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1. 发明申请

US20080293919A1 Fibrous Protein Fusions and Use Thereof in the Formation of Advanced Organic/Inorganic Composite Materials 有权
标题翻译：纤维蛋白融合及其在先进有机/无机复合材料的形成中的应用
公开(公告)号：US20080293919A1
公开(公告)日：2008-11-27
申请号：US11794934
申请日：2006-01-17
申请人： David L. Kaplan , Jia Huang , Cheryl Wong Po Foo , Rajesh Naik , Anne George
发明人： David L. Kaplan , Jia Huang , Cheryl Wong Po Foo , Rajesh Naik , Anne George
IPC分类号： C07K14/00 , C07H21/04 , C07K1/00
CPC分类号： A61L27/48 , A61L27/446 , A61L27/46 , A61L27/54 , A61L2430/00 , C07K14/43518 , C07K14/51 , C07K14/78 , C07K2319/00
摘要： The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These organic-inorganic composites can be constructed from the nano- to the macro-scale depending on the size of the fibrous protein fusion domain used. In one embodiment, the composites can also be loaded with other compounds (e.g., dyes, drugs, enzymes) depending on the goal for the materials, to further enhance function. This can be achieved during assembly of the material or during the mineralization step in materials formation.
摘要翻译：要求保护的发明提供了包含纤维蛋白结构域和矿化结构域的融合多肽。该融合用于形成有机 - 无机复合材料。这些有机 - 无机复合材料可以根据所使用的纤维蛋白融合结构域的大小从纳米级到大规模构建。在一个实施方案中，根据材料的目标，复合材料还可以加载其它化合物（例如染料，药物，酶），以进一步增强功能。这可以在组装材料期间或在矿化步骤期间在材料形成中实现。

2. 发明授权

US08129141B2 Fibrous protein fusions and use thereof in the formation of advanced organic/inorganic composite materials 有权
标题翻译：纤维蛋白融合及其在先进的有机/无机复合材料的形成中的应用
公开(公告)号：US08129141B2
公开(公告)日：2012-03-06
申请号：US13097538
申请日：2011-04-29
申请人： David L. Kaplan , Jia Huang , Cheryl Wong Po Foo , Rajesh Naik , Anne George
发明人： David L. Kaplan , Jia Huang , Cheryl Wong Po Foo , Rajesh Naik , Anne George
IPC分类号： C12P1/00
CPC分类号： A61L27/48 , A61L27/446 , A61L27/46 , A61L27/54 , A61L2430/00 , C07K14/43518 , C07K14/51 , C07K14/78 , C07K2319/00
摘要： The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These organic-inorganic composites can be constructed from the nano- to the macro-scale depending on the size of the fibrous protein fusion domain used. In one embodiment, the composites can also be loaded with other compounds (e.g., dyes, drugs, enzymes) depending on the goal for the materials, to further enhance function. This can be achieved during assembly of the material or during the mineralization step in materials formation.
摘要翻译：要求保护的发明提供了包含纤维蛋白结构域和矿化结构域的融合多肽。该融合用于形成有机 - 无机复合材料。这些有机 - 无机复合材料可以根据所使用的纤维蛋白融合结构域的大小从纳米级到大规模构建。在一个实施方案中，根据材料的目标，复合材料还可以加载其它化合物（例如染料，药物，酶），以进一步增强功能。这可以在组装材料期间或在矿化步骤期间在材料形成中实现。

3. 发明申请

US20110275788A1 FIBROUS PROTEIN FUSIONS AND USE THEREOF IN THE FORMATION OF ADVANCED ORGANIC/INORGANIC COMPOSITE MATERIALS 有权
标题翻译：纤维蛋白融合及其在先进有机/无机复合材料的形成中的应用
公开(公告)号：US20110275788A1
公开(公告)日：2011-11-10
申请号：US13097538
申请日：2011-04-29
申请人： David L. Kaplan , Jia Huang , Cheryl Wong Po Foo , Rajesh Naik , Anne George
发明人： David L. Kaplan , Jia Huang , Cheryl Wong Po Foo , Rajesh Naik , Anne George
IPC分类号： C07K7/08 , C07K17/00 , A61K38/17 , C07K14/00
CPC分类号： A61L27/48 , A61L27/446 , A61L27/46 , A61L27/54 , A61L2430/00 , C07K14/43518 , C07K14/51 , C07K14/78 , C07K2319/00
摘要： The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These organic-inorganic composites can be constructed from the nano- to the macro-scale depending on the size of the fibrous protein fusion domain used. In one embodiment, the composites can also be loaded with other compounds (e.g., dyes, drugs, enzymes) depending on the goal for the materials, to further enhance function. This can be achieved during assembly of the material or during the mineralization step in materials formation.
摘要翻译：要求保护的发明提供了包含纤维蛋白结构域和矿化结构域的融合多肽。该融合用于形成有机 - 无机复合材料。这些有机 - 无机复合材料可以根据所使用的纤维蛋白融合结构域的大小从纳米级到大规模构建。在一个实施方案中，根据材料的目标，复合材料还可以加载其它化合物（例如染料，药物，酶），以进一步增强功能。这可以在组装材料期间或在矿化步骤期间在材料形成中实现。

4. 发明授权

US07960509B2 Fibrous protein fusions and use thereof in the formation of advanced organic/inorganic composite materials 有权
标题翻译：纤维蛋白融合及其在先进的有机/无机复合材料的形成中的应用
公开(公告)号：US07960509B2
公开(公告)日：2011-06-14
申请号：US11794934
申请日：2006-01-17
申请人： David L. Kaplan , Jia Huang , Cheryl Wong Po Foo , Rajesh Naik , Anne George
发明人： David L. Kaplan , Jia Huang , Cheryl Wong Po Foo , Rajesh Naik , Anne George
IPC分类号： C07K14/00
CPC分类号： A61L27/48 , A61L27/446 , A61L27/46 , A61L27/54 , A61L2430/00 , C07K14/43518 , C07K14/51 , C07K14/78 , C07K2319/00
摘要： The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These organic-inorganic composites can be constructed from the nano- to the macro-scale depending on the size of the fibrous protein domain used. The composites can also be loaded with other compounds (e.g. dyes, drugs, enzymes) depending on the goal for the materials, to further enhance function. This can be achieved during assembly of the materials or during the mineralization step in materials formation.
摘要翻译：要求保护的发明提供了包含纤维蛋白结构域和矿化结构域的融合多肽。该融合用于形成有机 - 无机复合材料。这些有机 - 无机复合材料可以根据所使用的纤维蛋白结构域的大小从纳米级到大规模构建。根据材料的目标，复合材料还可以加载其它化合物（例如染料，药物，酶），以进一步增强功能。这可以在组装材料期间或在矿化步骤期间在材料形成中实现。

5. 发明授权

US08501437B2 Fibrous protein fusions and use thereof in the formation of advanced organic/inorganic composite materials 有权
标题翻译：纤维蛋白融合及其在先进的有机/无机复合材料的形成中的应用
公开(公告)号：US08501437B2
公开(公告)日：2013-08-06
申请号：US13347801
申请日：2012-01-11
申请人： David L. Kaplan , Jia Huang , Cheryl Wong Po Foo , Rajesh Naik , Anne George
发明人： David L. Kaplan , Jia Huang , Cheryl Wong Po Foo , Rajesh Naik , Anne George
IPC分类号： C12P1/00 , C07K14/00
CPC分类号： A61L27/48 , A61L27/446 , A61L27/46 , A61L27/54 , A61L2430/00 , C07K14/43518 , C07K14/51 , C07K14/78 , C07K2319/00
摘要： The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These organic-inorganic composites can be constructed from the nano- to the macro-scale depending on the size of the fibrous protein fusion domain used. In one embodiment, the composites can also be loaded with other compounds (e.g., dyes, drugs, enzymes) depending on the goal for the materials, to further enhance function. This can be achieved during assembly of the material or during the mineralization step in materials formation.
摘要翻译：要求保护的发明提供了包含纤维蛋白结构域和矿化结构域的融合多肽。该融合用于形成有机 - 无机复合材料。这些有机 - 无机复合材料可以根据所使用的纤维蛋白融合结构域的大小从纳米级到大规模构建。在一个实施方案中，根据材料的目标，复合材料还可以加载其它化合物（例如染料，药物，酶），以进一步增强功能。这可以在组装材料期间或在矿化步骤期间在材料形成中实现。

6. 发明申请

US20120308611A1 FIBROUS PROTEIN FUSIONS AND USE THEREOF IN THE FORMATION OF ADVANCED ORGANIC/INORGANIC COMPOSITE MATERIALS 有权
标题翻译：纤维蛋白融合及其在先进有机/无机复合材料的形成中的应用
公开(公告)号：US20120308611A1
公开(公告)日：2012-12-06
申请号：US13347801
申请日：2012-01-11
申请人： David L. Kaplan , Jia Huang , Cheryl Wong Po Foo , Rajesh Naik , Anne George
发明人： David L. Kaplan , Jia Huang , Cheryl Wong Po Foo , Rajesh Naik , Anne George
IPC分类号： A61K9/00
CPC分类号： A61L27/48 , A61L27/446 , A61L27/46 , A61L27/54 , A61L2430/00 , C07K14/43518 , C07K14/51 , C07K14/78 , C07K2319/00
摘要： The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These organic-inorganic composites can be constructed from the nano- to the macro-scale depending on the size of the fibrous protein fusion domain used. In one embodiment, the composites can also be loaded with other compounds (e.g., dyes, drugs, enzymes) depending on the goal for the materials, to further enhance function. This can be achieved during assembly of the material or during the mineralization step in materials formation.
摘要翻译：要求保护的发明提供了包含纤维蛋白结构域和矿化结构域的融合多肽。该融合用于形成有机 - 无机复合材料。这些有机 - 无机复合材料可以根据所使用的纤维蛋白融合结构域的大小从纳米级到大规模构建。在一个实施方案中，根据材料的目标，复合材料还可以加载其它化合物（例如染料，药物，酶），以进一步增强功能。这可以在组装材料期间或在矿化步骤期间在材料形成中实现。

7. 发明授权

US09011914B2 Hetero-assembled hydrogels 有权
标题翻译：异位组装的水凝胶
公开(公告)号：US09011914B2
公开(公告)日：2015-04-21
申请号：US12455996
申请日：2009-06-09
申请人： Cheryl Wong Po Foo , Sarah C Heilshorn
发明人： Cheryl Wong Po Foo , Sarah C Heilshorn
IPC分类号： A61K47/42 , A61K9/00
CPC分类号： A61K9/0024 , A61K47/42
摘要： A two-component, molecular-recognition gelation strategy that enables cell encapsulation without the need for environmental triggers is provided. The two components, which in one example contain WW and polyproline-rich peptide domains that interact via hydrogen bonds, undergo a sol-gel phase transition upon simple mixing. Hence, physical gelation is induced by the mixing of two components at constant environmental conditions, analogous to the formation of chemically crosslinked epoxies by the mixing of two components. Variations in the molecular-level design of the two components are used to predictably tune the association energy and hydrogel viscoelasticity. These hetero-assembly physical hydrogels encapsulate neural progenitor cells at constant physiological conditions within 10 seconds to create uniform 3D cell suspensions that continue to proliferate, differentiate, and adopt well-spread morphologies.
摘要翻译：提供了一种双组分的分子识别凝胶化策略，可以实现细胞封装而不需要环境触发。在一个实例中，两个组分含有通过氢键相互作用的WW和富含脯氨酸的肽结构域，在简单混合时经历溶胶 - 凝胶相变。因此，通过在恒定环境条件下混合两种组分来诱导物理胶凝，类似于通过混合两种组分形成化学交联的环氧化物。两个组分的分子水平设计的变化用于预测调节缔合能和水凝胶粘弹性。这些异构组装的物理水凝胶在10秒内在恒定的生理条件下封装神经祖细胞，以产生继续增殖，分化和采用良好扩散形态的均匀的3D细胞悬浮液。

8. 发明申请

US20100183720A1 Hetero-assembled hydrogels 有权
标题翻译：异位组装的水凝胶
公开(公告)号：US20100183720A1
公开(公告)日：2010-07-22
申请号：US12455996
申请日：2009-06-09
申请人： Cheryl Wong Po Foo , Sarah C. Heilshorn
发明人： Cheryl Wong Po Foo , Sarah C. Heilshorn
IPC分类号： A61K9/00 , A61K47/42
CPC分类号： A61K9/0024 , A61K47/42
摘要： A two-component, molecular-recognition gelation strategy that enables cell encapsulation without the need for environmental triggers is provided. The two components, which in one example contain WW and polyproline-rich peptide domains that interact via hydrogen bonds, undergo a sol-gel phase transition upon simple mixing. Hence, physical gelation is induced by the mixing of two components at constant environmental conditions, analogous to the formation of chemically crosslinked epoxies by the mixing of two components. Variations in the molecular-level design of the two components are used to predictably tune the association energy and hydrogel viscoelasticity. These hetero-assembly physical hydrogels encapsulate neural progenitor cells at constant physiological conditions within 10 seconds to create uniform 3D cell suspensions that continue to proliferate, differentiate, and adopt well-spread morphologies.
摘要翻译：提供了一种双组分的分子识别凝胶化策略，可以实现细胞封装而不需要环境触发。在一个实例中，两个组分含有通过氢键相互作用的WW和富含脯氨酸的肽结构域，在简单混合时经历溶胶 - 凝胶相变。因此，通过在恒定环境条件下混合两种组分来诱导物理胶凝，类似于通过混合两种组分形成化学交联的环氧化物。两个组分的分子水平设计的变化用于预测调节缔合能和水凝胶粘弹性。这些异构组装的物理水凝胶在10秒内在恒定的生理条件下封装神经祖细胞，以产生继续增殖，分化和采用良好扩散形态的均匀的3D细胞悬浮液。

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