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1. 发明授权

US07541577B2 Methods for analyzing ion mobility data 有权
标题翻译：分析离子迁移率数据的方法
公开(公告)号：US07541577B2
公开(公告)日：2009-06-02
申请号：US11426442
申请日：2006-06-26
申请人： David Michael Davenport , Thomas Paul Repoff , Pierino Gianni Bonanni , Richard Louis Zinser
发明人： David Michael Davenport , Thomas Paul Repoff , Pierino Gianni Bonanni , Richard Louis Zinser
IPC分类号： H01J49/04
CPC分类号： G01N27/622
摘要： Disclosed herein are methods for analyzing ion mobility data. In one embodiment, a method for analyzing ion mobility spectrometry data is disclosed. The method comprises conducting a number of ion mobility scans on a sample, generating an ion map comprising a first ion line, comparing the first ion line to a standard deviation, wherein the standard deviation is calculated from the system measurement noise, and determining if the sample is a contraband substance.
摘要翻译：本文公开了分析离子迁移率数据的方法。在一个实施方案中，公开了一种分析离子迁移谱分析数据的方法。该方法包括对样品进行多次离子迁移扫描，产生包括第一离子线的离子图，将第一离子线与标准偏差进行比较，其中根据系统测量噪声计算标准偏差，并确定是否样品是违禁品。

2. 发明申请

US20080067341A1 Methods for Analyzing Ion Mobility Data 有权
标题翻译：离子迁移率数据分析方法
公开(公告)号：US20080067341A1
公开(公告)日：2008-03-20
申请号：US11426442
申请日：2006-06-26
申请人： David Michael Davenport , Thomas Paul Repoff , Pierino Gianni Bonanni , Richard Louis Zinser
发明人： David Michael Davenport , Thomas Paul Repoff , Pierino Gianni Bonanni , Richard Louis Zinser
IPC分类号： H01J49/40
CPC分类号： G01N27/622
摘要： Disclosed herein are methods for analyzing ion mobility data. In one embodiment, a method for analyzing ion mobility spectrometry data is disclosed. The method comprises conducting a number of ion mobility scans on a sample, generating an ion map comprising a first ion line, comparing the first ion line to a standard deviation, wherein the standard deviation is calculated from the system measurement noise, and determining if the sample is a contraband substance.
摘要翻译：本文公开了分析离子迁移率数据的方法。在一个实施方案中，公开了一种分析离子迁移谱分析数据的方法。该方法包括对样品进行多次离子迁移扫描，产生包括第一离子线的离子图，将第一离子线与标准偏差进行比较，其中根据系统测量噪声计算标准偏差，并确定是否样品是违禁品。

3. 发明申请

US20110091081A1 METHOD AND SYSTEM FOR ANALYZING THE EXPRESSION OF BIOMARKERS IN CELLS IN SITU IN THEIR TISSUE OF ORIGIN 审中-公开
标题翻译：用于分析生物标志物在其原始组织中的表达的方法和系统
公开(公告)号：US20110091081A1
公开(公告)日：2011-04-21
申请号：US12580651
申请日：2009-10-16
申请人： Brion Daryl Sarachan , Thomas Paul Repoff , Colin Craig McCulloch , Fiona Mary Ginty , Megan Pearl Rothney , Zhengyu Pang
发明人： Brion Daryl Sarachan , Thomas Paul Repoff , Colin Craig McCulloch , Fiona Mary Ginty , Megan Pearl Rothney , Zhengyu Pang
IPC分类号： G06K9/00 , C12Q1/02 , C12Q1/68 , G06F19/00
CPC分类号： C12Q1/6881 , G01N33/5023 , G01N33/5082 , G06T7/11 , G06T7/174 , G06T2207/10056 , G06T2207/20221 , G06T2207/30024
摘要： The present application discloses a technique for obtaining and storing data on expression of multiple biomarkers in individual cells or the compartments of individual cells in a tissue specimen and methods of utilizing that data to create groups, the members of which share some degree of similarity greater than the general population from which the data is drawn, by an analysis of digital images of a portion of the tissue specimen which has been iteratively stained to generate optical signals, typically fluorescent, reflective of the amount of each of the biomarkers examined. The analysis of the images involves a segmentation routine whereby each pixel of the examined images is assigned to an individual cell or a compartment of an individual cell, the intensity of the signal representative of each biomarker is measured for each pixel, a dataset is created in which each cell or compartments of each cell is associated with a signal intensity for each biomarker examined, and the dataset is interrogated with appropriate numerical tools to create groups. It also discloses the display of such groups on images of the tissue examined such that the individual cells belonging to a particular group are marked or indicated on one of the images examined. It further discloses examining the biomarker data for each group for possible association with a biological condition or process in cases in which tissue specimens drawn from different subjects or different portions of the tissue of a subject have been examined. It also discloses using this examination in the diagnoses, prognoses or assessment of the response to therapy of a condition or disease.
摘要翻译：本申请公开了一种用于获得和存储组织样本中个体细胞或个体细胞的多个生物标志物表达的数据的技术，以及利用该数据创建组的方法，其成员具有一定程度的相似性，大于通过对经过迭代染色以产生光信号的组织标本的一部分的数字图像的分析，通常是荧光的，反映了所检查的每个生物标志物的量，绘制数据的一般群体。图像的分析涉及分割程序，其中检查的图像的每个像素被分配给单个单元的单个单元或隔室，针对每个像素测量代表每个生物标志物的信号的强度，数据集被创建在每个细胞的每个细胞或隔室与所检测的每个生物标志物的信号强度相关联，并且用适当的数值工具询问数据集以产生组。它还公开了在所检查的组织的图像上显示这样的组，使得属于特定组的各个细胞在所检查的图像之一上被标记或指示。它还公开了在从受试者的不同受试者或组织的不同部分抽取的组织标本已经被检查的情况下，检查每组的生物标志物数据与生物学条件或过程的可能关联。它还公开了在对病症或疾病的治疗反应的诊断，预后或评估中使用该检查。

4. 发明授权

US06834256B2 Method and system for determining motor reliability 有权
标题翻译：确定电机可靠性的方法和系统
公开(公告)号：US06834256B2
公开(公告)日：2004-12-21
申请号：US10231084
申请日：2002-08-30
申请人： Michael Brynn House , Gregory Lee Flickinger , Calvin Thomas Fritz , Hunt Adams Sutherland , Thomas Paul Repoff
发明人： Michael Brynn House , Gregory Lee Flickinger , Calvin Thomas Fritz , Hunt Adams Sutherland , Thomas Paul Repoff
IPC分类号： G06F1900
CPC分类号： G01R31/343 , H02P29/02
摘要： The reliability and remaining time before failure for electric motor systems and the like is determined with an ascertained statistical confidence based on continually monitored system parameters and a database comprised of historical failure mode/cause and repair data concerning the same motor and/or similar motor systems. A computational process is followed that relies upon hierarchical failure-tree structures, Weibull probability distributions and directed causal networks and which updates the probabilities and models used to forecast the remaining time before system failure based on the monitored parameters. Motor system operational parameter data is continually monitored at the site of the motor system and up-loaded via wireless or other communications network to a remote computer system where a database is maintained and reliability analysis is performed.
摘要翻译：基于持续监视的系统参数确定的确定的统计置信度的确定电动机系统故障之前的可靠性和剩余时间，以及包括关于相同电动机和/或类似电动机系统的历史故障模式/原因和修理数据的数据库。遵循计算过程，依赖于分层故障树结构，威布尔概率分布和有向因果网络，并且基于所监视的参数更新用于在系统故障之前预测剩余时间的概率和模型。电机系统运行参数数据在电机系统现场不断监测，并通过无线或其他通信网络上载到维护数据库的远程计算机系统，并进行可靠性分析。

5. 发明申请

US20120158640A1 METHOD AND SYSTEM FOR CREATING A DYNAMIC SYSTEMS BASED HYBRID MODEL FOR REASONING SYSTEMS 有权
标题翻译：用于创建基于动态系统的用于推理系统的混合模型的方法和系统
公开(公告)号：US20120158640A1
公开(公告)日：2012-06-21
申请号：US12971332
申请日：2010-12-17
申请人： Paul Venditti , Thomas Paul Repoff , Michael Craig Clark
发明人： Paul Venditti , Thomas Paul Repoff , Michael Craig Clark
IPC分类号： G06N5/02
CPC分类号： G06N5/04
摘要： A method for creating a dynamic systems based hybrid model for reasoning systems is described. The method receives, at a server, a plurality of expert identified deal attributes. The method presents a conjoint analysis questionnaire for input by one or more respondents. The conjoint analysis questionnaire includes questions based on the plurality of expert identified deal attributes. The method receives responses of the one or more respondents to the conjoint analysis questionnaire. The method then defines an expert reasoning model based on the responses of the one or more respondents to the conjoint analysis questionnaire. The method accesses historical deal information of one or more deals, the historical deal information including one or more deals, each deal including a plurality of expert identified deal attributes and a part-worth associated with each of the deal attributes. Finally, the method validates the expert reasoning model based on the historical deal information.
摘要翻译：描述了一种用于为推理系统创建基于动态系统的混合模型的方法。该方法在服务器处接收多个专家识别的交易属性。该方法提供了一个或多个受访者输入的联合分析问卷。联合分析问卷包括基于多个专家识别的交易属性的问题。该方法接收一个或多个受访者对联合分析问卷的回复。然后，该方法基于一个或多个受访者对联合分析问卷的响应来定义专家推理模型。该方法访问一个或多个交易的历史交易信息，历史交易信息包括一个或多个交易，每个交易包括多个专家识别交易属性和与每个交易属性相关联的零件价值。最后，该方法根据历史交易信息验证了专家推理模型。

6. 发明授权

US08533147B2 Method and system for creating a dynamic systems based hybrid model for reasoning systems 有权
标题翻译：用于为推理系统创建基于动态系统的混合模型的方法和系统
公开(公告)号：US08533147B2
公开(公告)日：2013-09-10
申请号：US12971332
申请日：2010-12-17
申请人： Paul Venditti , Thomas Paul Repoff , Michael Craig Clark
发明人： Paul Venditti , Thomas Paul Repoff , Michael Craig Clark
IPC分类号： G06F17/00 , G06N7/00
CPC分类号： G06N5/04
摘要： A method for creating a dynamic systems based hybrid model for reasoning systems is described. The method receives, at a server, a plurality of expert identified deal attributes. The method presents a conjoint analysis questionnaire for input by one or more respondents. The conjoint analysis questionnaire includes questions based on the plurality of expert identified deal attributes. The method receives responses of the one or more respondents to the conjoint analysis questionnaire. The method then defines an expert reasoning model based on the responses of the one or more respondents to the conjoint analysis questionnaire. The method accesses historical deal information of one or more deals, the historical deal information including one or more deals, each deal including a plurality of expert identified deal attributes and a part-worth associated with each of the deal attributes. Finally, the method validates the expert reasoning model based on the historical deal information.
摘要翻译：描述了一种用于为推理系统创建基于动态系统的混合模型的方法。该方法在服务器处接收多个专家识别的交易属性。该方法提供了一个或多个受访者输入的联合分析问卷。联合分析问卷包括基于多个专家识别的交易属性的问题。该方法接收一个或多个受访者对联合分析问卷的回复。然后，该方法基于一个或多个受访者对联合分析问卷的响应来定义专家推理模型。该方法访问一个或多个交易的历史交易信息，历史交易信息包括一个或多个交易，每个交易包括多个专家识别交易属性和与每个交易属性相关联的零件价值。最后，该方法根据历史交易信息验证了专家推理模型。

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