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1. 发明授权

US5631297A Anandamides useful for the treatment of intraocular hypertension, ophthalmic compositions containing the same and methods of use of the same 失效
标题翻译：可用于治疗眼内高血压的阿那酰胺，含有其的眼用组合物及其使用方法
公开(公告)号：US5631297A
公开(公告)日：1997-05-20
申请号：US272532
申请日：1994-07-11
申请人： David W. Pate , Tomi Jarvinen , Kristiina Jarvinen , Arto Urtti
发明人： David W. Pate , Tomi Jarvinen , Kristiina Jarvinen , Arto Urtti
IPC分类号： A61K9/00 , A61K31/164 , A61K31/165 , A61K31/275 , A61K31/5375 , A61K47/48 , A61K31/16
CPC分类号： B82Y5/00 , A61K31/164 , A61K31/165 , A61K31/275 , A61K31/5375 , A61K47/48969 , A61K9/0048 , Y10S514/912 , Y10S514/913
摘要： Anandamides useful for the treatment of intraocular hypertension, as well as ophthalmic compositions comprising the same and a cyclodextrin, and methods of use of these compounds to treat intraocular hypertension.
摘要翻译：可用于治疗眼内高血压的阿那酰胺，以及包含其的眼用组合物和环糊精，以及这些化合物用于治疗眼内高血压的方法。

2. 发明授权

US5977180A Anandamide analog compositions and method of treating intraocular hypertension using same 失效
标题翻译：阿那酰胺类似物组合物和使用其治疗眼内高血压的方法
公开(公告)号：US5977180A
公开(公告)日：1999-11-02
申请号：US776268
申请日：1997-01-10
申请人： David W. Pate , Tomi Jarvinen , Kristina Jarvinen , Arto Urtti
发明人： David W. Pate , Tomi Jarvinen , Kristina Jarvinen , Arto Urtti
IPC分类号： A61K9/00 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/275 , A61K31/5375 , A61K47/48
CPC分类号： B82Y5/00 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/275 , A61K31/5375 , A61K47/48969 , A61K9/0048 , Y10S514/912 , Y10S514/913
摘要： Anandamide analogues useful for the treatment of intraocular hypertension, as well as ophthalmic compositions comprising the same and a cyclodextrin, and methods of use of these compounds to treat intraocular hypertension.
摘要翻译： PCT No.PCT / US95 / 08226 Sec。 371日期1997年1月10日 102（e）日期1997年1月10日PCT提交1995年7月10日PCT公布。第WO96 / 01558号公报日期1996年1月25日可用于治疗眼内高血压的阿那酰胺类似物，以及包含其的眼用组合物和环糊精，以及这些化合物用于治疗眼内高血压的方法。

3. 发明授权

US06250301B1 Vaporizer for inhalation and method for extraction of active ingredients from a crude natural product or other matrix 失效
标题翻译：用于吸入的蒸发器和从粗天然产物或其它基质中提取活性成分的方法
公开(公告)号：US06250301B1
公开(公告)日：2001-06-26
申请号：US08919317
申请日：1997-08-28
申请人： David W. Pate
发明人： David W. Pate
IPC分类号： A61M1600
CPC分类号： A61M11/041 , A61M11/042 , Y10S261/65
摘要： A vaporizer apparatus and method for uniformly extracting active ingredients of a specimen of crude natural product or inert particulate matrix impregnated with volatile substances, without pyrolysis, which uses hot air or a heated inert gas stream to volatilize the specimen. The heated air or gas is introduced from below (from either a hot air gun or a high pressure tank connected to a heat exchanger) and ascends through a permeable support structure (e.g., fritted glass disk, etc.), subsequently causing specimen particles disposed on the permeable support structure to be suspended within the confines of an isolation chamber. This allows a maximized gas extraction exposure for each suspended particle, and promotes a uniform extraction of the aggregate charge through its periodic mixing. A filter prevents the particles from being inhaled by the user. During device disuse, the heated airstream flows through an optional side-arm of the vaporizer apparatus, preventing wasteful loss of active ingredients. In another embodiment, the side-arm can also be used to divert mixed purge gases from the specimen required to be under inert gas during its extraction.
摘要翻译：一种蒸发器装置和方法，用于均匀提取粗制天然产物或浸渍有挥发性物质的惰性颗粒基质的样品的活性成分，而不用热解，其使用热空气或加热的惰性气体流使样品挥发。加热的空气或气体从下方（从热风枪或连接到热交换器的高压罐）引入，并通过可渗透的支撑结构（例如，多孔玻璃盘等）上升，随后引起处理的样品颗粒在可渗透的支撑结构上悬挂在隔离室的范围内。这允许对每个悬浮颗粒进行最大化的气体提取暴露，并且通过其周期性混合促进总体电荷的均匀提取。过滤器防止颗粒被使用者吸入。在设备废弃期间，加热的气流流过蒸发器装置的可选侧臂，防止有效成分的浪费。在另一个实施方案中，侧臂还可用于在提取期间将需要在惰性气体下的试样的混合吹扫气体转移。

4. 发明授权

US09034395B2 Processes and apparatus for extraction of active substances and enriched extracts from natural products 有权
公开(公告)号：US09034395B2
公开(公告)日：2015-05-19
申请号：US12618347
申请日：2009-11-13
申请人： Brian Whittle , Geoffrey Guy , David Downs , David W. Pate
发明人： Brian Whittle , Geoffrey Guy , David Downs , David W. Pate
IPC分类号： A61K36/00 , B01D11/02 , B01D11/00
CPC分类号： A61K31/05 , A61K31/352 , A61K36/185 , B01D11/0242 , B01D11/0273 , B01D11/028 , B01D11/0288 , B01D2011/007
摘要： Processes for preparing extracts of natural products such as plant material, and for preparing purified extracts from crude extracts of natural products, by extraction with hot gas. Apparatus suitable for use in preparing extracts of natural products are also described.

5. 发明申请

US20100119606A1 PROCESSES AND APPARATUS FOR EXTRACTION OF ACTIVE SUBSTANCES AND ENRICHED EXTRACTS FROM NATURAL PRODUCTS 有权
标题翻译：从天然产物中提取活性物质和提取物的方法和装置
公开(公告)号：US20100119606A1
公开(公告)日：2010-05-13
申请号：US12618347
申请日：2009-11-13
申请人： Brian Whittle , Geoffrey Guy , David Downs , David W. Pate
发明人： Brian Whittle , Geoffrey Guy , David Downs , David W. Pate
IPC分类号： A61K36/00 , A61K9/00
CPC分类号： A61K31/05 , A61K31/352 , A61K36/185 , B01D11/0242 , B01D11/0273 , B01D11/028 , B01D11/0288 , B01D2011/007
摘要： Processes for preparing extracts of natural products such as plant material, and for preparing purified extracts from crude extracts of natural products, by extraction with hot gas. Apparatus suitable for use in preparing extracts of natural products are also described.
摘要翻译：用于制备天然产物如植物材料的提取物的方法，以及通过用热气提取从天然产物的粗提物制备纯化提取物的方法。还描述了适用于制备天然产物提取物的装置。

6. 发明授权

US06481437B1 Enhanced isolation chambers for ascending-stream extractive vaporizer 有权
标题翻译：用于上游萃取蒸发器的增强隔离室
公开(公告)号：US06481437B1
公开(公告)日：2002-11-19
申请号：US09485318
申请日：2000-03-24
申请人： David W. Pate
发明人： David W. Pate
IPC分类号： A61M1600
CPC分类号： A61M11/041 , A61M11/042 , Y10S261/65
摘要： The present invention is a vaporizer apparatus (1) and method for uniformly extracting active ingredients of specimen of crude natural product, or inert particulate matrix impregnated with volatile substances without pyrolysis which uses hot air (2), or a heated inert gas stream to volatilize the specimen. The heated air or gas in introduced from below (from either a hot air gun or a high-pressure tank connected to a heat exchanger), and ascends through in most embodiments through a permeable support structure (4) (e.g., fritted glass disk, etc.) subsequently causing specimen particules disposed on the permeable support structure to be suspended within the confines of an isolation chamber (5).
摘要翻译：本发明是一种蒸发器装置（1）和方法，用于均匀提取粗天然产物的试样的有效成分或浸渍有不含热空气的热解挥发物的惰性颗粒基质（2）或加热的惰性气流挥发标本。从下方引入的加热的空气或气体（来自连接到热交换器的热风枪或高压罐），并且在大多数实施例中通过可渗透的支撑结构（4）（例如烧结玻璃盘，等等），随后使设置在可渗透支撑结构上的样品颗粒悬浮在隔离室（5）的范围内。

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