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1. 发明申请

US20090130774A1 Elisa assays using prion-specific peptide reagents 审中-公开
标题翻译： Elisa测定使用朊病毒特异性肽试剂
公开(公告)号：US20090130774A1
公开(公告)日：2009-05-21
申请号：US11795163
申请日：2006-01-13
申请人： David Peretz , Melissa Michelitsch , Celine Hu , Xuemei Wang , Man Gao , Michael Connolly , Thomas Horn , Ronald Zuckermann , David Chien
发明人： David Peretz , Melissa Michelitsch , Celine Hu , Xuemei Wang , Man Gao , Michael Connolly , Thomas Horn , Ronald Zuckermann , David Chien
IPC分类号： G01N33/566
CPC分类号： B82Y30/00 , G01N33/6896 , G01N2800/2828
摘要： Peptide reagents that interact preferentially with the PrPsc form of the prion protein are described for use in detecting PrPsc in biological samples. In particular, ELISA assays are described.
摘要翻译：描述了与PrPsc形式的朊病毒蛋白优先相互作用的肽试剂用于检测生物样品中的PrPsc。特别地，描述了ELISA测定。

2. 发明申请

US20060188916A1 Peptoids incorporating chemoselective functionalities 失效
公开(公告)号：US20060188916A1
公开(公告)日：2006-08-24
申请号：US11398576
申请日：2006-04-04
申请人： Thomas Horn , Ronald Zuckermann
发明人： Thomas Horn , Ronald Zuckermann
IPC分类号： C12Q1/68 , C07K9/00
CPC分类号： B82Y30/00 , B82Y15/00 , C07K1/04 , C07K1/047 , C07K1/10 , C07K17/06
摘要： Molecules having potential biological activity, particularly peptoids, that are conjugated to solid phase supports, spacer groups, and/or ligation moieties, and methods of their preparation, are described. In some instances, the molecules of the invention are made entirely by solid phase synthesis. In other instances, the spacer groups are hydrophilic and compositions containing them, and to solid phase synthesis of varied structure peptoids using chemoselective ligation moieties.

3. 发明申请

US20130209910A1 EXPLOSION-PROTECTED FUEL CELL 审中-公开
标题翻译：爆炸保护燃料电池
公开(公告)号：US20130209910A1
公开(公告)日：2013-08-15
申请号：US13697571
申请日：2011-05-12
申请人： Thomas Horn , Ulrich Johannsmeyer , Anton Schimmele
发明人： Thomas Horn , Ulrich Johannsmeyer , Anton Schimmele
IPC分类号： H01M8/04
CPC分类号： H01M8/04029 , H01M8/04052 , H01M8/04343 , H01M8/0435 , H01M8/04358 , H01M8/04679 , H01M8/2475
摘要： A fuel cell arrangement operable in environments that are prone to explosions including a fuel cell stack 14 that is housed in a containment vessel 15 filled with a heat equalizing fluid 26 and provided with a cooling system. The heat equalizing fluid 26 flows around all sides of the fuel cell stack 14 and prevents a direct concentrated heat transfer from the surface of the fuel cell stack 14 to the containment housing 15. The heat equalizing fluid 26 buffers and distributes local heat peaks originating from the fuel cell stack 14 and thus eliminates ignition sources.
摘要翻译：燃料电池装置可在容易发生爆炸的环境中操作，所述环境包括燃料电池堆14，所述燃料电池堆14容纳在填充有均热流体26并设置有冷却系统的容纳容器15中。均热流体26流过燃料电池堆14的所有侧面，并且防止从燃料电池堆14的表面到容纳壳体15的直接集中的热传递。热均衡流体26缓冲并分配源自燃料电池堆14，从而消除点火源。

4. 发明申请

US20080143510A1 Radio frequency localization 失效
标题翻译：射频定位
公开(公告)号：US20080143510A1
公开(公告)日：2008-06-19
申请号：US11638865
申请日：2006-12-14
申请人： Thomas Horn
发明人： Thomas Horn
IPC分类号： G08B23/00 , G08B21/00 , H04B1/38
CPC分类号： H04B5/0087 , H04B17/27
摘要： One aspect of the invention relates to a system for and a method of monitoring a plurality of transceivers located in an area, e.g. a patch panel, to be monitored.In accordance with an aspect of the invention, there is provided a method for monitoring a plurality of transceivers located in an area to be monitored. The method includes enabling one transceiver of the plurality of transceivers. The method also includes disabling all other transceivers of the plurality of transceivers. A transmit coil emits a high frequency electromagnetic field, the one transceiver transmitting a signal in response to the field of the transmit coil. At least one of a plurality of reader coils receives the signal transmitted by the one transceiver, the plurality of reader coils being suitably arranged in the vicinity of the area to be monitored. An evaluator determines a position of the one transceiver from the signal received from the one transceiver by the at least one of the plurality of reader coils.
摘要翻译：本发明的一个方面涉及一种监视位于一个区域中的多个收发器的系统和方法，例如，一个接线板，待监控。根据本发明的一个方面，提供了一种用于监视位于待监视区域中的多个收发器的方法。该方法包括启用多个收发器中的一个收发器。该方法还包括禁用多个收发器的所有其他收发器。发射线圈发射高频电磁场，一个收发器响应于发射线圈的场发送信号。多个读取器线圈中的至少一个接收由一个收发器发送的信号，多个读取器线圈适当地布置在待监视的区域附近。评估器根据由多个读取器线圈中的至少一个从一个收发器接收的信号来确定一个收发器的位置。

5. 发明申请

US20050175634A1 Immunotherapy of epithelial tumors using intralesional injection of antigens that induce a delayed type hypersensitivity reaction 审中-公开
标题翻译：免疫治疗上皮性肿瘤使用病灶内注射诱导迟发型超敏反应的抗原
公开(公告)号：US20050175634A1
公开(公告)日：2005-08-11
申请号：US11061996
申请日：2005-02-21
申请人： Thomas Horn , Sandra Johnson
发明人： Thomas Horn , Sandra Johnson
IPC分类号： A61K39/00 , A61K39/165 , A61K39/12
CPC分类号： A61K39/165 , A61K39/0002 , A61K39/12 , A61K2039/58 , A61K2039/585
摘要： The pharmaceutical composition is useful for treating epithelial tumors in a subject and contains at least two antigens and a pharmaceutically acceptable carrier, where each of the antigens induces or is capable of inducing a cutaneous delayed type hypersensitivity (DTH) response in the subject. This composition is particularly useful in treating epithelial tumors, such as warts or verrucae, that are induced by or related to papillomavirus. Antigens useful in the present pharmaceutical composition are anergy panel antigens, such as killed mumps virus, candida extract, trichophyton extract or comparable antigenic extracts. An additional pharmaceutical composition, also useful for treating epithelial tumors, contains at least one antigen that induces or is capable of inducing a cutaneous DTH response in a subject, at least one cytokine or colony stimulating factor and a pharmaceutically acceptable carrier. Kits containing these pharmaceutical compositions are useful for this immunotherapy.
摘要翻译：药物组合物可用于治疗受试者中的上皮肿瘤，并且含有至少两种抗原和药学上可接受的载体，其中每种抗原诱导或能够诱导受试者的皮肤迟发型超敏反应（DTH）反应。该组合物特别可用于治疗由乳头瘤病毒引起或与乳头瘤病毒有关的上皮肿瘤，例如疣或疣。本发明药物组合物中有用的抗原是抗病毒抗原，例如杀死的腮腺炎病毒，念珠菌提取物，毛发提取物或类似抗原提取物。也可用于治疗上皮肿瘤的另外的药物组合物含有至少一种诱导或能诱导受试者皮肤DTH反应的抗原，至少一种细胞因子或集落刺激因子和药学上可接受的载体。含有这些药物组合物的试剂盒可用于该免疫疗法。

6. 发明申请

US20050121089A1 Pulse width modulated solenoid 有权
标题翻译：脉宽调制电磁铁
公开(公告)号：US20050121089A1
公开(公告)日：2005-06-09
申请号：US10989616
申请日：2004-11-16
申请人： Kenneth Morgan , Thomas Hemak , Aaron Wolfson , Thomas Horn , Gregory Lewis , Howard Saxon
发明人： Kenneth Morgan , Thomas Hemak , Aaron Wolfson , Thomas Horn , Gregory Lewis , Howard Saxon
IPC分类号： F15B13/044 , F16H61/00 , F16K27/00 , F16K31/06 , H01F7/16
CPC分类号： F16K31/0693 , F15B13/044 , F16K27/003 , Y10T137/86622 , Y10T137/87217 , Y10T137/87233
摘要： A pulse width modulated solenoid system having low noise characteristics is described. Noise reduction is primarily achieved by separating the solenoid device from the insulator and the manifold housing through the use of rubber isolators and multiple sets of o-rings, thus preventing metal to metal contact. Additional noise reduction is achieved by encapsulating all of the solenoids, using the insulator, the cover plate, the housing, and the screen carrier. Noise levels are also further reduced by minimizing the impact force of the armature against the sleeve by allowing fluid to vent into the upper area of the sleeve, thus causing a dampening effect.
摘要翻译：描述了具有低噪声特性的脉宽调制电磁阀系统。降噪主要是通过使用橡胶隔离器和多组O形环将螺线管装置从绝缘体和歧管壳体分离出来的，从而防止金属与金属的接触。通过使用绝缘体，盖板，壳体和屏幕载体封装所有螺线管来实现额外的降噪。通过允许流体排放到套筒的上部区域中，通过使衔铁抵抗套筒的冲击力最小化，从而进一步降低噪音水平，从而产生阻尼作用。

7. 发明授权

US5681702A Reduction of nonspecific hybridization by using novel base-pairing schemes 失效
标题翻译：通过使用新的碱基配对方案减少非特异性杂交
公开(公告)号：US5681702A
公开(公告)日：1997-10-28
申请号：US298073
申请日：1994-08-30
申请人： Mark L. Collins , Thomas Horn , Patrick J. Sheridan , Brian D. Warner , Michael S. Urdea
发明人： Mark L. Collins , Thomas Horn , Patrick J. Sheridan , Brian D. Warner , Michael S. Urdea
IPC分类号： C12N15/09 , C07H19/16 , C07H19/20 , C07H21/00 , C12N15/113 , C12Q1/68 , C07H19/04 , C07H21/02 , C12D19/24
CPC分类号： C12N15/113 , C07H19/16 , C07H19/20 , C07H21/00 , C12Q1/68 , C12Q1/6811 , C12Q1/6813 , C12Q1/682 , C12Q1/6832 , C12Q1/6837 , C12N2310/322 , C12N2310/336
摘要： Methods are provided for substantially reducing background signals encountered in nucleic acid hybridization assays. The method is premised on the elimination or significant reduction of the phenomenon of nonspecific hybridization, so as to provide a detectable signal which is produced only in the presence the target polynucleotide of interest. In addition, a novel method for the chemical synthesis of isoguanosine or 2'-deoxy-isoguanosine is provided. The invention also has applications in antisense and aptamer therapeutics and drug discovery.
摘要翻译：提供了用于基本上减少在核酸杂交测定中遇到的背景信号的方法。该方法的前提是消除或显着降低非特异性杂交的现象，从而提供仅在存在目标目的多核苷酸的情况下产生的可检测信号。另外，提供了一种用于化学合成异鸟嘌呤或2'-脱氧 - 异鸟嘌呤的新方法。本发明还可应用于反义和适体治疗剂和药物发现。

8. 发明授权

US5359100A Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers 失效
标题翻译：双功能封闭的亚磷酰胺可用于制备核酸诱变剂
公开(公告)号：US5359100A
公开(公告)日：1994-10-25
申请号：US107358
申请日：1993-08-13
申请人： Michael S. Urdea , Brian Warner , Joyce A. Running , Janice A. Kolberg , Jennifer M. Clyne , Ray Sanchez-Pescador , Thomas Horn
发明人： Michael S. Urdea , Brian Warner , Joyce A. Running , Janice A. Kolberg , Jennifer M. Clyne , Ray Sanchez-Pescador , Thomas Horn
IPC分类号： C07H19/06 , C07H21/00 , C12Q1/68 , C12Q1/70 , G01N33/532 , C07F9/24
CPC分类号： C07H19/06 , C07H21/00 , C12Q1/682 , C12Q1/689 , C12Q1/706 , G01N33/532 , G01N2333/045 , Y10S435/81 , Y10S435/948 , Y10S436/811
摘要： Linear or branched oligonucleotide multimers useful as amplifiers in biochemical assays which comprise (1) at least one first single-stranded oligonucleotide unit that is complementary to a single-stranded oligonucleotide sequence of interest, and (2) a multiplicity of second single-stranded oligonucleotide units that are complementary to a single-stranded labeled oligonucleotide. Amplified sandwich nucleic acid hybridizations and immunoassays using the multimers are exemplified.
摘要翻译：用作生物化学测定中放大器的线性或支化寡核苷酸多聚体，其包含（1）与目的单链寡核苷酸序列互补的至少一个第一单链寡核苷酸单元，和（2）多个第二单链寡核苷酸与单链标记的寡核苷酸互补的单元。示例了使用多聚体的扩增的夹心核酸杂交和免疫测定。

9. 发明申请

US20060101641A1 Armature pin and method for assembly 审中-公开
标题翻译：电枢销和组装方法
公开(公告)号：US20060101641A1
公开(公告)日：2006-05-18
申请号：US11217246
申请日：2005-09-01
申请人： Ryan True , Thomas Horn
发明人： Ryan True , Thomas Horn
IPC分类号： H01R43/00 , H01H9/00 , B22D11/126
CPC分类号： H01F41/0246 , Y10T29/49169 , Y10T29/49206 , Y10T29/49988 , Y10T29/5313
摘要： Armature pin assemblies and methods for forming the same are described. A first portion of a pin member is placed in a die cavity so as to expose a second portion of the pin member. An amount of metal powder is placed into the die cavity so as envelope the second portion of the pin member. A press member is then brought into contact with the metal powder so as to compress the same and form an armature member. The pin member is fastened to the armature member by the press operation so as to form a unitary armature pin assembly.
摘要翻译：描述了电枢销组件及其形成方法。销构件的第一部分被放置在模腔中，以便露出销构件的第二部分。将一定量的金属粉末放置在模腔中，以便将销部件的第二部分包围。然后将压制构件与金属粉末接触以将其压缩并形成电枢构件。销构件通过按压操作紧固到电枢构件，以形成单一的电枢销组件。

10. 发明授权

US07030216B2 Peptoids incorporating chemoselective functionalities 失效
公开(公告)号：US07030216B2
公开(公告)日：2006-04-18
申请号：US10117841
申请日：2002-04-05
申请人： Thomas Horn , Ronald N. Zuckermann
发明人： Thomas Horn , Ronald N. Zuckermann
IPC分类号： C07K1/00
CPC分类号： B82Y30/00 , B82Y15/00 , C07K1/04 , C07K1/047 , C07K1/10 , C07K17/06
摘要： Molecules having potential biological activity, particularly peptoids, that are conjugated to solid phase supports, spacer groups, and/or ligation moieties, and methods of their preparation, are described. In some instances, the molecules of the invention are made entirely by solid phase synthesis. In other instances, the spacer groups are hydrophilic and compositions containing them, and to solid phase synthesis of varied structure peptoids using chemoselective ligation moieties.

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