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1. 发明申请

US20080058697A1 Heat exchange systems, devices and methods 审中-公开
标题翻译：热交换系统，设备和方法
公开(公告)号：US20080058697A1
公开(公告)日：2008-03-06
申请号：US11787213
申请日：2007-04-13
申请人： Dean Kamen , Jason Demers , David Altobelli , Larry Gray , N. Perry , Brian Tracey , James Dale , Dirk van der Merwe , Kingston Owens
发明人： Dean Kamen , Jason Demers , David Altobelli , Larry Gray , N. Perry , Brian Tracey , James Dale , Dirk van der Merwe , Kingston Owens
IPC分类号： A61M1/36 , F28F13/06 , F28F27/00
CPC分类号： F04B43/0054 , A61F2007/126 , A61M1/1006 , A61M1/1012 , A61M1/1037 , A61M1/1062 , A61M1/1086 , A61M1/1087 , A61M1/1096 , A61M1/3626 , A61M1/369 , A61M2205/12 , A61M2205/127 , A61M2205/3334 , A61M2205/3368 , A61M2205/3606 , A61M2205/3653 , A61M2205/502 , F04B43/06 , F04B43/0736 , G01K1/08 , G01K1/16 , G01M3/188
摘要： Embodiments of the present invention relate generally to heat-exchanger systems that can be used to heat or cool a fluid such as blood. Pod pumps that provide low shear and low turbulence may be used in such systems, particularly for systems that pump blood. A certain heat-exchanger system used to heat blood or other fluids may be used to provide whole-body hyperthermic treatments or regional hyperthermic chemotherapy treatments. A disposable unit may be used to separate the fluid path from the fluid control systems. The disposable unit typically includes a heat-exchanger component that is received by a corresponding heat exchanger in a base unit. Fluid pumped through the heat-exchanger component is heated by the heat exchanger.
摘要翻译：本发明的实施例一般涉及可用于加热或冷却诸如血液的流体的热交换器系统。可以在这种系统中使用提供低剪切和低湍流的杓式泵，特别是用于泵送血液的系统。用于加热血液或其他液体的某种热交换器系统可用于提供全身热疗治疗或局部高热化疗治疗。可以使用一次性单元来将流体路径与流体控制系统分离。一次性单元通常包括由基本单元中的相应热交换器接收的热交换器部件。泵送通过热交换器部件的流体被热交换器加热。

2. 发明申请

US20080108968A1 Pump Cassette With Spiking Assembly 审中-公开
标题翻译：泵盒带有尖峰装配
公开(公告)号：US20080108968A1
公开(公告)日：2008-05-08
申请号：US11926646
申请日：2007-10-29
申请人： Jason Demers , David McGill , Brian Tracey , James Dale , Larry Gray
发明人： Jason Demers , David McGill , Brian Tracey , James Dale , Larry Gray
IPC分类号： A61B19/00
CPC分类号： A61M5/162 , A61M1/0281 , A61M5/1626 , A61M2205/12
摘要： An apparatus for use in a fluid processing system having a pump. The apparatus includes a pump cassette for use with the pump. The pump cassette includes at least one pump chamber and a first port in selective fluid communication with the at least one pump chamber. A spiking assembly includes at least one hollow spike having a piercing end for piercing a first container. The at least one hollow spike includes a first spike in fluid communication with the first port of the pump cassette.
摘要翻译：一种用于具有泵的流体处理系统的装置。该装置包括与泵一起使用的泵盒。所述泵盒包括至少一个泵室和与所述至少一个泵室选择性流体连通的第一端口。尖峰组件包括至少一个具有穿刺端部以刺穿第一容器的中空尖钉。所述至少一个中空尖钉包括与所述泵盒的所述第一端口流体连通的第一尖峰。

3. 发明申请

US20050096583A1 Pump cassette with spiking assembly 有权
标题翻译：带有加注组件的泵盒
公开(公告)号：US20050096583A1
公开(公告)日：2005-05-05
申请号：US10697862
申请日：2003-10-30
申请人： Jason Demers , David McGill , Brian Tracey , James Dale , Larry Gray
发明人： Jason Demers , David McGill , Brian Tracey , James Dale , Larry Gray
IPC分类号： A61F13/20
CPC分类号： A61M5/162 , A61M1/0281 , A61M5/1626 , A61M2205/12
摘要： An apparatus for use in a fluid processing system having a pump. The apparatus includes a pump cassette for use with the pump. The pump cassette includes at least one pump chamber and a first port in selective fluid communication with the at least one pump chamber. A spiking assembly includes at least one hollow spike having a piercing end for piercing a first container. The at least one hollow spike includes a first spike in fluid communication with the first port of the pump cassette.
摘要翻译：一种用于具有泵的流体处理系统的装置。该装置包括与泵一起使用的泵盒。所述泵盒包括至少一个泵室和与所述至少一个泵室选择性流体连通的第一端口。尖峰组件包括至少一个具有穿刺端部以刺穿第一容器的中空尖钉。所述至少一个中空尖钉包括与所述泵盒的所述第一端口流体连通的第一尖峰。

4. 发明申请

US20050095576A1 System, device, and method for mixing a substance with a liquid 有权
标题翻译：用于将物质与液体混合的系统，装置和方法
公开(公告)号：US20050095576A1
公开(公告)日：2005-05-05
申请号：US10696969
申请日：2003-10-30
申请人： Jason Demers , James Dale , Brian Tracey , David McGill , Larry Gray
发明人： Jason Demers , James Dale , Brian Tracey , David McGill , Larry Gray
IPC分类号： A61M1/02 , A61M1/36 , B01F13/10 , B01F15/02 , A01N1/02 , B01F1/00 , C12Q1/00
CPC分类号： B01F13/1013 , A61M1/0281 , A61M1/3687 , A61M2205/12 , B01F13/1016 , B01F15/0202 , B01F2015/0221
摘要： A system, device, and method for mixing a substance with a liquid pumps the liquid into a container of the substance to produce a solution. The container may be part of a container assembly including a port assembly for coupling with the container to produce an inlet and/or and outlet port for the container. The container assembly may be received within a receiving chamber for causing the coupling. The solution may be permitted to flow out of the outlet port when the solution rises within the container to a level of the outlet port so that the substance is partially diluted before flowing out of the outlet port.
摘要翻译：用于将物质与液体混合的系统，装置和方法将液体泵送到物质的容器中以产生溶液。容器可以是容器组件的一部分，其包括用于与容器联接以产生用于容器的入口和/或出口的端口组件。容器组件可以被容纳在接收室内以引起联接。当溶液在容器内升高到出口端口的水平面时，溶液可能被允许流出出口，使得物质在流出出口之前被部分地稀释。

5. 发明申请

US20080202591A1 Cassette System Integrated Apparatus 有权
公开(公告)号：US20080202591A1
公开(公告)日：2008-08-28
申请号：US11871803
申请日：2007-10-12
申请人： Kevin Grant , James Dale , Jason Demers
发明人： Kevin Grant , James Dale , Jason Demers
IPC分类号： F17D1/14 , A61M1/14 , B01D21/30
CPC分类号： F04B53/10 , A61M1/1006 , A61M1/1037 , A61M1/106 , A61M1/1062 , A61M1/1087 , A61M1/1096 , A61M1/16 , A61M1/1605 , A61M1/1639 , A61M1/1656 , A61M1/1664 , A61M1/1666 , A61M1/287 , A61M2205/12 , A61M2205/128 , A61M2205/3317 , A61M2205/3324 , A61M2205/3368 , F04B7/02 , F04B9/109 , F04B13/02 , F04B23/06 , F04B41/06 , F04B43/00 , F04B43/02 , F04B43/06 , F04B43/073 , F04B43/0733 , F04B43/0736 , F04B45/02 , F04B45/0536 , F04B49/22 , F04B53/06 , F04B53/16 , F17D3/00 , Y10T137/0324 , Y10T137/0379 , Y10T137/2521 , Y10T137/85978 , Y10T137/86139
摘要： A cassette integrated system. The cassette integrated system includes a mixing cassette, a balancing cassette, a middle cassette fluidly connected to the mixing cassette and the balancing cassette and at least one pod. The mixing cassette is fluidly connected to the middle cassette by at least one fluid line and the middle cassette is fluidly connected to the balancing cassette by at least one fluid line. The at least one pod is connected to at least two of the cassettes wherein the pod is located in an area between the cassettes.

6. 发明授权

US08053574B2 Organic compounds 失效
标题翻译：有机化合物
公开(公告)号：US08053574B2
公开(公告)日：2011-11-08
申请号：US12669536
申请日：2008-07-16
申请人： Ian Bruce , Darren Mark Legrand , James Dale , Thomas Anthony Hunt
发明人： Ian Bruce , Darren Mark Legrand , James Dale , Thomas Anthony Hunt
IPC分类号： C07D487/00 , C07D514/14 , C07D513/14 , C07D401/14 , A61K31/4427 , A61K31/4436 , A61K31/444 , A01N43/54 , A61K31/4439
CPC分类号： C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.
摘要翻译：磷脂酰肌醇（PI）3-激酶抑制剂化合物，其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗以生长因子，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶异常活性为特征的增殖性疾病中的用途。

7. 发明申请

US20070114178A1 Water treatment process for perchlorate, nitrate, chromate, arsenate and other oxyanions for using weak-base anion exchange resins 有权
标题翻译：使用弱碱阴离子交换树脂的高氯酸盐，硝酸盐，铬酸盐，砷酸盐和其他含氧阴离子的水处理过程
公开(公告)号：US20070114178A1
公开(公告)日：2007-05-24
申请号：US11287579
申请日：2005-11-23
申请人： Edward Coppola , John Baxley , Andrea Davis , Francis Boodoo , William Fries , James Dale
发明人： Edward Coppola , John Baxley , Andrea Davis , Francis Boodoo , William Fries , James Dale
IPC分类号： B01D15/00
CPC分类号： B01J49/57 , B01J41/07 , C02F2301/043
摘要： The invention consists of a water treatment process using selective and regenerable weak base anion exchange resins to remove any number of complex anions, especially oxyanions including perchlorate, nitrate, chlorate, arsenate, selenate, and chromate, from aqueous solutions. The treatment process is comprised of three key processes including 1) pretreatment to lower pH, 2) ion exchange, and 3) post treatment to adjust pH and alkalinity. The invention also includes processes for regenerating weak base anion resins and treatment of the residuals generated. This invention employs pressurized treatment, carbon dioxide management, and reuse of regenerating solution to minimize pumping and treatment costs.
摘要翻译：本发明包括使用选择性和可再生的弱碱性阴离子交换树脂从水溶液中除去任何数量的复合阴离子，特别是包括高氯酸盐，硝酸盐，氯酸盐，砷酸盐，硒酸盐和铬酸盐在内的含氧阴离子的水处理方法。处理过程由三个关键过程组成，包括1）预处理以降低pH值，2）离子交换，以及3）后处理以调节pH值和碱度。本发明还包括用于再生弱碱性阴离子树脂和处理生成的残余物的方法。本发明采用加压处理，二氧化碳管理和再生溶液的再利用以最小化泵送和处理成本。

8. 发明申请

US20060274303A1 Wheel aligner measurement module attachment system 有权
标题翻译：车轮定位器测量模块附件系统
公开(公告)号：US20060274303A1
公开(公告)日：2006-12-07
申请号：US11432766
申请日：2006-05-12
申请人： David Jackson , Brian Gray , Steven Rogers , Stephen Glickman , George Gill , James Dale
发明人： David Jackson , Brian Gray , Steven Rogers , Stephen Glickman , George Gill , James Dale
IPC分类号： G01C1/00 , G01B11/26 , G01B5/24 , G01B5/00
CPC分类号： G01B11/2755 , G01B2210/143 , G01B2210/28
摘要： In a vehicle alignment system an optical sensing mechanism is structurally coupled to a vehicle supporting lift for movement in unison with the lift so that the field of view of the sensing mechanism encompasses a wheel of a vehicle positioned on the lift during lift movement. Sensing modules may be selectively placed so that they are in correspondence with the vehicle wheel base. Modules may be deployed to extend outwardly from the lift, for viewing the wheel during an alignment procedure, or retract to a adjacent the lift for stowing. A protective cover extends above the sensing modules in the retracted position.
摘要翻译：在车辆对准系统中，光学感测机构在结构上耦合到车辆支撑升降机以与升降机一致运动，使得感测机构的视野包括在升降运动期间位于升降机上的车辆的车轮。可以选择性地放置感测模块，使得它们与车轮基座对应。模块可以被部署成从升降机向外延伸，以便在对准过程期间观察车轮，或者缩回到相邻的升降机以进行收起。保护盖在缩回位置上延伸到感测模块的上方。

9. 发明申请

US20050268707A1 Non-contact method and system for tire analysis 有权
标题翻译：轮胎分析的非接触方式和系统
公开(公告)号：US20050268707A1
公开(公告)日：2005-12-08
申请号：US10859151
申请日：2004-06-03
申请人： James Dale , Wen Zhou , Frederick Rogers
发明人： James Dale , Wen Zhou , Frederick Rogers
IPC分类号： G01B11/22 , G01M17/02 , E01C23/00
CPC分类号： G01M17/027 , G01B11/22
摘要： A non-contact method and system for analyzing tire conditions. The system includes an emitter source for emitting radiation signals towards a tire having a treaded surface between two sidewalls. A detector is provided to receive signals reflected by the tire in response to the emitted radiation signals. A data processing system, coupled to the emitter source and the detector, obtains geometrical information, such as height, of a plurality points on the tire based on the signals received from the detector. The data processing system determines a condition of the tire by comparing geometrical information for a designated portion of the plurality points with other portion points on the tire. A color-coded surface profile showing a height distribution of the tire is also generated to assist diagnosis of the tire.
摘要翻译：用于分析轮胎状况的非接触方法和系统。该系统包括用于向具有两个侧壁之间的踏面的轮胎发射辐射信号的发射源。提供检测器以响应于所发射的辐射信号接收由轮胎反射的信号。耦合到发射源和检测器的数据处理系统基于从检测器接收的信号，获得轮胎上的多个点的几何信息，例如高度。数据处理系统通过将多个点的指定部分的几何信息与轮胎上的其他部分点进行比较来确定轮胎的状况。还产生了显示轮胎高度分布的颜色编码的表面轮廓，以辅助轮胎的诊断。

10. 发明申请

US20050102711A1 Banana actin gene and its promoter 审中-公开
标题翻译：香蕉肌动蛋白基因及其启动子
公开(公告)号：US20050102711A1
公开(公告)日：2005-05-12
申请号：US10451889
申请日：2001-12-28
申请人： James Dale , Robert Maxwell Harding , Scott Hermann
发明人： James Dale , Robert Maxwell Harding , Scott Hermann
IPC分类号： C07K14/415 , C12N15/29 , C12N15/82 , C12Q1/68 , A01H1/00
CPC分类号： C07K14/415 , C12N15/8216
摘要： The present invention is directed to the isolation and identification of a non-graminaceous monocotyledonous plant promoter, the banana (Musa.Spp.) actinn gene associated promoter region. The promoter region has been found to unexpectedly direct constitutive gene expression not only in non-graminaceous monocotyledonous plants but also in graminaceous monocotydonous plants. The Invention is also concerned with a chimeric nucleic acid construct comprising the promoter of the invention oprably linked to a foreign or endogenous polynucleotide encoding a protein of interest or a transcript capable of modulating expression of a target gene. The invention further discloses transformed plant cells, as well as differentiated plants and plant parts, containing the construct.
摘要翻译：本发明涉及非禾本腺单子叶植物启动子，香蕉（Musa.Spp。）actinn基因相关启动子区域的分离和鉴定。已经发现启动子区域不仅在非禾本类单子叶植物中而且在禾本科单子叶植物中意外地指导组成型基因表达。本发明还涉及包含可编码感兴趣的蛋白质的外源或内源多核苷酸的本发明启动子的嵌合核酸构建体或能够调节靶基因表达的转录物。本发明还公开了转化的植物细胞，以及含有该构建体的分化植物和植物部分。

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