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1. 发明授权

US5612478A Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecan e 失效
标题翻译：制备1,1' - [1,4-亚苯基双（亚甲基）] - 双-1,4,8,11-四氮杂环十四烷的方法
公开(公告)号：US5612478A
公开(公告)日：1997-03-18
申请号：US413582
申请日：1995-03-30
申请人： David Xu , Prasad Kapa , Oljan Repic , Thomas J. Blacklock
发明人： David Xu , Prasad Kapa , Oljan Repic , Thomas J. Blacklock
IPC分类号： C07C233/00 , C07C233/36 , C07C303/00 , C07C311/18 , C07D257/02
CPC分类号： C07C233/36 , C07C311/18 , C07D257/02
摘要： An improved process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane comprising the selective functionalization of an acyclic tetraamine, and subsequent dimerization and hydrolyzation/tosylation to obtain a 1,4-phenylenebis-methylene bridged hexatosyl acyclic precursor in a first step, the cyclization of said precursor to obtain a hexatosyl cyclam dimer in a second step, and the detosylation of said cyclam dimer in a third step followed by basification to obtain the desired 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane.
摘要翻译：制备1,1' - [1,4-亚苯基双（亚甲基）] - 双-1,4,8,11-四氮杂环十四烷的改进方法，其包括无环四胺的选择性官能化，随后二聚和水解/甲苯磺酰化至在第一步中获得1,4-亚苯基双 - 亚甲基桥联的六碳酰基非环状前体，在第二步中环化所述前体以获得己糖基环胞二聚体，并在第三步中对所述环化二聚体进行脱甲苯基化，然后碱化得到所需的1,1' - [1,4-亚苯基双（亚甲基）] - 双-1,4,8,11-四氮杂环十四烷。

2. 发明授权

US5801281A Process for preparing 1,1'- (1,4- phenylenebis (methlene)-Bis 1,4,8,11-tetraazacyclotetradecane 失效
标题翻译：制备1,1'-（1,4-亚苯基双（甲基）） - 1,4,8,11-四氮杂环十四烷的方法
公开(公告)号：US5801281A
公开(公告)日：1998-09-01
申请号：US968086
申请日：1997-11-12
申请人： David Xu , Prasad Kapa , Oljan Repic , Thomas J. Blacklock
发明人： David Xu , Prasad Kapa , Oljan Repic , Thomas J. Blacklock
IPC分类号： C07C233/00 , C07C233/36 , C07C303/00 , C07C311/18 , C07D257/02
CPC分类号： C07C233/36 , C07C311/18 , C07D257/02
摘要： An improved process for preparing 1,1'-�1,4-phenylenebis-(methylene)!-bis-1,4,8,11-tetraazacyclotetradecane comprising the selective functionalization of an acyclic tetraamine, and subsequent dimerization and hydrolyzation/tosylation to obtain a 1,4-phenylenebis-methylene bridged hexatosyl acyclic precursor in a first step, the cyclization of said precursor to obtain a hexatosyl cyclam dimer in a second step, and the detosylation of said cyclam dimer in a third step followed by basification to obtain the desired 1,1'-�1,4-phenylenebis-(methylene)!-bis-1,4,8,11-tetraazacyclotetradecane.
摘要翻译：制备1,1' - [1,4-亚苯基双（亚甲基）] - 双-1,4,8,11-四氮杂环十四烷的改进方法，其包括无环四胺的选择性官能化，随后二聚和水解/甲苯磺酰化至在第一步中获得1,4-亚苯基双 - 亚甲基桥联的六碳酰基非环状前体，在第二步中环化所述前体以获得己糖基环胞二聚体，并在第三步中对所述环化二聚体进行脱甲苯基化，然后碱化得到所需的1,1' - [1,4-亚苯基双（亚甲基）] - 双-1,4,8,11-四氮杂环十四烷。

3. 发明授权

US5756728A Process for preparing 1,1'-�1,4-phenylenebis-(methylene)!-bis-1,4,8,11-tetraazacyclotetradecan e 失效
标题翻译：制备1,1' - [1,4-亚苯基双（亚甲基）] - 双-1,4,8,11-四氮杂环十四烷的方法
公开(公告)号：US5756728A
公开(公告)日：1998-05-26
申请号：US777072
申请日：1996-12-30
申请人： David Xu , Prasad Kapa , Oljan Repic , Thomas J. Blacklock
发明人： David Xu , Prasad Kapa , Oljan Repic , Thomas J. Blacklock
IPC分类号： C07C233/00 , C07C233/36 , C07C303/00 , C07C311/18 , C07D257/02 , C07D259/00 , A61K31/395
CPC分类号： C07C233/36 , C07C311/18 , C07D257/02
摘要： An improved process for preparing 1,1'-�1,4-phenylenebis-(methylene)!-bis-1,4,8,11-tetraazacyclotetradecane comprising the selective functionalization of an acyclic tetraamine, and subsequent dimerization and hydrolyzation/tosylation to obtain a 1,4-phenylenebis-methylene bridged hexatosyl acyclic precursor in a first step, the cyclization of said precursor to obtain a hexatosyl cyclam dimer in a second step, and the detosylation of said cyclam dimer in a third step followed by basification to obtain the desired 1,1'-�1,4-phenylenebis-(methylene)!-bis-1,4,8,11-tetraazacyclotetradecane.
摘要翻译：制备1,1' - [1,4-亚苯基双（亚甲基）] - 双-1,4,8,11-四氮杂环十四烷的改进方法，其包括无环四胺的选择性官能化，随后二聚和水解/甲苯磺酰化至在第一步中获得1,4-亚苯基双 - 亚甲基桥联的六碳酰基非环状前体，在第二步中环化所述前体以获得己糖基环胞二聚体，并在第三步中对所述环化二聚体进行脱甲苯基化，然后碱化得到所需的1,1' - [1,4-亚苯基双（亚甲基）] - 双-1,4,8,11-四氮杂环十四烷。

4. 发明申请

US20140119624A1 VOLUMETRIC ANALYSIS OF PATHOLOGIES 有权
标题翻译：病理学的体积分析
公开(公告)号：US20140119624A1
公开(公告)日：2014-05-01
申请号：US13850846
申请日：2013-03-26
申请人： Justis P. Ehlers , David Xu , Peter K. Kaiser , William J. Dupps , Sunil K. Srivastava
发明人： Justis P. Ehlers , David Xu , Peter K. Kaiser , William J. Dupps , Sunil K. Srivastava
IPC分类号： G06T7/00 , G06T7/60
CPC分类号： G06T7/0012 , A61B5/0066 , G06T7/0016 , G06T7/11 , G06T7/12 , G06T7/162 , G06T7/62 , G06T17/20 , G06T2207/10101 , G06T2207/20016 , G06T2207/20072 , G06T2207/30041
摘要： Systems and methods are provided for volumetric analysis of pathologies. A segmentation component is configured to determine, for each of a series of images of a region of interest containing a pathological feature, a set of segmentation boundaries within the image representing a cross-section of the pathological feature. A mesh generation component is configured to link the sets of segmentation boundaries from adjacent images in the series of images to generate a polygonal mesh representing a volumetric reconstruction of the pathological feature. A volumetric measurement component is configured to calculate volumetric parameters from the volumetric reconstruction representing the pathological feature. A user interface is configured to provide the calculated volumetric parameters to an associated display.
摘要翻译：提供系统和方法用于病理学的体积分析。分割部分被配置为针对包含病理特征的感兴趣区域的一系列图像中的每一个来确定代表病理特征的横截面的图像内的一组分割边界。网格生成组件被配置为将所述一组图像中的相邻图像的分割边界集合链接以生成表示病理特征的体积重建的多边形网格。体积测量部件被配置为从表示病理特征的体积重建计算体积参数。用户界面被配置为将计算的体积参数提供给相关联的显示。

5. 发明申请

US20080249318A1 Process for phenylacetic acid derivatives 审中-公开
标题翻译：苯乙酸衍生物工艺
公开(公告)号：US20080249318A1
公开(公告)日：2008-10-09
申请号：US11893481
申请日：2007-08-16
申请人： Murat Acemoglu , Thomas Allmendinger , John Vincent Calienni , Jacques Cercus , Olivier Loiseleur , Gottfried Sedelmeier , David Xu
发明人： Murat Acemoglu , Thomas Allmendinger , John Vincent Calienni , Jacques Cercus , Olivier Loiseleur , Gottfried Sedelmeier , David Xu
IPC分类号： C07D209/34 , C07C227/22 , C07C211/55 , C07C233/01
CPC分类号： C07C211/52 , C07C211/56 , C07C227/22 , C07C229/42 , C07C233/15 , C07C235/16 , C07C235/24 , C07C2601/16 , C07D209/34
摘要： A process for the production of a compound of Formula I, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable prodrug ester thereof, comprising cleaving a lactam of formula II wherein the symbols are as defined, with a base; and precursors therefor and processes for the preparation of the precursors. The compounds of Formula I are pharmaceutically active compounds which are selective inhibitors of Cyclooxygenase II.
摘要翻译：制备式I化合物或其药学上可接受的盐或其药学上可接受的前药酯的方法，其包括用碱定义其中符号如本文所定义的式II的内酰胺; 及其前体和制备前体的方法。式I的化合物是作为环加氧酶II的选择性抑制剂的药物活性化合物。

6. 发明申请

US20050069063A1 Broadband interference cancellation 审中-公开
标题翻译：宽带干扰消除
公开(公告)号：US20050069063A1
公开(公告)日：2005-03-31
申请号：US10674730
申请日：2003-09-30
申请人： Alan Waltho , David Xu
发明人： Alan Waltho , David Xu
IPC分类号： H04B1/12 , H04B1/52 , H04L1/00
CPC分类号： H04B1/525 , H04B1/123
摘要： A method and apparatus are provided for broadband cancellation of interference signals. A signal transmitted on one communication path acts as an interference signal to a receiver on a second communication path in the system. In an embodiment, a signal transmitted from an antenna using one wireless standard, or protocol, acts as an interference signal for another antenna, co-located in the same system, using another wireless standard, or protocol, and operating in the same or nearby frequency bands. A time delay is applied to a signal sampled from the interference signal to provide substantially broadband cancellation of the interference signal. The sampled signal may be attenuated to match the amplitude of the interference signal on the second communication path. Coupling of the sampled signal from one communication path to the other communication path can provide an 180° phase shift to the sampled signal.
摘要翻译：提供了用于宽带消除干扰信号的方法和装置。在一个通信路径上发送的信号作为系统中的第二通信路径上的接收机的干扰信号。在一个实施例中，使用一个无线标准或协议从天线发送的信号用作另一个天线的干扰信号，该另一个天线使用另一无线标准或协议共同位于同一系统中，并在相同或附近操作频带。对从干扰信号采样的信号应用时间延迟以提供干扰信号的基本宽带消除。采样信号可以被衰减以匹配第二通信路径上的干扰信号的幅度。将采样信号从一个通信路径耦合到另一个通信路径可以对采样信号提供180°的相移。

7. 发明申请

US20130252376A1 FORMING DIE BACKSIDE COATING STRUCTURES WITH CORELESS PACKAGES 审中-公开
标题翻译：形成背面涂层结构与无缝包装
公开(公告)号：US20130252376A1
公开(公告)日：2013-09-26
申请号：US13895546
申请日：2013-05-16
申请人： Rahul N. Manepalli , Mohit Mamodia , David Xu , Javier Soto Gonzalez , Edward R. Prack
发明人： Rahul N. Manepalli , Mohit Mamodia , David Xu , Javier Soto Gonzalez , Edward R. Prack
IPC分类号： H01L25/00
CPC分类号： H01L25/50 , H01L23/49816 , H01L23/5389 , H01L24/24 , H01L25/0657 , H01L2225/06527 , H01L2924/10253 , H01L2924/10523 , H01L2924/12042 , H01L2924/14 , H01L2924/00
摘要： Methods of forming a microelectronic packaging structure and associated structures formed thereby are described. Those methods may include attaching a patterned die backside film (DBF) on a backside of a die, wherein the patterned DBF comprises an opening surrounding at least one through silicon via (TSV) pad disposed on the backside of the die.
摘要翻译：描述了形成微电子封装结构的方法及由此形成的相关结构。这些方法可以包括将图案化的模具背面薄膜（DBF）附接到模具的背面，其中图案化的DBF包括围绕设置在模具背面的至少一个穿过硅通孔（TSV）垫的开口。

8. 发明申请

US20100064416A1 GLOVE THAT CAN BE HEATED BY THE USER'S BREATH 审中-公开
标题翻译：可以由用户的呼吸加热
公开(公告)号：US20100064416A1
公开(公告)日：2010-03-18
申请号：US12307165
申请日：2007-06-29
申请人： David Xu , Vincent Delepiere
发明人： David Xu , Vincent Delepiere
IPC分类号： A41D19/00
CPC分类号： A41D19/01535
摘要： The glove can be heated by the user's breath and comprises an outer layer with a through-hole on the back of the hand, a blowing element attached to the outer layer over the through-hole, and an inner lining. A guide pocket is arranged between the outer layer and the inner lining over an area of the back of the hand which extends from the blowing element all the way to the tips of the fingers, the thumb optionally excepted. The blowing element is attached to the upper wall of said pocket. The lower wall of the pocket is perforated, at each finger, by a through-orifice for air in an area at the tip of said finger. The inner lining is air-permeable in at least the area of the through-orifice.
摘要翻译：手套可以通过使用者的呼吸加热，并且包括在手背上具有通孔的外层，在通孔上附着到外层的吹风元件和内衬。引导袋被布置在外层和内衬之间的手背的区域上，该区域从吹塑元件一直延伸到手指的尖端，拇指可选地除外。吹风元件附接到所述口袋的上壁。口袋的下壁在每个指状物上穿过用于在所述手指尖端的区域中的空气的通孔。内衬至少在通孔的区域是透气的。

9. 发明申请

US20070141992A1 Interference mitigation by adjustment of interconnect transmission characteristics 失效
标题翻译：干扰减轻通过调整互连传输特性
公开(公告)号：US20070141992A1
公开(公告)日：2007-06-21
申请号：US11706623
申请日：2007-02-13
申请人： Seh Kwa , David Xu , Alan Waltho , Andrew Martwick , Ravid Shmuel
发明人： Seh Kwa , David Xu , Alan Waltho , Andrew Martwick , Ravid Shmuel
IPC分类号： H04B1/00 , H04B15/00
CPC分类号： H04B15/02 , H04B2215/067
摘要： Interference within a wireless apparatus is mitigated by adjusting one or more transmission characteristics associated with an interconnect of the apparatus. In at least one embodiment, the interconnect is a PCI Express interconnect.
摘要翻译：通过调节与装置的互连相关联的一个或多个传输特性来减轻无线装置内的干扰。在至少一个实施例中，互连是PCI Express互连。

10. 发明授权

US07906677B2 Process for phenylacetic acid derivatives 失效
标题翻译：苯乙酸衍生物工艺
公开(公告)号：US07906677B2
公开(公告)日：2011-03-15
申请号：US12436991
申请日：2009-05-07
申请人： Murat Acemoglu , Thomas Allmendinger , John Vincent Calienni , Jacques Cercus , Olivier Loiseleur , Gottfried Sedelmeier , David Xu
发明人： Murat Acemoglu , Thomas Allmendinger , John Vincent Calienni , Jacques Cercus , Olivier Loiseleur , Gottfried Sedelmeier , David Xu
IPC分类号： C07C227/22 , C07C209/62
CPC分类号： C07C211/52 , C07C211/56 , C07C227/22 , C07C229/42 , C07C233/15 , C07C235/16 , C07C235/24 , C07C2601/16 , C07D209/34
摘要： A process for the production of a compound of Formula I, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable prodrug ester thereof, comprising cleaving a lactam of formula II wherein the symbols are as defined, with a base; and precursors therefor and processes for the preparation of the precursors. The compounds of Formula I are pharmaceutically active compounds which are selective inhibitors of Cyclooxygenase II.
摘要翻译：制备式I化合物或其药学上可接受的盐或其药学上可接受的前药酯的方法，其包括用碱定义其中符号如本文所定义的式II的内酰胺; 及其前体和制备前体的方法。式I的化合物是作为环加氧酶II的选择性抑制剂的药物活性化合物。

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