子围绕凸缘枢转以夹紧针轴。 可以提供针支撑件来限制针的弯曲,否则可能会使针从夹子中松脱。 提供了用于限制针座和针保护壳的旋转的布置,保护罩也是如此,以减少针保护装置的无意的激活的风险。 此外,针护罩可以与导管组件一起使用。 还提供了改进的鸭嘴释放机构。
    • 2. 发明申请
    • Enclosed Needle Device with Duckbill Release Mechanism
    • 带鸭嘴释放机构的封闭针装置
    • US20070191776A1
    • 2007-08-16
    • US11276152
    • 2006-02-16
    • Dennis BialeckiNhut DiepAlan KingThomas Koehler
    • Dennis BialeckiNhut DiepAlan KingThomas Koehler
    • A61M5/178
    • A61M25/0631A61M5/3271A61M25/0606A61M2005/3247
    • An enclosed needle catheter insertion device (10) includes a catheter (12) and a needle insertion device (14) which are held together by cooperating arms (52, 53) with one or more detents (56) cooperating with a radially projecting surface (26) of the catheter hub (16). Insertion device (14) includes a guard housing (30) to enclose a needle (34) in a shielded position and a support housing (32) supporting the needle (34) for movement between a ready position, with the tip (36) of the needle (34) exposed, to the shielded position. Cooperating lock elements (47, 78) are provided for the housings (30, 32) which are positioned to define a lock actuation stage between the ready and shielded positions, whereat the needle is still within a passageway (54) defined by the cooperating arms (52, 53).
    • 封闭的针导管插入装置(10)包括导管(12)和针插入装置(14),它们通过配合的臂(52,53)与一个或多个与径向突出的表面配合的棘爪(56) 26)。 插入装置(14)包括用于将针(34)封闭在屏蔽位置的保护壳体(30)和支撑针(34)的支撑壳体(32),用于在就绪位置与准备位置之间移动,该就绪位置与尖端 针(34)暴露于屏蔽位置。 为壳体(30,32)设置合作的锁定元件(47,78),所述壳体(30,32)被定位成在准备位置和屏蔽位置之间限定锁定致动台,其中针仍在由协作臂限定的通道(54)内 (52,53)。
    • 8. 发明申请
    • Large volume ex vivo electroporation method
    • 大体积体外电穿孔法
    • US20060108229A1
    • 2006-05-25
    • US10537254
    • 2004-03-15
    • Richard WaltersAlan King
    • Richard WaltersAlan King
    • C25D5/18
    • C12N13/00A61K9/0009C12M1/42C12M3/00C12M3/006C12M3/02C12M35/02C12M45/07C12N15/87
    • An object of the invention is to provide an electroporation method for treating vesicles with exogenous material for insertion of the exogenous material into the vesicles which includes the steps of: a. retaining a suspension of the vesicles and the exogenous material in a treatment volume in a chamber which includes electrodes, wherein the chamber has a geometric factor (cm−1) defined by the quotient of the electrode gap squared (cm2) divided by the chamber volume (cm3), wherein the geometric factor is less than or equal to 0.1 cm−1, wherein the suspension of the vesicles and the exogenous material is in a medium which is adjusted such that the medium has conductivity in a range spanning 0.01 to 1.0 milliSiemens, wherein the suspension is enclosed in the chamber during treatment, and h. treating the suspension enclosed in the chamber with one or more pulsed electric fields. With the method, the treatment volume of the suspension is scalable, and the time of treatment of the vesicles in the chamber is substantially uniform.
    • 本发明的目的是提供一种用外源材料处理囊泡的电穿孔方法,用于将外源材料插入囊泡中,其包括以下步骤:a。 将囊泡和外源材料的悬浮液保持在包括电极的室中的处理体积中,其中所述室具有由电极间隙平方的商定义的几何因子(cm -1 -1 -1) cm 2)除以室容积(cm 3),其中几何因子小于或等于0.1cm -1,其中 囊泡和外源材料的悬浮液在调节介质中使介质具有在0.01至1.0毫西门子范围内的电导率的介质,其中悬浮液在处理过程中封闭在腔室中,而h。 用一个或多个脉冲电场处理封闭在腔室中的悬架。 利用该方法,悬浮液的处理体积是可扩展的,并且腔室中的囊泡的处理时间基本上是均匀的。