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1. 发明授权

US09170049B2 Method for monitoring primary drying of a freeze-drying process 有权
标题翻译：用于监测冷冻干燥过程的初步干燥的方法
公开(公告)号：US09170049B2
公开(公告)日：2015-10-27
申请号：US13518445
申请日：2010-12-22
申请人： Davide Fissore , Roberto Pisano , Antonello A. Barresi
发明人： Davide Fissore , Roberto Pisano , Antonello A. Barresi
IPC分类号： F26B5/06
CPC分类号： F26B5/06
摘要： A freeze-drying process includes a primary drying phase. Within this phase, a test is performed for causing a variation of partial pressure of solvent inside a drying chamber. At the beginning of the test, a product sublimation flux, a total pressure and a partial pressure of the solvent in the drying chamber are measured. A product temperature is estimated at the interface of sublimation at the beginning of the test. The solvent vapor pressure at the interface of sublimation is calculated as is a resistance of a dried layer of the product to the vapor flow of the solvent. Next, a thickness of a frozen layer of the product is calculated and a coefficient of heat transfer between heating surface and product is also calculated. An initial temperature profile of the frozen product is then calculated as is a total pressure in the drying chamber. A value of the product temperature at the interface of sublimation at the beginning of test is determined and a time constant of the freeze-drying process is calculated.
摘要翻译：冷冻干燥过程包括初级干燥阶段。在该阶段内，进行干燥室内的溶剂分压变化的试验。在测试开始时，测量干燥室中溶剂的产物升华通量，总压力和分压。产品温度在测试开始时在升华界面处估算。计算升华界面处的溶剂蒸汽压力，即产品的干燥层与溶剂的蒸气流的电阻。接下来，计算产品的冷冻层的厚度，并计算加热面与产品之间的热传递系数。然后按照干燥室中的总压力计算冷冻产品的初始温度分布。确定试验开始时升华界面处的产品温度值，并计算冷冻干燥过程的时间常数。

2. 发明申请

US20130006546A1 METHOD FOR MONITORING PRIMARY DRYING OF A FREEZE-DRYING PROCESS 有权
标题翻译：用于监测冷冻干燥原理干燥的方法
公开(公告)号：US20130006546A1
公开(公告)日：2013-01-03
申请号：US13518445
申请日：2010-12-22
申请人： Davide Fissore , Roberto Pisano , Antonello A. Barresi
发明人： Davide Fissore , Roberto Pisano , Antonello A. Barresi
IPC分类号： F26B5/06 , G06F19/00
CPC分类号： F26B5/06
摘要： A freeze-drying process includes a primary drying phase. Within this phase, a test is performed for causing a variation of partial pressure of solvent inside a drying chamber. At the beginning of the test, a product sublimation flux, a total pressure and a partial pressure of the solvent in the drying chamber are measured. A product temperature is estimated at the interface of sublimation at the beginning of the test. The solvent vapor pressure at the interface of sublimation is calculated as is a resistance of a dried layer of the product to the vapor flow of the solvent. Next, a thickness of a frozen layer of the product is calculated and a coefficient of heat transfer between heating surface and product is also calculated. An initial temperature profile of the frozen product is then calculated as is a total pressure in the drying chamber. A value of the product temperature at the interface of sublimation at the beginning of test is determined and a time constant of the freeze-drying process is calculated.
摘要翻译：冷冻干燥过程包括初级干燥阶段。在该阶段内，进行干燥室内的溶剂分压变化的试验。在测试开始时，测量干燥室中溶剂的产物升华通量，总压力和分压。产品温度在测试开始时在升华界面处估算。计算升华界面处的溶剂蒸汽压力，即产品的干燥层与溶剂的蒸气流的电阻。接下来，计算产品的冷冻层的厚度，并计算加热面与产品之间的热传递系数。然后按照干燥室中的总压力计算冷冻产品的初始温度分布。确定试验开始时升华界面处的产品温度值，并计算冷冻干燥过程的时间常数。

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