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1. 发明申请

US20110027346A1 Lyase Enzymes, Nucleic Acids Encoding Them and Methods for Making and Using Them 审中-公开
标题翻译：裂解酶，编码它们的核酸及其制备和使用方法
公开(公告)号：US20110027346A1
公开(公告)日：2011-02-03
申请号：US12303088
申请日：2007-05-29
申请人： David Weiner , Alexander Varvak , Toby Richardson , Mircea Podar , Ellen Burke , Shaun Healey
发明人： David Weiner , Alexander Varvak , Toby Richardson , Mircea Podar , Ellen Burke , Shaun Healey
IPC分类号： A61K9/127 , C07H21/04 , C12N15/63 , C12N1/21 , C12N5/10 , C12N1/15 , C12N1/19 , A61P7/00 , C12N9/88 , C12N11/16 , C12N11/14 , C12N11/08 , C40B40/10 , C12P7/40 , A61K38/51 , A61K9/14 , A23C9/12
CPC分类号： C12N9/88
摘要： This invention provides polypeptides having lyase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides having ammonia lyase activity, e.g., phenylalanine ammonia lyase, tyrosine ammonia lyase and/or histidine ammonia lyase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts.
摘要翻译：本发明提供了具有裂解酶活性的多肽，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。一方面，本发明涉及具有氨裂解酶活性的多肽，例如苯丙氨酸氨裂解酶，酪氨酸氨裂解酶和/或组氨酸氨裂解酶活性，包括耐热和耐热活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。本发明的多肽可用于多种药物，农业和工业环境。

2. 发明授权

US08735107B2 Lyase enzymes, nucleic acids encoding them and methods for making and using them 有权
标题翻译：裂解酶，编码它们的核酸和制备和使用它们的方法
公开(公告)号：US08735107B2
公开(公告)日：2014-05-27
申请号：US13287567
申请日：2011-11-02
申请人： David P. Weiner , Alexander Varvak , Toby Richardson , Mircea Podar , Ellen Burke , Shaun Healey
发明人： David P. Weiner , Alexander Varvak , Toby Richardson , Mircea Podar , Ellen Burke , Shaun Healey
IPC分类号： C12P13/24 , C12P13/22
CPC分类号： C12N9/88 , C12P7/42 , C12P13/222 , C12P13/225 , C12P13/24 , C12Y403/01005 , C12Y403/01023 , D06M16/003
摘要： This invention provides polypeptides having lyase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides having ammonia lyase activity, e.g., phenylalanine ammonia lyase, tyrosine ammonia lyase and/or histidine ammonia lyase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. X═NO2, Cl, Br, NH2, OH, H, alkyl at one or several o, m, and p positions R═H or alkyl.
摘要翻译：本发明提供了具有裂解酶活性的多肽，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。一方面，本发明涉及具有氨裂解酶活性的多肽，例如苯丙氨酸氨裂解酶，酪氨酸氨裂解酶和/或组氨酸氨裂解酶活性，包括耐热和耐热活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。本发明的多肽可用于多种药物，农业和工业环境。在一个或几个o，m和p位置R = H或烷基时，X = NO 2，Cl，Br，NH 2，OH，H。

3. 发明申请

US20120177722A1 Lyaseenzymes, Nucleic Acids Encoding Them and Methods For Making and Using Them 有权
标题翻译：裂解酶，核酸编码及其制备和使用方法
公开(公告)号：US20120177722A1
公开(公告)日：2012-07-12
申请号：US13287567
申请日：2011-11-02
申请人： David P. Weiner , Alexander Varvak , Toby Richardson , Mircea Podar , Ellen Burke , Shaun Healey
发明人： David P. Weiner , Alexander Varvak , Toby Richardson , Mircea Podar , Ellen Burke , Shaun Healey
IPC分类号： A61K9/127 , C12N15/63 , C12N9/88 , C40B50/06 , C40B30/00 , C12P7/40 , C12P7/42 , C12P7/22 , C12P13/22 , C12P17/10 , C12P13/24 , A61K38/51 , A61K31/7088 , A61K9/00 , A61K9/50 , A61K9/51 , A61K9/14 , A61P3/00 , C12N15/60 , B82Y5/00
CPC分类号： C12N9/88 , C12P7/42 , C12P13/222 , C12P13/225 , C12P13/24 , C12Y403/01005 , C12Y403/01023 , D06M16/003
摘要： This invention provides polypeptides having lyase activity, polynucleotides encoding these polypeptides, and meth-°ds of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides having ammonia lyase activity, e.g., phenylalanine ammonia lyase, tyrosine ammonia lyase and/or histidine ammonia lyase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. X═NO2, Cl, Br, NH2, OH, H, alkyl at one or several o, m, and p positions R═H or alkyl.
摘要翻译：本发明提供了具有裂解酶活性的多肽，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。一方面，本发明涉及具有氨裂解酶活性的多肽，例如苯丙氨酸氨裂解酶，酪氨酸氨裂解酶和/或组氨酸氨裂解酶活性，包括耐热和耐热活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。本发明的多肽可用于多种药物，农业和工业环境。在一个或几个o，m和p位置R = H或烷基时，X = NO 2，Cl，Br，NH 2，OH，H。

4. 发明申请

US20090038023A1 Lyase Enzymes, Nucleic Acids Encoding Them and Methods For Making and Using Them 审中-公开
标题翻译：裂解酶，编码它们的核酸及其制备和使用方法
公开(公告)号：US20090038023A1
公开(公告)日：2009-02-05
申请号：US11817997
申请日：2006-03-10
申请人： David P. Weiner , Alexander Varvak , Toby Richardson , Mircea Podar , Ellen Burke , Shaun Healey
发明人： David P. Weiner , Alexander Varvak , Toby Richardson , Mircea Podar , Ellen Burke , Shaun Healey
IPC分类号： C12N9/88 , C12N15/60 , C07H21/00 , C12P19/34 , C12N15/63 , C12N1/21 , C12N11/02 , C40B40/10 , G01N33/573 , A61K9/14 , A61K9/127 , A61K38/45 , C11D3/386 , C12N15/87 , A01H1/00 , C12Q1/02 , C12P7/40 , C40B50/06 , G06F19/00 , D21H17/22 , A23C9/127 , A23C23/00 , A23C9/152 , A23J1/00 , A23L2/66 , A21D2/08 , A21D10/00 , C07K16/40 , C12N11/14 , C12N9/96 , C12N5/10 , C12N5/12 , A01K67/00 , A01H5/00
CPC分类号： C12N9/88 , C12P7/42 , C12P13/222 , C12P13/225 , C12P13/24 , C12Y403/01005 , C12Y403/01023 , D06M16/003
摘要： This invention provides polypeptides having lyase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides having ammonia lyase activity, e.g., phenylalanine ammonia lyase, tyrosine ammonia lyase and/or histidine ammonia lyase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. X═NO2, Cl, Br, F, NH2, OH, H, alkyl at one or several o, m, and p positions R═H or alkyl
摘要翻译：本发明提供了具有裂解酶活性的多肽，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。一方面，本发明涉及具有氨裂解酶活性的多肽，例如苯丙氨酸氨裂解酶，酪氨酸氨裂解酶和/或组氨酸氨裂解酶活性，包括耐热和耐热活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。本发明的多肽可用于多种药物，农业和工业环境。 X-NO 2，Cl，Br，F，NH 2，OH，H，在一个或多个o，m和p位置的烷基R-H或烷基

5. 发明申请

US20120009634A1 ALDOLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 有权
标题翻译：阿尔法，核酸编码方法及其使用方法
公开(公告)号：US20120009634A1
公开(公告)日：2012-01-12
申请号：US13235107
申请日：2011-09-16
申请人： Ellen BURKE , Steven John Gort , Paula M. Hicks , Peter Luginbuhl , Sara C. McFarlan , Toby Richardson , Christopher Solheid , David Weiner , Lishan Zhao
发明人： Ellen BURKE , Steven John Gort , Paula M. Hicks , Peter Luginbuhl , Sara C. McFarlan , Toby Richardson , Christopher Solheid , David Weiner , Lishan Zhao
IPC分类号： C12P17/10
CPC分类号： C12P17/10 , C12N9/88 , C12P13/001 , Y02P20/52
摘要： This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S, R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.
摘要翻译：本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。在一些实施方案中，本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，包括耐热和耐热活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。根据本发明的多肽可以用于各种药物，农业和工业环境。在一些实施方案中，本发明提供了可用于制备R-2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸（R-MP）和莫纳甜的某些立体异构体的多肽和生物合成途径，例如R ，R和S，R莫纳甜及其盐，以及莫纳甜衍生物的某些立体异构体，例如R，R和S，R构型及其盐。

6. 发明申请

US20080020435A1 Aldolases, nucleic acids encoding them and methods for making and using them 有权
标题翻译：醛缩酶，编码它们的核酸和制备和使用它们的方法
公开(公告)号：US20080020435A1
公开(公告)日：2008-01-24
申请号：US11714909
申请日：2007-03-07
申请人： Ellen Burke , Steven Gort , Paula Hicks , Peter Luginbuhl , Sara McFarlan , Toby Richardson , Christopher Solheid , David Weiner , Lishan Zhao
发明人： Ellen Burke , Steven Gort , Paula Hicks , Peter Luginbuhl , Sara McFarlan , Toby Richardson , Christopher Solheid , David Weiner , Lishan Zhao
IPC分类号： C12P17/10
CPC分类号： C12P17/10 , C12N9/88 , C12P13/001 , Y02P20/52
摘要： This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.
摘要翻译：本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。在一些实施方案中，本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，包括耐热和耐热活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。根据本发明的多肽可以用于各种药物，农业和工业环境。在一些实施方案中，本发明提供了可用于制备R-2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸（R-MP）和莫纳甜的某些立体异构体的多肽和生物合成途径，例如R ，R和S，R莫纳甜及其盐，以及莫纳甜衍生物的某些立体异构体，例如R，R和S，R构型及其盐。

7. 发明申请

US20060252135A1 Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors 有权
公开(公告)号：US20060252135A1
公开(公告)日：2006-11-09
申请号：US11411229
申请日：2006-04-26
申请人： Brian Brazeau , Ellen Burke , Mervyn DeSouza , Steven Gort , Paula Hicks , Sherry Kollmann , Peter Luginbuhl , Sara McFarlan , Toby Richardson , Fernando Sanchez-Riera , Christopher Solheid , David Weiner , Lishan Zhao
发明人： Brian Brazeau , Ellen Burke , Mervyn DeSouza , Steven Gort , Paula Hicks , Sherry Kollmann , Peter Luginbuhl , Sara McFarlan , Toby Richardson , Fernando Sanchez-Riera , Christopher Solheid , David Weiner , Lishan Zhao
IPC分类号： C12N9/10 , C12P13/22 , C12N1/21
CPC分类号： C12P17/10 , C12N9/1096 , C12N9/90
摘要： Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways, including some biosynthetic pathways.

8. 发明授权

US09005938B2 Aldolases, nucleic acids encoding them and methods for making and using them 有权
标题翻译：醛缩酶，编码它们的核酸和制备和使用它们的方法
公开(公告)号：US09005938B2
公开(公告)日：2015-04-14
申请号：US13235107
申请日：2011-09-16
申请人： Ellen Burke , Steven John Gort , Paula M. Hicks , Peter Luginbuhl , Sara C. McFarlan , Toby Richardson , Christopher Solheid , David Weiner , Lishan Zhao
发明人： Ellen Burke , Steven John Gort , Paula M. Hicks , Peter Luginbuhl , Sara C. McFarlan , Toby Richardson , Christopher Solheid , David Weiner , Lishan Zhao
IPC分类号： C12P17/10 , C12P13/22 , C12N9/10 , C12P21/06 , C12P19/34 , C07H21/04 , C12N9/88 , C12P13/00
CPC分类号： C12P17/10 , C12N9/88 , C12P13/001 , Y02P20/52
摘要： This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.
摘要翻译：本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。在一些实施方案中，本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，包括耐热和耐热活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。根据本发明的多肽可以用于各种药物，农业和工业环境。在一些实施方案中，本发明提供了可用于制备R-2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸（R-MP）和莫纳甜的某些立体异构体的多肽和生物合成途径，例如R ，R和S，R莫纳甜及其盐，以及莫纳甜衍生物的某些立体异构体，例如R，R和S，R构型及其盐。

9. 发明授权

US08043837B2 Aldolases, nucleic acids encoding them and methods for making and using them 有权
标题翻译：醛缩酶，编码它们的核酸和制备和使用它们的方法
公开(公告)号：US08043837B2
公开(公告)日：2011-10-25
申请号：US11714909
申请日：2007-03-07
申请人： Ellen Burke , Steven John Gort , Paula M. Hicks , Peter Luginbuhl , Sara C. McFarlan , Toby Richardson , Christopher Solheid , David Weiner , Lishan Zhao
发明人： Ellen Burke , Steven John Gort , Paula M. Hicks , Peter Luginbuhl , Sara C. McFarlan , Toby Richardson , Christopher Solheid , David Weiner , Lishan Zhao
IPC分类号： C12P17/10 , C12P13/22 , C12P21/06 , C12N9/10 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12P17/10 , C12N9/88 , C12P13/001 , Y02P20/52
摘要： This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.
摘要翻译：本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。在一些实施方案中，本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，包括耐热和耐热活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。根据本发明的多肽可以用于各种药物，农业和工业环境。在一些实施方案中，本发明提供了可用于制备R-2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸（R-MP）和莫纳甜的某些立体异构体的多肽和生物合成途径，例如R ，R和S，R莫纳甜及其盐，以及莫纳甜衍生物的某些立体异构体，例如R，R和S，R构型及其盐。

10. 发明授权

US07582455B2 Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors 有权
标题翻译：用于生产莫纳甜及其前体的立体异构体的多肽和生物合成途径
公开(公告)号：US07582455B2
公开(公告)日：2009-09-01
申请号：US11411229
申请日：2006-04-26
申请人： Brian J. Brazeau , Ellen Burke , Mervyn DeSouza , Steven J. Gort , Paula M. Hicks , Sherry R. Kollmann , Peter Luginbuhl , Sara C. McFarlan , Toby Richardson , Fernando A. Sanchez-Riera , Christopher Solheid , David Weiner , Lishan Zhao
发明人： Brian J. Brazeau , Ellen Burke , Mervyn DeSouza , Steven J. Gort , Paula M. Hicks , Sherry R. Kollmann , Peter Luginbuhl , Sara C. McFarlan , Toby Richardson , Fernando A. Sanchez-Riera , Christopher Solheid , David Weiner , Lishan Zhao
IPC分类号： C12P17/10
CPC分类号： C12P17/10 , C12N9/1096 , C12N9/90
摘要： Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways, including some biosynthetic pathways.
摘要翻译：使用多肽和生物合成途径产生莫纳甜和莫纳甜的某些立体异构体，例如R，R莫纳甜和S，R莫纳甜及其盐。这些多肽和生物合成途径也可用于生产在特定莫纳甜合成途径中形成的包括一些生物合成途径的中间体R-2-羟基-2-（吲哚-3-基甲基）-4-酮戊二酸。

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