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1. 发明授权

US5169854A N-substituted-furylalkenyl hydroxamic acid and N-hydroxyurea compounds having lipoxygenase inhibitory activity 失效
标题翻译： N-取代呋喃基异羟肟酸和具有脂氧合酶抑制活性的N-羟基脲化合物
公开(公告)号：US5169854A
公开(公告)日：1992-12-08
申请号：US841968
申请日：1992-02-26
申请人： Dee W. Brooks , Andrew O. Stewart , Pramila Bhatia , Richard A. Craig
发明人： Dee W. Brooks , Andrew O. Stewart , Pramila Bhatia , Richard A. Craig
IPC分类号： A61K31/34 , A61K31/341 , A61P43/00 , C07D307/58 , C07D307/64 , C07D405/12
CPC分类号： C07D405/12 , C07D307/58 , C07D307/64
摘要： Compounds useful in inhibiting the biosynthesis of leukotrienes have the structure ##STR1## where M is hydrogen, a pharmaceutically acceptable cation, or a metabolically cleavable group, R.sup.4 is alkyl, cycloalkyl or --NR.sup.5 R.sup.6, where R.sup.5 and R.sup.6 are hydrogen, alkyl, cycloalkyl or alkanoyl, where A is a valence bond or is a straight or branched divalent alkylene group of from one to twelve carbon atoms, R.sup.2 and R.sup.3 are independently selected from hydrogen, straight or branched alkyl of from one to twelve carbon atoms, halogen, or trifluoroalkyl, and R.sup.1 is selected from phenoxy, phenylthio, 2-, 3-, or 4-pyridyloxy, 1 or 2-naphthyloxy, or 2,4,5, or 8-quinolyloxy, all optionally substituted with alkyl, haloalkyl, alkoxy, hydroxy or halogen.
摘要翻译：可用于抑制白细胞三烯生物合成的化合物具有其中M是氢，药学上可接受的阳离子或代谢可裂解基团的结构，R 4是烷基，环烷基或-NR 5 R 6，其中R 5和R 6是氢，烷基，环烷基或烷酰基，其中A是价键或是具有1至12个碳原子的直链或支链二价亚烷基，R 2和R 3独立地选自氢，具有1至12个碳原子的直链或支链烷基，卤素或三氟烷基，R1选自苯氧基，苯硫基，2-，3-或4-吡啶氧基，1或2-萘氧基或2,4,5或8-喹啉氧基，全部任选被烷基，卤代烷基，烷氧基，羟基或卤素。

2. 发明授权

US5288751A [(Substituted) phenyalkyl]furylalkynyl-and [substituted) phenyalkyl] thienylalkynyl-N-hydroxyurea inhibitors or leukotriene biosynthesis 失效
标题翻译： [（取代的）烷基]呋喃基炔基和[取代的]烷基]噻吩基炔基-N-羟基脲抑制剂或白三烯生物合成
公开(公告)号：US5288751A
公开(公告)日：1994-02-22
申请号：US973100
申请日：1992-11-06
申请人： Dee W. Brooks , Andrew O. Stewart , Anwer Basha , Pramila Bhatia , James D. Ratajczyk
发明人： Dee W. Brooks , Andrew O. Stewart , Anwer Basha , Pramila Bhatia , James D. Ratajczyk
IPC分类号： A61K31/17 , A61K31/38 , A61K31/381 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4433 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P25/00 , A61P27/16 , A61P29/00 , A61P37/08 , A61P43/00 , C07C273/18 , C07C275/24 , C07C275/64 , C07D213/61 , C07D277/28 , C07D307/52 , C07D333/20 , C07D333/22 , C07D405/06 , C07D409/04 , C07D409/06 , C07D417/04 , C07D307/36 , A61K31/34
CPC分类号： C07D405/06 , C07C275/64 , C07D213/61 , C07D277/28 , C07D307/52 , C07D333/20 , C07D409/06
摘要： The present invention relates to compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein Z is selected from optionally substituted phenyl, furyl, thienyl or thiazolyl; which inhibits leukotriene biosynthesis and is useful in the treatment of inflammatory disease states; also disclosed are leukotriene biosynthesis inhibiting compositions and a method for inhibiting 5-lipoxygenase activity and leukotriene biosynthesis.
摘要翻译：本发明涉及式IMA的化合物及其药学上可接受的盐，其中Z选自任选取代的苯基，呋喃基，噻吩基或噻唑基; 其抑制白细胞三烯生物合成并且可用于治疗炎性疾病状态; 还公开了白三烯生物合成抑制组合物和抑制5-脂氧合酶活性和白三烯生物合成的方法。

3. 发明授权

US5795900A Symmetrical bis-heteroaryl-methoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis 失效
标题翻译：对称双杂芳基 - 甲氧基 - 苯基烷基羧酸盐作为白三烯生物合成的抑制剂
公开(公告)号：US5795900A
公开(公告)日：1998-08-18
申请号：US703441
申请日：1996-09-17
申请人： Clint D. Brooks , Pramila Bhatia , Teodozyj Kolasa , Andrew O. Stewart , David E. Gunn , Richard A. Craig
发明人： Clint D. Brooks , Pramila Bhatia , Teodozyj Kolasa , Andrew O. Stewart , David E. Gunn , Richard A. Craig
IPC分类号： C07D239/26 , A61K31/4184 , A61K31/421 , A61K31/4402 , A61K31/454 , A61K31/47 , A61K31/498 , A61K31/506 , A61P37/08 , A61P43/00 , C07D213/30 , C07D215/14 , C07D215/18 , C07D235/12 , C07D241/42 , C07D263/56 , C07D277/24 , C07D277/64 , C07D417/14 , C07D401/10
CPC分类号： C07D213/30 , C07D215/14 , C07D215/18 , C07D235/12 , C07D241/42 , C07D277/64
摘要： Compounds having the formula: ##STR1## wherein W is the same at each occurrence and is selected from optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, optionally substituted benzimidazolyl, optionally substituted quinoxalyl, optionally substituted pyridyl, optionally substituted pyrimidyl, and optionally substituted thiazolyl; R.sup.1 and R.sup.2 are independently selected from hydrogen, alkyl, halolalkyl, alkoxy, halogen; R.sup.3 is a valence bond or is selected from hydrogen and alkyl; X is a valence bond or is selected from alkylene, alkenylen, and alkynylene; and Z is selected from (a) COM, (b) CH.dbd.N--O--A--COM, (c) CH.sub.2 --O--N.dbd.A--COM wherein A is selected from alkylene and cycloalkylene, and M is selected from (a) a pharmaceutically acceptable metabolically cleavable group, (b) --OR.sup.6, (c) --NR.sup.7 R.sup.8, (d)--NR.sup.6 SO.sub.2 R.sup.9, (e)-NH-Tetrazolyl, and (f) glycinyl inhibit leukotriene biosynthesis and are useful in the treatment of allergic and inflammatory disease states. Also disclosed are leukotriene biosynthesis inhibiting compositions and a method of inhibiting leukotriene biosynthesis.
摘要翻译：具有下式的化合物：其中W在每次出现时相同，并且选自任选取代的喹啉基，任选取代的苯并噻唑基，任选取代的苯并恶唑基，任选取代的苯并咪唑基，任选取代的喹喔啉基，任选取代的吡啶基，任选取代的嘧啶基，取代的噻唑基; R 1和R 2独立地选自氢，烷基，卤代烷基，烷氧基，卤素; R3是价键或选自氢和烷基; X是价键或选自亚烷基，烯基和亚炔基; 并且Z选自（a）COM，（b）CH = NOA-COM，（c）CH2-ON = A-COM其中A选自亚烷基和亚环烷基，M选自（a）药学上可接受的代谢可裂解基团，（b）-OR6，（c）-NR7R8，（d）-NR6SO2R9，（e）-NH-四唑基，（f）甘氨酰抑制白三烯生物合成，可用于治疗过敏性和炎性疾病状态。还公开了白三烯生物合成抑制组合物和抑制白三烯生物合成的方法。

4. 发明授权

US5616596A Substituted arylalkynyl-and heteroarylalkynl-N-hydroxyurea inhibitors of leukotriene biosynthesis 失效
标题翻译：白三烯生物合成的取代的芳基炔基和杂芳基炔基-N-羟基脲抑制剂
公开(公告)号：US5616596A
公开(公告)日：1997-04-01
申请号：US416807
申请日：1995-04-13
申请人： Anwer Basha , Clint D. W. Brooks , Pramila Bhatia , Richard A. Craig , James D. Ratajczyk , Andrew O. Stewart
发明人： Anwer Basha , Clint D. W. Brooks , Pramila Bhatia , Richard A. Craig , James D. Ratajczyk , Andrew O. Stewart
IPC分类号： A61K31/17 , A61K31/38 , A61K31/381 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4433 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P25/00 , A61P27/16 , A61P29/00 , A61P37/08 , A61P43/00 , C07C273/18 , C07C275/24 , C07C275/64 , C07D213/61 , C07D277/28 , C07D307/52 , C07D333/20 , C07D333/22 , C07D405/06 , C07D409/04 , C07D409/06 , C07D417/04 , A61K31/42 , C07D263/30 , C07D277/20
CPC分类号： C07D405/06 , C07C275/64 , C07D213/61 , C07D277/28 , C07D307/52 , C07D333/20 , C07D409/06
摘要： The invention relates to compounds having activity to inhibit lipoxygenase enzyme activity, to pharmaceutical compositions comprising these compounds, and to a medical method of treating. More particularly, this invention concerns certain substituted arylalkynyl- and ((heteroaryl)alkynyl)-N-hydroxy-ureas which inhibit leukotriene biosynthesis, to pharmaceutical compositions of these compounds and to a method of inhibiting leukotriene biosynthesis.
摘要翻译： PCT No.PCT / US93 / 10675 Sec。 371日期1995年04月13日 102（e）日期1995年4月13日PCT 1993年11月5日PCT公布。公开号WO94 / 11342 日期：1994年5月26日本发明涉及具有抑制脂氧合酶活性的活性的化合物，涉及包含这些化合物的药物组合物以及治疗方法。更具体地，本发明涉及抑制白细胞三烯生物合成的某些取代的芳基炔基 - 和（（杂芳基）炔基）-N-羟基脲，这些化合物的药物组合物和抑制白三烯生物合成的方法。

5. 发明授权

US5843968A Symmetrical bis-heteroarylmethoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis 失效
标题翻译：对称双杂芳基甲氧基 - 苯基烷基羧酸盐作为白三烯生物合成的抑制剂
公开(公告)号：US5843968A
公开(公告)日：1998-12-01
申请号：US958301
申请日：1997-10-27
申请人： Clint D. W. Brooks , Pramila Bhatia , Teodozyj Kolasa , Andrew O. Stewart , David E. Gunn , Richard A. Craig
发明人： Clint D. W. Brooks , Pramila Bhatia , Teodozyj Kolasa , Andrew O. Stewart , David E. Gunn , Richard A. Craig
IPC分类号： C07D239/26 , A61K31/4184 , A61K31/421 , A61K31/4402 , A61K31/454 , A61K31/47 , A61K31/498 , A61K31/506 , A61P37/08 , A61P43/00 , C07D213/30 , C07D215/14 , C07D215/18 , C07D235/12 , C07D241/42 , C07D263/56 , C07D277/24 , C07D277/64 , C07D417/14 , A61K31/38 , A61K31/405 , A61K31/42 , A61K31/425
CPC分类号： C07D213/30 , C07D215/14 , C07D215/18 , C07D235/12 , C07D241/42 , C07D277/64
摘要： Compounds having the formula: ##STR1## wherein W is the same at each occurrence and is selected from optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, optionally substituted benzimidazolyl, optionally substituted quinoxalyl, optionally substituted pyridyl, optionally substituted pyrimidyl, and optionally substituted thiazolyl; R.sup.1 and R.sup.2 are independently selected from hydrogen, alkyl, halolalkyl, alkoxy, halogen; R.sup.3 is a valence bond or is selected from hydrogen and alkyl; X is a valence bond or is selected from alkylene, alkenylen, and alkynylene; and Z is selected from (a) COM, (b) CH.dbd.N--O--A--COM, (c) CH.sub.2 --O--N.dbd.A--COM wherein A is selected from alkylene and cycloalkylene, and M is selected from (a) a pharmaceutically acceptable metabolically cleavable group, (b) --OR.sup.6, (c) --NR.sup.7 R.sup.8, (d) --NR.sup.6 SO.sub.2 R.sup.9, (e) --NH-Tetrazolyl, and (f) glycinyl inhibit leukotriene biosynthesis and are useful in the treatment of allergic and inflammatory disease states. Also disclosed are leukotriene biosynthesis inhibiting compositions and a method of inhibiting leukotriene biosynthesis.
摘要翻译：具有下式的化合物：其中W在每次出现时相同，并且选自任选取代的喹啉基，任选取代的苯并噻唑基，任选取代的苯并恶唑基，任选取代的苯并咪唑基，任选取代的喹喔啉基，任选取代的吡啶基，任选取代的嘧啶基，取代的噻唑基; R1和R2独立地选自氢，烷基，卤代烷基，烷氧基，卤素; R3是价键或选自氢和烷基; X是价键或选自亚烷基，烯基和亚炔基; 并且Z选自（a）COM，（b）CH = NOA-COM，（c）CH2-ON = A-COM其中A选自亚烷基和亚环烷基，M选自（a）药学上可接受的代谢可裂解基团，（b）-OR6，（c）-NR7R8，（d）-NR6SO2R9，（e）-NH-四唑基，（f）甘氨酰抑制白三烯生物合成，可用于治疗过敏性和炎性疾病状态。还公开了白三烯生物合成抑制组合物和抑制白三烯生物合成的方法。

6. 发明授权

US5420282A Thiopyrano(2,3,4-c,d) indolyloxime ether alkylcarboxylates 失效
标题翻译：噻哆醇（2,3,4-c，d）吲哚肟醚烷基羧酸盐
公开(公告)号：US5420282A
公开(公告)日：1995-05-30
申请号：US197422
申请日：1994-02-15
申请人： Dee W. Brooks , Pramila Bhatia
发明人： Dee W. Brooks , Pramila Bhatia
IPC分类号： C07D495/06 , C07D495/08 , A61K31/44 , A61K31/47
CPC分类号： C07D495/06
摘要： Compounds of the structure ##STR1## wherein R.sup.1 is selected from the group consisting of ##STR2## are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.
摘要翻译：结构的化合物，其中R1选自是脂氧合酶的有效抑制剂，从而抑制白细胞三烯的生物合成。这些化合物可用于治疗或改善过敏性和炎性疾病状态。

7. 发明授权

US5512581A Iminoxycarboxylates and derivatives as inhibitors of leukotriene biosynthesis 失效
标题翻译：亚氨基羧酸盐和衍生物作为白细胞三烯生物合成的抑制剂
公开(公告)号：US5512581A
公开(公告)日：1996-04-30
申请号：US432491
申请日：1995-05-01
申请人： Dee W. Brooks , Pramila Bhatia , Teodozyi Kolasa
发明人： Dee W. Brooks , Pramila Bhatia , Teodozyi Kolasa
IPC分类号： A61K31/426 , A61K31/428 , A61K31/437 , A61K31/4406 , A61K31/4409 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/47 , A61K31/4709 , A61K31/498 , A61K31/505 , A61P11/00 , A61P11/06 , A61P17/06 , A61P19/02 , A61P19/06 , A61P27/14 , A61P43/00 , C07D213/30 , C07D215/14 , C07D215/22 , C07D215/227 , C07D215/36 , C07D235/12 , C07D239/26 , C07D241/42 , C07D263/56 , C07D277/24 , C07D277/64 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D513/04 , C07D215/12
CPC分类号： C07D213/30 , C07D215/14 , C07D215/227 , C07D215/36 , C07D235/12 , C07D239/26 , C07D241/42 , C07D263/56 , C07D277/24 , C07D277/64 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D513/04
摘要： The present invention relates to a compound of formulaW--X--Q--Y--CH(R.sup.1)--O--N.dbd.C(R.sup.2)--A--COMor a pharmaceutically acceptable salt thereof wherein W is optionally substituted aryl or heteroaryl; X is a valence bond, or methylene, divalent alkylene, alkenylene, alkynylene or alkyloxy; Q is a valence bond, or --O--, --S--, >NR.sup.4 or >NCOR.sup.5 ; Y is optionally substituted phenyl, biphenyl, naphthyl, tetrahydronaphthyl, indolyl, pyridyl, or benzo b!thienyl, thienyl, thiazolyl, or thiazolylphenyl; R.sup.1 is alkyl, cycloalkyl, alkoxyalkyl, aryl or arylalkyl, heteroaryl or heteroarylalkyl; R.sup.2 is hydrogen, alkyl or hydroxyalkyl; A is a valence bond or is selected from alkylene, alkenylene, alkynylene, cycloalkylene, phenylene, pyridylene, thienylene and furylene; and M is a pharmaceutically acceptable, metabolically cleavable group, --OR.sup.6, --NR.sup.6 R.sup.7, --NH-tetrazoyl, --NH-2-, 3-, or 4-pyridyl, and --NH-2-, 4-, or 5-thiazolyl which inhibit leukotriene biosynthesis and are useful in the treatment of inflammatory disease states. Also disclosed are leukotriene biosynthesis inhibiting compositions and a method for inhibiting lipoxygenase activity and leukotriene biosynthesis.
摘要翻译：本发明涉及式W-X-Q-Y-CH（R 1）-O-N = C（R 2）-A-COM的化合物或其药学上可接受的盐，其中W为任选取代的芳基或杂芳基; X是价键，或亚甲基，二价亚烷基，亚烯基，亚炔基或烷氧基; Q是价键，或-O-，-S-，> NR4或> NCOR5; Y是任选取代的苯基，联苯基，萘基，四氢萘基，吲哚基，吡啶基或苯并[b]噻吩基，噻吩基，噻唑基或噻唑基苯基; R 1是烷基，环烷基，烷氧基烷基，芳基或芳基烷基，杂芳基或杂芳基烷基; R2是氢，烷基或羟烷基; A是价键或选自亚烷基，亚烯基，亚炔基，亚环烷基，亚苯基，亚吡啶基，亚噻吩基和亚芳基; 并且M是药学上可接受的代谢可裂解基团-OR 6，-NR 6 R 7，-NH-四唑基，-NH-2-，3-或4-吡啶基和-NH-2-，4-或5-噻唑基其抑制白细胞三烯生物合成并且可用于治疗炎性疾病状态。还公开了白三烯生物合成抑制组合物和抑制脂氧合酶活性和白三烯生物合成的方法。

8. 发明授权

US5399699A Indole iminooxy derivatives which inhibit leukotriene biosynthesis 失效
标题翻译：抑制白细胞三烯生物合成的吲哚亚氨氧基衍生物
公开(公告)号：US5399699A
公开(公告)日：1995-03-21
申请号：US186410
申请日：1994-01-24
申请人： Teodozyi Kolasa , Pramila Bhatia , Dee W. Brooks
发明人： Teodozyi Kolasa , Pramila Bhatia , Dee W. Brooks
IPC分类号： C07D401/12 , C07D417/12 , C07D401/02 , A61K31/425 , A61K31/47 , C07D417/02
CPC分类号： C07D401/12 , C07D417/12
摘要： Compounds of the structure ##STR1## where A.sub.1 is alkylene or cycloalkylene; A.sub.2 is a valence bond, alkylene, or cycloalkylene; R.sub.1 is selected from hydrogen, alkylthio, optionally substituted phenylthio, optionally substituted phenylalkylthio, optionally substituted 2-, 3- and 4-pyridylthio, optionally substituted 2- and 3-thienylthio, and optionally substituted 2-thiazolylthio; R.sup.2 is selected from optionally substituted phenylalkyl and optionally substituted heteroarylakyl; R.sup.3 is selected from alkyl, alkoxy, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylalkyl, optionally substituted phenylalkoxy, optionally substituted naphthyl,optionally substituted naphthyloxy, optionally substituted naphthylalkyl, optionally substituted naphthylalkoxy, optionally substituted heteroaryl, optionally substituted heteroaryloxy, optionally substituted heteroarylalkyl, and optionally substituted heteroarylalkoxy; R.sup.4 is selected from hydrogen and optionally substituted alkyl; and Z is selected from --COOB, --C(OB)R.sup.6 R.sup.6, --COOalkyl, --COOalkylaryl, --CONR.sup.5 R.sup.6, and --COR.sup.6 are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment of amelioration of allergic and inflammatory disease states.
摘要翻译：其中A1是亚烷基或亚环烷基的结构的化合物; A2是价键，亚烷基或亚环烷基; R 1选自氢，烷硫基，任选取代的苯硫基，任选取代的苯基烷硫基，任选取代的2-，3-和4-吡啶硫基，任选取代的2-和3-噻吩硫基，以及任选取代的2-噻唑基硫基; R2选自任选取代的苯基烷基和任选取代的杂芳基; R 3选自烷基，烷氧基，任选取代的苯基，任选取代的苯氧基，任选取代的苯基烷基，任选取代的苯基烷氧基，任选取代的萘基，任选取代的萘基氧基，任选取代的萘基烷基，任选取代的萘基烷氧基，任选取代的杂芳基，任选取代的杂芳氧基，杂芳基烷基和任选取代的杂芳基烷氧基; R4选自氢和任选取代的烷基; 并且Z选自-COOB，-C（OB）R 6 R 6，-COO烷基，-COO烷基芳基，-CONR 5 R 6和-COR 6是脂氧合酶的有效抑制剂，因此抑制白细胞三烯的生物合成。这些化合物可用于治疗改善变态反应和炎性疾病状态。

9. 发明授权

US06579882B2 Cell adhesion-inhibiting antiinflammatory compounds 失效
标题翻译：细胞粘附抑制性抗炎化合物
公开(公告)号：US06579882B2
公开(公告)日：2003-06-17
申请号：US09799729
申请日：2001-03-06
申请人： Andrew O. Stewart , Steven A. Boyd , David L. Arendsen , Pramila Bhatia , Kevin R. Condroski , Jennifer C. Freeman , Indrani W. Gunawardana , Gui-Dong Zhu , Kraig Lartey , Catherine M. McCarty , Nicholas A. Mort , Meena V. Patel , Michael A. Staeger , David M. Stout
发明人： Andrew O. Stewart , Steven A. Boyd , David L. Arendsen , Pramila Bhatia , Kevin R. Condroski , Jennifer C. Freeman , Indrani W. Gunawardana , Gui-Dong Zhu , Kraig Lartey , Catherine M. McCarty , Nicholas A. Mort , Meena V. Patel , Michael A. Staeger , David M. Stout
IPC分类号： A61K31519
CPC分类号： C07D493/04 , C07D495/04 , C07D513/04
摘要： Compounds having Formula I are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of inhibiting/treating inflammatory diseases in a mammal.
摘要翻译：具有式Iare的化合物可用于治疗炎症。还公开了包含式I化合物的药物组合物，以及哺乳动物抑制/治疗炎性疾病的方法。

10. 发明授权

US06232320B1 Cell adhesion-inhibiting antiinflammatory compounds 有权
标题翻译：细胞粘附抑制性抗炎化合物
公开(公告)号：US06232320B1
公开(公告)日：2001-05-15
申请号：US09325336
申请日：1999-06-03
申请人： Andrew O. Stewart , Steven A. Boyd , David L. Arendsen , Pramila Bhatia , Kevin R. Condroski , Jennifer C. Freeman , Indrani W. Gunawardana , Gui-Dong Zhu , Kraig Lartey , Catherine M. McCarty , Nicholas A. Mort , Meena V. Patel , Michael A. Staeger , David M. Stout
发明人： Andrew O. Stewart , Steven A. Boyd , David L. Arendsen , Pramila Bhatia , Kevin R. Condroski , Jennifer C. Freeman , Indrani W. Gunawardana , Gui-Dong Zhu , Kraig Lartey , Catherine M. McCarty , Nicholas A. Mort , Meena V. Patel , Michael A. Staeger , David M. Stout
IPC分类号： A61K314365
CPC分类号： C07D493/04 , C07D495/04 , C07D513/04
摘要： Compounds having Formula I are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of inhibiting/treating inflammatory diseases in a mammal.
摘要翻译：具有式Iare的化合物可用于治疗炎症。还公开了包含式I化合物的药物组合物，以及哺乳动物抑制/治疗炎性疾病的方法。

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