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1. 发明授权

US07431727B2 Magnetic components for use in forming anastomoses, creating ports in vessels and closing openings in tissue 失效
标题翻译：用于形成吻合的磁性部件，在血管中形成端口并封闭组织中的开口
公开(公告)号：US07431727B2
公开(公告)日：2008-10-07
申请号：US10774345
申请日：2004-02-06
申请人： David H. Cole , Samuel T. Crews , Michael L. Reo , Dean F. Carson , Keke J. Lepulu , Darin C. Gittings
发明人： David H. Cole , Samuel T. Crews , Michael L. Reo , Dean F. Carson , Keke J. Lepulu , Darin C. Gittings
IPC分类号： A61B17/08
CPC分类号： A61F2/2493 , A61B17/00491 , A61B17/0057 , A61B17/0469 , A61B17/064 , A61B17/0643 , A61B17/11 , A61B2017/00247 , A61B2017/00252 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00876 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61B2017/1139 , A61B2018/00392 , A61F2/064 , A61F2/07 , A61F2/94 , A61F2002/30079 , A61F2210/0076 , A61F2210/009 , H01F7/0263 , H01F41/026
摘要： Methods and devices for forming an anastomosis between hollow bodies utilize magnetic force to couple anastomotic securing components and connect the lumens of the hollow bodies. End-to-side, side-to-side and end-to-end anastomoses can be created without using suture or any other type of mechanical fasteners, although such attachment means may be used in practicing some aspects of the invention. The securing components have the ability to produce a magnetic field and may include materials or assemblies. A component may also be used to form a port into the lumen of a vessel, the component being attached to the vessel by mechanical and/or magnetic means. Magnetic components may include means for concentrating the magnetic flux between respective components to increase the attraction force, thereby enhancing the security of the anastomosis. Also, rather than form a port communicating with a lumen of a vessel or other cavity, the components may have an occlusion surface and be used to close an opening in tissue, e.g., an atrial septal defect.
摘要翻译：用于形成中空体之间的吻合的方法和装置利用磁力来联接吻合的固定部件并连接中空体的内腔。可以在不使用缝合线或任何其它类型的机械紧固件的情况下创建端对侧，侧向对侧和端对端吻合，尽管这些附接手段可用于实践本发明的某些方面。固定部件具有产生磁场的能力并且可以包括材料或组件。组件也可用于在容器的内腔中形成端口，该部件通过机械和/或磁性方式附接到容器。磁性部件可以包括用于将磁通集中在各个部件之间以增加吸引力的装置，从而增强吻合的安全性。而且，组件可以具有闭塞表面，并且用于封闭组织中的开口，例如房间隔缺损，而不是形成与容器或其它空腔的内腔连通的端口。

2. 发明授权

US06719768B1 Magnetic components for use in forming anastomoses, creating ports in vessels and closing openings in tissue 失效
标题翻译：用于形成吻合的磁性部件，在血管中形成端口并封闭组织中的开口
公开(公告)号：US06719768B1
公开(公告)日：2004-04-13
申请号：US09638805
申请日：2000-08-12
申请人： David H. Cole , Samuel T. Crews , Michael L. Reo , Dean F. Carson , Keke J. Lepulu , Darin C. Gittings
发明人： David H. Cole , Samuel T. Crews , Michael L. Reo , Dean F. Carson , Keke J. Lepulu , Darin C. Gittings
IPC分类号： A61B1708
CPC分类号： A61F2/2493 , A61B17/00491 , A61B17/0057 , A61B17/0469 , A61B17/064 , A61B17/0643 , A61B17/11 , A61B2017/00247 , A61B2017/00252 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00876 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61B2017/1139 , A61B2018/00392 , A61F2/064 , A61F2/07 , A61F2/94 , A61F2002/30079 , A61F2210/0076 , A61F2210/009 , H01F7/0263 , H01F41/026
摘要： Methods and devices for forming an anastomosis between hollow bodies utilize magnetic force to couple anastomotic securing components and connect the lumens of the hollow bodies. End-to-side, side-to-side and end-to-end anastomoses can be created without using suture or any other type of mechanical fasteners, although such attachment means may be used in practicing some aspects of the invention. The securing components have the ability to produce a magnetic field and may include materials or assemblies. A component may also be used to form a port into the lumen of a vessel, the component being attached to the vessel by mechanical and/or magnetic means. Magnetic components may include means for concentrating the magnetic flux between respective components to increase the attraction force, thereby enhancing the security of the anastomosis. Also, rather than form a port communicating with a lumen of a vessel or other cavity, the components may have an occlusion surface and be used to close an opening in tissue, e.g., an atrial septal defect.
摘要翻译：用于形成中空体之间的吻合的方法和装置利用磁力来联接吻合的固定部件并连接中空体的内腔。可以在不使用缝合线或任何其它类型的机械紧固件的情况下创建端对侧，侧向对侧和端对端吻合，尽管这些附接手段可用于实践本发明的某些方面。固定部件具有产生磁场的能力并且可以包括材料或组件。组件也可用于在容器的内腔中形成端口，该部件通过机械和/或磁性方式附接到容器。磁性部件可以包括用于将磁通集中在各个部件之间以增加吸引力的装置，从而增强吻合的安全性。而且，组件可以具有闭塞表面，并且用于封闭组织中的开口，例如房间隔缺损，而不是形成与容器或其它空腔的内腔连通的端口。

3. 发明授权

US07708181B2 Endoscopic stapling devices and methods 有权
公开(公告)号：US07708181B2
公开(公告)日：2010-05-04
申请号：US12052885
申请日：2008-03-21
申请人： David Cole , Andrew Smith , Samuel T. Crews , Bretton Swope , Daniel J. Balbierz
发明人： David Cole , Andrew Smith , Samuel T. Crews , Bretton Swope , Daniel J. Balbierz
IPC分类号： A61B17/068
CPC分类号： A61B17/072 , A61B17/064 , A61B17/115 , A61B17/32053 , A61B2017/00539 , A61B2017/00818 , A61B2017/07271 , A61B2017/306 , A61F5/0013 , A61F5/0083
摘要： Described herein are endoscopic staplers used to apply one or more fasteners to body tissue. In one embodiment, a fastener-applying device, which is preferably a stapler, is passed transorally into the stomach and used to plicate stomach tissue by engaging tissue from inside of the stomach and drawing it inwardly. In the disclosed embodiments, the tissue is drawn inwardly into a vacuum chamber, causing sections of serosal tissue on the exterior of the stomach to be positioned facing one another. The disclosed staplers allow the opposed sections of tissue to be moved into contact with one another, and preferably deliver staples for maintaining contact between the tissue sections at least until serosal bonds form between them. Each of these steps may be performed wholly from the inside of the stomach and thus can eliminate the need for any surgical or laparoscopic intervention. After one or more plications are formed, medical devices may optionally be coupled to the plication(s) for retention within the stomach.

4. 发明授权

US07641075B2 Mixing and dispensing fluid components of a multicomponent composition 失效
标题翻译：混合和分配多组分组合物的流体组分
公开(公告)号：US07641075B2
公开(公告)日：2010-01-05
申请号：US12194523
申请日：2008-08-19
申请人： Samuel T. Crews
发明人： Samuel T. Crews
IPC分类号： B67D5/60
CPC分类号： A61B17/0057 , A61B17/8833 , A61B2017/00495 , A61B2017/0065 , A61B2017/8838 , B01F5/0647 , B01F13/0023 , B05C17/00553
摘要： A device for dispensing a multicomponent composition composed of a mixture of different fluid components includes a first and at least a second fluid component inlet. The device also includes a mixing area located downstream from the fluid component inlets and an outlet extending from the mixing area. Each of the fluid component inlets is adapted to communicate with a source of a different fluid component. The mixing area is adapted to receive a flow of a first and at least second fluid component. Within the mixing area, the flow of the first fluid component is disrupted to allow mixing with the flow of a second fluid component to form a flow of multicomponent composition. The mixing area is further adapted to disrupt the flow of the multicomponent composition before the flow of the multicomponent composition exits through the outlet.
摘要翻译：用于分配由不同流体组分的混合物组成的多组分组合物的装置包括第一和至少第二流体组分入口。该装置还包括位于流体部件入口下游的混合区域和从混合区域延伸的出口。每个流体组分入口适于与不同流体组分的源连通。混合区域适于接收第一和至少第二流体组分的流动。在混合区域内，第一流体组分的流动被破坏以允许与第二流体组分的流动混合以形成多组分组合物流。混合区域还适于在多组分组合物的流动通过出口离开之前破坏多组分组合物的流动。

5. 发明授权

US08469977B2 Endoscopic plication device and method 有权
标题翻译：内镜矫治装置及方法
公开(公告)号：US08469977B2
公开(公告)日：2013-06-25
申请号：US12785268
申请日：2010-05-21
申请人： Daniel J. Balbierz , Dave Cole , Samuel T. Crews , Brett Swope , Andrew Smith , John Lunsford , Fiona Sander
发明人： Daniel J. Balbierz , Dave Cole , Samuel T. Crews , Brett Swope , Andrew Smith , John Lunsford , Fiona Sander
IPC分类号： A61B17/72
CPC分类号： A61B17/1155 , A61B17/0218 , A61B17/068 , A61B17/072 , A61B17/07292 , A61B17/1114 , A61B17/115 , A61B17/1285 , A61B2017/00535 , A61B2017/00827 , A61B2017/07214 , A61B2017/07228 , A61B2017/1139 , A61B2017/1157 , A61B2017/306 , A61F5/0036
摘要： Described herein are endoscopic plicators passed transorally into the stomach and used to plicate stomach tissue by engaging tissue from inside of the stomach and drawing it inwardly. In the disclosed embodiments, the tissue is drawn inwardly into a vacuum chamber, causing sections of serosal tissue on the exterior of the stomach to be positioned facing one another. The disclosed plicators allow the opposed sections of tissue to be moved into contact with one another, and preferably deliver sutures, staples or other means for maintaining contact between the tissue sections at least until serosal bonds form between them. Each of these steps may be performed wholly from the inside of the stomach and thus can eliminate the need for any surgical or laparoscopic intervention. After one or more plications is formed, medical devices may be coupled to the plication(s) for retention within the stomach.
摘要翻译：这里描述的是内窥镜检查器，其通过经腹部通过胃并用于通过从胃内部接合组织并将其向内抽吸来摧毁胃组织。在所公开的实施例中，将组织向内拉入真空室，使得胃外部的浆膜组织的部分彼此相对定位。所公开的调节器允许组织的相对部分彼此移动接触，并且优选地递送缝合线，缝钉或其它装置，用于保持组织切片之间的接触，至少在它们之间形成浆膜粘结。这些步骤中的每一个可以完全从胃内进行，因此可以消除对任何手术或腹腔镜干预的需要。在形成一个或多个脓肿之后，医疗装置可以连接到脓液以保持在胃中。

6. 发明申请

US20130012863A1 RESTRICTIVE AND/OR OBSTRUCTIVE IMPLANT SYSTEM FOR INDUCING WEIGHT LOSS 有权
标题翻译：用于诱导重量损失的限制性和/或阻碍性植入体系
公开(公告)号：US20130012863A1
公开(公告)日：2013-01-10
申请号：US13492732
申请日：2012-06-08
申请人： Richard S. Stack , Daniel J. Balbierz , William L. Athas , John Lunsford , Kevin van Bladel , Ashik Mohan , Samuel T. Crews , Shuji Uemura , Robert H. Hawes
发明人： Richard S. Stack , Daniel J. Balbierz , William L. Athas , John Lunsford , Kevin van Bladel , Ashik Mohan , Samuel T. Crews , Shuji Uemura , Robert H. Hawes
IPC分类号： A61M5/00
CPC分类号： A61F5/0086 , A61B17/00234 , A61B2017/00292 , A61B2017/00827 , A61B2017/00991 , A61F5/0089 , A61M25/0194
摘要： The present application describes an implant system useable for positioning an implant device such as a device useful for restricting passage of ingested food into the stomach. In one embodiment, the disclosed system includes a plurality of anchors that may be coupled to tissue within the stomach, or to a tissue tunnel formed by plicating stomach wall tissue. The anchor includes a loop. During use, the implant device is inserted through the loop and expanded such that it retains its position within the loop until removed. Instruments for implanting and explanting the implant device are also described.
摘要翻译：本申请描述了可用于定位植入装置的植入物系统，例如用于限制摄取的食物进入胃的通道的装置。在一个实施例中，所公开的系统包括可以连接到胃内的组织或通过使胃壁组织变细而形成的组织隧道的多个锚固件。锚包括一个环。在使用期间，植入装置插入通过环并且膨胀使得其保持其在环内的位置，直到移除。还描述了用于植入和外植植入装置的器械。

7. 发明申请

US20090024143A1 ENDOSCOPIC IMPLANT SYSTEM AND METHOD 审中-公开
标题翻译：内窥镜植入系统及方法
公开(公告)号：US20090024143A1
公开(公告)日：2009-01-22
申请号：US12175242
申请日：2008-07-17
申请人： Samuel T. Crews , Bretton Swope , Justen England
发明人： Samuel T. Crews , Bretton Swope , Justen England
IPC分类号： A61B17/122 , A61B17/32
CPC分类号： A61F5/0086 , A61B17/0643 , A61B17/0644 , A61B17/128 , A61B2017/00862 , A61B2017/0647 , A61F5/0003 , A61F5/0079 , A61F5/0083 , A61F5/0089
摘要： Disclosed is a system for endoscopically implanting a medical implant within a body cavity such as a human stomach. The system includes one or more anchors positionable within one or more openings formed in tissue within the body cavity, such as cutouts formed in plicated body tissue. Tools are disclosed for positioning the anchors within the openings, and for coupling the implant to the anchors.
摘要翻译：公开了一种用于将体内植入物内窥镜植入体腔（例如人胃）内的系统。该系统包括可定位在形成在体腔内的组织中的一个或多个开口内的一个或多个锚固件，例如形成在穿孔的身体组织中的切口。公开了用于将锚固件定位在开口内并且用于将植入物联接到锚固件的工具。

8. 发明授权

US09055942B2 Endoscopic plication devices and methods 有权
标题翻译：内镜矫治装置及方法
公开(公告)号：US09055942B2
公开(公告)日：2015-06-16
申请号：US11542457
申请日：2006-10-03
申请人： Daniel J. Balbierz , Dave Cole , Samuel T. Crews , Brett Swope , Andrew Smith , John Lunsford , Fiona Sander
发明人： Daniel J. Balbierz , Dave Cole , Samuel T. Crews , Brett Swope , Andrew Smith , John Lunsford , Fiona Sander
IPC分类号： A61B17/08 , A61B17/068 , A61B17/072 , A61B17/115 , A61B17/128 , A61B17/02 , A61B17/00 , A61B17/30
CPC分类号： A61B17/1155 , A61B17/0218 , A61B17/068 , A61B17/072 , A61B17/07292 , A61B17/1114 , A61B17/115 , A61B17/1285 , A61B2017/00535 , A61B2017/00827 , A61B2017/07214 , A61B2017/07228 , A61B2017/1139 , A61B2017/1157 , A61B2017/306 , A61F5/0036
摘要： Endoscopic plicators are passed transorally into the stomach and used to plicate stomach tissue by engaging tissue from inside of the stomach and drawing it inwardly. The tissue is drawn inwardly into a vacuum chamber, causing sections of serosal tissue on the exterior of the stomach to be positioned facing one another. The plicators allow the opposed sections of tissue to be moved into contact with one another, and preferably deliver sutures, staples or other means for maintaining contact between the tissue sections at least until serosal bonds form between them. Each of these steps may be performed wholly from the inside of the stomach and thus can eliminate the need for any surgical or laparscopic intervention. After one or more plications is formed, medical devices may be coupled to the plication(s) for retention within the stomach.
摘要翻译：将内窥镜矫正器经腹部通入胃中，并用于通过从胃内部接合组织并将其向内抽吸来摧毁胃组织。将组织向内拉入真空室，使得胃外部的浆膜组织部分彼此相对定位。调节器允许组织的相对部分彼此移动接触，并且优选地递送缝合线，缝钉或其它装置，用于保持组织切片之间的接触，至少在它们之间形成浆膜粘结。这些步骤中的每一个可以完全从胃内进行，因此可以消除对任何手术或腹腔镜干预的需要。在形成一个或多个脓肿之后，医疗装置可以连接到脓液以保持在胃中。

9. 发明授权

US08961539B2 Endoscopic implant system and method 有权
标题翻译：内镜植入系统及方法
公开(公告)号：US08961539B2
公开(公告)日：2015-02-24
申请号：US12435344
申请日：2009-05-04
申请人： Samuel T. Crews , Brett Swope , Justen England
发明人： Samuel T. Crews , Brett Swope , Justen England
IPC分类号： A61B17/10 , A61B17/29 , A61F5/00 , A61B17/00 , A61B17/064
CPC分类号： A61B17/29 , A61B2017/003 , A61B2017/00827 , A61B2017/0641 , A61F5/0086 , A61F5/0089
摘要： A system, device, device and method for implanting a food restrictor in a patient's stomach, by coupling the restrictor to a plurality of tissue-plication anchors already placed in the stomach, are disclosed. The device includes an elongate shaft assembly for accessing the stomach transorally, and on which the restrictor can be carried, and a plurality of cable members mounted on the shaft assembly. The cable members are disposed on the shaft assembly along a distal section thereof, and releasably attached to the shaft assembly's distal end. After a cable member engages a tissue-plication anchor, retracting the cable is operable to first release the member from a holder at the distal end of the shaft assembly, then pull a portion of the anchor through an aperture in the restrictor. This process is repeated for each anchor in the stomach for attaching the restrictor to the stomach.
摘要翻译：公开了一种用于将食物限制器植入患者胃内的系统，装置，装置和方法，其通过将限制器连接到已经放置在胃中的多个组织定位锚固件。该装置包括细长轴组件，其用于经腹地进入胃中，并且可以承载限制器，以及安装在轴组件上的多个电缆构件。电缆构件沿其远端部分设置在轴组件上，并且可释放地附接到轴组件的远端。在电缆构件接合组织折叠锚固件之后，缩回电缆可操作以首先将构件从轴组件的远端处的保持器释放，然后通过限制器中的孔拉动锚固件的一部分。对于胃中的每个锚重复该过程，以将节流器附接到胃。

10. 发明申请

US20110319924A1 Gastric Space Occupier Systems And Methods Of Use 有权
标题翻译：胃空间占用系统和使用方法
公开(公告)号：US20110319924A1
公开(公告)日：2011-12-29
申请号：US13224233
申请日：2011-09-01
申请人： David Cole , Samuel T. Crews , Bretton Swope , Andrew Smith , John Lunsford , Daniel J. Balbierz
发明人： David Cole , Samuel T. Crews , Bretton Swope , Andrew Smith , John Lunsford , Daniel J. Balbierz
IPC分类号： A61F2/04
CPC分类号： A61F5/0036 , A61F5/003
摘要： Systems for controlling obesity utilize a number of space occupiers positioned in the stomach to reduce the effective volume of the stomach. Such arrangements provides sufficient stomach volume consumption to induce weight loss, but enable use of space occupiers that are proportioned to minimize the threat of obstruction even if they should migrate into the intestine. In general, numerous small volume space occupiers are placed in the stomach such that the total volume equals or exceeds the single volume of prior art single unit space occupiers. However, each individual space occupier is proportioned so that it will pass without obstruction if it moves into the intestine.
摘要翻译：用于控制肥胖的系统利用位于胃中的多个空间占用者来减少胃的有效体积。这种布置提供足够的胃体积消耗以引起体重减轻，但是能够使用成比例的空间占用者，以尽量减少阻塞的威胁，即使它们应该迁移到肠中。通常，许多小容量空间占用者被放置在胃中，使得总体积等于或超过现有技术的单个单位空间占用者的单个体积。然而，每个单独的空间占有者是成比例的，以便如果它进入肠道，它将不会阻塞。

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