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1. 发明申请

US20060172323A1 Identification of compounds that modify transcriptional responses to hypoxia 审中-公开
标题翻译：鉴定修饰缺氧转录反应的化合物
公开(公告)号：US20060172323A1
公开(公告)日：2006-08-03
申请号：US11261834
申请日：2005-10-28
申请人： David Livingston , Andrew Kung , Shoumo Bhattacharya
发明人： David Livingston , Andrew Kung , Shoumo Bhattacharya
IPC分类号： C12Q1/68 , G01N33/53 , A61K38/17
CPC分类号： G01N33/5023 , A61K49/0008
摘要： The invention provides methods for identifying compounds that can be used to modify transcriptional responses to hypoxia, and use of such compounds in therapeutic and diagnostic methods.
摘要翻译：本发明提供了用于鉴定可用于修饰对缺氧的转录反应的化合物的方法，以及在治疗和诊断方法中使用这些化合物。

2. 发明申请

US20090023157A1 Proteome epitope tags and methods of use thereof in protein modification analysis 失效
标题翻译：蛋白质组表位标签及其在蛋白质修饰分析中的应用方法
公开(公告)号：US20090023157A1
公开(公告)日：2009-01-22
申请号：US12154664
申请日：2008-05-23
申请人： Frank D. Lee , Xun Meng , David Livingston
发明人： Frank D. Lee , Xun Meng , David Livingston
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： B82Y5/00 , B82Y10/00 , C12Q1/26 , C12Q1/34 , C12Q1/48 , C12Q1/485 , G01N33/6803 , G01N33/6842
摘要： Disclosed are methods for reliably detecting the presence of proteins, especially proteins with various post-translational modifications (phosphorylation, glycosylation, methylation, acetylation, etc.) in a sample by the use of one or more capture agents that recognize and interact with recognition sequences uniquely characteristic of a set of proteins (Proteome Epitope Tags, or PETs) in the sample. Arrays comprising these capture agents or PETs are also provided.
摘要翻译：公开了通过使用一种或多种识别并与识别序列相互作用的捕获剂来可靠地检测样品中存在蛋白质，特别是具有各种翻译后修饰（磷酸化，糖基化，甲基化，乙酰化等）的蛋白质的方法的方法样品中一组蛋白质（Proteome Epitope Tags，或PET）的独特特征。还提供了包含这些捕获剂或PET的阵列。

3. 发明申请

US20060292099A1 Treatment of eye disorders with sirtuin modulators 审中-公开
标题翻译：用sirtuin调节剂治疗眼部疾病
公开(公告)号：US20060292099A1
公开(公告)日：2006-12-28
申请号：US11440584
申请日：2006-05-24
申请人： Michael Milburn , Christoph Westphal , David Livingston , Peter Elliott , Philip Lambert , Karl Normington
发明人： Michael Milburn , Christoph Westphal , David Livingston , Peter Elliott , Philip Lambert , Karl Normington
IPC分类号： A61K8/00
CPC分类号： A61K9/0019 , A61K9/0024 , A61K9/0048 , A61K9/0056 , A61K31/724 , A61K38/13 , A61K45/06 , A61K47/40 , A61K2300/00
摘要： Sirtuin modulators, particularly sirtuin activators, are useful in treating vision impairment. In general, the sirtuin modulators inhibit the progression of vision impairment resulting from various eye disorders. The invention also includes pharmaceutically acceptable formulations of sirtuin modulators, particular ophthalmically acceptable formulations.
摘要翻译： Sirtuin调节剂，特别是sirtuin激活剂，可用于治疗视力障碍。通常，沉默调节蛋白调节剂抑制由各种眼睛疾病引起的视力障碍的进展。本发明还包括Sirtuin调节剂的药学上可接受的制剂，特别是眼用可接受的制剂。

4. 发明授权

US5658784A Nucleic acid encoding transcription factor p300 and uses of p300 失效
标题翻译：编码转录因子p300的核酸和p300的用途
公开(公告)号：US5658784A
公开(公告)日：1997-08-19
申请号：US227536
申请日：1994-04-14
申请人： Richard Eckner , Mark Ewen , David Livingston
发明人： Richard Eckner , Mark Ewen , David Livingston
IPC分类号： C07K14/47 , C07K16/18 , C12Q1/68 , G01N33/574 , C07H21/04
CPC分类号： C12Q1/6897 , C07K14/4702 , C07K16/18 , G01N33/57496 , G01N2333/075 , G01N2333/47 , G01N2333/4703
摘要： The invention features an isolated nucleic acid hybridizable with the complement of the coding strand nucleic acid sequence presented in SEQ ID NO:1, and encoding a protein that is necessary for adenovirus transformation of a mammalian cell. The encoded protein, p300, cooperates with adenovirus E1A (Early-region 1A) proteins to establish the transformed state.
摘要翻译：本发明的特征在于可与SEQ ID NO：1中提供的编码链核酸序列的互补序列杂交的分离的核酸，并编码哺乳动物细胞的腺病毒转化所必需的蛋白质。编码的蛋白质p300与腺病毒E1A（早期1A区）蛋白质配合以建立转化状态。

5. 发明授权

US07964362B2 Proteome epitope tags and methods of use thereof in protein modification analysis 失效
标题翻译：蛋白质组表位标签及其在蛋白质修饰分析中的应用方法
公开(公告)号：US07964362B2
公开(公告)日：2011-06-21
申请号：US12154664
申请日：2008-05-23
申请人： Frank D. Lee , Xun Meng , David Livingston
发明人： Frank D. Lee , Xun Meng , David Livingston
IPC分类号： G01N33/53
CPC分类号： B82Y5/00 , B82Y10/00 , C12Q1/26 , C12Q1/34 , C12Q1/48 , C12Q1/485 , G01N33/6803 , G01N33/6842
摘要： Disclosed are methods for reliably detecting the presence of proteins, especially proteins with various post-translational modifications (phosphorylation, glycosylation, methylation, acetylation, etc.) in a sample by the use of one or more capture agents that recognize and interact with recognition sequences uniquely characteristic of a set of proteins (Proteome Epitope Tags, or PETs) in the sample. Arrays comprising these capture agents or PETs are also provided.
摘要翻译：公开了通过使用一种或多种识别并与识别序列相互作用的捕获剂来可靠地检测样品中存在蛋白质，特别是具有各种翻译后修饰（磷酸化，糖基化，甲基化，乙酰化等）的蛋白质的方法的方法样品中一组蛋白质（Proteome Epitope Tags，或PET）的独特特征。还提供了包含这些捕获剂或PET的阵列。

6. 发明授权

US07493903B2 Adjustable hair holding device 有权
标题翻译：可调头发夹持装置
公开(公告)号：US07493903B2
公开(公告)日：2009-02-24
申请号：US10763846
申请日：2004-01-23
申请人： Bruce A. Rogers , David Livingston
发明人： Bruce A. Rogers , David Livingston
IPC分类号： A45D8/20
CPC分类号： A45D8/22
摘要： A hair holding device including hingedly connected first and second body members each including hair gripping portions adapted to be squeezed by a user whereby the hair gripping portions come into contact with gathered strands of a user's hair. The device further includes a friction-type adjustment mechanism coaxially arranged with respect to the hinge for causing the hair gripping portions to remain at a point at which the hair gripping portions are squeezed together by a user. Optionally, the device may include squeezable release handles or other release mechanism, as well as a torsion spring for biasing the hair gripping portions into either an open or a closed position.
摘要翻译：一种头发保持装置，包括铰接地连接的第一和第二主体部件，每个主体部件包括适于被使用者挤压的头发夹持部分，由此毛发夹持部分与用户头发的聚集的股线接触。该装置还包括相对于铰链同轴布置的摩擦式调节机构，用于使头发夹持部分保持在使用者将头发夹持部分挤压在一起的点处。可选地，该装置可以包括可挤压释放手柄或其它释放机构，以及用于将头发夹持部分偏压到打开或关闭位置的扭转弹簧。

7. 发明申请

US20080039449A1 Inhibitors of interleukin-1beta converting enzyme 失效
标题翻译：白细胞介素-1β转换酶抑制剂
公开(公告)号：US20080039449A1
公开(公告)日：2008-02-14
申请号：US11655938
申请日：2007-01-18
申请人： Mark Batchelor , David Bebbington , Guy Bemis , Wolf Fridman , Roger Gillespie , Julian Golec , David Lauffer , David Livingston , Saroop Matharu , Michael Mullican , Mark Murcko , Robert Murdoch , Robert Zelle
发明人： Mark Batchelor , David Bebbington , Guy Bemis , Wolf Fridman , Roger Gillespie , Julian Golec , David Lauffer , David Livingston , Saroop Matharu , Michael Mullican , Mark Murcko , Robert Murdoch , Robert Zelle
IPC分类号： A61K31/551 , A61K31/55 , A61P17/06 , A61P19/02 , A61P3/00 , A61P31/00 , A61P37/00 , C07D243/02 , C07D243/12 , C07D255/04
CPC分类号： C07D243/12 , A61K38/00 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07K5/0202 , C07K5/06139 , C07K5/0821
摘要： The present invention relates to novel classes of compounds which are inhibitors of interleukin-1β converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against IL-1-, apoptosis-, IGIF-, and IFN-γ-mediated diseases, inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, degenerative diseases, and necrotic diseases. This invention also relates to methods for inhibiting ICE activity, for treating interleukin-1-, apoptosis-, IGIF- and IFN-γ-mediated diseases and decreasing IGIF and IFN-γ production using the compounds and compositions of this invention. This invention also relates to methods for preparing-N-acylamino compounds.
摘要翻译：本发明涉及作为白细胞介素-1β转换酶抑制剂的新型化合物。本发明的ICE抑制剂的特征在于具体的结构和物理化学特征。本发明还涉及包含这些化合物的药物组合物。本发明的化合物和药物组合物特别适用于抑制ICE活性，因此可有利地用作抗IL-1，细胞凋亡，IGIF和IFN-γ介导的疾病，炎性疾病，自身免疫性疾病破坏性骨病，增殖性疾病，感染性疾病，退行性疾病和坏死性疾病。本发明还涉及使用本发明的化合物和组合物来抑制ICE活性，治疗白细胞介素-1，细胞凋亡，IGIF-和IFN-γ介导的疾病以及减少IGIF和IFN-γ产生的方法。本发明还涉及N-酰基氨基化合物的制备方法。

8. 发明申请

US20060204531A1 Robotic pest removal system 有权
标题翻译：机器人除虫系统
公开(公告)号：US20060204531A1
公开(公告)日：2006-09-14
申请号：US11374440
申请日：2006-03-13
申请人： James Squire , David Livingston , Daniel Sonenshine , Dennis Crump , Glenn Hammond , Justin Woulfe , Gerald Sullivan
发明人： James Squire , David Livingston , Daniel Sonenshine , Dennis Crump , Glenn Hammond , Justin Woulfe , Gerald Sullivan
IPC分类号： A01N25/00 , A01N65/00 , G06F15/18 , A01M13/00
CPC分类号： A01M5/06 , A01M1/02 , A01M1/023 , A01M1/145 , A01M1/20 , A01M2200/011
摘要： An autonomous robotic system and method for removing pests from a specific location. The robotic system of the invention preferably comprises a means for attracting pests to at least one specific location; and a robotic means for collecting and/or exterminating pests attracted to the specified location. In certain embodiments, the robotic means comprises a mobile robot and a means for navigating the robotic means. In operation, pests are attracted to at least one location by an attracting means, and these pests are then collected and/or exterminated by a mobile, autonomous robot of the invention.
摘要翻译：一种用于从特定位置去除害虫的自主机器人系统和方法。本发明的机器人系统优选地包括用于将害虫吸引到至少一个特定位置的装置; 以及吸引到指定地点的害虫的收集和/或灭绝的机器人装置。在某些实施例中，机器人装置包括移动机器人和用于导航机器人装置的装置。在操作中，害虫通过吸引手段被吸引到至少一个位置，然后这些害虫被本发明的移动的自主机器人收集和/或消灭。

9. 发明申请

US20050143436A1 Inhibitors of interleukin-1beta converting enzyme 审中-公开
标题翻译：白细胞介素-1β转换酶抑制剂
公开(公告)号：US20050143436A1
公开(公告)日：2005-06-30
申请号：US10999865
申请日：2004-11-29
申请人： Mark Batchelor , David Bebbington , Guy Bemis , Wolf Fridman , Roger Gillespie , Julian Golec , David Lauffer , David Livingston , Saroop Matharu , Michael Mullican , Mark Murcko , Robert Murdoch , Robert Zelle
发明人： Mark Batchelor , David Bebbington , Guy Bemis , Wolf Fridman , Roger Gillespie , Julian Golec , David Lauffer , David Livingston , Saroop Matharu , Michael Mullican , Mark Murcko , Robert Murdoch , Robert Zelle
IPC分类号： C07D243/12 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/675 , A61K38/00 , A61K38/04 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/55 , A61P13/12 , A61P19/08 , A61P19/10 , A61P25/00 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/04 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D243/10 , C07D243/14 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D473/00 , C07D487/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00 , C07F9/645 , C07F9/6561 , C07K5/02 , C07K5/023 , C07K5/06 , C07K5/078 , C07K5/097 , A61K31/41 , A61K31/195
CPC分类号： C07D243/12 , A61K38/00 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07K5/0202 , C07K5/06139 , C07K5/0821
摘要： The present invention relates to novel classes of compounds which are inhibitors of interleukin-1β converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against IL-1-, apoptosis-, IGIF-, and IFN-γ-mediated diseases, inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, degenerative diseases, and necrotic diseases. This invention also relates to methods for inhibiting ICE activity, for treating interleukin-1-, apoptosis-, IGIF- and IFN-γ-mediated diseases and decreasing IGIF and IFN-γ production using the compounds and compositions of this invention. This invention also relates to methods for preparing N-acylamino compounds.
摘要翻译：本发明涉及作为白细胞介素-1β转换酶抑制剂的新型化合物。本发明的ICE抑制剂的特征在于具体的结构和物理化学特征。本发明还涉及包含这些化合物的药物组合物。本发明的化合物和药物组合物特别适用于抑制ICE活性，因此可有利地用作抗IL-1，细胞凋亡，IGIF和IFN-γ介导的疾病，炎性疾病，自身免疫性疾病破坏性骨病，增殖性疾病，感染性疾病，退行性疾病和坏死性疾病。本发明还涉及使用本发明的化合物和组合物来抑制ICE活性，治疗白细胞介素-1，细胞凋亡，IGIF-和IFN-γ介导的疾病以及减少IGIF和IFN-γ产生的方法。本发明还涉及制备N-酰基氨基化合物的方法。

10. 发明授权

US08486648B2 Methods of detecting ovarian cancer 有权
标题翻译：检测卵巢癌的方法
公开(公告)号：US08486648B2
公开(公告)日：2013-07-16
申请号：US11883103
申请日：2006-02-16
申请人： David Livingston , Ronny Drapkin
发明人： David Livingston , Ronny Drapkin
IPC分类号： C12Q1/00 , G01N1/00 , G01N21/00 , G01N21/75 , G01N33/00 , G01N33/48 , G01N33/53 , G01N33/567 , G01N33/574
CPC分类号： G01N33/57449 , G01N33/57411 , G01N33/57442 , Y10T436/25
摘要： The present invention provides methods of detecting ovarian cancer using biomarkers.
摘要翻译：本发明提供使用生物标志物检测卵巢癌的方法。

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