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1. 发明授权

US07413568B2 Composite structures and methods for ablating tissue to form complex lesion patterns in the treatment of cardiac conditions and the like 失效
标题翻译：用于在治疗心脏病况等中烧蚀组织以形成复杂病变图案的复合结构和方法
公开(公告)号：US07413568B2
公开(公告)日：2008-08-19
申请号：US09870288
申请日：2001-05-29
申请人： David K. Swanson , Sidney D. Fleischman , Thomas F. Kordis , David L. McGee
发明人： David K. Swanson , Sidney D. Fleischman , Thomas F. Kordis , David L. McGee
IPC分类号： A61B18/18 , A61N1/00
CPC分类号： A61B18/1492 , A61B2017/003 , A61B2018/00083 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00577 , A61B2018/00839 , A61B2018/1437 , A61B2018/1467 , A61B2018/1497
摘要： A method of ablating tissue in the heart to treat atrial fibrillation introduces into a selected atrium an energy emitting element. The method exposes the element to a region of the atrial wall and applies ablating energy to the element to thermally destroy tissue. The method forms a convoluted lesion pattern comprising elongated straight lesions and elongated curvilinear lesions. The lesion pattern directs electrical impulses within the atrial myocardium along a path that activates the atrial myocardium while interrupting reentry circuits that, if not interrupted, would cause fibrillation. The method emulates the surgical maze procedure, but lends itself to catheter-based procedures that do not require open heart surgical techniques. A composite structure for performing the method is formed using a template that displays in planar view a desired lesion pattern for the tissue. An array of spaced apart element is laid on the template. Guided by the template, energy emitting and non-energy emitting zones are formed on the elements. By overlaying the elements, the composite structure is formed, which can be introduced into the body to ablate tissue using catheter-based, vascular access techniques.
摘要翻译：心脏中消融组织以治疗心房颤动的方法将所选择的心房引入能量发射元件。该方法将该元件暴露于心房壁的一个区域，并向该元件施加消融能量以热破坏组织。该方法形成包括细长的直线损伤和细长的曲线损伤的褶皱病变图案。病变图案沿着激活心房心肌的路径引导心房心肌内的电脉冲，同时中断再入电路，如果不中断，将引起原纤维化。该方法模拟外科迷宫手术，但适用于不需要开放心脏手术技术的基于导管的手术。用于执行该方法的复合结构使用在平面图中显示用于组织的期望损伤图案的模板来形成。间隔开的元件阵列放置在模板上。在模板的指导下，在元件上形成能量发射和非能量发射区。通过覆盖元件，形成复合结构，其可以引入体内以使用基于导管的血管通路技术来烧蚀组织。

2. 发明授权

US07837684B2 Composite structures and methods for ablating tissue to form complex lesion patterns in the treatment of cardiac conditions and the like 失效
标题翻译：用于在治疗心脏病况等中烧蚀组织以形成复杂病变图案的复合结构和方法
公开(公告)号：US07837684B2
公开(公告)日：2010-11-23
申请号：US11923373
申请日：2007-10-24
申请人： David K. Swanson , Sidney D. Fleischman , Thomas F. Kordis , David L. McGee
发明人： David K. Swanson , Sidney D. Fleischman , Thomas F. Kordis , David L. McGee
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2017/003 , A61B2018/00083 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00577 , A61B2018/00839 , A61B2018/1437 , A61B2018/1467 , A61B2018/1497
摘要： A method of ablating tissue in the heart to treat atrial fibrillation introduces into a selected atrium an energy emitting element. The method exposes the element to a region of the atrial wall and applies ablating energy to the element to thermally destroy tissue. The method forms a convoluted lesion pattern comprising elongated straight lesions and elongated curvilinear lesions. The lesion pattern directs electrical impulses within the atrial myocardium along a path that activates the atrial myocardium while interrupting reentry circuits that, if not interrupted, would cause fibrillation. The method emulates the surgical maze procedure, but lends itself to catheter-based procedures that do not require open heart surgical techniques. A composite structure for performing the method is formed using a template that displays in planar view a desired lesion pattern for the tissue. An array of spaced apart element is laid on the template. Guided by the template, energy emitting and non-energy emitting zones are formed on the elements. By overlaying the elements, the composite structure is formed, which can be introduced into the body to ablate tissue using catheter-based, vascular access techniques.
摘要翻译：心脏中消融组织以治疗心房颤动的方法将所选择的心房引入能量发射元件。该方法将该元件暴露于心房壁的一个区域，并向该元件施加消融能量以热破坏组织。该方法形成包括细长的直线损伤和细长的曲线损伤的褶皱病变图案。病变图案沿着激活心房心肌的路径引导心房心肌内的电脉冲，同时中断再入电路，如果不中断，将引起原纤维化。该方法模拟外科迷宫手术，但适用于不需要开放心脏手术技术的基于导管的手术。用于执行该方法的复合结构使用在平面图中显示用于组织的期望损伤图案的模板来形成。间隔开的元件阵列放置在模板上。在模板的指导下，在元件上形成能量发射和非能量发射区。通过覆盖元件，形成复合结构，其可以引入体内以使用基于导管的血管通路技术来烧蚀组织。

3. 发明授权

US06241754B1 Composite structures and methods for ablating tissue to form complex lesion patterns in the treatment of cardiac conditions and the like 失效
公开(公告)号：US06241754B1
公开(公告)日：2001-06-05
申请号：US08752162
申请日：1996-11-18
申请人： David K. Swanson , Sidney D. Fleischman , Thomas F. Kordis , David L. McGee
发明人： David K. Swanson , Sidney D. Fleischman , Thomas F. Kordis , David L. McGee
IPC分类号： A61F712
CPC分类号： A61B18/1492 , A61B2017/003 , A61B2018/00083 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00577 , A61B2018/00839 , A61B2018/1437 , A61B2018/1467 , A61B2018/1497
摘要： A method of ablating tissue in the heart to treat atrial fibrillation introduces into a selected atrium an energy emitting element. The method exposes the element to a region of the atrial wall and applies ablating energy to the element to thermally destroy tissue. The method forms a convoluted lesion pattern comprising elongated straight lesions and elongated curvilinear lesions. The lesion pattern directs electrical impulses within the atrial myocardium along a path that activates the atrial myocardium while interrupting reentry circuits that, if not interrupted, would cause fibrillation. The method emulates the surgical maze procedure, but lends itself to catheter-based procedures that do not require open heart surgical techniques. A composite structure for performing the method is formed using a template that displays in planar view a desired lesion pattern for the tissue. An array of spaced apart element is laid on the template. Guided by the template, energy emitting and non-energy emitting zones are formed on the elements. By overlaying the elements, the composite structure is formed, which can be introduced into the body to ablate tissue using catheter-based, vascular access techniques.

4. 发明授权

US07115122B1 Composite structures and methods for ablating tissue to form complex lesion patterns in the treatment of cardiac conditions and the like 失效
标题翻译：用于在治疗心脏病况等中烧蚀组织以形成复杂病变图案的复合结构和方法
公开(公告)号：US07115122B1
公开(公告)日：2006-10-03
申请号：US09505354
申请日：2000-02-16
申请人： David K. Swanson , Sidney D. Fleischman , Thomas F. Kordis , David L. McGee
发明人： David K. Swanson , Sidney D. Fleischman , Thomas F. Kordis , David L. McGee
IPC分类号： A61B18/18 , A61B19/00
CPC分类号： A61B18/1492 , A61B2017/003 , A61B2018/00083 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00577 , A61B2018/00839 , A61B2018/1437 , A61B2018/1467 , A61B2018/1497
摘要： A method of ablating tissue in the heart to treat atrial fibrillation introduces into a selected atrium an energy emitting element. The method exposes the element to a region of the atrial wall and applies ablating energy to the element to thermally destroy tissue. The method forms a convoluted lesion pattern comprising elongated straight lesions and elongated curvilinear lesions. The lesion pattern directs electrical impulses within the atrial myocardium along a path that activates the atrial myocardium while interrupting reentry circuits that, if not interrupted, would cause fibrillation. The method emulates the surgical maze procedure, but lends itself to catheter-based procedures that do not require open heart surgical techniques. A composite structure for performing the method is formed using a template that displays in planar view a desired lesion pattern for the tissue. An array of spaced apart element is laid on the template. Guided by the template, energy emitting and non-energy emitting zones are formed on the elements. By overlaying the elements, the composite structure is formed, which can be introduced into the body to ablate tissue using catheter-based, vascular access techniques.
摘要翻译：心脏中消融组织以治疗心房颤动的方法将所选择的心房引入能量发射元件。该方法将该元件暴露于心房壁的一个区域，并向该元件施加消融能量以热破坏组织。该方法形成包括细长的直线损伤和细长的曲线损伤的褶皱病变图案。病变图案沿着激活心房心肌的路径引导心房心肌内的电脉冲，同时中断再入电路，如果不中断，将引起原纤维化。该方法模拟外科迷宫手术，但适用于不需要开放心脏手术技术的基于导管的手术。用于执行该方法的复合结构使用在平面图中显示用于组织的期望损伤图案的模板来形成。间隔开的元件阵列放置在模板上。在模板的指导下，在元件上形成能量发射和非能量发射区。通过覆盖元件，形成复合结构，其可以引入体内以使用基于导管的血管通路技术来烧蚀组织。

5. 发明授权

US5575810A Composite structures and methods for ablating tissue to form complex lesion patterns in the treatment of cardiac conditions and the like 失效
公开(公告)号：US5575810A
公开(公告)日：1996-11-19
申请号：US528805
申请日：1995-09-15
申请人： David K. Swanson , Sidney D. Fleischman , Thomas F. Kordis , David L. McGee
发明人： David K. Swanson , Sidney D. Fleischman , Thomas F. Kordis , David L. McGee
IPC分类号： A61B18/14 , A61N1/06
CPC分类号： A61B18/1492 , A61B2017/003 , A61B2018/00083 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00577 , A61B2018/00839 , A61B2018/1437 , A61B2018/1467 , A61B2018/1497
摘要： A method of ablating tissue in the heart to treat atrial fibrillation introduces into a selected atrium an energy emitting element. The method exposes the element to a region of the atrial wall and applies ablating energy to the element to thermally destroy tissue. The method forms a convoluted lesion pattern comprising elongated straight lesions and elongated curvilinear lesions. The lesion pattern directs electrical impulses within the atrial myocardium along a path that activates the atrial myocardium while interrupting reentry circuits that, if not interrupted, would cause fibrillation. The method emulates the surgical maze procedure, but lends itself to catheter-based procedures that do not require open heart surgical techniques. A composite structure for performing the method is formed using a template that displays in planar view a desired lesion pattern for the tissue. An array of spaced apart element is laid on the template. Guided by the template, energy emitting and non-energy emitting zones are formed on the elements. By overlaying the elements, the composite structure is formed, which can be introduced into the body to ablate tissue using catheter-based, vascular access techniques.

6. 发明申请

US20080161802A1 Composite Structures and Methods for Ablating Tissue to Form Complex Lesion Patterns in the Treatment of Cardiac Conditions and the Like 失效
标题翻译：复合结构和方法，用于消除组织形成复杂病变模式的心脏病症等
公开(公告)号：US20080161802A1
公开(公告)日：2008-07-03
申请号：US11923373
申请日：2007-10-24
申请人： David K. Swanson , Sidney D. Fleischman , Thomas F. Kordis , David L. McGee
发明人： David K. Swanson , Sidney D. Fleischman , Thomas F. Kordis , David L. McGee
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2017/003 , A61B2018/00083 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00577 , A61B2018/00839 , A61B2018/1437 , A61B2018/1467 , A61B2018/1497
摘要： A method of ablating tissue in the heart to treat atrial fibrillation introduces into a selected atrium an energy emitting element. The method exposes the element to a region of the atrial wall and applies ablating energy to the element to thermally destroy tissue. The method forms a convoluted lesion pattern comprising elongated straight lesions and elongated curvilinear lesions. The lesion pattern directs electrical impulses within the atrial myocardium along a path that activates the atrial myocardium while interrupting reentry circuits that, if not interrupted, would cause fibrillation. The method emulates the surgical maze procedure, but lends itself to catheter-based procedures that do not require open heart surgical techniques. A composite structure for performing the method is formed using a template that displays in planar view a desired lesion pattern for the tissue. An array of spaced apart element is laid on the template. Guided by the template, energy emitting and non-energy emitting zones are formed on the elements. By overlaying the elements, the composite structure is formed, which can be introduced into the body to ablate tissue using catheter-based, vascular access techniques.
摘要翻译：心脏中消融组织以治疗心房颤动的方法将所选择的心房引入能量发射元件。该方法将该元件暴露于心房壁的一个区域，并向该元件施加消融能量以热破坏组织。该方法形成包括细长的直线损伤和细长的曲线损伤的褶皱病变图案。病变图案沿着激活心房心肌的路径引导心房心肌内的电脉冲，同时中断再入电路，如果不中断，将引起原纤维化。该方法模拟外科迷宫手术，但适用于不需要开放心脏手术技术的基于导管的手术。用于执行该方法的复合结构使用在平面图中显示用于组织的期望损伤图案的模板来形成。间隔开的元件阵列放置在模板上。在模板的指导下，在元件上形成能量发射和非能量发射区。通过覆盖元件，形成复合结构，其可以引入体内以使用基于导管的血管通路技术来烧蚀组织。

7. 发明授权

US5968040A Systems and methods using asymmetric multiple electrode arrays 失效
标题翻译：使用不对称多电极阵列的系统和方法
公开(公告)号：US5968040A
公开(公告)日：1999-10-19
申请号：US728698
申请日：1996-10-28
申请人： David K. Swanson , Sidney D. Fleischman , Dorin Panescu , James G. Whayne , Thomas F. Kordis
发明人： David K. Swanson , Sidney D. Fleischman , Dorin Panescu , James G. Whayne , Thomas F. Kordis
IPC分类号： A61N1/00 , A61B17/39
CPC分类号： A61N1/00
摘要： Systems and methods support arrays of multiple electrodes in asymmetric pattern, either radially, or axially, or both. Radial asymmetry makes it possible provide localized density of electrodes. Axial asymmetry makes it possible to locate electrodes in a pattern that closely conforms to the irregular contours of an interior body cavity, like the heart. In a preferred embodiment, the systems and methods operate the multiple electrode arrays to form continuous lesion patterns.
摘要翻译：系统和方法以径向或轴向或两者不对称的方式支持多个电极的阵列。径向不对称使得可能提供电极的局部密度。轴向不对称使得可以将电极定位成与内部体腔的不规则轮廓紧密一致的图案，如心脏。在优选实施例中，系统和方法操作多个电极阵列以形成连续的病变图案。

8. 发明授权

US6014590A Systems and methods employing structures having asymmetric mechanical properties to support diagnostic or therapeutic elements in contact with tissue in interior body regions 失效
标题翻译：使用具有不对称机械性能的结构以支持与内部身体区域中的组织接触的诊断或治疗元件的系统和方法
公开(公告)号：US6014590A
公开(公告)日：2000-01-11
申请号：US742564
申请日：1996-10-28
申请人： James G. Whayne , Sidney D. Fleischman , Dorin Panescu , Thomas F. Kordis , David K. Swanson
发明人： James G. Whayne , Sidney D. Fleischman , Dorin Panescu , Thomas F. Kordis , David K. Swanson
IPC分类号： A61B17/39
摘要： Structures having asymmetric mechanical properties provide enhanced ability to support therapeutic or diagnostic elements in contact with tissue in an interior body region. The support structure includes a first region, which exhibits a first mechanical property affecting tissue contact, and a second region spaced from the first region about the axis, which exhibits a second mechanical property, different than the first mechanical property, affecting tissue contact. In a preferred embodiment, the first and second mechanical properties correlate with stiffness of the respective first and second regions, with the first region being more flexible (i.e., less stiff) than the second region. The first region, due to its greater flexibility, is more conformal to tissue than the second region. The less flexible (i.e., more stiff) second region imparts greater force against the tissue to urge the more flexible first region toward intimate tissue contact. In a preferred embodiment, the more flexible first region carries at least one therapeutic or diagnostic element.
摘要翻译：具有不对称机械特性的结构提供增强的能力，以支持与内部身体区域中的组织接触的治疗或诊断元件。支撑结构包括表现出影响组织接触的第一机械特性的第一区域以及围绕轴线与第一区域隔开的第二区域，该第二区域具有影响组织接触的第二机械特性，该第二机械特性不同于第一机械特性。在优选实施例中，第一和第二机械特性与相应的第一和第二区域的刚度相关，其中第一区域比第二区域更加柔性（即，较不硬）。第一个区域由于其更大的灵活性，比第二个区域更适合组织。较不柔性（即更硬）的第二区域赋予组织更大的力以促使更柔性的第一区域朝向紧密的组织接触。在优选实施方案中，更灵活的第一区域携带至少一种治疗或诊断元件。

9. 发明授权

US5911739A Structures for supporting diagnostic or therapeutic elements in internal body regions 失效
标题翻译：用于支持内部身体区域的诊断或治疗元件的结构
公开(公告)号：US5911739A
公开(公告)日：1999-06-15
申请号：US738856
申请日：1996-10-28
申请人： Thomas F. Kordis , James G. Whayne , Dorin Panescu , David K. Swanson , Sidney D. Fleischman
发明人： Thomas F. Kordis , James G. Whayne , Dorin Panescu , David K. Swanson , Sidney D. Fleischman
IPC分类号： A61N1/00 , A61B17/36
CPC分类号： A61B5/0422 , A61B18/1492 , A61B5/6852 , A61B5/6858 , A61N1/056 , A61B18/14 , A61B18/18 , A61B2018/00214 , A61B2018/00267 , A61B2018/00351 , A61B2018/00839 , A61B2018/1407 , A61B2018/1435 , A61B2018/1465 , A61B2562/0209 , A61B2562/043
摘要： Elongated spline members are threaded through a hub to form depending spline legs. In one embodiment, the spline members are threaded through a puncturable material on the hub. In another embodiment, the spline members are threaded through a slotted hub, which is then encapsulated by a sealing, elastomeric material. In another embodiment, multiple spline members are looped and woven together beyond a distal end of the hub, and the distal end of the hub serves to exert a force that maintains the woven relationship of the spline members. The spline legs, which radiate from the hub, preferable carry one or more diagnostic or therapeutic elements, such as electrodes. Preferably, a base constrains the terminal ends of the spline legs in a normally expanded geometry between the hub and base.
摘要翻译：细长的花键构件穿过轮毂以形成悬垂的花键腿。在一个实施例中，花键构件穿过轮毂上的可刺破材料。在另一个实施例中，花键构件穿过开槽的毂，然后由密封的弹性体材料包封。在另一个实施例中，多个花键构件环绕并且一起超越轮毂的远端编织，轮毂的远端用于施加维持花键构件的编织关系的力。从轮毂辐射的花键腿优选携带一个或多个诊断或治疗元件，例如电极。优选地，基座以轮毂和底座之间的正常展开的几何形状约束花键腿的末端。

10. 发明授权

US5853411A Enhanced electrical connections for electrode structures 失效
标题翻译：电极结构的增强电连接
公开(公告)号：US5853411A
公开(公告)日：1998-12-29
申请号：US629363
申请日：1996-04-08
申请人： James G. Whayne , Thomas F. Kordis , Sidney D. Fleischman , Dorin Panescu , David K. Swanson , Patrick M. Owens , Jerome Jackson , Russell B. Thompson , David McGee
发明人： James G. Whayne , Thomas F. Kordis , Sidney D. Fleischman , Dorin Panescu , David K. Swanson , Patrick M. Owens , Jerome Jackson , Russell B. Thompson , David McGee
IPC分类号： A61B17/00 , A61B17/22 , A61B18/14 , A61N1/05 , A61B17/39 , A61B5/042
CPC分类号： A61N1/056 , A61B18/1492 , A61B2017/00053 , A61B2017/00243 , A61B2017/22051 , A61B2017/22061 , A61B2018/00083 , A61B2018/00095 , A61B2018/00107 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022
摘要： Enhanced electrical connections for electrodes are provided. In one implementation, an electrode body comprises a first electrically nonconductive layer and a second electrically nonconductive layer overlying at least a portion of the first layer. An intermediate region is formed between the first and second layers. An electrically conductive pathway extends within the intermediate region. An formed opening extends to the intermediate region, exposing a part of the electrically conductive pathway. An electrically conductive material is deposited on the second layer so that a part of the electrically conductive material passes through the opening to establish electrical contact between the electrically conductive material and the electrically conductive pathway.
摘要翻译：提供了电极的增强电连接。在一个实施方案中，电极体包括覆盖在第一层的至少一部分上的第一非导电层和第二非导电层。在第一和第二层之间形成中间区域。导电通路在中间区域内延伸。形成的开口延伸到中间区域，暴露导电路径的一部分。导电材料沉积在第二层上，使得导电材料的一部分通过开口以在导电材料和导电通路之间建立电接触。

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