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1. 发明授权

US4851426A Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids and pharmaceutical compositions thereof 失效
标题翻译：非甾族抗炎羧酸的乙氧基羰氧基乙酯及其药物组合物
公开(公告)号：US4851426A
公开(公告)日：1989-07-25
申请号：US810393
申请日：1986-02-12
申请人： David Ladkani , Haim Yellin , Ben Z. Weiner , David Avnir
发明人： David Ladkani , Haim Yellin , Ben Z. Weiner , David Avnir
IPC分类号： A61K31/22 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/405 , A61P25/04 , A61P29/00 , C07C67/00 , C07C68/06 , C07C69/96 , C07C209/74 , C07C211/56 , C07C229/38 , C07C229/58 , C07C313/00 , C07C317/44 , C07D207/32 , C07D207/337 , C07D209/26 , C07D209/28
CPC分类号： C07C68/06 , A61K31/22 , C07C229/38 , C07C229/58 , C07C69/96 , C07D207/337 , C07D209/26 , C07D209/28
摘要： Novel esters of the general formula ##STR1## in which ##STR2## is the acyl residue of a non-steroidal anti-inflammatory compound containing a carboxylic acid function. The novel esters are prepared by reacting an acide R--COOH when R is as above, with 1-haloethyl ethyl carbonate. There are also provided pharmaceutical compositions containing any of the said novel esters.
摘要翻译：新颖的通式（I）的酯，其中是含有羧酸官能团的非甾族抗炎化合物的酰基残基。当R如上所述时，通过使酰基R-COOH与1-卤代乙基碳酸乙酯反应来制备新的酯。还提供含有任何所述新型酯的药物组合物。

2. 发明申请

US20130039964A1 METAL ENTRAPPED BIOACTIVE COMPOSITES 有权
标题翻译：金属生物活性复合材料
公开(公告)号：US20130039964A1
公开(公告)日：2013-02-14
申请号：US13643247
申请日：2011-04-26
申请人： David Avnir , Rachel Ben-Knaz , Rami Pedahzur
发明人： David Avnir , Rachel Ben-Knaz , Rami Pedahzur
IPC分类号： A61K9/00 , A01P1/00 , A01P3/00 , A61P31/04 , A01N37/52 , A61P31/10 , A61P25/00 , A61P17/00 , A61K31/155 , A01N25/08 , A61P31/12
CPC分类号： A61K31/155 , A61K33/34 , A61K33/38 , A61K45/06 , A61L2/00 , B01J31/12 , C02F1/50 , C02F1/505 , C08K9/10 , A61K2300/00
摘要： The present invention provides composites comprising at least one bioactive agent entrapped within a matrix of at least one metal; wherein said composite controllably releases at least one of said bioactive agent and metal or ion thereof, processes for the preparation of composites of the invention, compositions and products comprising composites of the invention and various uses thereof.
摘要翻译：本发明提供复合材料，其包含截留在至少一种金属的基体内的至少一种生物活性剂; 其中所述复合物可控地释放所述生物活性剂和金属或其离子中的至少一种，制备本发明复合材料的方法，包含本发明复合材料的组合物和产品及其各种用途。

3. 发明申请

US20120015014A1 COMPOSITION EXHIBITING ENHANCED FORMULATION STABILITY AND DELIVERY OF TOPICAL ACTIVE INGREDIENTS 有权
标题翻译：组合物展示增强配方稳定性和局部活性成分的输送
公开(公告)号：US20120015014A1
公开(公告)日：2012-01-19
申请号：US13243189
申请日：2011-09-23
申请人： Noa LAPIDOT , Shlomo Magdassi , David Avnir , Claudi Rottman , Orit Gans , Alon Seri-Levy
发明人： Noa LAPIDOT , Shlomo Magdassi , David Avnir , Claudi Rottman , Orit Gans , Alon Seri-Levy
IPC分类号： A61K9/50 , A61K31/327 , A61P3/02 , A61Q19/00 , A61K31/07 , A61K8/67 , A61K8/38 , A61K8/11 , A61P17/10
CPC分类号： A61K8/042 , A61K8/11 , A61K8/25 , A61K8/37 , A61K8/38 , A61K8/602 , A61K8/671 , A61K9/501 , A61K9/5031 , A61K9/5115 , A61K9/5138 , A61K2800/412 , A61K2800/75 , A61Q1/00 , A61Q5/02 , A61Q5/12 , A61Q11/00 , A61Q17/04 , A61Q19/00 , B82Y5/00 , Y10S514/844 , Y10S514/937 , Y10S514/944 , Y10S514/945
摘要： A therapeutic, cosmetic or cosmeceutic composition for topical application, capable of stabilizing an active ingredient and delivering the active ingredient, comprising a plurality of microcapsules having a core-shell structure. The microcapsules have a diameter of approximately 0.1 to 100 micron. The core of each microcapsule includes at least one active ingredient, and is encapsulated within a microcapsular shell. The shell is comprised of at least one inorganic polymer obtained by a sol-gel process, and the shell protects the active ingredient before topical application and is designed to release the active ingredient from the microcapsules following application. The composition is useful in encapsulating active ingredients, such as benzoyl peroxide, that are unstable in other formulation, or are irritating to the skin.
摘要翻译：一种用于局部施用的治疗性，化妆品或药妆组合物，其能够稳定活性成分并递送活性成分，其包含多个具有核 - 壳结构的微胶囊。微胶囊的直径约为0.1至100微米。每个微胶囊的核心包含至少一种活性成分，并被包封在微胶囊壳内。壳由至少一种通过溶胶 - 凝胶法获得的无机聚合物组成，并且外壳在局部施用之前保护活性成分，并被设计成在施用后从微胶囊中释放活性成分。该组合物可用于包封在其它制剂中不稳定或对皮肤有刺激性的活性成分，例如过氧化苯甲酰。

4. 发明授权

US06303149B1 Method for the preparation of oxide microcapsules loaded with functional molecules and the products obtained thereof 有权
标题翻译：制备负载有功能分子的氧化物微胶囊的方法及其获得的产品
公开(公告)号：US06303149B1
公开(公告)日：2001-10-16
申请号：US09372176
申请日：1999-08-11
申请人： Shlomo Magdassi , David Avnir , Alon Seri-Levy , Noa Lapidot , Claudio Rottman , Yoram Sorek , Orit Gans
发明人： Shlomo Magdassi , David Avnir , Alon Seri-Levy , Noa Lapidot , Claudio Rottman , Yoram Sorek , Orit Gans
IPC分类号： A61K914
CPC分类号： A61K8/042 , A23L27/72 , A61K8/11 , A61K8/35 , A61K8/37 , A61K9/5146 , A61K2800/412 , A61Q17/04 , Y10S514/937 , Y10S514/951 , Y10T428/2984
摘要： The present invention relates to a novel process for preparing sol-gel microcapsules loaded with up to 95% (w/w) functional molecules or substances and to the products obtained by said process. Said process is conducted in two steps: (a) creating an oil-in-water emulsion by emulsification of a water insoluble solution comprising the sol-gel precursors and the molecules to be loaded, in an aqueous solution under appropriate shear forces; (b) mixing and stirring said emulsion with an aqueous solution at a suitably selected pH to obtain loaded sol-gel microcapsules in suspension. The microcapsules so obtained can further be subjected to cycles of isolation and rinsing. Incorporation of the final product, either in the form of a suspension or a powder, in cosmetic formulations affords a transparent cream when applying to skin and has a smooth and pleasant contact.
摘要翻译：本发明涉及一种制备负载高达95％（w / w）功能分子或物质的溶胶 - 凝胶微胶囊以及通过所述方法获得的产品的新方法。所述方法分两步进行：（a）通过在适当的剪切力下在水溶液中乳化包含溶胶 - 凝胶前体和待加载的分子的水不溶性溶液来产生水包油乳液; （b）在适当选择的pH下用水溶液混合和搅拌所述乳液，以得到负载的溶胶 - 凝胶微胶囊悬浮液。如此获得的微胶囊可以进一步进行分离和漂洗的循环。在化妆品配方中以悬浮液或粉末的形式加入最终产品，当应用于皮肤并具有光滑和愉快的接触时，可提供透明的乳膏。

5. 发明授权

US5824526A Doped sol-gel glasses for obtaining chemical interactions 失效
标题翻译：用于获得化学相互作用的掺杂溶胶 - 凝胶玻璃
公开(公告)号：US5824526A
公开(公告)日：1998-10-20
申请号：US667746
申请日：1996-06-21
申请人： David Avnir , Michael Ottolenghi , Sergei Braun , Rivka Zusman
发明人： David Avnir , Michael Ottolenghi , Sergei Braun , Rivka Zusman
IPC分类号： C07K16/00 , B01J20/281 , B01J20/283 , B01J20/291 , C03B8/02 , C03C4/00 , C07K1/14 , C12N11/04 , C12N11/14 , C12P1/00 , C12Q1/00 , G01N21/77 , G01N27/327 , G01N30/02 , G01N30/88 , G01N30/92 , G01N31/22 , G01N33/543 , G01N33/552 , G01N33/68 , G01N33/84 , G01N1/00 , A61K9/50 , B01J13/18
CPC分类号： G01N33/6869 , B01J20/283 , B01J20/291 , C03C4/0007 , C12N11/14 , C12P1/00 , G01N31/22 , G01N33/5436 , G01N33/552 , G01N33/84 , B01J2220/54 , G01N2030/484 , G01N30/02 , G01N30/92 , Y02P20/588 , Y10S514/944 , Y10S514/965 , Y10S530/811 , Y10T428/2989 , Y10T436/10
摘要： A sol-gel glass doped with one or more reagent that provides chemical interactions with diffusible solutes or components in an adjacent liquid or gas phase. The reagent(s), the solutes or the components can be any organic or inorganic compounds or materials of biological origin, including enzymes. The doped sol-gel glass in various forms is useful as an analytical test, chromatographic medium, sensor, catalyst or biocatalyst, electrode or enzyme electrode, and other detection devices.
摘要翻译：掺有一种或多种试剂的溶胶 - 凝胶玻璃，其与相邻液相或气相中的可扩散溶质或组分提供化学相互作用。试剂，溶质或组分可以是任何有机或无机化合物或生物来源的材料，包括酶。各种形式的掺杂溶胶 - 凝胶玻璃可用作分析测试，色谱介质，传感器，催化剂或生物催化剂，电极或酶电极以及其他检测装置。

6. 发明申请

US20100255107A1 COMPOSITION EXHIBITING ENHANCED FORMULATION STABILITY AND DELIVERY OF TOPICAL ACTIVE INGREDIENTS 有权
标题翻译：组合物展示增强配方稳定性和局部活性成分的输送
公开(公告)号：US20100255107A1
公开(公告)日：2010-10-07
申请号：US12818924
申请日：2010-06-18
申请人： Noa Lapidot , Shlomo Magdassi , David Avnir , Claudio Rottman , Orit Gans , Alon Seri-Levy
发明人： Noa Lapidot , Shlomo Magdassi , David Avnir , Claudio Rottman , Orit Gans , Alon Seri-Levy
IPC分类号： A61K9/50 , A61K8/11 , A61K31/235 , A61K8/37 , A61K31/7048 , A61P17/06 , A61P17/10 , A61P29/00 , A61P31/12 , A61P31/04 , A61Q90/00 , A61K8/60
CPC分类号： A61K8/042 , A61K8/11 , A61K8/25 , A61K8/37 , A61K8/38 , A61K8/602 , A61K8/671 , A61K9/501 , A61K9/5031 , A61K9/5115 , A61K9/5138 , A61K2800/412 , A61K2800/75 , A61Q1/00 , A61Q5/02 , A61Q5/12 , A61Q11/00 , A61Q17/04 , A61Q19/00 , B82Y5/00 , Y10S514/844 , Y10S514/937 , Y10S514/944 , Y10S514/945
摘要： A therapeutic, cosmetic or cosmeceutic composition for topical application, capable of stabilizing an active ingredient and delivering the active ingredient, comprising a plurality of microcapsules having a core-shell structure. The microcapsules have a diameter of approximately 0.1 to 100 micron. The core of each microcapsule includes at least one active ingredient, and is encapsulated within a microcapsular shell. The shell is comprised of at least one inorganic polymer obtained by a sol-gel process, and the shell protects the active ingredient before topical application and is designed to release the active ingredient from the microcapsules following application. The composition is useful in encapsulating active ingredients, such as benzoyl peroxide, that are unstable in other formulation, or are irritating to the skin.
摘要翻译：一种用于局部施用的治疗性，化妆品或药妆组合物，其能够稳定活性成分并递送活性成分，其包含多个具有核 - 壳结构的微胶囊。微胶囊的直径约为0.1至100微米。每个微胶囊的核心包含至少一种活性成分，并被包封在微胶囊壳内。壳由至少一种通过溶胶 - 凝胶法获得的无机聚合物组成，并且外壳在局部施用之前保护活性成分，并被设计成在施用后从微胶囊中释放活性成分。该组合物可用于包封在其它制剂中不稳定或对皮肤有刺激性的活性成分，例如过氧化苯甲酰。

7. 发明授权

US07109993B2 Method and system for the automatic computerized audio visual dubbing of movies 有权
公开(公告)号：US07109993B2
公开(公告)日：2006-09-19
申请号：US10279097
申请日：2002-10-24
申请人： Shmuel Peleg , Ran Cohen , David Avnir
发明人： Shmuel Peleg , Ran Cohen , David Avnir
IPC分类号： G06T15/00
CPC分类号： H04N5/222 , G06T9/001 , G11B27/028 , G11B27/034 , G11B27/10 , Y10S345/949
摘要： A method for automated computerized audio visual dubbing of a movie comprises (i) generating a three-dimensional head model of an actor in a movie, the head model being representative of specific facial features of the actor, and (ii) generating a three-dimensional head model of a dubber making target sounds for the actor, the dubber head model being representative of specific facial features of the dubber, as the target sounds are made. The method also comprises modifying at least a portion of the specific facial features of the actor head model according to the dubber head model such that the actor appears to be producing target sounds made by the dubber.

8. 发明授权

US06238650B1 Sunscreen composition containing sol-gel microcapsules 有权
标题翻译：含有溶胶 - 凝胶微胶囊的防晒组合物
公开(公告)号：US06238650B1
公开(公告)日：2001-05-29
申请号：US09318828
申请日：1999-05-26
申请人： Noa Lapidot , Shlomo Magdassi , David Avnir , Claudio Rottman , Orit Gans , Alon Seri-Levy
发明人： Noa Lapidot , Shlomo Magdassi , David Avnir , Claudio Rottman , Orit Gans , Alon Seri-Levy
IPC分类号： A61K742
CPC分类号： A61K8/042 , A61K8/11 , A61K8/25 , A61K8/35 , A61K8/37 , A61K8/40 , A61K8/445 , A61K2800/412 , A61Q17/04 , Y10S514/962
摘要： The present invention generally relates to safe and stable sunscreen compositions comprising of at least one sunscreen active ingredient in the form of an inert sol-gel microcapsules encapsulating ultraviolet absorbing compounds in any acceptable cosmetic vehicle. The composition according to the present invention can comprise several ultraviolet absorbers that may be encapsulated in the same sol-gel microcapsule or in different capsules. The encapsulation of the ultraviolet absorbers reduces or even prevents the contact between the sunscreen compounds and the human tissue, thus reducing various adverse effects that are associated with the use of sunscreens, such as photoallergy and phototoxicity, and makes the composition safer for use. The encapsulation also reduces or even prevents cross reactivity between the sunscreen compounds and the packaging material and between the sunscreen compounds and any other component present in the composition, thus enhance the compositions stability. The hydophobicity/hydrophilicity character of the sol-gel microcapsules can be controlled by selecting suitable sol-gel precursors and suitable reaction conditions and can be chosen to be compatible with the cosmetic vehicle to be used in the sunscreen composition, thus, the present invention facilitates an easy incorporation of the composite sol-gel encapsulated sunscreen in all types of cosmetic vehicles including oil free compositions, with no necessary steps of heating or high shear forces. The sunscreen compositions of the present invention can comprise any acceptable UVA and/or UVB absorbing compounds at any desired ratio to obtain a desired accumulative ultraviolet screening spectrum.
摘要翻译：本发明一般涉及安全和稳定的防晒组合物，其包含至少一种防霉活性成分，其形式为在任何可接受的化妆品载体中包封紫外线吸收化合物的惰性溶胶 - 凝胶微胶囊形式。根据本发明的组合物可以包含几种可以包封在相同溶胶 - 凝胶微胶囊或不同胶囊中的紫外线吸收剂。紫外线吸收剂的封装减少或甚至防止防晒化合物与人体组织之间的接触，从而减少与防晒剂的使用相关的各种不利影响，例如光过敏和光毒性，并使组合物更安全地使用。封装还降低或甚至防止防晒化合物和包装材料之间以及防晒化合物和组合物中存在的任何其它组分之间的交叉反应性，从而增强组合物的稳定性。可以通过选择合适的溶胶 - 凝胶前体和合适的反应条件来控制溶胶 - 凝胶微胶囊的疏水性/亲水性，并且可以选择与化妆品相容以用于防晒组合物，因此本发明有利于将复合溶胶 - 凝胶包胶的防晒剂容易地并入包括无油组合物的所有类型的化妆品载体中，没有必要的加热步骤或高剪切力。本发明的防晒组合物可以以任何所需的比例包含任何可接受的UVA和/或UVB吸收化合物，以获得所需的累积紫外线屏蔽谱。

9. 发明授权

US5650311A Doped sol-gel glasses for obtaining chemical interactions 失效
标题翻译：用于获得生物化学相互作用的掺杂溶胶 - 凝胶玻璃
公开(公告)号：US5650311A
公开(公告)日：1997-07-22
申请号：US266441
申请日：1994-06-28
申请人： David Avnir , Michael Ottolenghi , Sergei Braun , Rivka Zusman
发明人： David Avnir , Michael Ottolenghi , Sergei Braun , Rivka Zusman
IPC分类号： C07K16/00 , B01J20/281 , B01J20/283 , B01J20/291 , C03B8/02 , C03C4/00 , C07K1/14 , C12N11/04 , C12N11/14 , C12P1/00 , C12Q1/00 , G01N21/77 , G01N27/327 , G01N30/02 , G01N30/88 , G01N30/92 , G01N31/22 , G01N33/543 , G01N33/552 , G01N33/68 , G01N33/84 , G01N1/00 , A61K9/50 , B01J13/18
CPC分类号： G01N33/6869 , B01J20/283 , B01J20/291 , C03C4/0007 , C12N11/14 , C12P1/00 , G01N31/22 , G01N33/5436 , G01N33/552 , G01N33/84 , B01J2220/54 , G01N2030/484 , G01N30/02 , G01N30/92 , Y02P20/588 , Y10S514/944 , Y10S514/965 , Y10S530/811 , Y10T428/2989 , Y10T436/10
摘要： A metod is proposed of obtaining a chemical interaction between at least one reagent trapped in sol-gel glass by doping it with the reagent(s), and diffusible solutes or components in an adjacent liquid or gas phase. The reagents, the solutes or the components can be any organic or inorganic compounds or materials of biological origins including enzymes. The doped sol-gel glass in various forms may be useful as analytical test, chromatographic medium, sensor, catalyst or biocatalyst, electrode or enzyme electrode, or other detection device.
摘要翻译：提出了通过将其与试剂掺杂，以及相邻液相或气相中的可扩散溶质或组分，获得捕获在溶胶 - 凝胶玻璃中的至少一种试剂之间的化学相互作用的方法。试剂，溶质或组分可以是任何有机或无机化合物或生物来源的材料，包括酶。各种形式的掺杂溶胶 - 凝胶玻璃可用作分析测试，色谱介质，传感器，催化剂或生物催化剂，电极或酶电极或其他检测装置。

10. 发明授权

US5371018A Qualitative and quantitative processes for reactive chemicals in liquids using doped sol-gel glasses 失效
标题翻译：使用掺杂溶胶凝胶眼镜的液体中反应性化学物质的定性和定量过程
公开(公告)号：US5371018A
公开(公告)日：1994-12-06
申请号：US953358
申请日：1992-09-30
申请人： David Avnir , Michael Ottolenghi , Ovadia Lev
发明人： David Avnir , Michael Ottolenghi , Ovadia Lev
IPC分类号： B01J20/283 , B01J20/291 , C03C4/00 , G01N30/02 , G01N30/92 , G01N31/22 , G01N33/543 , G01N33/552 , G01N33/68 , G01N33/84 , G01N33/20
CPC分类号： B01J20/291 , B01J20/283 , C03C4/0007 , G01N31/22 , G01N33/5436 , G01N33/552 , G01N33/6869 , G01N33/84 , B01J2220/54 , G01N30/02 , G01N30/92
摘要： A process for qualitative or quantitative determination of a reactive chemical contained in a liquid sample by forming doped sol-gel glass pellets from a metal alkoxide, arranging the porous doped sol-gel glass pellets in a glass tube, contacting a liquid sample containing a reactive chemical with the porous doped sol-gel glass pellets contained in the glass tube, and measuring a length of a stained portion of the glass tube resulting from a color change in the sol-gel glass pellets. The sol-gel glass pellets are formed by a gelling step conducted at room temperature in the presence of a colorimetric reagent dopant which produces a color change in the presence of the reactive chemical, and a drying step conducted at not greater than 41.degree. C. The doped sol-gel glass pellets contain the colorimetric reagent dopant encapsulated therein and the encapsulated colorimetric reagent dopant is color changeable in the presence of the reactive chemical in the pores of the doped sol-gel glass pellets.
摘要翻译：一种用于通过从金属醇盐形成掺杂的溶胶 - 凝胶玻璃颗粒来定性或定量测定液体样品中所含的反应性化学品的方法，将多孔掺杂的溶胶 - 凝胶玻璃颗粒放置在玻璃管中，使含有反应性与玻璃管中所含的多孔掺杂的溶胶 - 凝胶玻璃颗粒化学，并测量由溶胶 - 凝胶玻璃颗粒中的颜色变化导致的玻璃管的染色部分的长度。溶胶 - 凝胶玻璃颗粒通过在室温下在存在反应性化学物质的情况下产生颜色变化的比色试剂掺杂剂的存在下进行胶凝化步骤而形成，并且干燥步骤在不大于41℃的条件下进行。掺杂的溶胶 - 凝胶玻璃颗粒包含其中包含的比色试剂掺杂剂，并且包被的比色试剂掺杂剂在掺杂的溶胶 - 凝胶玻璃颗粒的孔隙中的反应性化学物的存在下是可颜色变化的。

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