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1. 发明申请

US20050153000A1 Herbal extract and compound lupinoside and its analogues as anti-diabetic type II drugs from plant pueraria tuberosa 失效
标题翻译：草药提取物和化合物lupinoside及其类似物作为来自植物葛根结节的抗糖尿病II型药物
公开(公告)号：US20050153000A1
公开(公告)日：2005-07-14
申请号：US10809645
申请日：2004-03-25
申请人： Debleena Dey , Swapan Mandal , Mohua Mukherjee , Bikash Pal , Tanushree Biswas , Malabika Datta , Sib Roy , Arun Bandyopadhyay , Samir Bhattacharya , B. Giri , Santu Bandopadhyay , Aditya Konar
发明人： Debleena Dey , Swapan Mandal , Mohua Mukherjee , Bikash Pal , Tanushree Biswas , Malabika Datta , Sib Roy , Arun Bandyopadhyay , Samir Bhattacharya , B. Giri , Santu Bandopadhyay , Aditya Konar
IPC分类号： A61K31/70 , A61K36/488 , A61K35/78
CPC分类号： A61K31/70 , A61K36/488 , Y10S514/866
摘要： The present invention relates to a method of preventing and/or treating diabetes type 2, also, it relates to a method of augmenting Glut4 phosphorylation and Glut4 translocation to a target cell membrane to enhance insulin signal in a signal transduction pathway; further, it relates to a simplified and inexpensive process of obtaining extract and thereafter selectively, its active n-butanol fraction and active molecule Lupinoside PA (LPA4), useful in preventing and/or treating diabetes type 2; and lastly, a pharmaceutical composition thereof.
摘要翻译：本发明涉及预防和/或治疗糖尿病2型的方法，还涉及增加Glut4磷酸化和Glut4易位到靶细胞膜以增强信号转导途径中的胰岛素信号的方法; 此外，本发明涉及一种简单且便宜的获得提取物的方法，其后选择性地，其活性正丁醇级分和活性分子Lupinoside PA（LPA 4 S）可用于预防和/或治疗糖尿病2型 ; 最后是其药物组合物。

2. 发明授权

US07276258B2 Herbal extract and compound lupinoside and its analogues as anti-diabetic type II drugs from plant Pueraria tuberosa 失效
标题翻译：草药提取物和化合物lupinoside及其类似物作为来自植物葛根结节的抗糖尿病II型药物
公开(公告)号：US07276258B2
公开(公告)日：2007-10-02
申请号：US10809645
申请日：2004-03-25
申请人： Debleena Dey , Swapan Kumar Mandal , Mohua Mukherjee , Bikash Chandra Pal , Tanushree Biswas , Malabika Datta , Sib Sankar Roy , Arun Bandyopadhyay , Samir Bhattacharya , Bir Bhanu Giri , Santu Bandopadhyay , Aditya Konar
发明人： Debleena Dey , Swapan Kumar Mandal , Mohua Mukherjee , Bikash Chandra Pal , Tanushree Biswas , Malabika Datta , Sib Sankar Roy , Arun Bandyopadhyay , Samir Bhattacharya , Bir Bhanu Giri , Santu Bandopadhyay , Aditya Konar
IPC分类号： A01N65/00 , A61N43/04 , A61K31/70
CPC分类号： A61K31/70 , A61K36/488 , Y10S514/866
摘要： The present invention relates to a method of preventing and/or treating diabetes type 2, also, it relates to a method of augmenting Glut4 phosphorylation and Glut4 translocation to a target cell membrane to enhance insulin signal in a signal transduction pathway; further, it relates to a simplified and inexpensive process of obtaining extract and thereafter selectively, its active n-butanol fraction and active molecule Lupinoside PA (LPA4), useful in preventing and/or treating diabetes type 2; and lastly, a pharmaceutical composition thereof.
摘要翻译：本发明涉及预防和/或治疗糖尿病2型的方法，还涉及增加Glut4磷酸化和Glut4易位到靶细胞膜以增强信号转导途径中的胰岛素信号的方法; 此外，本发明涉及一种简单且便宜的获得提取物的方法，其后选择性地，其活性正丁醇级分和活性分子Lupinoside PA（LPA 4 S）可用于预防和/或治疗糖尿病2型 ; 最后是其药物组合物。

3. 发明授权

US06569464B1 Coelomic fluid extract from Pheretima posthuma for providing sperm immotility 失效
标题翻译：来自Pheretima posthuma的脑膜液提取物用于提供精子不育
公开(公告)号：US06569464B1
公开(公告)日：2003-05-27
申请号：US09822756
申请日：2001-03-30
申请人： Mohua Mukherjee , Shampa Biswas , Malabika Datta , Samir Bhattacharya , Ranjan Bhadra , Alok Pal
发明人： Mohua Mukherjee , Shampa Biswas , Malabika Datta , Samir Bhattacharya , Ranjan Bhadra , Alok Pal
IPC分类号： A01N6300
CPC分类号： A61K35/62
摘要： A sperm immotility and anti-fertility agent is provided. The agent comprises coelomic fluid extract which is obtained from an Indian earthworm, Pheretima posthuma, belonging to the phylum, Annelida. The agent may further comprise pharmaceutically acceptable additives and can be in the form of a solution, gel, powder, capsules, tablets or cream. The agent is a non-steroid and also can be used externally. Upon further purification a protein can be isolated having a molecular weight of 20 kilodaltons. This protein is anionic and non-toxic and also is without hemolytic activity. Also the protein as well as the extract can provide 100% sperm immotility within 2 minutes. In addition, methods of isolation of an active factor of the coelomic fluid, determination of toxicity and hemolytic activity of the agent as well as preparing a sperm suspension from male rats and mice useful for bio-assay are disclosed.
摘要翻译：提供精子不育和抗生育剂。该药剂包括得自印度蚯蚓Pheretima posthuma，属于门，Annelida的肠液提取物。该试剂可以进一步包含药学上可接受的添加剂，并且可以是溶液，凝胶，粉末，胶囊，片剂或霜剂的形式。该药剂是非类固醇，也可以在外用。进一步纯化后，可以分离出分子量为20千道尔顿的蛋白质。该蛋白质是阴离子和无毒的，也没有溶血活性。蛋白质和提取物也可以在2分钟内提供100％的精子不育。此外，公开了分离体液的活性因子的方法，药物的毒性测定和溶血活性以及从用于生物测定的雄性大鼠和小鼠制备精子悬浮液的方法。

4. 发明授权

US07129211B2 Adipocyte Insulin adpinsl with Insulin A and B chains and an effective method of treating type 2 diabetes in a subject using adipocyte insulin 失效
标题翻译：胰岛素A和B链的脂肪细胞胰岛素Adpinsl和使用脂肪细胞胰岛素治疗受试者的2型糖尿病的有效方法
公开(公告)号：US07129211B2
公开(公告)日：2006-10-31
申请号：US10396551
申请日：2003-03-26
申请人： Samir Bhattacharya , Sib Sankar Roy , Subrata Dasgupta , Mohua Mukherjee
发明人： Samir Bhattacharya , Sib Sankar Roy , Subrata Dasgupta , Mohua Mukherjee
IPC分类号： A61K38/28 , C07H21/04 , C07K14/62
CPC分类号： C07K14/461 , A61K38/00
摘要： The present invention relates to an adipocyte Insulin adpInsl with Insulin A and B chains of SEQ ID Nos. 1 and 2, a effective method of treating type 2 diabetes in a subject using adipocyte insulin, said method comprising steps of administering the insulin to a diabetic intraperitoneally, an Insulin gene of SEQ ID No. 3, a process of isolating protein Insulin from the adipocytes of the Carp, said method comprising steps of reverse transcripting RNA of adipocytes to obtain cDNA, using oligonucleotide primers of SEQ ID Nos. 5 and 6 to identify AdpInsl gene from cDNA, and deducing amino acid sequence from cDNA to obtain protein Insulin, and an adipocyte of Catla Catla useful for producing the said Insulin.
摘要翻译：本发明涉及具有SEQ ID NO.1和2的胰岛素A和B链的脂肪细胞胰岛素adpInl，这是使用脂肪细胞胰岛素治疗受试者的2型糖尿病的有效方法，所述方法包括以下步骤：将胰岛素给予糖尿病腹膜内地是SEQ ID No.3的胰岛素基因，从鲤鱼的脂肪细胞中分离蛋白质胰岛素的方法，所述方法包括使用SEQ ID No.5和6的寡核苷酸引物的脂肪细胞的逆转录RNA以获得cDNA的步骤从cDNA中鉴定AdpInsl基因，并从cDNA中推导氨基酸序列以获得蛋白质胰岛素，以及可用于产生所述胰岛素的Catla Catla的脂肪细胞。

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