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1. 发明申请

US20100305309A1 NANODIAMOND PARTICLE COMPLEXES 审中-公开
标题翻译：纳米颗粒复合物
公开(公告)号：US20100305309A1
公开(公告)日：2010-12-02
申请号：US12789966
申请日：2010-05-28
申请人： Dean Ho , Mark Chen , Erik Pierstorff , Erik Robinson , Robert Lam , Rafael Shimkunas , Xueqing Zhang
发明人： Dean Ho , Mark Chen , Erik Pierstorff , Erik Robinson , Robert Lam , Rafael Shimkunas , Xueqing Zhang
IPC分类号： C07K17/14 , C07H21/00 , C07C237/26
CPC分类号： C07K17/14 , A61K47/6921 , A61K47/6929 , B82Y5/00
摘要： The present invention provides various functionalized nanodiamond particles. In particular, the present invention provides soluble complexes of nanodiamond particles and therapeutic agents, for example insoluble therapeutics, anthracycline and/or tetracycline compounds, nucleic acids, proteins, etc.
摘要翻译：本发明提供了各种官能化纳米金刚石颗粒。特别地，本发明提供了纳米金刚石颗粒和治疗剂的可溶性复合物，例如不溶性治疗剂，蒽环类抗生素和/或四环素化合物，核酸，蛋白质等。

2. 发明申请

US20100040672A1 DELIVERY OF THERAPEUTICS 审中-公开
标题翻译：交付治疗
公开(公告)号：US20100040672A1
公开(公告)日：2010-02-18
申请号：US12481400
申请日：2009-06-09
申请人： Dean Ho , Robert Lam , Mark Chen , Houjin Huang , Erik Pierstorff , Erik Robinson
发明人： Dean Ho , Robert Lam , Mark Chen , Houjin Huang , Erik Pierstorff , Erik Robinson
IPC分类号： A61K9/70 , A61K31/56 , A61K31/351
CPC分类号： A61K31/573 , A61K9/0024 , A61K9/5115 , A61K9/7007 , A61K31/704 , A61K47/6957 , A61L27/34 , A61L27/54 , A61L2300/222 , A61L2300/41 , A61L2300/416 , A61L2300/602 , A61L2300/608 , A61L2300/624 , A61L2420/08 , C08L65/04
摘要： The present invention provides materials and devices for the controlled release of therapeutics, and methods for uses thereof.
摘要翻译：本发明提供用于控制释放治疗剂的材料和装置及其用途的方法。

3. 发明申请

US20130004560A1 Polymer Nanofilm Coatings 审中-公开
标题翻译：聚合物纳米薄膜
公开(公告)号：US20130004560A1
公开(公告)日：2013-01-03
申请号：US13609588
申请日：2012-09-11
申请人： Dean Ho , Mark Chen , Erik Pierstorff , Houjin Huang , Edward K. Chow , Genhong Cheng
发明人： Dean Ho , Mark Chen , Erik Pierstorff , Houjin Huang , Edward K. Chow , Genhong Cheng
IPC分类号： A61K9/70 , B32B27/08 , B32B7/02 , B32B27/28 , B82Y5/00
CPC分类号： A61L27/34 , A61L27/18 , A61L27/54 , A61L27/56 , A61L2300/41 , A61L2300/416 , A61L2300/606 , A61L2400/12 , Y10T428/24355 , Y10T428/24975 , C08L83/04 , C08L71/02
摘要： Disclosed herein are nanofilm coatings for implantable medical devices comprising a diblock or triblock copolymer (PEO-PMMA or PMOXA-PDMS-PMOXA, respectively). Such nanofilms, may be used, for example, as amphiphilic supports for therapeutic agents. These materials are conducive towards the formation of active substrates for a suite of biological and medical applications.
摘要翻译：本文公开了包含二嵌段或三嵌段共聚物（分别为PEO-PMMA或PMOXA-PDMS-PMOXA）的可植入医疗装置的纳米薄膜。这样的纳米膜可以用作例如治疗剂的两亲性载体。这些材料有助于形成用于一系列生物和医学应用的活性底物。

4. 发明申请

US20090004241A1 POLYMER NANOFILM COATINGS 有权
标题翻译：聚合物纳米薄膜涂料
公开(公告)号：US20090004241A1
公开(公告)日：2009-01-01
申请号：US12135640
申请日：2008-06-09
申请人： Dean Ho , Mark Chen , Erik Pierstorff , Houjin Huang , Edward K. Chow , Genhong Cheng
发明人： Dean Ho , Mark Chen , Erik Pierstorff , Houjin Huang , Edward K. Chow , Genhong Cheng
IPC分类号： A61F2/02 , A61K31/56
CPC分类号： A61L27/34 , A61L27/18 , A61L27/54 , A61L27/56 , A61L2300/41 , A61L2300/416 , A61L2300/606 , A61L2400/12 , Y10T428/24355 , Y10T428/24975 , C08L83/04 , C08L71/02
摘要： Disclosed herein are nanofilm coatings for implantable medical devices comprising a diblock or triblock copolymer (PEO-PMMA or PMOXA-PDMS-PMOXA, respectively). Such nanofilms, may be used, for example, as amphiphilic supports for therapeutic agents. These materials are conducive towards the formation of active substrates for a suite of biological and medical applications.
摘要翻译：本文公开了包含二嵌段或三嵌段共聚物（分别为PEO-PMMA或PMOXA-PDMS-PMOXA）的可植入医疗装置的纳米薄膜。这样的纳米膜可以用作例如治疗剂的两亲性载体。这些材料有助于形成用于一系列生物和医学应用的活性底物。

5. 发明授权

US08263104B2 Polymer nanofilm coatings 有权
标题翻译：聚合物纳米薄膜涂层
公开(公告)号：US08263104B2
公开(公告)日：2012-09-11
申请号：US12135640
申请日：2008-06-09
申请人： Dean Ho , Mark Chen , Erik Pierstorff , Houjin Huang , Edward K Chow , Genhong Cheng
发明人： Dean Ho , Mark Chen , Erik Pierstorff , Houjin Huang , Edward K Chow , Genhong Cheng
IPC分类号： A61F2/02 , A61K31/56
CPC分类号： A61L27/34 , A61L27/18 , A61L27/54 , A61L27/56 , A61L2300/41 , A61L2300/416 , A61L2300/606 , A61L2400/12 , Y10T428/24355 , Y10T428/24975 , C08L83/04 , C08L71/02
摘要： Disclosed herein are nanofilm coatings for implantable medical devices comprising a diblock or triblock copolymer (PEO-PMMA or PMOXA-PDMS-PMOXA, respectively). Such nanofilms, may be used, for example, as amphiphilic supports for therapeutic agents. These materials are conducive towards the formation of active substrates for a suite of biological and medical applications.
摘要翻译：本文公开了包含二嵌段或三嵌段共聚物（分别为PEO-PMMA或PMOXA-PDMS-PMOXA）的可植入医疗装置的纳米薄膜。这样的纳米膜可以用作例如治疗剂的两亲性载体。这些材料有助于形成用于一系列生物和医学应用的活性底物。

6. 发明申请

US20110256150A1 Modulation of Axon Degeneration 有权
标题翻译：轴突退化的调制
公开(公告)号：US20110256150A1
公开(公告)日：2011-10-20
申请号：US13125333
申请日：2009-10-22
申请人： Ryan Watts , Mark Chen , Joseph Wesley Lewcock , Christine Pozniak , Arundhati Sengupta-Ghosh
发明人： Ryan Watts , Mark Chen , Joseph Wesley Lewcock , Christine Pozniak , Arundhati Sengupta-Ghosh
IPC分类号： A61K39/395 , A61K33/14 , A61K31/277 , A61K31/52 , A61K38/12 , A61K31/40 , A61K31/45 , A61P25/00 , A61P25/28 , A61P27/02 , A61P25/18 , C12N5/0784 , C12Q1/02 , C12Q1/68 , A61K38/06
CPC分类号： A61K38/12 , A61K31/12 , A61K31/165 , A61K31/277 , A61K31/35 , A61K31/352 , A61K31/40 , A61K31/4015 , A61K31/416 , A61K31/4184 , A61K31/426 , A61K31/433 , A61K31/4439 , A61K31/45 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/7088 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K33/14 , A61K38/05 , A61K38/185 , C07K16/22 , C07K16/40 , C07K2317/76 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2320/30 , G01N33/5058
摘要： The invention relates generally to treatment of neurological disorders and nervous system injuries. The invention specifically provides methods of using modulators of particular target proteins to modulate degeneration of neurons or portions thereof, such as axons.
摘要翻译：本发明一般涉及治疗神经系统疾病和神经系统损伤。本发明具体提供了使用特定靶蛋白的调节剂调节神经元或其部分如轴突的变性的方法。

7. 发明授权

US07782767B1 Method and system for calculating burst bit rate for IP interactive applications 有权
标题翻译：用于计算IP交互应用程序的突发比特率的方法和系统
公开(公告)号：US07782767B1
公开(公告)日：2010-08-24
申请号：US11185098
申请日：2005-07-20
申请人： Lisan Lin , Michael Reiman , Mark Chen , Charles Moore
发明人： Lisan Lin , Michael Reiman , Mark Chen , Charles Moore
IPC分类号： G01R31/08 , H04L1/00
CPC分类号： H04L29/06027 , H04L43/0888 , H04L65/80 , H04W24/00 , H04W28/22 , H04W80/00
摘要： A method and apparatus for determining the burst bit rate for data in the transport layer of a network is described. The burst bit rate is determined by measuring the time for a total number of bytes to be transferred across a point in the network and adding that time to an estimated network delay. The total number of bytes transferred is then divided by the transfer time plus the estimated network delay thereby calculating the burst bit rate for the transfer.
摘要翻译：描述了用于确定网络的传输层中的数据的突发比特率的方法和装置。突发比特率通过测量要在网络中的一个点上传送的总字节数的时间来确定，并将该时间添加到估计的网络延迟。然后将传输的总字节数除以传输时间加上估计的网络延迟，从而计算传输的突发比特率。

8. 发明授权

US07677923B1 Double visual-interface socket 失效
标题翻译：双视觉接口插座
公开(公告)号：US07677923B1
公开(公告)日：2010-03-16
申请号：US12499975
申请日：2009-07-09
申请人： Mark Chen , Ching-Tung Lu
发明人： Mark Chen , Ching-Tung Lu
IPC分类号： H01R13/60
CPC分类号： H01R12/7029 , H01R12/712
摘要： A double visual-interface socket compliant with socket design rules set forth in the Digital Visual Interface standard comprises: a lower socket unit including plural L-shaped terminal pins; an upper socket unit disposed above the lower socket unit and including plural terminal pins; an adapter module including plural L-shaped pins arranged in rows; and a circuit board having plural terminal guide holes and plural extension guide holes. The terminal guide holes are inserted by, soldered to, and therefore electrically connected with the terminal pins of the upper socket unit, respectively. The extension guide holes are electrically connected with the terminal guide holes, respectively, and are inserted by, soldered to, and therefore electrically connected with ends of the L-shaped pins of the adapter module, respectively. The opposite ends of the L-shaped pins of the adapter module are substantially aligned with bottom ends of the L-shaped terminal pins of the lower socket unit.
摘要翻译：符合数字视觉接口标准中规定的插座设计规则的双视觉接口插座包括：下部插座单元，包括多个L形端子引脚; 上插座单元设置在下插座单元上方并且包括多个端子销; 适配器模块，包括排成行的多个L形销; 以及具有多个端子引导孔和多个延伸引导孔的电路板。端子引导孔分别被插入，焊接到并因此与上部插座单元的端子引脚电连接。延伸引导孔分别与端子引导孔电连接，并且分别插入，焊接到并因此与适配器模块的L形销的端部电连接。适配器模块的L形销的相对端基本上与下部插座单元的L形端子销的底端对齐。

9. 发明授权

US07542430B2 System and method for measuring end-to-end network delay and user-perspective delay 有权
标题翻译：用于测量端到端网络延迟和用户视角延迟的系统和方法
公开(公告)号：US07542430B2
公开(公告)日：2009-06-02
申请号：US11035145
申请日：2005-01-13
申请人： Lisan Lin , Michael Reiman , Mark Chen , Charles Moore
发明人： Lisan Lin , Michael Reiman , Mark Chen , Charles Moore
IPC分类号： G01R31/08 , G06F11/00 , G08C15/00 , H04J1/16 , H04J3/14 , H04L1/00 , H04L12/26
CPC分类号： H04L43/0858 , H04L43/106 , H04L43/12
摘要： A system and method for measuring user-perceived delay in an IP network, comprising detecting request and corresponding response messages at a monitoring point in the network, calculating an uplink delay based upon the time elapsed between the request and corresponding response messages, detecting response and corresponding transport acknowledgement messages at the monitoring point, wherein the response message is sent in response to the request message, calculating a downlink network delay based upon the time elapsed between the response and corresponding transport acknowledgement messages; and calculating a user-perceived delay by adding uplink delay and downlink network delay, wherein the user-perceived delay represents a time required for an IP message to travel from a user device to a network destination plus the time required for the service (server) to respond and return the response to the user device.
摘要翻译：一种用于测量IP网络中的用户感知延迟的系统和方法，包括在网络的监控点检测请求和对应的响应消息，基于请求与相应响应消息之间经过的时间计算上行链路延迟，检测响应和在所述监视点处的相应的传输确认消息，其中响应于所述请求消息发送所述响应消息，基于所述响应和相应的传输确认消息之间经过的时间计算下行链路网络延迟; 以及通过添加上行链路延迟和下行链路网络延迟来计算用户感知的延迟，其中用户感知延迟表示IP消息从用户设备移动到网络目的地所需的时间加上服务所需的时间（服务器）以响应并将响应返回给用户设备。

10. 发明授权

US06273761B1 Jack-plug socket 失效
标题翻译：插头插座
公开(公告)号：US06273761B1
公开(公告)日：2001-08-14
申请号：US09747997
申请日：2000-12-27
申请人： Chang-Hsing Hsu , Mark Chen
发明人： Chang-Hsing Hsu , Mark Chen
IPC分类号： H01R2400
CPC分类号： H01R13/64 , H01R24/62
摘要： An improved jack-plug socket which has a restraint means located in the socket which has a jack (connection slot) of a larger size for prohibiting phone (or Internet link) plugs of smaller size from inserting into the jack.
摘要翻译：一种改进的插座插座，其具有位于插座中的约束装置，该限位装置具有较大尺寸的插孔（连接槽），用于禁止较小尺寸的电话插头插入插孔。

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