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1. 发明申请

US20060141597A1 Valency platform molecules comprising aminooxy groups 审中-公开
标题翻译：价值平台分子包含氨氧基
公开(公告)号：US20060141597A1
公开(公告)日：2006-06-29
申请号：US11303591
申请日：2005-12-16
申请人： David Jones , Huong-Thu Ton-Nu , Fang Xie , Anping Tao , Tong Xu , Jeffrey Hammaker
发明人： David Jones , Huong-Thu Ton-Nu , Fang Xie , Anping Tao , Tong Xu , Jeffrey Hammaker
IPC分类号： C12N9/00 , C07H21/02 , C08B37/00 , C07K17/14 , C07K14/575 , C07K14/47 , C07K16/46 , C07C237/02
CPC分类号： C07D295/185 , A61K47/54 , A61K47/60 , C07C251/60 , C07C271/16 , C07C271/20 , C07C323/60 , C07D295/205 , C07K14/775 , C08B37/0012 , C08G65/329 , C08G65/33396 , C08G83/003
摘要： Molecules comprising aminooxy groups are provided, wherein the aminooxy groups provide attachment sites for the covalent attachment of other molecules. In one embodiment, polyoxyethylene molecules comprising aminooxy groups are provided that can be conjugated to wide variety of biologically active molecules including poly(amino acids). In another embodiment, valency platform molecules comprising aminooxy groups are provided. The aminooxy groups can be used to form covalent bonds with biological molecules such as poly(amino acids). The aminooxy groups can, for example, react with poly(amino acids) modified to contain carbonyl groups, such as glyoxyl groups, to form a conjugate of the valency platform molecule and the biologically active molecule via an oxime bond. The valency platform molecules comprising aminooxy groups are advantageously reactive in the formation of conjugates, and they also can be readily synthesized to form a composition with very low polydispersity.
摘要翻译：提供包含氨基氧基的分子，其中氨基氧基为其它分子的共价连接提供附着位点。在一个实施方案中，提供了包含氨基氧基的聚氧乙烯分子，其可与多种生物活性分子（包括聚（氨基酸））缀合。在另一个实施方案中，提供了包含氨基氧基的化合物平台分子。氨基氧基可用于与生物分子如聚（氨基酸）形成共价键。例如，氨基氧基可以与经修饰以含有羰基（例如乙醛基）的聚（氨基酸）反应，以通过肟键形成价态平台分子和生物活性分子的缀合物。包含氨基氧基的价态平台分子在缀合物的形成中有利地是反应性的，并且它们也可以容易地合成以形成具有非常低的多分散性的组合物。

2. 发明申请

US20070191263A1 Valency platform molecules comprising aminooxy groups 审中-公开
标题翻译：价值平台分子包含氨氧基
公开(公告)号：US20070191263A1
公开(公告)日：2007-08-16
申请号：US11728853
申请日：2007-03-26
申请人： David Jones , Huong-Thu Ton-Nu , Fang Xie , Anping Tao , Tong Xu , Jeffrey Hammaker
发明人： David Jones , Huong-Thu Ton-Nu , Fang Xie , Anping Tao , Tong Xu , Jeffrey Hammaker
IPC分类号： A61K38/16 , A61K48/00 , A61K31/715
CPC分类号： C07D295/185 , A61K47/54 , A61K47/60 , C07C251/60 , C07C271/16 , C07C271/20 , C07C323/60 , C07D295/205 , C07K14/775 , C08B37/0012 , C08G65/329 , C08G65/33396 , C08G83/003
摘要： Molecules comprising aminooxy groups are provided, wherein the aminooxy groups provide attachment sites for the covalent attachment of other molecules. In one embodiment, polyoxyethylene molecules comprising aminooxy groups are provided that can be conjugated to wide variety of biologically active molecules including poly(amino acids). In another embodiment, valency platform molecules comprising aminooxy groups are provided. The aminooxy groups can be used to form covalent bonds with biological molecules such as poly(amino acids). The aminooxy groups can, for example, react with poly(amino acids) modified to contain carbonyl groups, such as glyoxyl groups, to form a conjugate of the valency platform molecule and the biologically active molecule via an oxime bond. The valency platform molecules comprising aminooxy groups are advantageously reactive in the formation of conjugates, and they also can be readily synthesized to form a composition with very low polydispersity.
摘要翻译：提供包含氨基氧基的分子，其中氨基氧基为其它分子的共价连接提供附着位点。在一个实施方案中，提供了包含氨基氧基的聚氧乙烯分子，其可与多种生物活性分子（包括聚（氨基酸））缀合。在另一个实施方案中，提供了包含氨基氧基的化合物平台分子。氨基氧基可用于与生物分子如聚（氨基酸）形成共价键。例如，氨基氧基可以与经修饰以含有羰基（例如乙醛基）的聚（氨基酸）反应，以通过肟键形成价态平台分子和生物活性分子的缀合物。包含氨基氧基的价态平台分子在共轭物的形成中有利地是反应性的，并且它们也可以容易地合成以形成具有非常低的多分散性的组合物。

3. 发明申请

US20110053152A1 METHOD FOR CANCER DETECTION, DIAGNOSIS AND PROGNOSIS 有权
标题翻译：癌症检测，诊断和预防方法
公开(公告)号：US20110053152A1
公开(公告)日：2011-03-03
申请号：US12784446
申请日：2010-05-20
申请人： Amir Goldkorn , Yu-Chong Tai , Tong Xu , Bo Lu
发明人： Amir Goldkorn , Yu-Chong Tai , Tong Xu , Bo Lu
IPC分类号： C12Q1/68 , G01N33/574 , C12M3/06 , C12N5/09
CPC分类号： G01N33/57496 , C12N5/0693 , C12N2503/00 , C12Q1/6806 , C12Q1/6886 , C12Q2600/118 , C12Y207/07049 , G01N1/30 , G01N1/4077 , G01N33/5094 , G01N2001/4088 , G01N2333/9128 , Y10T436/25375
摘要： The present invention provides a method for diagnosing cancer, predicting a disease outcome or response to therapy in a patient sample. The method involves isolating a circulating tumor cell (CTC), for example, a viable CTC, from a sample using a parylene microfilter device comprising a membrane filter having or consisting of a parylene substrate, which has an array of holes with a predetermined shape and size; and detecting and quantifying telomerase activity in blood circulating tumor cells. The invention further provides methods of using cells live-captured in various applications.
摘要翻译：本发明提供一种用于诊断癌症的方法，预测患者样品中的疾病结果或对治疗的反应。该方法包括使用聚对二甲苯微型过滤器装置从样品中分离循环肿瘤细胞（CTC），例如可行的CTC，所述聚对二甲苯微型过滤器包括具有具有预定形状的孔阵列的具有聚对二甲苯衬底或由聚对二甲苯衬底组成的膜过滤器，尺寸; 并检测和定量血液循环肿瘤细胞中的端粒酶活性。本发明还提供了使用在各种应用中实时捕获的细胞的方法。

4. 发明申请

US20150120197A1 Method of Transforming Reservoir Properties to a Seismic Attribute for Hydrocarbon and Lithology Identification 审中-公开
标题翻译：将油藏特性转化为烃类和岩性识别的地震属性的方法
公开(公告)号：US20150120197A1
公开(公告)日：2015-04-30
申请号：US14067528
申请日：2013-10-30
申请人： Tong Xu
发明人： Tong Xu
IPC分类号： G01V1/48 , G01V1/40
CPC分类号： G01V1/48 , G01V1/307 , G01V1/40 , G01V1/50 , G01V2210/6169 , G01V2210/6242 , G01V2210/632
摘要： Embodiments of a method for transforming petrophysical properties into seismic attributes are disclosed herein. Embodiments of the method utilize an AVO expression which maps lithology to P-wave reflectivity at a particular angle through their λ/μ values (or equivalent elastic properties K/μ and γ). Rocks with different λ/μ will be projected to the different angle and reflectivity. The equation which transforms λ/μ to reflection angle may be referred to as a Generalized Angle Transform Equation (GATE). Further details and advantages of various embodiments of the method are described in more herein.
摘要翻译：本文公开了将岩石物理性质转换成地震属性的方法的实施例。该方法的实施例利用AVO表达式，其通过λ/μ值（或等效弹性特性K /μ和γ）以特定角度将岩性映射到P波反射率。具有不同λ/μ的岩石将投射到不同的角度和反射率。将λ/μ变换为反射角的方程可以称为广义角度变换方程（GATE）。该方法的各种实施例的更多细节和优点在本文中更详细地描述。

5. 发明授权

US08551425B2 Method for cancer detection, diagnosis and prognosis 有权
标题翻译：癌症检测，诊断和预后的方法
公开(公告)号：US08551425B2
公开(公告)日：2013-10-08
申请号：US12784446
申请日：2010-05-20
申请人： Amir Goldkorn , Yu-Chong Tai , Tong Xu , Bo Lu
发明人： Amir Goldkorn , Yu-Chong Tai , Tong Xu , Bo Lu
IPC分类号： B01D35/00 , B01D41/00 , B01D21/00 , B01D61/00 , G01N1/18 , C02F1/44
CPC分类号： G01N33/57496 , C12N5/0693 , C12N2503/00 , C12Q1/6806 , C12Q1/6886 , C12Q2600/118 , C12Y207/07049 , G01N1/30 , G01N1/4077 , G01N33/5094 , G01N2001/4088 , G01N2333/9128 , Y10T436/25375
摘要： The present invention provides a method for diagnosing cancer, predicting a disease outcome or response to therapy in a patient sample. The method involves isolating a circulating tumor cell (CTC), for example, a viable CTC, from a sample using a parylene microfilter device comprising a membrane filter having or consisting of a parylene substrate, which has an array of holes with a predetermined shape and size; and detecting and quantifying telomerase activity in blood circulating tumor cells. The invention further provides methods of using cells live-captured in various applications.
摘要翻译：本发明提供一种用于诊断癌症的方法，预测患者样品中的疾病结果或对治疗的反应。该方法包括使用聚对二甲苯微型过滤器装置从样品中分离循环肿瘤细胞（CTC），例如可行的CTC，所述聚对二甲苯微型过滤器包括具有具有预定形状的孔阵列的具有聚对二甲苯衬底或由聚对二甲苯衬底组成的膜过滤器，尺寸; 并检测和定量血液循环肿瘤细胞中的端粒酶活性。本发明还提供了使用在各种应用中实时捕获的细胞的方法。

6. 发明申请

US20070265528A1 Method and apparatus for real-time tumor tracking 失效
标题翻译：用于实时肿瘤追踪的方法和装置
公开(公告)号：US20070265528A1
公开(公告)日：2007-11-15
申请号：US11786401
申请日：2007-04-10
申请人： Tong Xu , Jerry Wong , Sabee Molloi
发明人： Tong Xu , Jerry Wong , Sabee Molloi
IPC分类号： A61B5/05 , A61B6/00
CPC分类号： G01T1/2985 , A61B6/4258
摘要： Method and apparatus for real-time tracking of a target in a human body. In one embodiment of the invention, positron emission marker may be implanted into a target, the positron emission marker having a low activity positron isotope. In one embodiment, annihilation gamma rays associated with the low activity positron isotope may be detected using a plurality of position-sensitive detectors. In another embodiment, the target may be tracked in real-time based on a position of the positron emission marker.
摘要翻译：用于实时跟踪人体目标的方法和装置。在本发明的一个实施方案中，可以将正电子发射标记物植入目标物，正电子发射标记具有低活性正电子同位素。在一个实施例中，可以使用多个位置敏感检测器来检测与低活性正电子同位素相关联的湮灭伽马射线。在另一个实施例中，可以基于正电子发射标记的位置实时跟踪目标。

7. 发明申请

US20120185171A1 MULTIPLE ANISOTROPIC PARAMETER INVERSION FOR A TTI EARTH MODEL USING WELL DATA 失效
标题翻译：使用良好数据的TTI地球模型的多个ANISOTROPIC参数反演
公开(公告)号：US20120185171A1
公开(公告)日：2012-07-19
申请号：US13368134
申请日：2012-02-07
申请人： Yonghe Sun , Yue Wang , Tong Xu , Leonard Lin Zhang
发明人： Yonghe Sun , Yue Wang , Tong Xu , Leonard Lin Zhang
IPC分类号： G06F19/00
CPC分类号： G01V1/303
摘要： A method for determining values of anisotropic model parameters of a Tilted Transversely Isotropic (TTI) Earth model, the method including obtaining an initial TTI earth model that substantially flattens common-imaging-point gathers and substantially ties seismic data to well data; inputting checkshot data and/or VSP data to determine updated values of Vp0 near the well locations; determining an incremental improvement Δδ; extrapolating the relative change Δδ from near-well locations to the entire three dimensional TTI earth model; determining updated values of Vp0=Vp0 (1−Δδ); inputting near-to-mid-offset/angle and mid-to-far-offset/angle residual moveout information; and providing updated values of δ and η.
摘要翻译：一种用于确定倾斜横向各向同性（TTI）地球模型的各向异性模型参数值的方法，该方法包括获得基本平坦的共同成像点集合并且将地震数据实质上与井数据相关联的初始TTI地球模型; 输入检查数据和/或VSP数据以确定井位置附近的Vp0的更新值; 确定渐进式改进; 将相对变化＆Dgr;δ从近井位推导到整个三维TTI地球模型; 确定Vp0 = Vp0（1-＆Dgr;δ）的更新值; 输入近中偏移/角度和中到远偏移/角度剩余移动信息; 并提供δ和eegr的更新值。

8. 发明授权

US08447387B2 Method and apparatus for real-time tumor tracking by detecting annihilation gamma rays from low activity position isotope fiducial markers 失效
标题翻译：通过从低活动位置同位素基准标记物检测湮灭伽马射线，实时肿瘤跟踪的方法和装置
公开(公告)号：US08447387B2
公开(公告)日：2013-05-21
申请号：US11786401
申请日：2007-04-10
申请人： Tong Xu , Jerry Thwin Wong , Sabee Molloi
发明人： Tong Xu , Jerry Thwin Wong , Sabee Molloi
IPC分类号： A61B6/12
CPC分类号： G01T1/2985 , A61B6/4258
摘要： Method and apparatus for real-time tracking of a target in a human body. In one embodiment of the invention, positron emission marker may be implanted into a target, the positron emission marker having a low activity positron isotope. In one embodiment, annihilation gamma rays associated with the low activity positron isotope may be detected using a plurality of position-sensitive detectors. In another embodiment, the target may be tracked in real-time based on a position of the positron emission marker.
摘要翻译：用于实时跟踪人体目标的方法和装置。在本发明的一个实施方案中，可以将正电子发射标记物植入目标物，正电子发射标记具有低活性正电子同位素。在一个实施例中，可以使用多个位置敏感检测器来检测与低活性正电子同位素相关联的湮灭伽马射线。在另一个实施例中，可以基于正电子发射标记的位置实时跟踪目标。

9. 发明授权

US09240637B2 High density terminal block 有权
标题翻译：高密度接线端子
公开(公告)号：US09240637B2
公开(公告)日：2016-01-19
申请号：US14366765
申请日：2011-12-23
申请人： Hao Lu , Tong Xu , Jiuhong Geng
发明人： Hao Lu , Tong Xu , Jiuhong Geng
IPC分类号： H01R9/24 , H01R13/46 , H01R13/62 , H01R43/18 , H01R43/26
CPC分类号： H01R9/2408 , H01R9/2416 , H01R13/46 , H01R13/62 , H01R43/18 , H01R43/26 , Y10T29/49174
摘要： A module of a terminal block (100) comprises a body (104) having an input configured to be coupled to an input wire and an output configured to be coupled to a plurality of output wires, a conductive element disposed within the input, and a plurality of terminals, each terminal having a first portion and a second portion configured to be coupled to an output wire, wherein the first portions of the plurality of terminals are nested together to achieve a single conductive structure, and wherein the conductive element is configured to engage and compress the input wire against the single conductive structure.
摘要翻译：端子块（100）的模块包括主体（104），其具有被配置为耦合到输入线的输入端和被配置为耦合到多个输出线的输出，设置在输入内的导电元件，以及多个端子，每个端子具有第一部分和第二部分，被配置为耦合到输出导线，其中多个端子的第一部分嵌套在一起以实现单个导电结构，并且其中导电元件被配置为将输入线接合并压缩抵抗单个导电结构。

10. 发明申请

US20150149469A1 METHODS AND APPARATUS FOR ASSOCIATING INTEREST TAGS WITH MEDIA ITEMS BASED ON SOCIAL DIFFUSIONS AMONG USERS 审中-公开
标题翻译：基于用户社会差距的媒体项目相关标签的方法和装置
公开(公告)号：US20150149469A1
公开(公告)日：2015-05-28
申请号：US14400943
申请日：2012-06-14
申请人： Tong Xu , Hengshu Zhu , Huanhuan Cao , Dong Liu , Jilei Tian
发明人： Tong Xu , Hengshu Zhu , Huanhuan Cao , Dong Liu , Jilei Tian
IPC分类号： G06F17/30 , H04L29/06
CPC分类号： G06F16/955 , G06F16/48 , H04L65/403
摘要： An approach is provided for associating interest tags with media items based on social diffusions among users. The media tagging platform processes and/or facilitates a processing of one or more user profiles to determine one or more interest tags relating to one or more users, captured at one or more user devices to determine one or more frequencies of the one or more signals. Next, the media tagging platform determines one or more social diffusions of the one or more media items among the one or more users. Then, the media tagging platform causes, at least in part, an association of the one or more media items with the one or more interest tags based, at least in part, on the one or more social diffusions.
摘要翻译：提供了一种用于将兴趣标签与基于用户之间的社会扩散的媒体项目相关联的方法。媒体标签平台处理和/或促进一个或多个用户简档的处理以确定在一个或多个用户设备处捕获的与一个或多个用户相关的一个或多个兴趣标签，以确定一个或多个信号的一个或多个频率。接下来，媒体标签平台确定一个或多个用户中的一个或多个媒体项目的一个或多个社会扩散。然后，媒体标签平台至少部分地至少部分地使一个或多个媒体项目与一个或多个兴趣标签的关联，至少部分地基于一个或多个社会扩散。

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