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1. 发明授权

US06329140B1 Identification of molecular sequence signatures and methods involving the same 失效
标题翻译：识别分子序列特征及涉及相同的方法
公开(公告)号：US06329140B1
公开(公告)日：2001-12-11
申请号：US08933219
申请日：1997-09-18
申请人： David J. Lockhart , Gordon G. Wong , Pennina Langer-Safer
发明人： David J. Lockhart , Gordon G. Wong , Pennina Langer-Safer
IPC分类号： C12Q168
CPC分类号： B82Y30/00 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , C12Q1/6827 , C12Q1/6837 , C40B40/06 , C12Q2565/515
摘要： Novel means and methods for analyzing hybridization data derived from hybridization assays between a target nucleic acid and differently sequenced polynucleotide probes involve selecting probe sets that define reference sequences for sequence signatures and deriving useful data about the nature of the target nucleic acid molecule based its hybridization to the probes. The methods are useful for determining whether the target contains a nucleic acid or polypeptide or sequence signature, whether the target encodes a member of a gene family, or whether the target is derived from one of any number of genes.
摘要翻译：用于分析衍生自靶核酸和不同测序的多核苷酸探针之间的杂交测定的杂交数据的新颖方法和方法包括选择定义用于序列特征的参考序列的探针组，并且基于其与核酸分子的杂交获得关于靶核酸分子的性质的有用数据探针。所述方法对于确定靶是否含有核酸或多肽或序列特征，靶标是否编码基因家族的成员，或者靶是否衍生自任何数量的基因之一是有用的。

2. 发明授权

US06391550B1 Identification of molecular sequence signatures and methods involving the same 有权
标题翻译：鉴定分子序列特征及涉及相同的方法
公开(公告)号：US06391550B1
公开(公告)日：2002-05-21
申请号：US09321481
申请日：1999-05-27
申请人： David J. Lockhart , Gordon G. Wong , Pennina Langer-Safer
发明人： David J. Lockhart , Gordon G. Wong , Pennina Langer-Safer
IPC分类号： C12Q168
CPC分类号： C12Q1/6827 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C12Q1/6837 , C40B40/06 , C12Q2565/515
摘要： Novel means and methods for analyzing hybridization data derived from hybridization assays between a target nucleic acid and differently sequenced polynucleotide probes involve selecting probe sets that define reference sequences for sequence signatures and deriving useful data about the nature of the target nucleic acid molecule based on its hybridization to the probes. The methods are useful for determining whether the target contains a nucleic acid or polypeptide sequence signature, whether the target encodes a member of a gene family, or whether the target is derived from one of any number of genes.
摘要翻译：用于分析衍生自靶核酸和不同序列多核苷酸探针之间的杂交测定的杂交数据的新颖方法和方法涉及选择定义用于序列特征的参考序列的探针组，并且基于其杂交获得关于靶核酸分子的性质的有用数据到探头。所述方法对于确定靶是否含有核酸或多肽序列特征，靶是否编码基因家族的成员，或者靶是否衍生自任何数量的基因之一是有用的。

3. 发明授权

US08084197B2 Identification of molecular sequence signatures and methods involving the same 有权
标题翻译：鉴定分子序列特征及涉及相同的方法
公开(公告)号：US08084197B2
公开(公告)日：2011-12-27
申请号：US11745987
申请日：2007-05-08
申请人： David J. Lockhart , Gordon G. Wong , Pennina Langer-Safer
发明人： David J. Lockhart , Gordon G. Wong , Pennina Langer-Safer
IPC分类号： C12Q1/68 , C07H21/00 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6827 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C12Q1/6837 , C40B40/06 , C12Q2565/515
摘要： Novel means and methods for analyzing hybridization data derived from hybridization assays between a target nucleic acid and differently sequenced polynucleotide probes involve selecting probe sets that define reference sequences for sequence signatures and deriving useful data about the nature of the target nucleic acid molecule based on its hybridization to the probes. The methods are useful for determining whether the target contains a nucleic acid or polypeptide sequence signature, whether the target encodes a member of a gene family, or whether the target is derived from one of any number of genes.
摘要翻译：用于分析衍生自靶核酸和不同序列多核苷酸探针之间的杂交测定的杂交数据的新颖方法和方法涉及选择定义用于序列特征的参考序列的探针组，并且基于其杂交获得关于靶核酸分子的性质的有用数据到探头。所述方法对于确定靶是否含有核酸或多肽序列特征，靶是否编码基因家族的成员，或者靶是否衍生自任何数量的基因之一是有用的。

4. 发明授权

US07135285B2 Identification of molecular sequence signatures and methods involving the same 有权
公开(公告)号：US07135285B2
公开(公告)日：2006-11-14
申请号：US10099442
申请日：2002-03-14
申请人： David J. Lockhart , Gordon G. Wong , Pennina Langer-Safer
发明人： David J. Lockhart , Gordon G. Wong , Pennina Langer-Safer
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6827 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C12Q1/6837 , C40B40/06 , C12Q2565/515
摘要： Novel means and methods for analyzing hybridization data derived from hybridization assays between a target nucleic acid and differently sequenced polynucleotide probes involve selecting probe sets that define reference sequences for sequence signatures and deriving useful data about the nature of the target nucleic acid molecule based on its hybridization to the probes. The methods are useful for determining whether the target contains a nucleic acid or polypeptide sequence signature, whether the target encodes a member of a gene family, or whether the target is derived from one of any number of genes.

5. 发明授权

US07323307B2 Identification of molecular sequence signatures and methods involving the same 有权
标题翻译：鉴定分子序列特征及涉及相同的方法
公开(公告)号：US07323307B2
公开(公告)日：2008-01-29
申请号：US10911065
申请日：2004-08-04
申请人： David J. Lockhart , Gordon G. Wong , Pennina Langer-Safer
发明人： David J. Lockhart , Gordon G. Wong , Pennina Langer-Safer
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6827 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C12Q1/6837 , C40B40/06 , C12Q2565/515
摘要： Novel means and methods for analyzing hybridization data derived from hybridization assays between a target nucleic acid and differently sequenced polynucleotide probes involve selecting probe sets that define reference sequences for sequence signatures and deriving useful data about the nature of the target nucleic acid molecule based on its hybridization to the probes. The methods are useful for determining whether the target contains a nucleic acid or polypeptide sequence signature, whether the target encodes a member of a gene family, or whether the target is derived from one of any number of genes.
摘要翻译：用于分析衍生自靶核酸和不同序列多核苷酸探针之间的杂交测定的杂交数据的新颖方法和方法涉及选择定义用于序列特征的参考序列的探针组，并且基于其杂交获得关于靶核酸分子的性质的有用数据到探头。所述方法对于确定靶是否含有核酸或多肽序列特征，靶是否编码基因家族的成员，或者靶是否衍生自任何数量的基因之一是有用的。

6. 发明申请

US20120077701A1 Identification of Molecular Sequence Signatures and Methods Involving the Same 审中-公开
标题翻译：鉴定分子序列特征及涉及其的方法
公开(公告)号：US20120077701A1
公开(公告)日：2012-03-29
申请号：US13300341
申请日：2011-11-18
申请人： David J. Lockhart , Gordon G. Wong , Pennina Langer-Safer
发明人： David J. Lockhart , Gordon G. Wong , Pennina Langer-Safer
IPC分类号： C40B30/04 , C40B40/06
CPC分类号： B82Y30/00 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , C12Q1/6827 , C12Q1/6837 , C40B40/06 , C12Q2565/515
摘要： Novel means and methods for analyzing hybridization data derived from hybridization assays between a target nucleic acid and differently sequenced polynucleotide probes involve selecting probe sets that define reference sequences for sequence signatures and deriving useful data about the nature of the target nucleic acid molecule based on its hybridization to the probes. The methods are useful for determining whether the target contains a nucleic acid or polypeptide sequence signature, whether the target encodes a member of a gene family, or whether the target is derived from one of any number of genes.
摘要翻译：用于分析衍生自靶核酸和不同序列多核苷酸探针之间的杂交测定的杂交数据的新颖方法和方法涉及选择定义用于序列特征的参考序列的探针组，并且基于其杂交获得关于靶核酸分子的性质的有用数据到探头。所述方法对于确定靶是否含有核酸或多肽序列特征，靶是否编码基因家族的成员，或者靶是否衍生自任何数量的基因之一是有用的。

7. 发明申请

US20090029865A1 IDENTIFICATION OF MOLECULAR SEQUENCE SIGNATURES AND METHODS INVOLVING THE SAME 有权
标题翻译：识别分子序列符号及涉及其的方法
公开(公告)号：US20090029865A1
公开(公告)日：2009-01-29
申请号：US11745987
申请日：2007-05-08
申请人： David J. Lockhart , Gordon G. Wong , Pennina Langer-Safer
发明人： David J. Lockhart , Gordon G. Wong , Pennina Langer-Safer
IPC分类号： C40B30/04
CPC分类号： C12Q1/6827 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C12Q1/6837 , C40B40/06 , C12Q2565/515
摘要： Novel means and methods for analyzing hybridization data derived from hybridization assays between a target nucleic acid and differently sequenced polynucleotide probes involve selecting probe sets that define reference sequences for sequence signatures and deriving useful data about the nature of the target nucleic acid molecule based on its hybridization to the probes. The methods are useful for determining whether the target contains a nucleic acid or polypeptide sequence signature, whether the target encodes a member of a gene family, or whether the target is derived from one of any number of genes.
摘要翻译：用于分析衍生自靶核酸和不同序列多核苷酸探针之间的杂交测定的杂交数据的新颖方法和方法涉及选择定义用于序列特征的参考序列的探针组，并且基于其杂交获得关于靶核酸分子的性质的有用数据到探头。所述方法对于确定靶是否含有核酸或多肽序列特征，靶是否编码基因家族的成员，或者靶是否衍生自任何数量的基因之一是有用的。

8. 发明授权

US06410229B1 Expression monitoring by hybridization to high density nucleic acid arrays 有权
标题翻译：通过与高密度核酸阵列杂交进行表达监测
公开(公告)号：US06410229B1
公开(公告)日：2002-06-25
申请号：US09212004
申请日：1998-12-14
申请人： David J. Lockhart , Eugene L. Brown , Gordon G. Wong , Mark S. Chee , Thomas R. Gingeras
发明人： David J. Lockhart , Eugene L. Brown , Gordon G. Wong , Mark S. Chee , Thomas R. Gingeras
IPC分类号： C12Q168
CPC分类号： C12Q1/6809 , C12Q1/6837 , G01N15/1475 , C12Q2565/507
摘要： This invention provides methods of monitoring the expression levels of a multiplicity of genes. The methods involve hybridizing a nucleic acid sample to a high density array of oligonucleotide probes where the high density array contains oligonucleotide probes complementary to subsequences of target nucleic acids in the nucleic acid sample. In one embodiment, the method involves providing a pool of target nucleic acids comprising RNA transcripts of one or more target genes, or nucleic acids derived from the RNA transcripts, hybridizing said pool of nucleic acids to an array of oligonucleotide probes immobilized on surface, where the array comprising more than 100 different oligonucleotides and each different oligonucleotide is localized in a predetermined region of the surface, the density of the different oligonucleotides is greater than about 60 different oligonucleotides per 1 cm2, and the olignucleotide probes are complementary to the RNA transcripts or nucleic acids derived from the RNA transcripts; and quantifying the hybridized nucleic acids in the array.
摘要翻译：本发明提供监测多种基因的表达水平的方法。所述方法包括将核酸样品与寡核苷酸探针的高密度阵列杂交，其中高密度阵列含有与核酸样品中靶核酸的子序列互补的寡核苷酸探针。在一个实施方案中，所述方法包括提供包含一个或多个靶基因的RNA转录物或衍生自RNA转录物的核酸的靶核酸库，将所述核酸库与固定在表面上的寡核苷酸探针阵列杂交，其中包含超过100种不同寡核苷酸的阵列和每种不同的寡核苷酸被定位在表面的预定区域中，不同寡核苷酸的密度大于每1cm 2大约60个不同的寡核苷酸，并且寡核苷酸探针与RNA转录物互补衍生自RNA转录物的核酸; 并定量阵列中的杂交核酸。

9. 发明授权

US6040138A Expression monitoring by hybridization to high density oligonucleotide arrays 失效
公开(公告)号：US6040138A
公开(公告)日：2000-03-21
申请号：US529115
申请日：1995-09-15
申请人： David J. Lockhart , Eugene L. Brown , Gordon G. Wong , Mark S. Chee , Thomas R. Gingeras
发明人： David J. Lockhart , Eugene L. Brown , Gordon G. Wong , Mark S. Chee , Thomas R. Gingeras
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , G01N15/14 , G01N37/00 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6809 , C12Q1/6837 , G01N15/1475
摘要： This invention provides methods of monitoring the expression levels of a multiplicity of genes. The methods involve hybridizing a nucleic acid sample to a high density array of oligonucleotide probes where the high density array contains oligonucleotide probes complementary to subsequences of target nucleic acids in the nucleic acid sample. In one embodiment, the method involves providing a pool of target nucleic acids comprising RNA transcripts of one or more target genes, or nucleic acids derived from the RNA transcripts, hybridizing said pool of nucleic acids to an array of oligonucleotide probes immobilized on surface, where the array comprising more than 100 different oligonucleotides and each different oligonucleotide is localized in a predetermined region of the surface, the density of the different oligonucleotides is greater than about 60 different oligonucleotides per 1 cm.sup.2, and the olignucleotide probes are complementary to the RNA transcripts or nucleic acids derived from the RNA transcripts; and quantifying the hybridized nucleic acids in the array.

10. 发明授权

US06927032B2 Expression monitoring by hybridization to high density oligonucleotide arrays 失效
标题翻译：通过与高密度寡核苷酸阵列杂交进行表达监测
公开(公告)号：US06927032B2
公开(公告)日：2005-08-09
申请号：US10353792
申请日：2003-01-28
申请人： David J. Lockhart , Eugene L. Brown , Gordon G. Wong , Mark Chee , Thomas R. Gingeras
发明人： David J. Lockhart , Eugene L. Brown , Gordon G. Wong , Mark Chee , Thomas R. Gingeras
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , G01N15/14 , G01N37/00 , C07H21/02 , C07H21/04 , C12M1/34 , C12P19/34
CPC分类号： C12Q1/6809 , C12Q1/6837 , G01N15/1475 , C12Q2565/507
摘要： This invention provides methods of monitoring the expression levels of a multiplicity of genes. The methods involve hybridizing a nucleic acid sample to a high density array of oligonucleotide probes where the high density array contains oligonucleotide probes complementary to subsequences of target nucleic acids in the nucleic acid sample. In one embodiment, the method involves providing a pool of target nucleic acids comprising RNA transcripts of one or more target genes, or nucleic acids derived from the RNA transcripts, hybridizing said pool of nucleic acids to an array of oligonucleotide probes immobilized on surface, where the array comprising more than 100 different oligonucleotides and each different oligonucleotide is localized in a predetermined region of the surface, the density of the different oligonucleotides is greater than about 60 different oligonucleotides per 1 cm2, and the olignucleotide probes are complementary to the RNA transcripts or nucleic acids derived from the RNA transcripts; and quantifying the hybridized nucleic acids in the array.
摘要翻译：本发明提供监测多种基因的表达水平的方法。所述方法包括将核酸样品与寡核苷酸探针的高密度阵列杂交，其中高密度阵列含有与核酸样品中靶核酸的子序列互补的寡核苷酸探针。在一个实施方案中，所述方法包括提供包含一个或多个靶基因的RNA转录物或衍生自RNA转录物的核酸的靶核酸库，将所述核酸库与固定在表面上的寡核苷酸探针阵列杂交，其中包含超过100种不同寡核苷酸的阵列和每种不同的寡核苷酸被定位在表面的预定区域中，不同寡核苷酸的密度大于每1cm 2大约60个不同的寡核苷酸，并且寡核苷酸探针与衍生自RNA转录物的RNA转录物或核酸互补; 并定量阵列中的杂交核酸。

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