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1. 发明申请

US20110033391A1 Transferases and Oxidoreductases, Nucleic Acids Encoding them and methods for making and using them 有权
标题翻译：转移酶和氧化还原酶，编码它们的核酸和制备和使用它们的方法
公开(公告)号：US20110033391A1
公开(公告)日：2011-02-10
申请号：US12810057
申请日：2008-12-31
申请人： David P. Weiner , Peter Luginbuhl , Analia Bueno , Joslin M. Cuenca , Erin Marasco
发明人： David P. Weiner , Peter Luginbuhl , Analia Bueno , Joslin M. Cuenca , Erin Marasco
IPC分类号： A61K9/68 , C07H21/00 , C12N15/63 , C12N5/10 , C12N1/21 , C12N1/15 , C12N1/19 , C12N9/10 , C12N9/02 , C12N9/06 , C12N11/14 , C40B40/10 , C12P19/34 , C12P7/40 , C12P13/14 , C12P13/04 , C12P7/26 , A61K38/44 , A61K38/45 , A61K38/54 , A61Q11/00 , A21D8/04 , C12C7/00 , C12C11/00
CPC分类号： C12N9/1096 , A21D8/042 , A61K38/00 , C12N9/0004 , C12N9/0006 , C12N9/0014 , C12N9/10 , C12N15/1137 , C12N15/63 , C12N15/86 , C12P7/10 , C12Q1/6876 , C12Y206/01021 , D06L4/40 , D06M16/003 , G01N33/573 , Y02E50/16 , Y02P20/52 , Y02T50/678
摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having transferase activity, e.g., transaminase activity, e.g., d-amino-acid transferase activity, and/or oxidoreductase activity, e.g., dehydrogenase activity, e.g., damino-acid dehydrogenase activity, and/or catalyze the transfer of a chemical group, catalyze transamination, catalyze the reaction: D-alanine+2-oxoglutarate pyruvate+D-glutamate, and/or catalyze an oxidation-reduction reaction, catalyze the removal of hydrogen atoms, and/or catalyze the reaction: D-amino acid+H2O+acceptor a 2-oxo acid+NH3+reduced acceptor. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermediates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.
摘要翻译：本发明一般涉及酶，编码酶的多核苷酸，这种多核苷酸和多肽的用途，更具体地涉及具有转移酶活性的酶，例如转氨酶活性，例如d-氨基酸转移酶活性和/或氧化还原酶活性，例如，脱氢酶活性，例如脱氨酸脱氢酶活性和/或催化化学基团的转移，催化转氨酶，催化反应：D-丙氨酸+ 2-氧戊二酸酯<=>丙酮酸盐+ D-谷氨酸盐和/或催化催化氢原子的去除和/或催化反应：D-氨基酸+ H 2 O +受体 2-氧代酸+ NH 3 +还原受体。因此，本发明提供了用于生产药物组合物，药物中间体，抗生素，甜味剂，肽酶，肽激素，燃料和燃料添加剂组合物，食品和食品添加剂，饮料和饮料添加剂，饲料和饲料添加剂的酶，组合物，药物和药物添加剂，膳食补充剂，纺织品，木材，纸，纸浆和洗涤剂，其包含根据本发明的多肽或多核苷酸。

2. 发明申请

US20110053245A1 ISOMERASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 有权
标题翻译：异构体，编码它们的核酸及其制备和使用它们的方法
公开(公告)号：US20110053245A1
公开(公告)日：2011-03-03
申请号：US12810067
申请日：2008-12-22
申请人： David P. Weiner , Peter Luginbuhl , Analia Bueno , Joslin M. Cuenca , Mervyn L. De Souza , Sherry Kollmann
发明人： David P. Weiner , Peter Luginbuhl , Analia Bueno , Joslin M. Cuenca , Mervyn L. De Souza , Sherry Kollmann
IPC分类号： C12N9/90 , C12N15/52 , C12N15/80 , C12N15/81 , C12N15/82 , C12N15/85 , C12P21/02 , C12P19/34 , A23L1/172 , D21C3/20 , C12N9/42 , C12N9/48 , C12N9/24 , C12N9/08 , C12N9/10 , C12N9/16 , C12N9/88
CPC分类号： C12N9/90 , A01K67/0275 , A01K2217/05 , A01K2227/10 , A23G3/366 , A23G4/123 , A23G4/14 , A23K20/189 , A23L29/06 , A23V2002/00 , A61K38/00 , A61K38/52 , C12Q1/533 , C12Y501/00 , C12Y501/01
摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having isomerase activity, e.g., racemase activity, e.g., amino acid racemase activity, alanine racemase activity, and/or epimerase activity, and/or catalyze the re-, arrangement of atoms within a molecule, catalyze the conversion of one isomer into another, catalyze the conversion of an optically active substrate into a raceme, which is optically inactive, catalyze the interconversion of substrate enantiomers, catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry, catalyze the stereochemical inversion of the configuration around an asymmetric carbon atom in a substrate having more than one asymmetric center, and/or catalyze the racemization of amino acids. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermerdiates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.
摘要翻译：本发明一般涉及酶，编码酶的多核苷酸，这种多核苷酸和多肽的用途，更具体地涉及具有异构酶活性的酶，例如消旋酶活性，例如氨基酸消旋酶活性，丙氨酸消旋酶活性和/或差向异构酶活性，和/或催化原子在分子内的重新排列，催化一种异构体转化为另一种异构体，催化光学活性底物转化为光学无活性的外消旋体，催化底物对映异构体的相互转化，催化仅具有一个不对称中心的基底中的不对称碳原子周围的立体化学反转，催化具有多于一个不对称中心的底物中不对称碳原子周围的构型的立体化学反转，和/或催化氨基酸的外消旋化。因此，本发明提供了酶，组合物，药物组合物的制备方法，药物中间体，抗生素，甜味剂，肽酶，肽激素，燃料和燃料添加剂组合物，食品和食品添加剂，饮料和饮料添加剂，饲料和饲料添加剂，药物和药物添加剂，膳食补充剂，纺织品，木材，纸，纸浆和洗涤剂，其包含根据本发明的多肽或多核苷酸。

3. 发明授权

US08541220B2 Isomerases, nucleic acids encoding them and methods for making and using them 有权
标题翻译：异构酶，编码它们的核酸和制备和使用它们的方法
公开(公告)号：US08541220B2
公开(公告)日：2013-09-24
申请号：US12810067
申请日：2008-12-22
申请人： David P. Weiner , Ellen G. Burke , Peter Luginbuhl , Analia Bueno , Joslin M. Cuenca , Mervyn L. De Souza , Sherry Kollmann
发明人： David P. Weiner , Ellen G. Burke , Peter Luginbuhl , Analia Bueno , Joslin M. Cuenca , Mervyn L. De Souza , Sherry Kollmann
IPC分类号： C12N9/90 , C12N9/88 , C12N9/48 , C12N9/42 , C12N9/16 , C02F3/34 , A62D3/00 , C07H21/04 , C07K1/00 , A21D2/00 , A23L1/10 , D21C3/20
CPC分类号： C12N9/90 , A01K67/0275 , A01K2217/05 , A01K2227/10 , A23G3/366 , A23G4/123 , A23G4/14 , A23K20/189 , A23L29/06 , A23V2002/00 , A61K38/00 , A61K38/52 , C12Q1/533 , C12Y501/00 , C12Y501/01
摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having isomerase activity, e.g., racemase activity, e.g., amino acid racemase activity, alanine racemase activity, and/or epimerase activity, and/or catalyze the re-arrangement of atoms within a molecule, catalyze the conversion of one isomer into another, catalyze the conversion of an optically active substrate into a raceme, which is optically inactive, catalyze the interconversion of substrate enantiomers, catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry, catalyze the stereochemical inversion of the configuration around an asymmetric carbon atom in a substrate having more than one asymmetric center, and/or catalyze the racemization of amino acids. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermediates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.
摘要翻译：本发明一般涉及酶，编码酶的多核苷酸，这种多核苷酸和多肽的用途，更具体地涉及具有异构酶活性的酶，例如消旋酶活性，例如氨基酸消旋酶活性，丙氨酸消旋酶活性和/或差向异构酶活性，和/或催化分子内原子的重新排列，催化一种异构体转化为另一种异构体，催化光学活性底物转化为光学无活性的外消旋体，催化底物对映异构体的相互转化，催化立体化学在仅具有一个不对称中心的底物中的不对称碳原子周围反转，催化具有多于一个不对称中心的底物中不对称碳原子周围的构型的立体化学反转，和/或催化氨基酸的外消旋化。因此，本发明提供了用于生产药物组合物，药物中间体，抗生素，甜味剂，肽酶，肽激素，燃料和燃料添加剂组合物，食品和食品添加剂，饮料和饮料添加剂，饲料和饲料添加剂的酶，组合物，药物和药物添加剂，膳食补充剂，纺织品，木材，纸，纸浆和洗涤剂，其包含根据本发明的多肽或多核苷酸。

4. 发明授权

US08785162B2 Aminotransferase and oxidoreductase nucleic acids and polypeptides and methods of using 有权
标题翻译：氨基转移酶和氧化还原酶核酸和多肽及其使用方法
公开(公告)号：US08785162B2
公开(公告)日：2014-07-22
申请号：US12811491
申请日：2008-12-31
申请人： Mervyn L. De Souza , Paula M. Hicks , Sherry R. Kollmann , Jose Laplaza , Joshua M. Lundorff , Sara C. McFarlan , Erin Marasco , Wei Niu , Fernando A. Sanchez-Riera , Christopher Solheid , David P. Weiner , Peter Luginbuhl , Analia Bueno , Joslin Cuenca
发明人： Mervyn L. De Souza , Paula M. Hicks , Sherry R. Kollmann , Jose Laplaza , Joshua M. Lundorff , Sara C. McFarlan , Erin Marasco , Wei Niu , Fernando A. Sanchez-Riera , Christopher Solheid , David P. Weiner , Peter Luginbuhl , Analia Bueno , Joslin Cuenca
IPC分类号： C12P17/10 , C12P13/22 , C12P13/04 , C12N9/10 , C12P21/06 , C12P19/34 , C12N1/20 , C07H21/04 , C07K1/00
CPC分类号： C12P13/227 , C12N9/0004 , C12N9/1096 , C12P17/10
摘要： The invention provides for aminotransferase and oxidoreductase polypeptides and nucleic acids encoding such polypeptides. Also provided are methods of using such aminotransferase and oxidoreductase nucleic acids and polypeptides.
摘要翻译：本发明提供氨基转移酶和氧化还原酶多肽以及编码这种多肽的核酸。还提供了使用这种氨基转移酶和氧化还原酶核酸和多肽的方法。

5. 发明授权

US08709772B2 Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them 有权
标题翻译：转移酶和氧化还原酶，编码它们的核酸以及制备和使用它们的方法
公开(公告)号：US08709772B2
公开(公告)日：2014-04-29
申请号：US12810057
申请日：2008-12-31
申请人： David P. Weiner , Peter Luginbuhl , Analia Bueno , Joslin Cuenca , Erin Marasco
发明人： David P. Weiner , Peter Luginbuhl , Analia Bueno , Joslin Cuenca , Erin Marasco
IPC分类号： C12N9/10 , C12Q1/00 , C12Q1/68 , C12P21/06 , C12P21/04 , C12N1/20 , C12N15/00 , C12P7/00 , C12P13/04 , C07H21/04
CPC分类号： C12N9/1096 , A21D8/042 , A61K38/00 , C12N9/0004 , C12N9/0006 , C12N9/0014 , C12N9/10 , C12N15/1137 , C12N15/63 , C12N15/86 , C12P7/10 , C12Q1/6876 , C12Y206/01021 , D06L4/40 , D06M16/003 , G01N33/573 , Y02E50/16 , Y02P20/52 , Y02T50/678
摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having transferase activity, e.g., transaminase activity, e.g., d-amino-acid transferase activity, and/or oxidoreductase activity, e.g., dehydrogenase activity, e.g., damino-acid dehydrogenase activity, and/or catalyze the transfer of a chemical group, catalyze transamination, catalyze the reaction: D-alanine+2-oxoglutarate pyruvate+D-glutamate, and/or catalyze an oxidation-reduction reaction, catalyze the removal of hydrogen atoms, and/or catalyze the reaction: D-amino acid+H2O+acceptor a 2-oxo acid+NH3+reduced acceptor. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermediates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.
摘要翻译：本发明一般涉及酶，编码酶的多核苷酸，这种多核苷酸和多肽的用途，更具体地涉及具有转移酶活性的酶，例如转氨酶活性，例如d-氨基酸转移酶活性和/或氧化还原酶活性，例如，脱氢酶活性，例如脱氨酸脱氢酶活性和/或催化化学基团的转移，催化转氨酶，催化反应：D-丙氨酸+ 2-氧戊二酸酯<=>丙酮酸盐+ D-谷氨酸盐和/或催化催化氢原子的去除和/或催化反应：D-氨基酸+ H 2 O +受体 2-氧代酸+ NH 3 +还原受体。因此，本发明提供了用于生产药物组合物，药物中间体，抗生素，甜味剂，肽酶，肽激素，燃料和燃料添加剂组合物，食品和食品添加剂，饮料和饮料添加剂，饲料和饲料添加剂的酶，组合物，药物和药物添加剂，膳食补充剂，纺织品，木材，纸，纸浆和洗涤剂，其包含根据本发明的多肽或多核苷酸。

6. 发明申请

US20110020882A1 AMINOTRANSFERASE AND OXIDOREDUCTASE NUCLEIC ACIDS AND POLYPEPTIDES AND METHODS OF USING 有权
标题翻译：氨基转移酶和氧化还原酶核酸和多肽及其使用方法
公开(公告)号：US20110020882A1
公开(公告)日：2011-01-27
申请号：US12811491
申请日：2008-12-31
申请人： Mervyn L. de Souza , Paula M. Hicks , Sherry R. Kollmann , Jose Laplaza , Joshua M. Lundorff , Sara C. McFarlan , Erin Marasco , Wei Niu , Fernando A. Sanchez-Riera , Christopher Solheid , David P. Weiner , Ellen Burke , Peter Luginbuhl , Analia Bueno , Joslin Cuenca
发明人： Mervyn L. de Souza , Paula M. Hicks , Sherry R. Kollmann , Jose Laplaza , Joshua M. Lundorff , Sara C. McFarlan , Erin Marasco , Wei Niu , Fernando A. Sanchez-Riera , Christopher Solheid , David P. Weiner , Ellen Burke , Peter Luginbuhl , Analia Bueno , Joslin Cuenca
IPC分类号： C12P17/10
CPC分类号： C12P13/227 , C12N9/0004 , C12N9/1096 , C12P17/10
摘要： The invention provides for aminotransferase and oxidoreductase polypeptides and nucleic acids encoding such polypeptides. Also provided are methods of using such aminotransferase and oxidoreductase nucleic acids and polypeptides.
摘要翻译：本发明提供氨基转移酶和氧化还原酶多肽以及编码这种多肽的核酸。还提供了使用这种氨基转移酶和氧化还原酶核酸和多肽的方法。

7. 发明申请

US20110045547A1 ISOMERASES AND EPIMERASES AND METHODS OF USING 审中-公开
标题翻译：异构体和硫化物及其使用方法
公开(公告)号：US20110045547A1
公开(公告)日：2011-02-24
申请号：US12828714
申请日：2010-07-01
申请人： Mervyn L. de Souza , Wei Niu , Jose Laplaza , Christopher Solheid , Sherry R. Kollmann , Joshua M. Lundorff , Paula M. Hicks , Sara C. McFarlan , Fernando A. Sanchez-Riera , David P. Weiner , Ellen Burke , Peter Luginbuhl , Analia Bueno , Joslin Cuenca
发明人： Mervyn L. de Souza , Wei Niu , Jose Laplaza , Christopher Solheid , Sherry R. Kollmann , Joshua M. Lundorff , Paula M. Hicks , Sara C. McFarlan , Fernando A. Sanchez-Riera , David P. Weiner , Ellen Burke , Peter Luginbuhl , Analia Bueno , Joslin Cuenca
IPC分类号： C12P13/22 , C12P17/10
CPC分类号： C12N9/90 , C12P13/06 , C12P13/22 , C12P17/10
摘要： The invention provides for isomerase (e.g., racemase) and epimerase polypeptides and nucleic acids encoding such polypeptides. Also provided are methods of using such isomerase (e.g., racemase) and epimerase nucleic acids and polypeptides.
摘要翻译：本发明提供异构酶（例如消旋酶）和差向异构酶多肽以及编码这种多肽的核酸。还提供了使用这种异构酶（例如消旋酶）和差向异构酶核酸和多肽的方法。

8. 发明授权

US08546118B2 Aldolases, nucleic acids encoding them and methods for making and using them 有权
公开(公告)号：US08546118B2
公开(公告)日：2013-10-01
申请号：US12281052
申请日：2007-03-07
申请人： David P. Weiner , Lishan Zhao , Peter Luginbuhl , Ellen Burke , Toby Richardson , Paula M. Hicks
发明人： David P. Weiner , Lishan Zhao , Peter Luginbuhl , Ellen Burke , Toby Richardson , Paula M. Hicks
IPC分类号： C12N9/10 , C12N15/00 , C12N1/20 , C12Q1/68 , C12P21/04 , C12P21/06 , C07H21/04
CPC分类号： C12N9/88 , A01K2217/05 , A61K38/00 , C07K2317/92 , C12N9/1022 , C12N15/8243 , C12P17/10 , C12Y401/03016 , C12Y401/03017 , Y02E50/16 , Y02E50/17
摘要： This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.

9. 发明申请

US20100095390A1 Aldolases, Nucleic Acids Encoding Them and Methods for Making and Using Them 有权
标题翻译：醛缩酶，编码它们的核酸及其制备和使用方法
公开(公告)号：US20100095390A1
公开(公告)日：2010-04-15
申请号：US12281052
申请日：2007-03-07
申请人： David P. Weiner , Lishan Zhao , Peter Luginbuhl , Ellen Burke , Toby H. Richardson , Paula M. Hicks
发明人： David P. Weiner , Lishan Zhao , Peter Luginbuhl , Ellen Burke , Toby H. Richardson , Paula M. Hicks
IPC分类号： C12N9/88 , C07H21/04 , C07H21/00 , C12N15/74 , C12N5/07 , C12N5/04 , C12N1/15 , C12N1/21 , A01K67/033 , A01H5/00 , C12N9/24 , C07K16/00 , C12P21/00 , C07K7/08 , C07K14/00 , A61K38/47 , C12P1/00 , C12P13/14 , C07C205/01 , A61P35/00 , A23K1/00
CPC分类号： C12N9/88 , A01K2217/05 , A61K38/00 , C07K2317/92 , C12N9/1022 , C12N15/8243 , C12P17/10 , C12Y401/03016 , C12Y401/03017 , Y02E50/16 , Y02E50/17
摘要： This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.
摘要翻译：本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。在一些实施方案中，本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，包括耐热和耐热活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。根据本发明的多肽可以用于各种药物，农业和工业环境。在一些实施方案中，本发明提供了可用于制备R-2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸（R-MP）和莫纳甜的某些立体异构体的多肽和生物合成途径，例如R ，R和S，R莫纳甜及其盐，以及莫纳甜衍生物的某些立体异构体，例如R，R和S，R构型及其盐。

10. 发明授权

US09234216B2 Variant CBH I polypeptides 有权
标题翻译：变体CBH I多肽
公开(公告)号：US09234216B2
公开(公告)日：2016-01-12
申请号：US13824315
申请日：2011-10-06
申请人： Justin T. Stege , Alexander Varvak , John Poland , Chris S. Lyon , Shaun Healey , Peter Luginbuhl
发明人： Justin T. Stege , Alexander Varvak , John Poland , Chris S. Lyon , Shaun Healey , Peter Luginbuhl
IPC分类号： C12P7/14 , C12N9/42 , C12P19/02 , C12P19/14
CPC分类号： C12P7/14 , C12N9/2437 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01091 , Y02E50/16 , Y02E50/17
摘要： In alternative embodiments, the invention provides polypeptides having a lignocellulolytic (lignocellulosic) activity, e.g., a ligninolytic and cellulolytic activity, including, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase (cbhl) (e.g., an exo-cellobiohydrolase, e.g., having an “exo” activity that can processively release cellobiose units β-1,4 glucose-glucose disaccharide), a beta-glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a (β-xylosidase) and/or an arabinofuranosidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one embodiment, the invention provides thermostable and thermotolerant forms of polypeptides of the invention. The polypeptides and nucleic acids of the invention are used in a variety of pharmaceutical, agricultural and industrial contexts; for example, as enzymes for the bioconversion of a biomass, e.g., lignocellulosic residues, into fermentable sugars, where in one aspect these sugars are used as a chemical feedstock for the production of ethanol and fuels, e.g., biofuels, e.g., synthetic liquid or gas fuels, including ethanol, methanol and the like.
摘要翻译：在替代实施方案中，本发明提供具有木质纤维素分解（木质纤维素）活性的多肽，例如木质素分解和纤维素分解活性，包括例如糖基水解酶，纤维素酶，内切葡聚糖酶，纤维二糖水解酶（cbhl）（例如，外切纤维二糖水解酶例如具有可以逐步释放纤维二糖单元和-1,4葡萄糖 - 葡萄糖二糖的“外显子”活性，β-葡糖苷酶，木聚糖酶，甘露聚糖，木糖苷酶（例如，（β-谷氨酸）和/或阿拉伯呋喃糖苷酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法在一个实施方案中，本发明提供了本发明的多肽的热稳定性和耐热性形式，使用本发明的多肽和核酸在各种制药，农业和工业环境中;例如，作为生物质生物转化的酶，例如木质纤维素残基，i 在一方面，这些糖用作生产乙醇和燃料的化学原料，例如生物燃料，例如合成液体或气体燃料，包括乙醇，甲醇等。

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