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1. 发明申请

US20070238735A1 Cyclooxygenase-2 selective inhibitors, compositions and methods of use 审中-公开
标题翻译：环氧合酶-2选择性抑制剂，组合物和使用方法
公开(公告)号：US20070238735A1
公开(公告)日：2007-10-11
申请号：US11802161
申请日：2007-05-21
申请人： David Garvey , Subhash Khanapure , Ramani Ranatunge , Stewart Richardson , Joseph Schroeder
发明人： David Garvey , Subhash Khanapure , Ramani Ranatunge , Stewart Richardson , Joseph Schroeder
IPC分类号： A61K31/495 , A61K31/415 , C07D213/00 , C07D241/10
CPC分类号： C07D213/55 , C07D213/50 , C07D231/12 , C07D231/14
摘要： The invention provides novel cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions and kits comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The novel cyclooxygenase 2 selective inhibitors of the invention can be optionally nitrosated and/or nitrosylated. The invention also provides methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 selective inhibitors; for facilitating wound healing; for treating and/or preventing renal and/or respiratory toxicity; for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2; and for improving the cardiovascular profile of COX-2 selective inhibitors.
摘要翻译：本发明提供新型环氧合酶2（COX-2）选择性抑制剂和包含至少一种环加氧酶2（COX-2）选择性抑制剂的新型组合物和试剂盒，以及任选地，至少一种捐赠，转移或释放一氧化氮的化合物，内源性合成一氧化氮，提高内源性内源性松弛因子水平，或是一氧化氮合成酶的底物和/或至少一种治疗剂。本发明的新型环加氧酶2选择性抑制剂可以任选地亚硝化和/或亚硝化。本发明还提供了治疗炎症，疼痛和发烧的方法; 用于治疗和/或改善COX-2选择性抑制剂的胃肠性质; 促进伤口愈合; 用于治疗和/或预防肾和/或呼吸毒性; 用于治疗和/或预防由环氧合酶-2水平升高引起的其他疾病; 并用于改善COX-2选择性抑制剂的心血管外形。

2. 发明申请

US20060194861A1 Cyclooxygenase-2 selective inhibitors, compositions and methods of use 失效
标题翻译：环氧合酶-2选择性抑制剂，组合物和使用方法
公开(公告)号：US20060194861A1
公开(公告)日：2006-08-31
申请号：US11418187
申请日：2006-05-05
申请人： Ipul Bandarage , Richard Earl , Maiko Ezawa , Xinqin Fang , David Garvey , Subhash Khanapure , Ramani Ranatunge , Stewart Richardson , Joseph Schroeder , Cheri Stevenson , Shiow-Jyi Wey
发明人： Ipul Bandarage , Richard Earl , Maiko Ezawa , Xinqin Fang , David Garvey , Subhash Khanapure , Ramani Ranatunge , Stewart Richardson , Joseph Schroeder , Cheri Stevenson , Shiow-Jyi Wey
IPC分类号： C07D231/06 , A61K31/415
CPC分类号： C07D231/12 , C07D261/08 , C07D401/04
摘要： The invention describes novel cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one COX-2 selective inhibitor, optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor, and/or, optionally, at least one therapeutic agent. The novel cyclooxygenase 2 selective inhibitors of the invention can be optionally nitrosated and/or nitrosylated. The invention also provides methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 selective inhibitors; for facilitating wound healing; for treating and/or preventing renal and/or respiratory toxicity; for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2; and for improving the cardiovascular profile of COX-2 selective inhibitors.
摘要翻译：本发明描述了新型环氧合酶2（COX-2）选择性抑制剂和包含至少一种环氧合酶2（COX-2）选择性抑制剂的新型组合物，以及任选地至少一种捐赠，转移或释放一氧化氮的化合物，刺激内源性合成的一氧化氮，提高内源性内源性释放因子水平，或者是一氧化氮合酶的底物和/或至少一种治疗剂。本发明还提供了包含至少一种COX-2选择性抑制剂，任选地亚硝基化和/或亚硝基化的新的试剂盒，以及任选的至少一种一氧化氮供体，和/或任选的至少一种治疗剂。本发明的新型环加氧酶2选择性抑制剂可以任选地亚硝化和/或亚硝化。本发明还提供了治疗炎症，疼痛和发烧的方法; 用于治疗和/或改善COX-2选择性抑制剂的胃肠性质; 促进伤口愈合; 用于治疗和/或预防肾和/或呼吸毒性; 用于治疗和/或预防由环氧合酶-2水平升高引起的其他疾病; 并用于改善COX-2选择性抑制剂的心血管外形。

3. 发明申请

US20050222243A1 Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use 有权
标题翻译：硝化非甾体抗炎化合物，组合物和使用方法
公开(公告)号：US20050222243A1
公开(公告)日：2005-10-06
申请号：US11134358
申请日：2005-05-23
申请人： Richard Earl , Maiko Ezawa , Xinqin Fang , David Garvey , Ricky Gaston , Subhash Khanapure , L. Gordon Letts , Chia-En Lin , Ramani Ranatunga , Stewart Richardson , Joseph Schroeder , Cheri Stevenson , Shiow-Jyi Wey
发明人： Richard Earl , Maiko Ezawa , Xinqin Fang , David Garvey , Ricky Gaston , Subhash Khanapure , L. Gordon Letts , Chia-En Lin , Ramani Ranatunga , Stewart Richardson , Joseph Schroeder , Cheri Stevenson , Shiow-Jyi Wey
IPC分类号： C07D295/08 , A61K31/21 , A61K31/405 , A61K31/445 , A61K45/00 , A61P1/00 , A61P1/04 , A61P1/10 , A61P1/14 , A61P3/04 , A61P17/02 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07C203/04 , C07C205/40 , C07C205/56 , C07C219/10 , C07C229/42 , C07C235/08 , C07C235/12 , C07C235/34 , C07C235/42 , C07C237/08 , C07C243/28 , C07C271/16 , C07C271/64 , C07C291/02 , C07C311/17 , C07C317/18 , C07C317/32 , C07C317/46 , C07C323/12 , C07C327/28 , C07D209/18 , C07D209/28 , C07D211/22 , C07D211/56 , C07D493/04 , C07F9/40 , C07D209/20
CPC分类号： C07D493/04 , C07C291/02 , C07C311/17 , C07C317/18 , C07C323/12 , C07C327/28 , C07D209/18 , C07D211/22 , C07D211/56
摘要： The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders.
摘要翻译：本发明描述了新型亚硝化非甾体抗炎药（NSAID）及其药学上可接受的盐，以及包含至少一种亚硝化NSAID的新组合物，以及任选地至少一种捐赠，转移或释放一氧化氮的化合物，刺激一氧化氮的内源性合成升高内源性内源性松弛因子水平，或是一氧化氮合酶的底物和/或至少一种治疗剂。本发明还提供了包含至少一种亚硝化NSAID和至少一种捐赠，转移或释放一氧化氮的化合物的新型组合物，提高内源性内皮衍生的舒张因子水平，刺激一氧化氮的内源性合成，或是一氧化氮的底物合酶和/或至少一种治疗剂。本发明还提供了包含至少一种亚硝化NSAID和任选的至少一种一氧化氮供体和/或至少一种治疗剂的新型试剂盒。本发明还提供了治疗炎症，疼痛和发烧的方法; 用于治疗胃肠道疾病; 促进伤口愈合; 用于治疗和/或预防由使用非甾体抗炎化合物引起的胃肠道，肾脏和/或呼吸道毒性物质; 用于治疗炎性疾病状态和/或病症; 并用于治疗和/或预防眼科疾病和/或病症。

4. 发明申请

US20070060571A1 Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use 失效
标题翻译：亚硝基化和亚硝基化环加氧酶-2抑制剂，组合物和使用方法
公开(公告)号：US20070060571A1
公开(公告)日：2007-03-15
申请号：US11599519
申请日：2006-11-15
申请人： Ramani Bandarage , Upul Bandarage , Xinqin Fang , David Garvey , L. Letts , Joseph Schroeder , Sang Tam
发明人： Ramani Bandarage , Upul Bandarage , Xinqin Fang , David Garvey , L. Letts , Joseph Schroeder , Sang Tam
IPC分类号： A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D207/333 , C07C317/46 , C07C381/00 , C07D209/12 , C07D209/18 , C07D231/12 , C07D231/14 , C07D233/64 , C07D237/14 , C07D261/08 , C07D263/20 , C07D307/58 , C07D311/12 , C07D413/12 , C07D471/04
摘要： The present invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitors and novel compositions comprising at least one nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or optionally, at least one therapeutic agent. The present invention also provides novel compositions comprising at least one parent COX-2 inhibitor and at least one nitric oxide donor, and, optionally, at least one therapeutic agent. The present invention also provides kits and methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 inhibitors; for facilitating wound healing; for treating and/or preventing renal toxicity; and for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2.
摘要翻译：本发明描述了新的亚硝化和/或亚硝基化的环氧合酶2（COX-2）抑制剂和包含至少一种亚硝化和/或亚硝基化的环氧合酶2（COX-2）抑制剂的新组合物，和任选的至少一种可以提供，转移或释放一氧化氮，刺激一氧化氮的内源性合成，提高内皮衍生的松弛因子的内源水平，或者是一氧化氮合酶的底物和/或任选的至少一种治疗剂。本发明还提供了包含至少一种母体COX-2抑制剂和至少一种一氧化氮供体以及任选的至少一种治疗剂的新型组合物。本发明还提供用于治疗炎症，疼痛和发烧的试剂盒和方法; 用于治疗和/或改善COX-2抑制剂的胃肠性质; 促进伤口愈合; 用于治疗和/或预防肾毒性; 并且用于治疗和/或预防由环氧合酶-2水平升高引起的其它疾病。

5. 发明申请

US20050065161A1 Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses 审中-公开
标题翻译：亚硝化和亚硝酰化的α-肾上腺素能受体拮抗剂化合物，组合物及其用途
公开(公告)号：US20050065161A1
公开(公告)日：2005-03-24
申请号：US10951778
申请日：2004-09-29
申请人： David Garvey , Joseph Schroeder , Inigo De Tejada
发明人： David Garvey , Joseph Schroeder , Inigo De Tejada
IPC分类号： A61K45/06 , C07C381/00 , C07D211/62 , C07D233/24 , C07D239/95 , C07D401/04 , C07D405/12 , C07D459/00 , A61K31/517 , C07D43/02
CPC分类号： C07D459/00 , A61K45/06 , C07C381/00 , C07D211/62 , C07D233/24 , C07D239/95 , C07D401/04 , C07D405/12
摘要： The invention is directed to nitrosated or nitrosylated alpha-adrenergic receptor antagonists, compositions comprising alpha-adrenergic receptor antagonists that are optionally substituted with at least one NO or NO2 moiety and compounds that donate, transfer or release nitric oxide or elevate levels of endogenous endothelium-derived relaxing factor, and methods for treating sexual dysfunctions in males and females. The invention also provides methods for treating female sexual dysfunctions by administering S-nitrosothiol compounds.
摘要翻译：本发明涉及亚硝化或亚硝酰化的α-肾上腺素能受体拮抗剂，包含任选被至少一个NO或NO 2部分取代的α-肾上腺素能受体拮抗剂的组合物和捐赠，转移或释放一氧化氮或提高内源性内皮 - 衍生松弛因子，以及治疗男性和女性性功能障碍的方法。本发明还提供了通过施用S-亚硝基硫醇化合物治疗女性性功能障碍的方法。

6. 发明授权

US09814874B2 Implantable lead electrode with asymmetrically distributed current density and methods for imparting current density directionality in lead electrodes 有权
公开(公告)号：US09814874B2
公开(公告)日：2017-11-14
申请号：US12946266
申请日：2010-11-15
申请人： Timothy R. Jackson , Joseph Schroeder
发明人： Timothy R. Jackson , Joseph Schroeder
IPC分类号： A61N1/00 , A61N1/05
CPC分类号： A61N1/056 , A61N2001/0585
摘要： Lead electrodes having an asymmetrically distributed current density and methods for imparting current density directionality in lead electrodes are described. An implantable medical lead includes a lead body having a proximal section that connects to another implantable device and a distal section having a pre-biased shape configured to secure the lead to an inner wall of a body vessel. An electrode coupled to the distal section of the lead body includes a conductor mass having an asymmetrically distributed current density that imparts a directionality to one or more active portions of the electrode.

7. 发明申请

US20110160821A1 ELECTRODE SURFACE MODIFICATION FOR IMPARTING CURRENT DENSITY DIRECTIONALITY IN LEAD ELECTRODES 有权
标题翻译：电极表面修正电极密度电流密度限制
公开(公告)号：US20110160821A1
公开(公告)日：2011-06-30
申请号：US12946214
申请日：2010-11-15
申请人： Timothy R. Jackson , Joseph Schroeder
发明人： Timothy R. Jackson , Joseph Schroeder
IPC分类号： A61N1/05 , H01R43/20
CPC分类号： A61N1/056 , A61N2001/0585 , Y10T29/49208
摘要： An implantable medical lead having a modified electrode surface for imparting current density directionality within an electrode is disclosed. An implantable medical lead includes a lead body having a proximal section and a distal section having a pre-biased shape configured to secure the lead to an inner wall of a blood vessel. An electrode coupled to the distal section of the lead body includes a number of surface features on an inactive portion of the electrode that impart a current density directionality towards an active portion of the electrode that contacts the inner wall of the vessel. Methods for imparting current density directionality within an implantable lead electrode are also disclosed.
摘要翻译：公开了一种植入式医用引线，其具有用于在电极内施加电流密度方向性的改性电极表面。可植入医疗引线包括具有近端部分的引线主体和具有被配置为将引线固定到血管内壁的预偏置形状的远端部分。耦合到引线主体的远端部分的电极包括在电极的非活性部分上的许多表面特征，其向接触容器的内壁的电极的有源部分赋予电流密度方向性。还公开了在可植入引线电极内赋予电流密度方向性的方法。

8. 发明申请

US20070093373A1 Visible polarizing glass and process 有权
标题翻译：可见偏光玻璃及工艺
公开(公告)号：US20070093373A1
公开(公告)日：2007-04-26
申请号：US11257968
申请日：2005-10-24
申请人： Nicholas Borrelli , George Hares , David McEnroe , Joseph Schroeder
发明人： Nicholas Borrelli , George Hares , David McEnroe , Joseph Schroeder
IPC分类号： C03C10/00 , C03C1/00
CPC分类号： G02B5/3025 , C03B23/047 , C03C3/064 , C03C4/08 , C03C14/006 , C03C2214/08
摘要： The invention is directed to a silver-containing polarizing boroaluminosilicate glass composition that has been doped with a noble metal selected from the group consisting of Pt, Pd, Os, Ir, Rh and Ru, including mixtures thereof,to nucleate and precipitate silver ions to silver metal without the need for a reducing atmosphere step. The invention is further directed to a method for making the glass composition of the invention. Using the composition and method of the invention, one can prepare a glass having a selected null transmission range.
摘要翻译：本发明涉及掺杂有选自Pt，Pd，Os，Ir，Rh和Ru（包括它们的混合物）的贵金属的含银极化硼铝硅酸盐玻璃组合物，以使银离子成核并沉淀银金属不需要还原气氛的步骤。本发明还涉及制备本发明的玻璃组合物的方法。使用本发明的组合物和方法，可以制备具有选定的无效透射范围的玻璃。

9. 发明申请

US20070079755A1 Material application system having component with wireless identification capabilities 审中-公开
标题翻译：具有无线识别能力的组件的物料应用系统
公开(公告)号：US20070079755A1
公开(公告)日：2007-04-12
申请号：US10596106
申请日：2005-01-28
申请人： Gregory Strack , Jeffrey Perkins , Cynthia Skelton-Becker , Stephen Nemethy , Herman Turner , Kenneth Kreeger , Joseph Schroeder
发明人： Gregory Strack , Jeffrey Perkins , Cynthia Skelton-Becker , Stephen Nemethy , Herman Turner , Kenneth Kreeger , Joseph Schroeder
IPC分类号： B05B15/12
CPC分类号： B05B7/1454 , B05B7/1404 , B05B12/00 , B05B12/122 , B05B14/48
摘要： Material application system provided with a wireless identification technology for parts being processed and for components of the material application system. An exemplary technology is RFID. The RFID device can be used for many different functions including part identification, repair and maintenance programs, and inventory control.
摘要翻译：材料应用系统为被处理的零件和材料应用系统的组件提供无线识别技术。一种示例性技术是RFID。 RFID设备可用于许多不同的功能，包括部件识别，维修和维护程序以及库存控制。

10. 发明申请

US20070007894A1 Glass package that is hermetically sealed with a frit and method of fabrication 有权
标题翻译：用玻璃料和制造方法气密密封的玻璃包装
公开(公告)号：US20070007894A1
公开(公告)日：2007-01-11
申请号：US11521888
申请日：2006-09-15
申请人： Bruce Aitken , Joel Carberry , Steven DeMartino , Henry Hagy , Lisa Lamberson , Richard Miller , Robert Morena , Joseph Schroeder , Alexander Streltsov , Sujanto Widjaja
发明人： Bruce Aitken , Joel Carberry , Steven DeMartino , Henry Hagy , Lisa Lamberson , Richard Miller , Robert Morena , Joseph Schroeder , Alexander Streltsov , Sujanto Widjaja
IPC分类号： H05B33/04 , H05B33/10 , H01L51/50
CPC分类号： C03C27/06 , C03C3/072 , C03C3/17 , C03C3/19 , C03C3/21 , C03C8/24 , C03C8/245 , C03C27/005 , H01L51/5246
摘要： A hermetically sealed glass package and method for manufacturing the hermetically sealed glass package are described herein using an OLED display as an example. Basically, the hermetically sealed OLED display is manufactured by providing a first substrate plate and a second substrate plate and depositing a frit onto the second substrate plate. OLEDs are deposited on the first substrate plate. An irradiation source (e.g., laser, infrared light) is then used to heat the frit which melts and forms a hermetic seal that connects the first substrate plate to the second substrate plate and also protects the OLEDs. The frit is glass that was doped with at least one transition metal and possibly a CTE lowering filler such that when the irradiation source heats the frit, it softens and forms a bond. This enables the frit to melt and form the hermetic seal while avoiding thermal damage to the OLEDs.
摘要翻译：这里使用OLED显示器作为示例来描述气密密封的玻璃封装和制造密封玻璃封装的方法。基本上，通过提供第一基板和第二基板并将玻璃料沉积到第二基板上来制造密封的OLED显示器。 OLED沉积在第一基板上。然后使用照射源（例如，激光，红外光）来加热玻璃料，其熔化并形成将第一衬底板连接到第二衬底板并且还保护OLED的气密密封。玻璃料是掺杂有至少一种过渡金属和可能的CTE降低填料的玻璃，使得当照射源加热玻璃料时，其软化并形成结合。这使得玻璃料熔化并形成气密密封，同时避免对OLED的热损伤。

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