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1. 发明申请

US20050032752A1 8-Azaprostaglandin carbonate and thiocarbonate analogs as therapeutic agents 有权
标题翻译： 8-Azaprostaglandin碳酸酯和硫代碳酸酯类似物作为治疗剂
公开(公告)号：US20050032752A1
公开(公告)日：2005-02-10
申请号：US10932669
申请日：2004-09-01
申请人： David Old , Thang Dinh , Robert Burk
发明人： David Old , Thang Dinh , Robert Burk
IPC分类号： A61P27/06 , C07D207/26 , C07D403/06 , C07F9/572 , A61K31/66 , A61K31/557
CPC分类号： C07D207/26 , C07D403/06 , C07F9/572
摘要： The present invention provides a compound represented by the general formula I; wherein A, Ar, X, Z, n, x, y, R and R3 are as defined in the specification.
摘要翻译：本发明提供由通式I表示的化合物; 其中A，Ar，X，Z，n，x，y，R和R 3如说明书中所定义。

2. 发明申请

US20060247215A1 Cyclohexyl prostaglandin analogs as rp4-receptor agonists 有权
标题翻译：环己基前列腺素类似物作为rp4-受体激动剂
公开(公告)号：US20060247215A1
公开(公告)日：2006-11-02
申请号：US10565340
申请日：2004-08-16
申请人： David Old , Robert Burk , Thang Dinh
发明人： David Old , Robert Burk , Thang Dinh
IPC分类号： A61K31/66 , A61K31/41 , A61K31/18 , A61K31/12 , A61K31/557
CPC分类号： C07D333/62 , A61K31/557 , A61K31/662 , C07C59/90 , C07C69/738 , C07D333/56 , C07F9/3826 , C07F9/4015 , C07F9/655354
摘要： The invention relates to the use of novel cyclohexyl analogues of E-type prostaglandins as EP4 agonists, in general, and, in particular as ocular hypotensives. The cyclohexyl analogues used in accordance with the invention are represented by the following formula I: wherein the wavy segments represent α or β bond, dashed line represents the presence or absence of a bond W, Y, Z, R, R1, R2 and R3 are as defined in the specification.
摘要翻译：本发明涉及E型前列腺素的新型环己基类似物通常用作EP 4激动剂，特别是作为眼部低血压剂。根据本发明使用的环己基类似物由下式I表示：其中波浪段表示α或β键，虚线表示存在或不存在键W，Y，Z，R，R 1 R 2，R 2和R 3如说明书中所定义。

3. 发明申请

US20060030606A1 Cyclohexyl prostaglandin analogs as EP4-receptor agonists 有权
标题翻译：环己基前列腺素类似物作为EP4-受体激动剂
公开(公告)号：US20060030606A1
公开(公告)日：2006-02-09
申请号：US11241089
申请日：2005-09-30
申请人： David Old , Robert Burk , Thang Dinh
发明人： David Old , Robert Burk , Thang Dinh
IPC分类号： A61K31/426 , A61K31/421 , A61K31/41
CPC分类号： C07D333/62 , A61K31/557 , A61K31/662 , C07C59/90 , C07C69/738 , C07D333/56 , C07F9/3826 , C07F9/4015 , C07F9/655354
摘要： The invention relates to the use of novel cyclohexyl analogues of E-type prostaglandins as EP4 agonists, in general, and, in particular as ocular hypotensives. The cyclohexyl analogues used in accordance with the invention are represented by the following formula I: wherein the wavy segments represent α or β bond, dashed line represents the presence or absence of a bond W, Y, Z, R, R1, R2 and R3 are as defined in the specification.
摘要翻译：本发明涉及E型前列腺素的新型环己基类似物通常用作EP 4激动剂，特别是作为眼部低血压剂。根据本发明使用的环己基类似物由下式I表示：其中波浪段表示α或β键，虚线表示存在或不存在键W，Y，Z，R，R 1 R 2，R 2和R 3如说明书中所定义。

4. 发明申请

US20050049227A1 Cyclohexyl prostaglandin analogs as EP4-receptor agonists 有权
标题翻译：环己基前列腺素类似物作为EP4-受体激动剂
公开(公告)号：US20050049227A1
公开(公告)日：2005-03-03
申请号：US10652634
申请日：2003-08-28
申请人： David Old , Robert Burk , Thang Dinh
发明人： David Old , Robert Burk , Thang Dinh
IPC分类号： A61K31/557 , A61K31/662 , A61P27/06 , C07C59/90 , C07C69/738 , C07D333/56 , C07D333/62 , C07F9/38 , C07F9/40 , C07F9/6553 , A61K31/66 , A61K31/045 , A61K31/16 , A61K31/18 , A61K31/41
CPC分类号： C07D333/62 , A61K31/557 , A61K31/662 , C07C59/90 , C07C69/738 , C07D333/56 , C07F9/3826 , C07F9/4015 , C07F9/655354
摘要： The invention relates to the use of novel cyclohexyl analogues of E-type prostaglandins as EP4 agonists, in general, and, in particular as ocular hypotensives. The cyclohexyl analogues used in accordance with the invention are represented by the following formula I: wherein the wavy segments represent α or β bond, dashed line represents the presence or absence of a bond W, Y, Z, R, R1, R2 and R3 are as defined in the specification.
摘要翻译：本发明涉及E型前列腺素的新型环己基类似物通常用作EP4激动剂，特别是作为眼低血糖剂。根据本发明使用的环己基类似物由下式I表示：其中波浪段表示α或β键，虚线表示W，Y，Z，R，R 1， R 2和R 3如说明书中所定义。

5. 发明授权

US07053056B2 C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases 有权
公开(公告)号：US07053056B2
公开(公告)日：2006-05-30
申请号：US09765105
申请日：2001-01-16
申请人： Donald S. Karanewsky , Robert J. Ternansky , Steven D. Linton , Thang Dinh
发明人： Donald S. Karanewsky , Robert J. Ternansky , Steven D. Linton , Thang Dinh
IPC分类号： C07K5/06
CPC分类号： C07D295/185 , C07B2200/07 , C07C237/22 , C07C317/50 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2603/74 , C07D295/135 , C07F9/3264
摘要： This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.

6. 发明申请

US20120186785A1 HEAT PIPE SYSTEM HAVING COMMON VAPOR RAIL FOR USE IN A VENTILATION SYSTEM 审中-公开
标题翻译：具有常用蒸汽轮的热管系统用于通风系统
公开(公告)号：US20120186785A1
公开(公告)日：2012-07-26
申请号：US13247714
申请日：2011-09-28
申请人： Khanh Dinh , Thang Dinh
发明人： Khanh Dinh , Thang Dinh
IPC分类号： F28D15/02
CPC分类号： F28D15/0266 , F24F12/002 , F24F12/003 , F28D15/0275 , F28D15/06 , F28D21/0014 , F28D2015/0216 , F28F1/32 , F28F2210/10 , Y02B30/563
摘要： A heat transfer system is adapted for transferring heat between two different ducts in a ventilation system. The system has a heat pipe having a plurality of conduits. Each conduit including an evaporator section extending laterally from a first open end of the respective conduit, a condenser section extending laterally from a second open end of the respective conduit, and a liquid return section. The liquid return section of at least one conduit being distinct from the liquid return section of another of the conduits. A common vapor manifold is in fluid communication with and extends between the first and second open ends of each of said plurality of conduits so vapors produced in the evaporator sections can flow from the first open ends through the common vapor manifold to the second open ends without flowing through the conduits.
摘要翻译：传热系统适于在通风系统中的两个不同管道之间传递热量。该系统具有多个导管的热管。每个导管包括从相应管道的第一开口端横向延伸的蒸发器部分，从相应导管的第二开口端横向延伸的冷凝器部分和液体返回部分。至少一个导管的液体返回部分不同于另一导管的液体返回部分。常见的蒸汽歧管与所述多个管道中的每一个的第一和第二开口端流体连通并且在其中延伸，因此在蒸发器部分中产生的蒸汽可以从第一开放端流过共同蒸气歧管至第二开口端，而没有流经管道。

7. 发明授权

US07183260B2 C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases 有权
标题翻译： C末端修饰的oxamyl二肽作为ICE / ced-3家族半胱氨酸蛋白酶的抑制剂
公开(公告)号：US07183260B2
公开(公告)日：2007-02-27
申请号：US10926800
申请日：2004-08-25
申请人： Donald S Karanewsky , Robert J Ternansky , Steven D Linton , Thang Dinh
发明人： Donald S Karanewsky , Robert J Ternansky , Steven D Linton , Thang Dinh
IPC分类号： C07K5/06
CPC分类号： C07D295/185 , C07B2200/07 , C07C237/22 , C07C317/50 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2603/74 , C07D295/135 , C07F9/3264
摘要： This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
摘要翻译：本发明涉及新型牛磺酰二肽ICE / ced-3家族抑制剂化合物。本发明还涉及含有这些化合物的药物组合物，以及这些组合物在治疗患有炎症，自身免疫和神经变性疾病的患者中的用途，用于预防缺血性损伤以及用于保护进行移植手术。

8. 发明申请

US20050020504A1 C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases 有权
标题翻译： C末端修饰的oxamyl二肽作为ICE / ced-3家族半胱氨酸蛋白酶的抑制剂
公开(公告)号：US20050020504A1
公开(公告)日：2005-01-27
申请号：US10926800
申请日：2004-08-25
申请人： Donald Karanewsky , Robert Ternansky , Steven Linton , Thang Dinh
发明人： Donald Karanewsky , Robert Ternansky , Steven Linton , Thang Dinh
IPC分类号： C07D307/33 , A61K31/341 , A61K38/00 , A61K38/05 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P7/04 , A61P7/06 , A61P9/10 , A61P11/00 , A61P13/12 , A61P17/02 , A61P17/12 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/20 , A61P37/00 , A61P37/02 , A61P43/00 , C07C237/12 , C07C237/22 , C07C317/50 , C07D295/135 , C07D295/185 , C07F9/32 , C07K5/023 , C07K5/06
CPC分类号： C07D295/185 , C07B2200/07 , C07C237/22 , C07C317/50 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2603/74 , C07D295/135 , C07F9/3264
摘要： This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
摘要翻译：本发明涉及新型牛磺酰二肽ICE / ced-3家族抑制剂化合物。本发明还涉及含有这些化合物的药物组合物，以及这些组合物在治疗患有炎症，自身免疫和神经变性疾病的患者中的用途，用于预防缺血性损伤以及用于保护进行移植手术。

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