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1. 发明申请

US20090253148A1 FLUORESCENCE POLARIZATION hERG ASSAY 有权
标题翻译：荧光偏振测定
公开(公告)号：US20090253148A1
公开(公告)日：2009-10-08
申请号：US12394605
申请日：2009-02-27
申请人： David Piper , Stephen Hess , Mohammed Saleh Shekhani , Thomas Livelli , Zhong Zhong , Steve Duff , Kurt Vogel
发明人： David Piper , Stephen Hess , Mohammed Saleh Shekhani , Thomas Livelli , Zhong Zhong , Steve Duff , Kurt Vogel
IPC分类号： G01N33/53 , G01N33/566 , C12N5/06 , C12N5/08 , C07D491/10
CPC分类号： G01N33/582 , C07D491/107 , G01N33/6872 , Y10T436/13
摘要： Disclosed are assays, methods, and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. In particular, whether a test compound has the effect to prolong the Q-T interval as measured by an electrocardiogram in a human. The assays, methods, and kits disclosed herein make use of the binding interaction between novel fluorescent tracers and the hERG K+ channel, and the propensity of a test compound to influence that binding interaction.
摘要翻译：公开了用于筛选测试化合物在受试者中诱导心脏毒性的能力的测定，方法和试剂盒。特别地，测试化合物是否具有延长通过人心电图测量的Q-T间期的作用。本文公开的测定法，方法和试剂盒利用新型荧光示踪剂和hERG K +通道之间的结合相互作用以及测试化合物影响该结合相互作用的倾向。

2. 发明申请

US20120231541A1 FLUORESCENCE POLARIZATION hERG ASSAY 审中-公开
标题翻译：荧光偏振测定
公开(公告)号：US20120231541A1
公开(公告)日：2012-09-13
申请号：US13417008
申请日：2012-03-09
申请人： David Piper , Stephen Hess , Mohammed Saleh Shekhani , Thomas Livelli , Zhong Zhong , Steve Duff , Kurt Vogel
发明人： David Piper , Stephen Hess , Mohammed Saleh Shekhani , Thomas Livelli , Zhong Zhong , Steve Duff , Kurt Vogel
IPC分类号： C12N5/071 , C12N5/10 , C12N5/073
CPC分类号： G01N33/582 , C07D491/107 , G01N33/6872 , Y10T436/13
摘要： Disclosed are assays, methods, and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. In particular, whether a test compound has the effect to prolong the Q-T interval as measured by an electrocardiogram in a human. The assays, methods, and kits disclosed herein make use of the binding interaction between novel fluorescent tracers and the hERG K+ channel, and the propensity of a test compound to influence that binding interaction.
摘要翻译：公开了用于筛选测试化合物在受试者中诱导心脏毒性的能力的测定，方法和试剂盒。特别地，测试化合物是否具有延长通过人心电图测量的Q-T间期的作用。本文公开的测定法，方法和试剂盒利用新型荧光示踪剂和hERG K +通道之间的结合相互作用以及测试化合物影响该结合相互作用的倾向。

3. 发明授权

US08133695B2 Fluorescence polarization hERG assay 有权
标题翻译：荧光偏振hERG测定
公开(公告)号：US08133695B2
公开(公告)日：2012-03-13
申请号：US12394605
申请日：2009-02-27
申请人： David Piper , Kurt Vogel , Mohammed Saleh Shekhani , Stephen Hess , Steve Duff , Thomas Livelli , Zhong Zhong
发明人： David Piper , Kurt Vogel , Mohammed Saleh Shekhani , Stephen Hess , Steve Duff , Thomas Livelli , Zhong Zhong
IPC分类号： G01N33/53 , G01N33/532 , G01N33/533
CPC分类号： G01N33/582 , C07D491/107 , G01N33/6872 , Y10T436/13
摘要： Disclosed are assays, methods, and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. In particular, whether a test compound has the effect to prolong the Q-T interval as measured by an electrocardiogram in a human. The assays, methods, and kits disclosed herein make use of the binding interaction between novel fluorescent tracers and the hERG K+ channel, and the propensity of a test compound to influence that binding interaction.
摘要翻译：公开了用于筛选测试化合物在受试者中诱导心脏毒性的能力的测定，方法和试剂盒。特别地，测试化合物是否具有延长通过人心电图测量的Q-T间期的作用。本文公开的测定法，方法和试剂盒利用新型荧光示踪剂和hERG K +通道之间的结合相互作用以及测试化合物影响该结合相互作用的倾向。

4. 发明授权

US07395458B2 Diagnostic instrumentation 有权
标题翻译：诊断仪器
公开(公告)号：US07395458B2
公开(公告)日：2008-07-01
申请号：US11133633
申请日：2005-05-20
申请人： Sandeep Shrivastava , Rajendra Inamdar , Ryan LeCompte , R. Sean Lindsay , Stephen Hess , Richard Mousseau
发明人： Sandeep Shrivastava , Rajendra Inamdar , Ryan LeCompte , R. Sean Lindsay , Stephen Hess , Richard Mousseau
IPC分类号： G06F11/00
CPC分类号： G06F11/2294 , G06F11/0709 , G06F11/0748
摘要： Diagnostic Instrumentation system can use diagnostic monitors. The diagnostic monitors can be indicated using instrumentation at class loading time. The diagnostic monitors can have associated diagnostic functions which can be enabled or disenabled while the server software is running.
摘要翻译：诊断仪表系统可以使用诊断监视器。诊断监视器可以在上课时间使用仪器来指示。诊断监视器可以具有相关的诊断功能，可在服务器软件运行时启用或禁用。

5. 发明申请

US20050273667A1 Diagnostic instrumentation 有权
标题翻译：诊断仪器
公开(公告)号：US20050273667A1
公开(公告)日：2005-12-08
申请号：US11133633
申请日：2005-05-20
申请人： Sandeep Shrivastava , Rajendra Inamdar , Ryan LeCompte , R. Lindsay , Stephen Hess , Rich Mousseau
发明人： Sandeep Shrivastava , Rajendra Inamdar , Ryan LeCompte , R. Lindsay , Stephen Hess , Rich Mousseau
IPC分类号： G06F11/00 , G06F11/273
CPC分类号： G06F11/2294 , G06F11/0709 , G06F11/0748
摘要： Diagnostic Instrumentation system can use diagnostic monitors. The diagnostic monitors can be indicated using instrumentation at class loading time. The diagnostic monitors can have associated diagnostic functions which can be enabled or disenabled while the server software is running.
摘要翻译：诊断仪表系统可以使用诊断监视器。诊断监视器可以在上课时间使用仪器来指示。诊断监视器可以具有相关的诊断功能，可在服务器软件运行时启用或禁用。

6. 发明授权

US07921084B2 Timer-driven diagnostic image inhibition for statement cache/connection pool 有权
标题翻译：定时器驱动诊断图像禁止语句高速缓存/连接池
公开(公告)号：US07921084B2
公开(公告)日：2011-04-05
申请号：US11338965
申请日：2006-01-25
申请人： Rahul Srivastava , Sandeep Shrivastava , Rajendra Inamdar , Ryan LeCompte , R. Sean Lindsay , Stephen Hess , Richard Mousseau
发明人： Rahul Srivastava , Sandeep Shrivastava , Rajendra Inamdar , Ryan LeCompte , R. Sean Lindsay , Stephen Hess , Richard Mousseau
IPC分类号： G06F7/00 , G06F17/00 , G06F11/00 , G06F17/40
CPC分类号： H04L69/04
摘要： Upon an event, diagnostic information about the state of server software can be compiled. The diagnostic information can include information concerning the JDBC subsystem. A timer can be used to inhibit a compilation of a new diagnostic image if the old diagnostic image was recently compiled.
摘要翻译：事件发生后，可以编译有关服务器软件状态的诊断信息。诊断信息可以包括有关JDBC子系统的信息。如果最近编译了旧的诊断图像，则可以使用定时器来禁止新诊断图像的编译。

7. 发明授权

US07359831B2 Diagnostic context 有权
标题翻译：诊断环境
公开(公告)号：US07359831B2
公开(公告)日：2008-04-15
申请号：US11133568
申请日：2005-05-20
申请人： Sandeep Shrivastava , Rajendra Inamdar , Ryan LeCompte , R. Sean Lindsay , Stephen Hess , Richard Mousseau
发明人： Sandeep Shrivastava , Rajendra Inamdar , Ryan LeCompte , R. Sean Lindsay , Stephen Hess , Richard Mousseau
IPC分类号： G06F17/00 , G06F17/40
CPC分类号： G06F11/079 , G06F11/0715 , G06F11/366
摘要： A diagnostic context can be associated with a request and the diagnostic context can be used for determining whether to do diagnosis functions at predetermined points.
摘要翻译：诊断上下文可以与请求相关联，并且诊断上下文可用于确定是否在预定点执行诊断功能。

8. 发明申请

US20070094383A1 JDBC Diagnostic image 有权
标题翻译： JDBC诊断映像
公开(公告)号：US20070094383A1
公开(公告)日：2007-04-26
申请号：US11338965
申请日：2006-01-25
申请人： Rahul Srivastava , Sandeep Shrivastava , Rajendra Inamdar , Ryan LeCompte , R. Lindsay , Stephen Hess , Richard Mousseau
发明人： Rahul Srivastava , Sandeep Shrivastava , Rajendra Inamdar , Ryan LeCompte , R. Lindsay , Stephen Hess , Richard Mousseau
IPC分类号： G06F15/173
CPC分类号： H04L69/04
摘要： A diagnostic image can be used to store JDBC subsystem information.
摘要翻译：诊断映像可用于存储JDBC子系统信息。

9. 发明申请

US20050261878A1 Diagnostic image 有权
标题翻译：诊断图像
公开(公告)号：US20050261878A1
公开(公告)日：2005-11-24
申请号：US11133566
申请日：2005-05-20
申请人： Sandeep Shrivastava , Rajendra Inamdar , Ryan LeCompte , R. Lindsay , Stephen Hess , Richard Mousseau
发明人： Sandeep Shrivastava , Rajendra Inamdar , Ryan LeCompte , R. Lindsay , Stephen Hess , Richard Mousseau
IPC分类号： G06F11/30
CPC分类号： G06F11/0766 , G06F11/0709 , G06F11/0715 , G06F11/0751 , G06F11/3476 , G06F11/3495 , G06F11/366
摘要： Diagnostic information can be stored and then collected into a large diagnostic image file upon an event, such as a prefailure condition. The diagnostic image can be compressed for emailing to a second site to allow the determination of problems with server software at the server software site.
摘要翻译：诊断信息可以存储，然后在事件（例如预设条件）下收集到大型诊断图像文件中。诊断图像可以压缩，以便电子邮件发送到第二个站点，以允许在服务器软件站点确定服务器软件的问题。

10. 发明申请

US20050028268A1 Bathtub and shower threshold 审中-公开
标题翻译：浴缸和淋浴门槛
公开(公告)号：US20050028268A1
公开(公告)日：2005-02-10
申请号：US10637103
申请日：2003-08-08
申请人： Stephen Hess
发明人： Stephen Hess
IPC分类号： A47K3/02 , A47K3/40
CPC分类号： A47K3/40 , A47K3/02
摘要： A threshold for a bathtub or shower base assembly includes a slope configured to direct water away from an exterior toward an interior of the tub or assembly. The slope declines as it extends inwardly, thereby preventing water from leaking. The slope includes an outer portion that is higher than an inner portion, and a surface in between that faces upwardly and inwardly. The slope is disposed along an axial length of an outer side of the tub or base assembly. The slope is disposed outwardly of a horizontally flat surface which, in a tub, may be configured for supporting a sliding door.
摘要翻译：浴缸或淋浴器底座组件的阈值包括一个斜面，其配置成将水从外部引导到桶或组件的内部。斜坡向内延伸，从而防止水泄漏。斜坡包括高于内部部分的外部部分，以及面向上和向内的表面。斜面沿着桶或基座组件的外侧的轴向长度设置。斜坡设置在水平平坦的表面的外侧，水平的表面可以被配置为支撑滑动门。

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