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1. 发明授权

US06974684B2 Therapeutic polypeptides, nucleic acids encoding same, and methods of use 失效
公开(公告)号：US06974684B2
公开(公告)日：2005-12-13
申请号：US10211689
申请日：2002-08-01
申请人： David W. Anderson , John P. Alsobrook II , Ferenc L. Boldog , Catherine E. Burgess , Stacie J. Casman , Shlomit R. Edinger , Esha A. Gangolli , Linda Gorman , Xiaojia Sasha Guo , Nikolai Khramtsov , Denise M. Lepley , John R. MacDougall , Carol E. A. Pena , John A. Peyman , Meera Patturajan , Daniel K. Rieger , Richard A. Shimkets , Glennda Smithson , Kimberly A. Spytek , Corine A. M. Vernet , Edward Z. Voss , Mei Zhong
发明人： David W. Anderson , John P. Alsobrook II , Ferenc L. Boldog , Catherine E. Burgess , Stacie J. Casman , Shlomit R. Edinger , Esha A. Gangolli , Linda Gorman , Xiaojia Sasha Guo , Nikolai Khramtsov , Denise M. Lepley , John R. MacDougall , Carol E. A. Pena , John A. Peyman , Meera Patturajan , Daniel K. Rieger , Richard A. Shimkets , Glennda Smithson , Kimberly A. Spytek , Corine A. M. Vernet , Edward Z. Voss , Mei Zhong
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C12N15/12 , C12Q1/68 , C07H21/02
CPC分类号： C07K14/47 , A61K38/00 , C07K14/705
摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

2. 发明授权

US6022863A Regulation of gene expression 失效
标题翻译：调控基因表达
公开(公告)号：US6022863A
公开(公告)日：2000-02-08
申请号：US646789
申请日：1996-05-21
申请人： John A. Peyman
发明人： John A. Peyman
IPC分类号： A61K48/00 , C12N15/113 , C12N15/67 , C12N15/11
CPC分类号： C12N15/113 , C12N15/67 , A01K2217/05 , A61K48/00 , C12N2310/111 , C12N2310/13 , C12N2310/53
摘要： The present invention relates to utrons, RNA molecules which contain promoter regulatory motif(s) and DNA analogs thereof and DNA molecules that can be transcribed to produce the foregoing. In particular, the invention provides gene promoter suppressing nucleic acids which suppress transcription from a promoter of interest. In a preferred embodiment, the invention provides the TSU gene, nucleotide sequences of the TSU gene and RNA, as well as fragments, homologs and derivatives thereof. Methods of isolating TSU genes are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are also provided. In particular, the invention relates to methods for cell replacement therapy, gene therapy or organ transplantation wherein TSU nucleic acids suppress MHC class I and II gene expression, thus preventing immuno-rejection of non-autologous cells or organs. The invention also provides methods for treatment of diseases or disorders by suppression of MHC class I, MHC class II, ICAM-1, B7-1, B7-2, and/or Fc.gamma.R expression by provision of TSU function.
摘要翻译：本发明涉及包含其启动子调节基序和DNA类似物的RNA分子和可被转录以产生前述的DNA分子。特别地，本发明提供抑制来自目的启动子的转录的抑制核酸的基因启动子。在优选的实施方案中，本发明提供TSU基因，TSU基因和RNA的核苷酸序列，以及其片段，同源物及其衍生物。还提供了分离TSU基因的方法。还提供了治疗和诊断方法以及药物组合物。特别地，本发明涉及细胞置换治疗，基因治疗或器官移植的方法，其中TSU核酸抑制MHC I类和II类基因表达，从而防止非自体细胞或器官的免疫排斥。本发明还提供了通过提供TSU功能抑制MHC I类，II类，ICAM-1，B7-1，B7-2和/或FcγR表达来治疗疾病或病症的方法。

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