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1. 发明授权

US07309716B2 Benzimidazoles useful as modulators of ion channels 失效
标题翻译：苯并咪唑可用作离子通道的调节剂
公开(公告)号：US07309716B2
公开(公告)日：2007-12-18
申请号：US10977609
申请日：2004-10-28
申请人： Dean M. Wilson , Andreas P. Termin , Jesus E. Gonzalez, III , Nicole Zimmermann , Yulian Zhang , Lev T. D. Fanning
发明人： Dean M. Wilson , Andreas P. Termin , Jesus E. Gonzalez, III , Nicole Zimmermann , Yulian Zhang , Lev T. D. Fanning
IPC分类号： A61K31/4184 , C07D235/06
CPC分类号： C07D405/12 , C04B35/632 , C07D209/42 , C07D235/14 , C07D235/18 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the R1, Z, Y, RA, and W groups of formula I are as defined herein. The invention also provides pharmaceutically acceptable compositions and methods of using the compositions in the treatment of various disorders.
摘要翻译：本发明涉及式I化合物或其药学上可接受的盐，其中R 1，Z，Y，R A和W分别为如本文所定义。本发明还提供药学上可接受的组合物和使用该组合物治疗各种疾病的方法。

2. 发明授权

US07705031B2 Benzimidazoles useful as modulators of ion channels 有权
标题翻译：苯并咪唑可用作离子通道的调节剂
公开(公告)号：US07705031B2
公开(公告)日：2010-04-27
申请号：US11933724
申请日：2007-11-01
申请人： Dean M. Wilson , Andreas P. Termin , Jesus E. Gonzalez, III , Nicole Zimmermann , Yulian Zhang , Lev T. D. Fanning
发明人： Dean M. Wilson , Andreas P. Termin , Jesus E. Gonzalez, III , Nicole Zimmermann , Yulian Zhang , Lev T. D. Fanning
IPC分类号： A61K31/4184 , A61K31/165
CPC分类号： C07D405/12 , C04B35/632 , C07D209/42 , C07D235/14 , C07D235/18 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the R1, Z, Y, RA, and W groups of formula I are as defined herein. The invention also provides pharmaceutically acceptable compositions and methods of using the compositions in the treatment of various disorders.
摘要翻译：本发明涉及式I化合物或其药学上可接受的盐，其中式I的R 1，Z，Y，RA和W基团如本文所定义。本发明还提供药学上可接受的组合物和使用该组合物治疗各种疾病的方法。

3. 发明申请

US20080306129A1 BENZIMIDAZOLES USEFUL AS MODULATORS OF ION CHANNELS 有权
标题翻译：苯并咪唑作为离子通道的调节剂有用
公开(公告)号：US20080306129A1
公开(公告)日：2008-12-11
申请号：US11933724
申请日：2007-11-01
申请人： Dean M. Wilson , Andreas P. Termin , Jesus E. Gonzalez, III , Nicole Zimmermann , Yulian Zhang , Lev T.D. Fanning
发明人： Dean M. Wilson , Andreas P. Termin , Jesus E. Gonzalez, III , Nicole Zimmermann , Yulian Zhang , Lev T.D. Fanning
IPC分类号： A61K31/4184 , A61P29/00
CPC分类号： C07D405/12 , C04B35/632 , C07D209/42 , C07D235/14 , C07D235/18 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the R1, Z, Y, RA, and W groups of formula I are as defined herein. The invention also provides pharmaceutically acceptable compositions and methods of using the compositions in the treatment of various disorders.
摘要翻译：本发明涉及式I化合物或其药学上可接受的盐，其中式I的R 1，Z，Y，RA和W基团如本文所定义。本发明还提供药学上可接受的组合物和使用该组合物治疗各种疾病的方法。

4. 发明授权

US07713983B2 Quinazolines useful as modulators of ion channels 有权
标题翻译：喹唑啉可用作离子通道的调节剂
公开(公告)号：US07713983B2
公开(公告)日：2010-05-11
申请号：US10935008
申请日：2004-09-02
申请人： Jesus E. Gonzalez, III , Dean M. Wilson , Andreas P. Termin , Peter D. J. Grootenhuis , Yulian Zhang , Benjamin J. Petzoldt , Lev Tyler Dewey Fanning , Timothy D. Neubert , Roger D. Tung , Esther Martinborough , Nicole Zimmerman
发明人： Jesus E. Gonzalez, III , Dean M. Wilson , Andreas P. Termin , Peter D. J. Grootenhuis , Yulian Zhang , Benjamin J. Petzoldt , Lev Tyler Dewey Fanning , Timothy D. Neubert , Roger D. Tung , Esther Martinborough , Nicole Zimmerman
IPC分类号： C07D239/94 , C07D403/12 , A61K31/517 , A61P35/00
CPC分类号： C07D239/91 , C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译：本发明涉及可用作电压门控钠通道和钙通道抑制剂的化合物。本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。

5. 发明申请

US20100160316A1 QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS 失效
公开(公告)号：US20100160316A1
公开(公告)日：2010-06-24
申请号：US12714871
申请日：2010-03-01
申请人： Jesus E. Gonzalez, III , Dean M. Wilson , Andreas P. Termin , Peter D. J. Grootenhuis , Yulian Zhang , Benjamin J. Petzoldt , Lev Tyler Dewey Fanning , Timothy D. Neubert , Roger D. Tung , Esther Martinborough , Nicole Zimmerman
发明人： Jesus E. Gonzalez, III , Dean M. Wilson , Andreas P. Termin , Peter D. J. Grootenhuis , Yulian Zhang , Benjamin J. Petzoldt , Lev Tyler Dewey Fanning , Timothy D. Neubert , Roger D. Tung , Esther Martinborough , Nicole Zimmerman
IPC分类号： A61K31/5377 , C07D239/86 , A61K31/517 , C07D239/88 , C07D413/10 , A61K31/496 , A61P19/10 , A61P19/02 , A61P17/02 , A61P21/00 , A61P13/02 , A61P11/00 , C07D403/04
CPC分类号： C07D239/91 , C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

6. 发明申请

US20120040935A1 COMPOSITIONS USEFUL AS INHIBITORS OF VOLTAGE-GATED ION CHANNELS 审中-公开
标题翻译：组合物作为电压离子通道的抑制剂有用
公开(公告)号：US20120040935A1
公开(公告)日：2012-02-16
申请号：US13110173
申请日：2011-05-18
申请人： Dean M. Wilson , Andreas P. Termin , Timothy D. Neubert , Jian Wang , Yulian Zhang , Jesus E. Gonzalez, III , Esther Martinborough , Nicole Zimmerman
发明人： Dean M. Wilson , Andreas P. Termin , Timothy D. Neubert , Jian Wang , Yulian Zhang , Jesus E. Gonzalez, III , Esther Martinborough , Nicole Zimmerman
IPC分类号： A61K31/675 , A61K31/517 , C12N5/071 , A61P29/00 , A61P25/04 , A61P19/02 , A61P25/06 , A61P25/00 , A61P25/22 , A61P25/24 , A61P9/06 , A61P25/14 , A61P25/28 , A61P1/00 , A61P21/00 , A61K31/5377
CPC分类号： C07D401/04 , C07D239/70 , C07D239/91 , C07D239/94 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D471/04 , C07D495/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译：本发明涉及可用作电压门控钠通道抑制剂的化合物。本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。

7. 发明授权

US07968545B2 Compositions useful as inhibitors of voltage-gated ion channels 失效
标题翻译：可用作电压门控离子通道抑制剂的组合物
公开(公告)号：US07968545B2
公开(公告)日：2011-06-28
申请号：US10912912
申请日：2004-08-05
申请人： Dean M. Wilson , Andreas P. Termin , Timothy D. Neubert , Jian Wang , Yulian Zhang , Jesus E. Gonzalez, III , Esther Martinborough , Nicole Zimmerman
发明人： Dean M. Wilson , Andreas P. Termin , Timothy D. Neubert , Jian Wang , Yulian Zhang , Jesus E. Gonzalez, III , Esther Martinborough , Nicole Zimmerman
IPC分类号： C07D413/04 , C07D403/04 , C07D401/04 , A61K31/5355 , A61K31/517 , A61K31/497 , A61K31/519 , A61P21/00 , A61P19/02 , A61P25/06 , A61P25/08 , A61P25/22 , A61P25/24 , A61P9/10
CPC分类号： C07D401/04 , C07D239/70 , C07D239/91 , C07D239/94 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D471/04 , C07D495/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译：本发明涉及可用作电压门控钠通道抑制剂的化合物。本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。

8. 发明授权

US5480334A Nested automatically separable flying disk assembly 失效
标题翻译：嵌套自动可分离飞盘组件
公开(公告)号：US5480334A
公开(公告)日：1996-01-02
申请号：US231165
申请日：1994-04-22
申请人： James M. Wilson , Dean M. Wilson
发明人： James M. Wilson , Dean M. Wilson
IPC分类号： A63H33/18 , A63H27/00
CPC分类号： A63H33/18
摘要： The nested automatically separable flying disk assembly includes an outer or cover disk assembly enclosing a nested or inner disk assembly. The outer or cover disk assembly is of a generally cylinderical disk shape having an air space between itself and the nested or inner disk assembly provided by a central nub projection cooperating with flange nub projections. The nested or inner disk assembly is provided with an outer peripheral flange section extended downwardly and below a similar peripheral rim section on the outer or cover disk assembly for allowing air to flow therebetween to cause the desired separation between the nested disk assemblies. An adjustable central nub projection is provided to adjustably change separation between the outer or cover disk assembly and the nested or inner disk assembly. The nested or inner disk assembly is provided with a plurality of inclined concentric aerodynamic ridges to alter air flow and resultant turbulence of air flow between the nested disk assemblies to vary the aerodynamic flight characteristics thereof. Second and third embodiments provide different angular relationships, either inwardly or outwardly, of the outer adjacent peripheral rim section of the outer or cover disk assembly and the peripheral flange section of the nested or inner disk assembly to achieve an increase or decrease in the time of separation of the outer or cover disk assembly from the nested or inner disk assembly.
摘要翻译：嵌套的可自动分离的飞盘组件包括封闭嵌套或内部盘组件的外部或盖板组件。外盘或盖盘组件具有大致圆柱形盘形，在其与由与凸缘凸起突起配合的中心凸起突起提供的嵌套或内盘组件之间具有空气空间。嵌套或内盘组件设置有外周凸缘部分，该外周边凸缘部分在外盘盖组件或盖盘组件上向下延伸并位于类似的周边边缘部分下面，以允许空气在其间流动，从而在嵌套盘组件之间产生期望的间隔。提供可调节的中央凸起凸起以可调节地改变外部或盖盘组件与嵌套或内部盘组件之间的间隔。嵌套或内盘组件设置有多个倾斜的同心空气动力学脊，以改变空中流动，并导致嵌套圆盘组件之间的空气流动的湍流，以改变其空气动力学飞行特性。第二和第三实施例提供外部或覆盖盘组件的外部相邻外围边缘部分的内向或向外的不同的角度关系，以及嵌套或内部盘组件的周边凸缘部分以实现时间的增加或减少外部或盖盘组件与嵌套或内部盘组件的分离。

9. 发明授权

US07297708B2 Heteroaromatic substituted cyclopropane as corticotropin releasing hormone ligands 有权
标题翻译：杂环取代环丙烷作为促肾上腺皮质激素释放激素配体
公开(公告)号：US07297708B2
公开(公告)日：2007-11-20
申请号：US10235436
申请日：2002-09-05
申请人： Andreas Termin , Peter D. J. Grootenhuis , Dean M. Wilson , Valentina Molteni , Long Mao , Angelo Castellino , Zhicai Yang , Anthony Pechulis , Mark Suto
发明人： Andreas Termin , Peter D. J. Grootenhuis , Dean M. Wilson , Valentina Molteni , Long Mao , Angelo Castellino , Zhicai Yang , Anthony Pechulis , Mark Suto
IPC分类号： A61K31/4164 , C07D233/54
CPC分类号： C07D213/30 , C07D233/64 , C07D239/26 , C07D241/12 , C07D249/08
摘要： Provided herein are novel heteroaromatic substituted cyclopropanes of the Formula (I): as well as compositions, including pharmaceutical compositions, containing the same, and the use thereof in the treatment of various neurological and psychological disorders, e.g., anxiety and depression, treatable by antagonizing CRF receptors.
摘要翻译：本文提供了式（I）的新型杂芳族取代的环丙烷：以及包含其的组合物，包括药物组合物，以及其用于治疗各种神经和心理障碍，例如焦虑和抑郁症的用途，可通过拮抗 CRF受体。

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