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1. 发明申请

US20060148742A1 Polynucleotide delivery to cardiac tissue 审中-公开
标题翻译：多核苷酸转运到心脏组织
公开(公告)号：US20060148742A1
公开(公告)日：2006-07-06
申请号：US11212049
申请日：2005-08-25
申请人： David Kaye , John Power , Clifton Alferness , Adam Bilney , Kenneth Chien , Athanasios Preovolos
发明人： David Kaye , John Power , Clifton Alferness , Adam Bilney , Kenneth Chien , Athanasios Preovolos
IPC分类号： A61K48/00
CPC分类号： C12N9/14 , A61B2017/00252 , A61M1/3653 , A61M25/1002 , A61M25/1011 , A61M2025/1047 , A61M2025/1052 , A61M2210/127 , C12N2799/022 , C12N2799/025
摘要： A method for delivering a polynucleotide to cardiac tissue, including substantially isolating the coronary venous circulation from systemic circulation, and introducing a polynucleotide into the isolated coronary venous circulation to effect localized transfection of cardiac tissue. The polynucleotide advantageously produces a therapeutic effect, such as increasing or decreasing the expression level of a protein in the cardiac tissue.
摘要翻译：一种将多核苷酸递送至心脏组织的方法，包括从全身循环基本上分离冠状静脉循环，以及将多核苷酸引入分离的冠状静脉循环中，以实现心脏组织的局部转染。多核苷酸有利地产生治疗效果，例如增加或降低心脏组织中蛋白质的表达水平。

2. 发明申请

US20070203445A1 Isolating cardiac circulation 审中-公开
标题翻译：隔离心脏循环
公开(公告)号：US20070203445A1
公开(公告)日：2007-08-30
申请号：US11510203
申请日：2006-08-25
申请人： David Kaye , Clifton Alferness , John Power , Adam Bilney
发明人： David Kaye , Clifton Alferness , John Power , Adam Bilney
IPC分类号： A61M37/00 , A61M29/00
CPC分类号： A61M1/3666 , A61B17/12136 , A61B2017/00252 , A61B2017/22068 , A61M1/32 , A61M1/3624 , A61M1/3653 , A61M1/3655 , A61M1/3659 , A61M25/0074 , A61M25/0082 , A61M25/1002 , A61M25/1011 , A61M29/00 , A61M2025/0096 , A61M2025/1052 , A61M2202/07 , A61M2202/206 , A61M2210/125 , A61M2210/127
摘要： In a method for substantially isolating cardiac circulation from systemic circulation, flow between the coronary sinus and the right atrium is occluded. A venous collection device having a collection lumen and a support structure is located in the coronary sinus. The support structure is used to maintain patency of the coronary sinus during collection of fluid through the collection lumen. An artificial flow path is provided between the collection lumen and the one or more coronary arteries, thus isolating the cardiac circulation. According to the method, cardiac pumping for systemic circulation can be maintained during isolation of the cardiac circulation.
摘要翻译：在用于基本上分离心脏循环与全身循环的方法中，阻塞冠状窦和右心房之间的流动。具有收集腔和支撑结构的静脉收集装置位于冠状窦中。支撑结构用于在通过收集腔收集流体期间保持冠状窦的通畅。在收集腔和一个或多个冠状动脉之间提供人造流路，从而隔离心脏循环。根据该方法，可以在分离心脏循环期间维持心脏泵送全身循环。

3. 发明申请

US20060235265A1 Cardiac support device with anti-fibrosis coating 有权
公开(公告)号：US20060235265A1
公开(公告)日：2006-10-19
申请号：US11451209
申请日：2006-06-12
申请人： Clifton Alferness , Jai Raman , John Power
发明人： Clifton Alferness , Jai Raman , John Power
IPC分类号： A61F2/00 , A61F13/00
CPC分类号： A61F2/2481 , A61F2002/0068
摘要： A jacket of biological compatible material has an internal volume dimensioned for an apex of the heart to be inserted into the volume and for the jacket to be slipped over the heart. The jacket has a longitudinal dimension between upper and lower ends sufficient for the jacket to surround a lower portion of the heart with the jacket surrounding a valvular annulus of the heart and further surrounding the lower portion to cover at least the ventricular lower extremities of the heart. The jacket is adapted to be secured to the heart with the jacket surrounding at least the valvular annulus and the ventricular lower extremities. The jacket is adjustable on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain circumferential expansion of the heart beyond the maximum adjusted volume during diastole and to permit unimpeded contraction of the heart during systole.

4. 发明申请

US20060111607A1 Cardiac support with metallic structure 有权
标题翻译：心脏支持与金属结构
公开(公告)号：US20060111607A1
公开(公告)日：2006-05-25
申请号：US11329808
申请日：2006-01-10
申请人： Clifton Alferness , Jai Raman , John Power
发明人： Clifton Alferness , Jai Raman , John Power
IPC分类号： A61F2/00 , A61F13/00
CPC分类号： A61F2/2481 , A61F2002/0068
摘要： A jacket of biological compatible material has an internal volume dimensioned for an apex of the heart to be inserted into the volume and for the jacket to be slipped over the heart. The jacket has a longitudinal dimension between upper and lower ends sufficient for the jacket to surround a lower portion of the heart with the jacket surrounding a valvular annulus of the heart and further surrounding the lower portion to cover at least the ventricular lower extremities of the heart. The jacket is adapted to be secured to the heart with the jacket surrounding at least the valvular annulus and the ventricular lower extremities. The jacket is adjustable on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain circumferential expansion of the heart beyond the maximum adjusted volume during diastole and to permit unimpeded contraction of the heart during systole.
摘要翻译：生物相容材料的护套具有尺寸设计用于心脏顶点的内部容积，以将其插入体积中并使护套滑过心脏。护套具有在上下端之间的纵向尺寸，足以使护套围绕心脏的下部围绕心脏的瓣膜环并且进一步围绕下部以至少覆盖心脏的心室下端。护套适于固定在心脏上，护套至少围绕瓣膜环和心室下肢。护套在心脏上是可调节的，以贴合地符合心脏的外部几何形状，并假设护套的最大调节体积以约束舒张期心脏超过最大调节体积的周向扩张，并允许心脏收缩期间不受阻碍的收缩。

5. 发明申请

US20050033419A1 Mitral valve therapy device, system and method 审中-公开
公开(公告)号：US20050033419A1
公开(公告)日：2005-02-10
申请号：US10925714
申请日：2004-08-24
申请人： Clifton Alferness , John Adams , John Power
发明人： Clifton Alferness , John Adams , John Power
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , Y10S623/904
摘要： An assembly and method for effecting the condition of a mitral valve annulus of a heart includes a guide wire configured to be fed into the coronary sinus of the heart, and a mitral valve annulus therapy device configured to be slidingly received on the guide wire and advanced into the coronary sinus of the heart on the guide wire. A guide tube may further be employed for guiding the device into the coronary sinus. An introducer which may be employed for pushing the device into or pulling device out of the heart has a mechanism for releasably locking to the device. This enables substitution of the device if needed. Also, the crossover point of the circumflex artery and coronary sinus may be determined and avoided when the device is deployed.

6. 发明申请

US20070004962A1 CARDIAC SUPPORT DEVICE WITH DIFFERENTIAL COMPLIANCE 审中-公开
标题翻译： CARDIAC支持设备与差异合规
公开(公告)号：US20070004962A1
公开(公告)日：2007-01-04
申请号：US11469224
申请日：2006-08-31
申请人： Clifton Alferness , Jai Raman , John Power
发明人： Clifton Alferness , Jai Raman , John Power
IPC分类号： A61F13/00 , A61F2/00
CPC分类号： A61F2/2481 , A61F2002/0068
摘要： A cardiac support device comprising a jacket of flexible and biocompatible material having a first axis for alignment generally parallel to a longitudinal axis of a patient's heart and a second axis that is transverse to the first axis. The material exhibits an amount of expansion in response to a force applied to the material along the first axis that is different than an amount of expansion in response to the force applied to the material along the second axis.
摘要翻译：一种心脏支持装置，其包括柔性和生物相容性材料的护套，其具有大致平行于患者心脏的纵向轴线的对准的第一轴线和横向于第一轴线的第二轴线。该材料响应于沿着第一轴施加到材料上的力而响应于沿着沿着第二轴施加到材料的力而产生的膨胀量不同的膨胀量。

7. 发明申请

US20050027353A1 Mitral valve therapy device, system and method 有权
标题翻译：二尖瓣治疗装置，系统及方法
公开(公告)号：US20050027353A1
公开(公告)日：2005-02-03
申请号：US10925571
申请日：2004-08-24
申请人： Clifton Alferness , John Adams , John Power
发明人： Clifton Alferness , John Adams , John Power
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , Y10S623/904
摘要： An assembly and method for effecting the condition of a mitral valve annulus of a heart includes a guide wire configured to be fed into the coronary sinus of the heart, and a mitral valve annulus therapy device configured to be slidingly received on the guide wire and advanced into the coronary sinus of the heart on the guide wire. A guide tube may further be employed for guiding the device into the coronary sinus. An introducer which may be employed for pushing the device into or pulling device out of the heart has a mechanism for releasably locking to the device. This enables substitution of the device if needed. Also, the crossover point of the circumflex artery and coronary sinus may be determined and avoided when the device is deployed.
摘要翻译：用于实现心脏二尖瓣环的状态的组件和方法包括：构造成供给到心脏的冠状窦内的导线，以及构造成滑动地容纳在导丝上并提前的二尖瓣环空间治疗装置进入导丝的心脏冠状窦。还可以使用导管来将装置引导到冠状窦中。可以用于将装置推入或拉出装置离开心脏的导引器具有用于可释放地锁定到装置的机构。如果需要，这可以替代设备。此外，当部署装置时，可以确定并避免回旋动脉和冠状窦的交叉点。

8. 发明申请

US20050038507A1 Mitral valve therapy device, system and method 有权
公开(公告)号：US20050038507A1
公开(公告)日：2005-02-17
申请号：US10925570
申请日：2004-08-24
申请人： Clifton Alferness , John Adams , John Power
发明人： Clifton Alferness , John Adams , John Power
IPC分类号： A61F2/24 , A61B5/107
CPC分类号： A61F2/2451 , Y10S623/904
摘要： An assembly and method for effecting the condition of a mitral valve annulus of a heart includes a guide wire configured to be fed into the coronary sinus of the heart, and a mitral valve annulus therapy device configured to be slidingly received on the guide wire and advanced into the coronary sinus of the heart on the guide wire. A guide tube may further be employed for guiding the device into the coronary sinus. An introducer which may be employed for pushing the device into or pulling device out of the heart has a mechanism for releasably locking to the device. This enables substitution of the device if needed. Also, the crossover point of the circumflex artery and coronary sinus may be determined and avoided when the device is deployed.

9. 发明授权

US08196573B2 Methods and systems for operating an aerosol generator 有权
标题翻译：用于操作气溶胶发生器的方法和系统
公开(公告)号：US08196573B2
公开(公告)日：2012-06-12
申请号：US12018716
申请日：2008-01-23
申请人： James B. Fink , John Power , Ehud Ivri , Niall Smith , Paul Dunne , Gavan O'Sullivan , Declan Moran , Keith Gibbons
发明人： James B. Fink , John Power , Ehud Ivri , Niall Smith , Paul Dunne , Gavan O'Sullivan , Declan Moran , Keith Gibbons
IPC分类号： A61M11/00 , A61M11/06 , A61M16/10
CPC分类号： A61M16/20 , A61K9/0078 , A61K31/7036 , A61M11/00 , A61M11/005 , A61M16/0833 , A61M16/0858 , A61M16/1065 , A61M16/208 , A61M2016/0021 , A61M2016/0027 , A61M2205/3561 , A61M2205/3569
摘要： A system for intermittent delivery of an aerosolized medicament is disclosed. The system may include an aerosol generator, a controller and a conduit. The aerosol generator may be configured to aerosolize a medicament. The controller may be configured to receive physiological characteristic information about a patient, and control the aerosol generator based at least in part on the physiological characteristic information. The conduit may be configured to supply the aerosolized medicament to the patient's airway.
摘要翻译：公开了用于间歇递送雾化药物的系统。该系统可以包括气溶胶发生器，控制器和导管。气溶胶发生器可以构造成使药物雾化。控制器可以被配置为接收关于患者的生理特征信息，并且至少部分地基于生理特征信息来控制气溶胶发生器。导管可以被构造成将雾化的药物供应到患者的气道。

10. 发明授权

US08078576B2 Network management information (NMI) distribution 有权
标题翻译：网络管理信息（NMI）分发
公开(公告)号：US08078576B2
公开(公告)日：2011-12-13
申请号：US12098621
申请日：2008-04-07
申请人： John Power , Edwin Tse
发明人： John Power , Edwin Tse
IPC分类号： G06F7/00 , G06F17/00
CPC分类号： H04L41/00 , H04L41/042 , Y10S707/922 , Y10S707/959
摘要： A device associated with a network provides a query for specific network management information (NMI) to a registry, and receives, based on the query, metadata associated with the specific network management information (NMI). The device also provides a request for the specific network management information (NMI) to a plurality of producer devices identified from the metadata associated with the specific network management information (NMI), and receives one or more portions of the specific network management information (NMI) from each of the plurality of producer devices. The device further combines the one or more portions of the specific network management information (NMI) to create the specific network management information (NMI).
摘要翻译：与网络相关联的设备提供对注册表的特定网络管理信息（NMI）的查询，并且基于查询接收与特定网络管理信息（NMI）相关联的元数据。设备还向从与特定网络管理信息（NMI）相关联的元数据识别的多个生产者设备提供对特定网络管理信息（NMI）的请求，并且接收特定网络管理信息（NMI）的一个或多个部分）从多个生产者设备中的每一个产生。该设备进一步组合特定网络管理信息（NMI）的一个或多个部分以创建特定网络管理信息（NMI）。

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