专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20140094384A1 STROMAL ANTIGEN 2 (STAG2) COMPOSITIONS AND METHODS 审中-公开
标题翻译： STROTAL ANTIGEN 2（STAG2）组合物和方法
公开(公告)号：US20140094384A1
公开(公告)日：2014-04-03
申请号：US14088932
申请日：2013-11-25
申请人： David SOLOMON , Jung-Sik Kim , Todd Waldman
发明人： David SOLOMON , Jung-Sik Kim , Todd Waldman
IPC分类号： C07K14/47 , C12Q1/68 , C12N15/85 , G01N33/574 , G01N33/50
CPC分类号： C07K14/47 , C12N15/85 , C12Q1/6886 , C12Q2600/118 , G01N33/5011 , G01N33/574 , G01N33/57407 , G01N33/5743 , G01N33/57484 , G01N2800/52
摘要： Compositions and methods related to stromal antigen 2 (STAG2) and its role in diverse human cancers, including nucleic acids, polypeptides, vectors, cells and cell lines.
摘要翻译：与基质抗原2（STAG2）相关的组合物和方法及其在多种人类癌症中的作用，包括核酸，多肽，载体，细胞和细胞系。

2. 发明申请

US20130029865A1 Stromal Antigen 2 (STAG2) Compositions and Methods 审中-公开
标题翻译：基质抗原2（STAG2）组合物和方法
公开(公告)号：US20130029865A1
公开(公告)日：2013-01-31
申请号：US13547966
申请日：2012-07-12
申请人： David SOLOMON , Jung-Sik Kim , Todd Waldman
发明人： David SOLOMON , Jung-Sik Kim , Todd Waldman
IPC分类号： C12N15/12 , G01N33/53 , C12Q1/68 , C07K14/47 , C40B30/04
CPC分类号： C07K14/47 , C12N15/85 , C12Q1/6886 , C12Q2600/118 , G01N33/5011 , G01N33/574 , G01N33/57407 , G01N33/5743 , G01N33/57484 , G01N2800/52
摘要： Compositions and methods related to stromal antigen 2 (STAG2) and its role in diverse human cancers, including nucleic acids, polypeptides, vectors, cells and cell lines.
摘要翻译：与基质抗原2（STAG2）相关的组合物和方法及其在多种人类癌症中的作用，包括核酸，多肽，载体，细胞和细胞系。

3. 发明授权

US5882865A Cancer drug screen based on cell cycle uncoupling 失效
公开(公告)号：US5882865A
公开(公告)日：1999-03-16
申请号：US781201
申请日：1997-01-10
申请人： Bert Vogelstein , Todd Waldman , Christoph Lengauer , Kenneth W. Kinzler
发明人： Bert Vogelstein , Todd Waldman , Christoph Lengauer , Kenneth W. Kinzler
IPC分类号： C12N5/08 , C12Q1/68 , G01N33/50
CPC分类号： G01N33/5044 , C12Q1/6841 , C12Q1/6886 , G01N33/5008 , G01N33/5011 , C12Q2600/136 , G01N2510/00
摘要： Checkpoint gene-defective human cells are useful for screening potential anti-tumor agents. Potential therapeutic agents are screened for the ability to cause DNA accumulation or cell death in a checkpoint gene-defective human cell.

4. 发明授权

US06214616B1 Homozygous p53 gene-defective human colonic cell line 有权
标题翻译：纯合p53基因缺陷型人结肠细胞系
公开(公告)号：US06214616B1
公开(公告)日：2001-04-10
申请号：US09298822
申请日：1999-04-26
申请人： Bert Vogelstein , Todd Waldman , Kenneth W. Kinzler
发明人： Bert Vogelstein , Todd Waldman , Kenneth W. Kinzler
IPC分类号： C12N508
CPC分类号： G01N33/5044 , C12Q1/6841 , C12Q1/6886 , C12Q2600/136 , G01N33/5008 , G01N33/5011 , G01N2510/00 , C12Q2563/173
摘要： Checkpoint gene-defective human cells are useful for screening potential anti-tumor agents. Potential therapeutic agents are screened for the ability to cause DNA accumulation or cell death in a checkpoint gene-defective human cell.
摘要翻译：检查点基因缺陷的人细胞可用于筛选潜在的抗肿瘤剂。筛选潜在的治疗剂在检查点基因缺陷型人细胞中引起DNA积累或细胞死亡的能力。

5. 发明授权

US5888735A Cancer drug screen based on cell cycle uncoupling 失效
公开(公告)号：US5888735A
公开(公告)日：1999-03-30
申请号：US781200
申请日：1997-01-10
申请人： Bert Vogelstein , Todd Waldman , Christoph Lengauer , Kenneth W. Kinzler
发明人： Bert Vogelstein , Todd Waldman , Christoph Lengauer , Kenneth W. Kinzler
IPC分类号： C12N5/08 , C12Q1/68 , G01N33/50
CPC分类号： G01N33/5044 , C12Q1/6841 , C12Q1/6886 , G01N33/5008 , G01N33/5011 , C12Q2600/136 , G01N2510/00
摘要： Checkpoint gene-defective human cells are useful for screening potential anti-tumor agents. Potential therapeutic agents are screened for the ability to cause DNA accumulation or cell death in a checkpoint gene-defective human cell.

6. 发明授权

US06511818B2 Cancer drug screen based on cell cycle uncoupling 有权
标题翻译：基于细胞周期解偶联的癌症药物筛选
公开(公告)号：US06511818B2
公开(公告)日：2003-01-28
申请号：US09828906
申请日：2001-04-10
申请人： Bert Vogelstein , Todd Waldman , Christoph Lengauer , Kenneth W. Kinzler
发明人： Bert Vogelstein , Todd Waldman , Christoph Lengauer , Kenneth W. Kinzler
IPC分类号： C12Q102
CPC分类号： G01N33/5044 , C12Q1/6841 , C12Q1/6886 , C12Q2600/136 , G01N33/5008 , G01N33/5011 , G01N2510/00 , C12Q2563/173
摘要： Checkpoint gene-defective human cells are useful for screening potential anti-tumor agents. Potential therapeutic agents are screened for the ability to cause DNA accumulation or cell death in a checkpoint gene-defective human cell.
摘要翻译：检查点基因缺陷的人细胞可用于筛选潜在的抗肿瘤剂。筛选潜在的治疗剂在检查点基因缺陷型人细胞中引起DNA积累或细胞死亡的能力。

7. 发明授权

US07148009B2 Cancer drug screen based on cell cycle uncoupling 有权
公开(公告)号：US07148009B2
公开(公告)日：2006-12-12
申请号：US10320639
申请日：2002-12-17
申请人： Bert Vogelstein , Todd Waldman , Christoph Lengauer , Kenneth W. Kinzler
发明人： Bert Vogelstein , Todd Waldman , Christoph Lengauer , Kenneth W. Kinzler
IPC分类号： C12Q1/68
CPC分类号： G01N33/5044 , C12Q1/6841 , C12Q1/6886 , C12Q2600/136 , G01N33/5008 , G01N33/5011 , G01N2510/00 , C12Q2563/173
摘要： Checkpoint gene-defective human cells are useful for screening potential anti-tumor agents. Potential therapeutic agents are screened for the ability to cause DNA accumulation or cell death in a checkpoint gene-defective human cell.

8. 发明申请

US20050208652A1 Isogenic beta-catenin cell lines, and methods of making and using same 审中-公开
标题翻译：异源β-连环蛋白细胞系，以及制备和使用它们的方法
公开(公告)号：US20050208652A1
公开(公告)日：2005-09-22
申请号：US11104063
申请日：2005-04-11
申请人： Todd Waldman
发明人： Todd Waldman
IPC分类号： C07K14/47 , C12N5/09 , G01N33/50 , C12N5/08
CPC分类号： G01N33/5011 , C07K14/4702 , C12N5/0693 , C12N2510/00 , G01N2500/10
摘要： A set of isogenic cell lines, which includes a first population of cells that express only a wild type β-catenin polypeptide and at least a second population of cells that express only an activated β-catenin polypeptide, is provided. A set of isogenic cells, including a first population of cells that are null for β-catenin expression, and at least a second population of cells that express a wild type β-catenin polypeptide that functions as an activated β-catenin polypeptide in the cells, also is provided. In addition, a recombinant nucleic acid molecule, which includes at least a first linear polynucleotide that is flanked at each end by nucleotide sequences of a β-catenin gene is provided, as is a method of using the recombinant nucleic acid molecule to produce a set of isogenic cell lines as defined above. Also provide is a method of using the set of isogenic cell lines to identify a therapeutic agent that allows selective killing of cells expressing an activated β-catenin polypeptide, but not cells expressing a wild type β-catenin polypeptide is provided.
摘要翻译：提供了一组等基因细胞系，其包括仅表达野生型β-连环蛋白多肽的细胞的第一群和至少仅表达活化的β-连环蛋白多肽的第二细胞群。一组等位基因细胞，包括对于β-连环蛋白表达无效的第一个细胞群，以及至少第二个表达野生型β-连环蛋白多肽的第二细胞群，其在细胞中用作活化的β-连环蛋白多肽，也被提供。此外，提供了重组核酸分子，其包括至少第一线性多核苷酸，其每端末端具有β-连环蛋白基因的核苷酸序列，正如使用重组核酸分子产生组的方法一样的等位基因细胞系。还提供使用该组等基因细胞系鉴定允许选择性杀死表达活化的β-连环蛋白多肽的细胞但不表达野生型β-连环蛋白多肽的细胞的治疗剂的方法。

9. 发明授权

US5897999A Cancer drug screen based on cell cycle uncoupling 失效
公开(公告)号：US5897999A
公开(公告)日：1999-04-27
申请号：US620340
申请日：1996-03-22
申请人： Bert Vogelstein , Todd Waldman , Kenneth W. Kinzler
发明人： Bert Vogelstein , Todd Waldman , Kenneth W. Kinzler
IPC分类号： C12N5/08 , C12Q1/68 , G01N33/50 , B24B19/00 , C12N5/10
CPC分类号： G01N33/5044 , C12Q1/6841 , C12Q1/6886 , G01N33/5008 , G01N33/5011 , C12Q2600/136 , G01N2510/00
摘要： Checkpoint gene-defective human cells are useful for screening potential anti-tumor agents. Potential therapeutic agents are screened for the ability to cause DNA accumulation or cell death in a checkpoint gene-defective human cell.

10. 发明授权

US5879889A Cancer drug screen based on cell cycle upcoupling 失效
标题翻译：基于细胞周期加载的癌症药物筛选
公开(公告)号：US5879889A
公开(公告)日：1999-03-09
申请号：US781203
申请日：1997-01-10
申请人： Bert Vogelstein , Todd Waldman , Christoph Lengauer , Kenneth W. Kinzler
发明人： Bert Vogelstein , Todd Waldman , Christoph Lengauer , Kenneth W. Kinzler
IPC分类号： C12N5/08 , C12Q1/68 , G01N33/50 , C12Q1/00
CPC分类号： G01N33/5044 , C12Q1/6841 , C12Q1/6886 , G01N33/5008 , G01N33/5011 , C12Q2600/136 , G01N2510/00
摘要： Checkpoint gene-defective human cells are useful for screening potential anti-tumor agents. Potential therapeutic agents are screened for the ability to cause DNA accumulation or cell death in a checkpoint gene-defective human cell.
摘要翻译：检查点基因缺陷的人细胞可用于筛选潜在的抗肿瘤剂。筛选潜在的治疗剂在检查点基因缺陷型人细胞中引起DNA积累或细胞死亡的能力。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式