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1. 发明授权

US06884842B2 Molecular compounds having complementary surfaces to targets 失效
标题翻译：具有与靶的互补表面的分子化合物
公开(公告)号：US06884842B2
公开(公告)日：2005-04-26
申请号：US10055837
申请日：2001-10-26
申请人： David S. Soane , Stephen E. Barry , Andrew Goodwin , David A. Offord , Michael G. Perrott
发明人： David S. Soane , Stephen E. Barry , Andrew Goodwin , David A. Offord , Michael G. Perrott
IPC分类号： C08B37/02 , C08F2/00 , C08G83/00 , G01N33/531 , G01N33/68 , C08G63/48 , C08G63/91 , C08H1/00 , C08G89/00
CPC分类号： C08G83/00 , C08B37/0021 , G01N33/531 , G01N33/68 , G01N2333/976 , G01N2400/22 , G01N2600/00
摘要： Synthetic polymer complements (SPCs) are provided, as well as methods for their synthesis and use. The SPCs may have surfaces that include functional groups that are complementary to surface sites of targets such as nanostructures or macromolecular targets, and may be capable of specifically interacting with such targets. The positions of the functional groups in one embodiment are stabilized by a polymer network. The SPCs are formed by contacting the target with a set of monomers which self-assemble on the target, and then are polymerized into a network to form the synthetic polymer complement. At least a portion of the surface of the resulting SPC thus may include an imprint of the target. The complex of the SPC and the target may be the desired product. Alternatively, the target is released, for example, by controllably expanding and contracting the crosslinked network. The SPC is isolated and used in many applications.
摘要翻译：提供合成聚合物互补物（SPC），以及其合成和使用的方法。 SPCs可以具有包括与诸如纳米结构或大分子靶标的靶的表面位点互补的官能团的表面，并且可能能够与这些靶特异性相互作用。在一个实施方案中，官能团的位置由聚合物网络稳定。 SPC通过使靶与在靶上自组装的一组单体接触而形成，然后聚合成网络以形成合成聚合物互补体。因此，所得SPC的表面的至少一部分可以包括靶的印痕。 SPC和目标物的复合物可能是所需的产品。或者，目标被释放，例如通过可控地扩展和收缩交联网络。 SPC被隔离并用于许多应用。

2. 发明授权

US06217901B1 Liposome-assisted synthesis of polymeric nanoparticles 失效
标题翻译：脂质体辅助合成聚合物纳米粒子
公开(公告)号：US06217901B1
公开(公告)日：2001-04-17
申请号：US09579860
申请日：2000-05-25
申请人： Michael G. Perrott , Stephen E. Barry
发明人： Michael G. Perrott , Stephen E. Barry
IPC分类号： A61K9127
CPC分类号： A61K9/5138 , A61K9/127 , Y10S977/897 , Y10S977/907 , Y10S977/927
摘要： Synthetic polymer complements (SPCs) are provided, as well as methods for their synthesis and use. The SPCs range in size from about 20 to about 1000 nm. The SPCs have surfaces that are complementary to surface sites of target molecules, resulting in the ability of the SPCs to selectively bind to molecular targets. The molecular recognition capability of these particles enables their use in diagnostic, therapeutic, and separation applications. The SPC is formed by contacting a target template molecule with a set of building blocks solubilized in the interior of a liposome, which building blocks are then polymerized into a network to form the synthetic polymer complement in the interior of the liposome. The target templates are removed to produce complementary sites in a SPC that map the surface of the target, resulting in a water-soluble SPC nanoparticle of similar dimensions as the interior of the liposome that originally supported it and capable of molecular recognition.
摘要翻译：提供合成聚合物互补物（SPC），以及其合成和使用的方法。 SPCs的尺寸范围为约20至约1000nm。 SPCs具有与靶分子的表面位点互补的表面，导致SPC选择性地结合分子靶标的能力。这些颗粒的分子识别能力使其可用于诊断，治疗和分离应用。通过使靶模板分子与溶解在脂质体内部的一组结构单元接触形成SPC，然后将该构建块聚合成网络以在脂质体的内部形成合成聚合物补体。去除目标模板以在映射目标表面的SPC中产生互补位点，产生与原来支持它并能够进行分子识别的脂质体内部相似尺寸的水溶性SPC纳米颗粒。

3. 发明授权

US06951712B2 Cryoprotective system comprising polymeric nano- or micro-particles 失效
标题翻译：包含聚合物纳米颗粒或微粒的冷冻保护体系
公开(公告)号：US06951712B2
公开(公告)日：2005-10-04
申请号：US10221381
申请日：2001-03-14
申请人： David S. Soane , Stephen E. Barry , Rachel Decor
发明人： David S. Soane , Stephen E. Barry , Rachel Decor
IPC分类号： A01N1/02 , A01N1/00
CPC分类号： A01N1/02 , A01N1/0221
摘要： The present invention is directed to a cryoprotective system that comprises an aqueous solution containing polymeric nano- and micro-particles that exhibit a reversible temperature-dependent volume change. It is also directed to a method for providing cryoprotection to an organism or parts of an organism by pumping the cryoprotective system into the vasculature of the organism prior to exposing the organism to a lower, preferably below 0° C., temperature.
摘要翻译：本发明涉及一种冷冻保护系统，其包含含有可逆温度依赖性体积变化的聚合物纳米微粒和微粒的水溶液。还涉及通过在将生物体暴露于较低的，优选低于0℃的温度之前将冷冻保护系统泵送到生物体的脉管系统中来向生物体或生物体的一部分提供冷冻保护的方法。

4. 发明授权

US5026147A Non-linear optical polymeric article and method 失效
标题翻译：非线性光学聚合物制品及方法
公开(公告)号：US5026147A
公开(公告)日：1991-06-25
申请号：US498028
申请日：1990-03-23
申请人： David S. Soane , Stephen E. Barry
发明人： David S. Soane , Stephen E. Barry
IPC分类号： B29C70/62 , B29C71/00 , G02F1/361
CPC分类号： B29C71/0009 , B29C70/62 , G02F1/3615 , B29C2071/0054
摘要： Articles exhibiting non-linear optical properties useful as electrooptic devices are prepared where the dopant moieties are aligned at relatively low temperatures. An intermediate article is formed by swelling with a diluent including a pressurized gas, such as carbon dioxide. The dopant moieties dispersed in the polymer are aligned by applying an electric field while maintaining the polymer in the swollen state caused by diluent sorption. Substantially all the diluent can then be removed without the necessity of a temperature elevation above about room temperature since the pressurized gas of the diluent can be removed by lowering the pressure to about atmospheric conditions. Polymers with high glass transition temperatures, preferably at or above about 150.degree. C., can thus be used in preparing electrooptic devices.
摘要翻译：制备具有用作电光器件的非线性光学性质的物质，其中掺杂剂部分在较低温度下排列。通过用包括加压气体如二氧化碳的稀释剂溶胀来形成中间制品。分散在聚合物中的掺杂剂部分通过施加电场而排列，同时保持聚合物处于由稀释剂吸附引起的溶胀状态。因此，基本上所有的稀释剂可以被除去，而不需要在大约室温以上的温度升高，因为稀释剂的加压气体可以通过将压力降低到大气条件来去除。因此，具有高玻璃化转变温度，优选在约150℃以上的聚合物可用于制备电光装置。

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