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1. 发明申请

US20090326889A1 High Frequency Multi-axis Simulation System 有权
标题翻译：高频多轴仿真系统
公开(公告)号：US20090326889A1
公开(公告)日：2009-12-31
申请号：US12146094
申请日：2008-06-25
申请人： David L. Dingmann , Eric T. Gagner , Troy D. Nickel , Steven R. Seeman , Andrew D. White
发明人： David L. Dingmann , Eric T. Gagner , Troy D. Nickel , Steven R. Seeman , Andrew D. White
IPC分类号： G06G7/48 , G06G7/57
CPC分类号： G01N3/32 , G01N2203/0008 , G01N2203/0026 , G01N2203/0208 , G01N2203/0264 , G01N2203/027
摘要： A multi-axis fatigue testing device includes a multi-axis test fixture having a multiple input, multiple output mechanical linkage driven by a plurality of actuators and a controller operating each of the plurality of actuators in real time and in synchronization to produce user-defined multiple fatigue cycle profiles. At least one of the actuators driving the mechanical linkage acts against an artificial load characterized by a stiffness. The stiffness is selected to increase a resonance frequency of the test fixture to allow fatigue testing at higher frequencies for a wider range of samples.
摘要翻译：多轴疲劳测试装置包括多轴测试夹具，其具有由多个致动器驱动的多输入多输出机械联动器和实时地并且同步地产生用户定义的多个致动器中的每一个的控制器多个疲劳循环曲线。驱动机械连杆的致动器中的至少一个作用于以刚度为特征的人造负载。选择刚度以增加测试夹具的共振频率，以允许在更宽范围的样品的较高频率下的疲劳测试。

2. 发明申请

US20090282927A1 Multi-sample Conditioning System 有权
标题翻译：多样品调节系统
公开(公告)号：US20090282927A1
公开(公告)日：2009-11-19
申请号：US12119830
申请日：2008-05-13
申请人： Aaron M. Owens , David L. Dingmann , Steven R. Seeman , Troy D. Nickel
发明人： Aaron M. Owens , David L. Dingmann , Steven R. Seeman , Troy D. Nickel
IPC分类号： G01N3/02
CPC分类号： G01N3/32 , G01N2203/0222 , G01N2203/0242 , G01N2203/027 , G01N2203/0435 , G01N2203/0447 , G01N2203/0476
摘要： A multi-sample conditioning system may include a sample chamber for each sample or a sample chamber holding one or more samples. Multiple samples enable replication for statistical analysis and individual sample chambers enable individual nutrient flow profiles for each sample. A mechanical imbalance may be created when a sample chamber is removed or when samples of different stiffness are conditioned together. The mechanical imbalance may result in an undesired alteration of the desired conditioning profile and increase the variation in the conditioning profile applied to each sample. An asymmetric-loading support assembly provides a low friction support to reduce the undesired alteration of the desired conditioning profile applied to the samples and reduce unwanted reaction loads on the conditioning drive mechanisms. The asymmetric-loading support assembly preferably includes a flexure as the low-friction, high-stiffness support. Other examples that can provide low-friction, high-stiffness support include air bearings, magnetic bearings, and hydraulic bearings.
摘要翻译：多样品调节系统可以包括用于每个样品的样品室或容纳一个或多个样品的样品室。多个样品能够进行统计分析的复制，并且每个样品室可以对每个样品进行单独的营养物流量分布。当样品室被移除或不同刚度的样品被调节在一起时，可能产生机械不平衡。机械不平衡可能导致期望的调节曲线的不期望的改变并且增加了施加到每个样品的调理轮廓的变化。不对称加载支撑组件提供低摩擦支撑以减少施加到样品的期望的调节曲线的不期望的改变，并减少调节驱动机构上的不必要的反应负荷。不对称加载支撑组件优选地包括作为低摩擦，高刚度支撑件的挠曲。可以提供低摩擦，高刚度支撑的其他实例包括空气轴承，磁性轴承和液压轴承。

3. 发明授权

US07587949B2 System and method for stimulation and characterization of biologic materials 有权
标题翻译：生物材料刺激和表征的系统和方法
公开(公告)号：US07587949B2
公开(公告)日：2009-09-15
申请号：US11780729
申请日：2007-07-20
申请人： David L. Dingmann , Frank C. Conati , Troy D. Nickel , Aaron M. Owens , Chrysanthi Williams
发明人： David L. Dingmann , Frank C. Conati , Troy D. Nickel , Aaron M. Owens , Chrysanthi Williams
IPC分类号： G01N1/20 , G01N17/00
CPC分类号： G01N3/08 , A61F2/042 , A61F2/06 , A61F2/062 , A61F2002/046 , G01N35/1097 , G01N2203/0016 , G01N2203/0048 , G01N2203/0089 , G01N2203/0222 , G01N2203/0242 , G01N2203/0246 , G01N2203/0476
摘要： A multi-sample biologic material stimulation and characterization system includes individual flow paths for each sample. Each individual flow path can maintain sterile conditions and may be chemically monitored. The mean flow rate and pulsatile flow rate through each sample may be individually controlled. Pressure at the sample is controlled independently of the flow rate through downstream variable flow restrictors. An axial force may be applied to each sample. A radial force may be applied via hydrostatic pressure of chamber fluid surrounding each sample. A real-time controller manages the system and saves information gathered from the transducers and actuators of the system.
摘要翻译：多样本生物材料刺激和表征系统包括每个样品的单独流动路径。每个单独的流动路径可以保持无菌条件并且可以进行化学监测。可以单独控制通过每个样品的平均流速和脉动流量。样品的压力独立于通过下游可变流量限制器的流量进行控制。可以向每个样品施加轴向力。可以通过围绕每个样品的腔室流体的静水压力施加径向力。实时控制器管理系统并保存从传感器和系统执行器收集的信息。

4. 发明申请

US20090019950A1 System and Method For Stimulation And Characterization Of Biologic materials 有权
标题翻译：生物材料的刺激和表征的系统和方法
公开(公告)号：US20090019950A1
公开(公告)日：2009-01-22
申请号：US11780729
申请日：2007-07-20
申请人： David L. Dingmann , Frank C. Conati , Troy D. Nickel , Aaron M. Owens , Chrysanthi Williams
发明人： David L. Dingmann , Frank C. Conati , Troy D. Nickel , Aaron M. Owens , Chrysanthi Williams
IPC分类号： G01N1/14
CPC分类号： G01N3/08 , A61F2/042 , A61F2/06 , A61F2/062 , A61F2002/046 , G01N35/1097 , G01N2203/0016 , G01N2203/0048 , G01N2203/0089 , G01N2203/0222 , G01N2203/0242 , G01N2203/0246 , G01N2203/0476
摘要： A multi-sample biologic material stimulation and characterization system includes individual flow paths for each sample. Each individual flow path can maintain sterile conditions and may be chemically monitored. The mean flow rate and pulsatile flow rate through each sample may be individually controlled. Pressure at the sample is controlled independently of the flow rate through downstream variable flow restrictors. An axial force may be applied to each sample. A radial force may be applied via hydrostatic pressure of chamber fluid surrounding each sample. A real-time controller manages the system and saves information gathered from the transducers and actuators of the system.
摘要翻译：多样本生物材料刺激和表征系统包括每个样品的单独流动路径。每个单独的流动路径可以保持无菌条件并且可以进行化学监测。可以单独控制通过每个样品的平均流速和脉动流量。样品的压力独立于通过下游可变流量限制器的流量进行控制。可以向每个样品施加轴向力。可以通过围绕每个样品的腔室流体的静水压力施加径向力。实时控制器管理系统并保存从传感器和系统执行器收集的信息。

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