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1. 发明申请

US20050036910A1 Specimen collection and application apparatus 有权
标题翻译：标本采集和应用仪器
公开(公告)号：US20050036910A1
公开(公告)日：2005-02-17
申请号：US10913899
申请日：2004-08-05
申请人： David Zhou , Nai Wang , Claudia Shen , Angela Shen
发明人： David Zhou , Nai Wang , Claudia Shen , Angela Shen
IPC分类号： A61B10/00 , G01N1/00
CPC分类号： A61B10/0096 , A61B10/0038 , Y10T436/25
摘要： A device for quantitively collecting, preserving and mailing a fresh and wet specimen of fecal or other biological matter for later analysis comprises a tubular vessel defining a chamber closed at one axial end by a plug and restricted at the opposite end by a narrow aperture. A stopper for closing the open end of the vessel extends into a stick whose distal portion comprises indentations capable of retaining a portion of the biological matter when the stick is dipped into it. The distal portion of the stick is shaped and dimensioned to intimately and circumferentially contact the edge of the aperture so that the amount of matter introduced into the chamber is limited to the part having penetrated into the indentations. The shank of the stick is dimensioned to seal the aperture once the stopper has been screwed upon the open end of the vessel. The plug mounts a breakable hollow nib and is installed after introduction into the chamber of a metered volume of preserving solution. A cover caps the plug and nib to provide additional sealing of that end of the vessel during transportation.
摘要翻译：一种用于定量收集，保存和邮寄新鲜和潮湿的粪便或其他生物物质样品用于稍后分析的装置包括管状容器，该管状容器限定在一个轴向端部处由塞子封闭并且在相对端通过窄孔限制的腔室。用于封闭容器的开口端的塞子延伸成棒，其远端部分包括当棒浸入其中时能够保留生物物质的一部分的凹痕。棒的远端部分的形状和尺寸被设计成紧密地和圆周地接触孔的边缘，使得引入腔室的物质的数量被限制在已经穿入凹口的部分上。一旦塞子已经拧紧在容器的开口端，则该杆的柄的尺寸被设计成密封孔。插头安装了可破碎的空心笔尖，并在导入计量体积的保存溶液的腔室后安装。盖子盖住塞子和笔尖，以便在运输过程中提供该容器端部的额外密封。

2. 发明申请

US20060078622A1 Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent 审中-公开
公开(公告)号：US20060078622A1
公开(公告)日：2006-04-13
申请号：US11204756
申请日：2005-08-15
申请人： Shingai Majuru , Puchun Liu , Steve Dinh , Jun Liao , Jongbin Lee , Ehud Arbit , Nikhil Dhoot , Halina Levchik , George Klcin , Jamila Harris , Nai Wang
发明人： Shingai Majuru , Puchun Liu , Steve Dinh , Jun Liao , Jongbin Lee , Ehud Arbit , Nikhil Dhoot , Halina Levchik , George Klcin , Jamila Harris , Nai Wang
IPC分类号： A61K9/14
CPC分类号： A61K47/12 , A61K9/145 , A61K9/1617 , A61K9/2013 , A61K9/2027 , A61K9/2077 , A61K9/2081 , A61K9/2846 , A61K9/4858 , A61K38/28
摘要： This invention relates to microparticles and/or nanoparticles containing a delivery agent and/or an active agent. This invention also relates to pharmaceutical formulations and solid dosage forms, including controlled release solid dosage forms of active agent and a delivery agent.

3. 发明申请

US20050255138A1 Active agent transport systems 审中-公开
标题翻译：活性剂运输系统
公开(公告)号：US20050255138A1
公开(公告)日：2005-11-17
申请号：US11042960
申请日：2005-01-24
申请人： Sam Milstein , Evgueni Barantsevitch , Andrea Leone-Bay , Nai Wang , Donald Sarubbi , Noemi Santiago
发明人： Sam Milstein , Evgueni Barantsevitch , Andrea Leone-Bay , Nai Wang , Donald Sarubbi , Noemi Santiago
IPC分类号： A61K8/04 , A61K8/64 , A61K9/16 , A61K9/20 , A61K31/16 , A61K31/28 , A61K31/35 , A61K31/352 , A61K31/727 , A61K38/00 , A61K38/21 , A61K38/23 , A61K38/25 , A61K38/27 , A61K38/28 , A61K39/395 , A61K47/12 , A61K47/18 , A61K47/48 , A61Q13/00 , C07C229/42 , C07C233/55 , C07C233/63 , C07C233/87 , C07C235/38 , C07C235/64 , C07C235/84 , C07C237/22 , C07C279/14 , C07K1/107 , C07K5/06
CPC分类号： A61K31/715 , A61K8/0241 , A61K8/64 , A61K9/1617 , A61K9/1641 , A61K9/167 , A61K9/2013 , A61K31/16 , A61K31/28 , A61K31/35 , A61K31/352 , A61K31/727 , A61K38/212 , A61K38/23 , A61K38/25 , A61K38/27 , A61K38/28 , A61K47/12 , A61K47/18 , A61K47/183 , A61K47/62 , A61K2800/56 , A61Q13/00 , C07C229/42 , C07C233/55 , C07C233/63 , C07C233/87 , C07C235/38 , C07C235/64 , C07C235/84 , C07C237/22 , C07C279/14 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07K1/1077 , C07K5/06043
摘要： Methods for transporting a biologically active agent across a cellular membrane or a lipid bilayer. A first method includes the steps of: (a) providing a biologically active agent which can exist in a native conformational state, a denatured conformational state, and an intermediate conformational state which is reversible to the native state and which is conformationally between the native and denatured states; (b) exposing the biologically active agent to a complexing perturbant to reversibly transform the biologically active agent to the intermediate state and to form a transportable supramolecular complex; and (c) exposing the membrane or bilayer to the supramolecular complex, to transport the biologically active agent across the membrane or bilayer. The perturbant has a molecular weight between about 150 and about 600 daltons, and contains at least one hydrophilic moiety and at least one hydrophobic moiety. The supramolecular complex comprises the perturbant non-covalently bound or complexed with the biologically active agent. In the present Invention, the biologically active agent does not form a microsphere after interacting with the perturbant. A method for preparing an orally administrable biologically active agent comprising steps (a) and (b) above is also provided as are oral delivery compositions. Additionally, mimetics and methods for preparing mimetics are contemplated.
摘要翻译：运输生物活性剂穿过细胞膜或脂质双层的方法。第一种方法包括以下步骤：（a）提供可以以天然构象状态，变性构象状态和中和构象状态存在的生物活性剂，其可天然状态是可逆的，并且在天然和/或变性状态（b）将生物活性剂暴露于络合扰动剂以将生物活性剂可逆地转化为中间状态并形成可运输的超分子复合物; 和（c）将膜或双层暴露于超分子复合物，以将生物活性剂转运穿过膜或双层。扰动剂具有约150至约600道尔顿之间的分子量，并且含有至少一个亲水部分和至少一个疏水部分。超分子复合物包括与生物活性剂非共价结合或络合的扰动剂。在本发明中，生物活性剂在与扰动剂相互作用后不形成微球体。还提供了包含上述步骤（a）和（b）的可口服给药的生物活性剂的制备方法，口服递送组合物也是如此。另外，可以考虑用于制备模拟物的模拟物和方法。

4. 发明申请

US20070141022A1 POLYMERIC DELIVERY AGENTS AND DELIVERY AGENT COMPOUNDS 失效
标题翻译：聚合物递送代理和交付代理化合物
公开(公告)号：US20070141022A1
公开(公告)日：2007-06-21
申请号：US11669649
申请日：2007-01-31
申请人： Sam Milstein , Eugene Barantsevitch , Nai Wang , Jun Liao , John Smart , Richard Conticello , Raphael Ottenbrite
发明人： Sam Milstein , Eugene Barantsevitch , Nai Wang , Jun Liao , John Smart , Richard Conticello , Raphael Ottenbrite
IPC分类号： A61K38/17 , A61K31/785 , C08G63/91
CPC分类号： C08G65/33396 , A61K9/0019 , A61K38/27 , A61K38/29 , A61K47/10 , A61K47/32 , A61K47/56 , A61K47/60 , C08F8/30 , C08G65/329 , C08L2203/02
摘要： Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
摘要翻译：提供了可用于递送活性剂的聚合物递送剂，递送剂化合物和包含它们的组合物。也提供给药和制备方法。

5. 发明申请

US20050272638A1 Compounds and compositions for delivering active agents 有权
公开(公告)号：US20050272638A1
公开(公告)日：2005-12-08
申请号：US11173075
申请日：2005-06-30
申请人： David Gschneidner , Andrea Leone-Bay , Eric Wang , Lynn Errigo , Koc-Kan Ho , Jeffrey Press , Nai Wang , Pingwah Tang
发明人： David Gschneidner , Andrea Leone-Bay , Eric Wang , Lynn Errigo , Koc-Kan Ho , Jeffrey Press , Nai Wang , Pingwah Tang
IPC分类号： A61K9/00 , A61K31/727 , A61K38/22 , A61K38/27 , A61K47/10 , A61K47/16 , A61K47/18 , A61K47/22 , A61P5/18 , C07C233/25 , C07C233/51 , C07C233/54 , C07C233/81 , C07C233/83 , C07C235/24 , C07C235/34 , C07C235/64 , C07C235/74 , C07C271/28 , C07C271/54 , C07C271/58 , C07C275/42 , C07C309/59 , C07C317/44 , C07D239/91 , C07D239/94 , C07D239/96 , C07D265/26 , C07D311/18 , C07D311/68 , C07D317/68 , A61K31/195
CPC分类号： C07C233/83 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K38/00 , A61K47/18 , C07C233/51 , C07C235/24 , C07C235/34 , C07C235/60 , C07C235/64 , C07C235/74 , C07C271/28 , C07C271/54 , C07C271/58 , C07C275/42 , C07C309/59 , C07C317/44 , C07D239/91 , C07D239/94 , C07D239/96 , C07D265/26 , C07D311/18 , C07D317/68
摘要： Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.

6. 发明申请

US20070010422A1 COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS 有权
公开(公告)号：US20070010422A1
公开(公告)日：2007-01-11
申请号：US11531602
申请日：2006-09-13
申请人： David Gschneidner , Andrea Leone-Bay , Eric Wang , Lynn Errigo , Koc-Kan Ho , Jeffrey Press , Nai Wang , Pingwah Tang
发明人： David Gschneidner , Andrea Leone-Bay , Eric Wang , Lynn Errigo , Koc-Kan Ho , Jeffrey Press , Nai Wang , Pingwah Tang
IPC分类号： A61K38/16 , A61K38/22 , A61K31/715 , A61K31/56 , C07C237/10
CPC分类号： C07C233/83 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K38/00 , A61K47/18 , C07C233/51 , C07C235/24 , C07C235/34 , C07C235/60 , C07C235/64 , C07C235/74 , C07C271/28 , C07C271/54 , C07C271/58 , C07C275/42 , C07C309/59 , C07C317/44 , C07D239/91 , C07D239/94 , C07D239/96 , C07D265/26 , C07D311/18 , C07D317/68
摘要： Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.

7. 发明申请

US20060078623A1 Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent 审中-公开
标题翻译：含有递送剂的微粒或纳米颗粒的药物制剂
公开(公告)号：US20060078623A1
公开(公告)日：2006-04-13
申请号：US11204778
申请日：2005-08-15
申请人： Nikhil Dhoot , Halina Levchik , Shingai Majuru , George Klein , Jamila Harris , Puchun Liu , Steven Dinh , Jun Liao , Jongbin Lee , Ehud Arbit , Nai Wang
发明人： Nikhil Dhoot , Halina Levchik , Shingai Majuru , George Klein , Jamila Harris , Puchun Liu , Steven Dinh , Jun Liao , Jongbin Lee , Ehud Arbit , Nai Wang
IPC分类号： A61K9/50 , A61K9/16 , A61K9/14
CPC分类号： A61K47/12 , A61K9/145 , A61K9/1617 , A61K9/2013 , A61K9/2027 , A61K9/2077 , A61K9/2081 , A61K9/2846 , A61K9/4858 , A61K38/28
摘要： This invention relates to microparticles and/or nanoparticles containing a delivery agent and/or an active agent. This invention also relates to pharmaceutical formulations and solid dosage forms, including controlled release solid dosage forms of active agent and a delivery agent.
摘要翻译：本发明涉及含有递送剂和/或活性剂的微粒和/或纳米颗粒。本发明还涉及药物制剂和固体剂型，包括活性剂的控释固体剂型和递送剂。

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