专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20140315796A1 MODULATORS OF PROTEASE ACTIVATED RECEPTORS 有权
标题翻译：蛋白激活受体的调节剂
公开(公告)号：US20140315796A1
公开(公告)日：2014-10-23
申请号：US14235640
申请日：2012-07-27
申请人： David Fairlie , Ligong Liu , Mei-Kwan Yau , Jacky Yung Suen , Robert Reid , Rink-Jan Lohman , Abishek Venkatasubramania Iyer , Junxian Lim , Lindsay Charles Brown
发明人： David Fairlie , Ligong Liu , Mei-Kwan Yau , Jacky Yung Suen , Robert Reid , Rink-Jan Lohman , Abishek Venkatasubramania Iyer , Junxian Lim , Lindsay Charles Brown
IPC分类号： C07K5/08 , C07K5/02 , C07K5/06
CPC分类号： C07K5/08 , A61K38/05 , C07K5/02 , C07K5/06 , C07K5/06078
摘要： The present invention provides novel compounds of the Formula (I), pharmaceutical compositions comprising such compounds and methods for using such compounds as tools for biological studies or as agents or drugs for therapies such as metabolic syndrome, obesity, type II diabetes, fibrosis and cardiovascular diseases, whether they are used alone or in combination with other treatment modalities.
摘要翻译：本发明提供新的式（I）化合物，包含这些化合物的药物组合物和使用这些化合物作为生物学研究的工具的方法，或作为代谢综合征，肥胖症，II型糖尿病，纤维化和心血管疾病的治疗药物或药物疾病，无论是单独使用还是与其他治疗方式结合使用。

2. 发明授权

US09868763B2 Modulators of protease activated receptors 有权
公开(公告)号：US09868763B2
公开(公告)日：2018-01-16
申请号：US14235640
申请日：2012-07-27
申请人： David Fairlie , Ligong Liu , Mei-Kwan Yau , Jacky Yung Suen , Robert Reid , Rink-Jan Lohman , Abishek Venkatasubramanian Iyer , Junxian Lim , Lindsay Charles Brown
发明人： David Fairlie , Ligong Liu , Mei-Kwan Yau , Jacky Yung Suen , Robert Reid , Rink-Jan Lohman , Abishek Venkatasubramanian Iyer , Junxian Lim , Lindsay Charles Brown
IPC分类号： C07K5/08 , A61K38/05 , C07K5/065 , C07K5/02 , C07K5/06
CPC分类号： C07K5/08 , A61K38/05 , C07K5/02 , C07K5/06 , C07K5/06078
摘要： The present invention provides novel compounds of the Formula (I), pharmaceutical compositions comprising such compounds and methods for using such compounds as tools for biological studies or as agents or drugs for therapies such as metabolic syndrome, obesity, type II diabetes, fibrosis and cardiovascular diseases, whether they are used alone or in combination with other treatment modalities.

3. 发明授权

US08901085B2 Modulations of protease activated receptors 有权
公开(公告)号：US08901085B2
公开(公告)日：2014-12-02
申请号：US13812728
申请日：2011-07-28
申请人： David Paul Fairlie , Ligong Liu , Mei Kwan Yau , Jacky Yung Suen , Robert Reid
发明人： David Paul Fairlie , Ligong Liu , Mei Kwan Yau , Jacky Yung Suen , Robert Reid
IPC分类号： A61K38/06 , A61K38/07 , A61K38/05 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , C07D401/00 , C07D451/00 , C07D453/00 , C07D455/00 , C07D471/00 , C07K5/083 , C07K5/065 , C07K5/062 , A61K38/00
摘要： The present invention provides novel compounds of the Formula (1), pharmaceutical compositions comprising such compounds and methods for using such compounds as tools for biological studies or as agents or drugs for modulating Protease Activated Receptor-2 (PAR2) and for treating a subject at risk of—or susceptible to—a disease or disorder, or having a disease or disorder associated with undesirable PAR2 activity.

4. 发明授权

US08927503B2 Modulations of protease activated receptors 有权
标题翻译：蛋白酶活化受体的调节
公开(公告)号：US08927503B2
公开(公告)日：2015-01-06
申请号：US13812728
申请日：2011-07-28
申请人： David Paul Fairlie , Ligong Liu , Mei Kwan Yau , Jacky Yung Suen , Robert Reid
发明人： David Paul Fairlie , Ligong Liu , Mei Kwan Yau , Jacky Yung Suen , Robert Reid
IPC分类号： A61K38/06 , A61K38/07 , A61K38/05 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , C07D401/00 , C07D451/00 , C07D453/00 , C07D455/00 , C07D471/00 , C07K5/083 , C07K5/065 , C07K5/062 , A61K38/00
CPC分类号： C07K5/0812 , A61K38/00 , C07K5/00 , C07K5/06034 , C07K5/06078 , C07K5/0806 , C07K5/0808 , C07K5/081 , C07K5/0823 , C07K5/0825
摘要： The present invention provides novel compounds of the Formula (1), pharmaceutical compositions comprising such compounds and methods for using such compounds as tools for biological studies or as agents or drugs for modulating Protease Activated Receptor-2 (PAR2) and for treating a subject at risk of—or susceptible to—a disease or disorder, or having a disease or disorder associated with undesirable PAR2 activity.
摘要翻译：本发明提供新颖的式（1）化合物，包含这些化合物的药物组合物和使用这些化合物作为生物学研究的工具的方法，或用于调节蛋白酶活化受体-2（PAR2）的药剂或药物，以及用于治疗受试者疾病或病症的风险或易感性，或具有与不良PAR2活性相关的疾病或病症。

5. 发明申请

US20050119167A1 Process for the preparation of cyclic peptides 审中-公开
标题翻译：制备环肽的方法
公开(公告)号：US20050119167A1
公开(公告)日：2005-06-02
申请号：US10839760
申请日：2004-05-05
申请人： Giovanni Abbenante , David Fairlie , Robert Reid , Hua Williams
发明人： Giovanni Abbenante , David Fairlie , Robert Reid , Hua Williams
IPC分类号： A61K38/00 , C07K7/56 , A61K38/12 , C07K5/12
CPC分类号： C07K7/56 , A61K38/00
摘要： The present invention relates to a process for the preparation of cyclic peptides, in particular the preparation of Ac-Phe[Orn-Pro-D-Cha-Trp-Arg] known as 3D53 or PMX53 which is a macrocyclic peptidomimetic of the human plasma protein C5a and displays excellent anti-inflammatory activity.
摘要翻译：本发明涉及制备环肽的方法，特别是制备称为3D53的Ac-Phe [Orn-Pro-D-Cha-Trp-Arg]或PMX53，其是人血浆蛋白的大环肽模拟物 C5a并显示出优异的抗炎活性。

6. 发明申请

US20070249526A1 PROCESS FOR THE PREPARATION OF CYCLIC PEPTIDES 审中-公开
标题翻译：制备循环肽的方法
公开(公告)号：US20070249526A1
公开(公告)日：2007-10-25
申请号：US11736517
申请日：2007-04-17
申请人： Giovanni Abbenante , David Fairlie , Robert Reid
发明人： Giovanni Abbenante , David Fairlie , Robert Reid
IPC分类号： A61K38/08 , C07K7/00
CPC分类号： C07K7/56 , A61K38/00
摘要： The present invention relates to a process for the preparation of cyclic peptides, in particular the preparation of Ac-Phe[Orn-Pro-D-Cha-Trp-Arg] known as 3D53 or PMX53 which is a macrocyclic peptidomimetic of the human plasma protein C5a and displays excellent anti-inflammatory activity.
摘要翻译：本发明涉及制备环肽的方法，特别是制备称为3D53的Ac-Phe [Orn-Pro-D-Cha-Trp-Arg]或PMX53，其是人血浆蛋白的大环肽模拟物 C5a并显示出优异的抗炎活性。

7. 发明授权

US6043357A HIV protease inhibitors 失效
标题翻译： HIV蛋白酶抑制剂
公开(公告)号：US6043357A
公开(公告)日：2000-03-28
申请号：US849599
申请日：1997-09-09
申请人： John Abbenante , Doug Bergman , Ross Brinkworth , Robert Dancer , Bronwyn Garnham , Peter Hunt , David Fairlie , Darren March , Jennifer Martin , Robert Reid
发明人： John Abbenante , Doug Bergman , Ross Brinkworth , Robert Dancer , Bronwyn Garnham , Peter Hunt , David Fairlie , Darren March , Jennifer Martin , Robert Reid
IPC分类号： A61K38/00 , C07D273/00 , C07D273/02 , C07D285/00 , C07D291/02 , C07D413/06 , C07K5/02 , C07K5/078 , C07K14/16 , C07D245/00
CPC分类号： C07D273/00 , C07D273/02 , C07D285/00 , C07D291/02 , C07D413/06 , C07K14/005 , C07K5/021 , C07K5/06139 , C07K5/06165 , A61K38/00 , C12N2740/16122
摘要： A HIV-1 protease inhibitor which includes a n-terminal cycle (A) or a C-terminal cycle (B) or both cycles (A) and (B) wherein Y is selected from side chains of Asn or Ilc or Val or Glu and alkyl of 1-6 carbon atoms inclusive of linear branched chains as well as cycloalkyl; and X is selected from (CH2)n where n=3-6, --CH(OH)--CH(OH)--CH2; CH(CO2H)--CH2--CH2; CH2CONHCHR where R=D or L amino acids and alkyl of 1-6 carbon atoms inclusive of linear or branched chains.
摘要翻译： PCT No.PCT / AU95 / 00817 Sec。 371日期1997年9月9日 102（e）1997年9月9日PCT 1995年12月4日PCT PCT。第WO96 / 16950号公报日期1996年6月6日包括n末端循环（A）或C末端循环（B）或两个循环（A）和（B）的HIV-1蛋白酶抑制剂，其中Y选自Asn的侧链或 Ilc或Val或Glu和1-6个碳原子的烷基，包括直链支链以及环烷基; 并且X选自（CH 2）n，其中n = 3-6，-CH（OH）-CH（OH）-CH 2; CH（CO 2 H）-CH 2 -CH 2; CH2CONHCHR其中R = D或L氨基酸和1-6个碳原子的烷基，包括直链或支链。

8. 发明申请

US20070179925A1 Expert system for prescribing and tracking physical activity programs for patients with coronary artery disease and method of creating same 审中-公开
标题翻译：冠状动脉疾病患者处方和跟踪体力活动方案的专家系统及其创建方法
公开(公告)号：US20070179925A1
公开(公告)日：2007-08-02
申请号：US11342831
申请日：2006-01-31
申请人： Robert Reid , Louise Morrin , Sophia Papadakis , Louise Beaton
发明人： Robert Reid , Louise Morrin , Sophia Papadakis , Louise Beaton
IPC分类号： G06N5/04
CPC分类号： G06F19/3481 , G16H40/20 , G16H50/20
摘要： An expert system for assigning and tracking physical activity programs for patients with coronary artery disease provides user interfaces for recruiters who screen and enroll the patients as program participants in the physical activity programs; for coaches who monitor program participants and guide them through the physical activity program; and for program participants who create their own physical activity schedules,and log their physical activities. Expert system algorithms assign predefined physical activity programs to the program participants at predefined program milestones based on predefined criteria.
摘要翻译：为冠状动脉疾病患者分配和跟踪身体活动计划的专家系统为在身体活动计划中筛选和登记患者作为计划参与者的招募者提供用户界面; 对于监督计划参与者并指导他们进行身体活动计划的教练; 并为计划参与者创建自己的体力活动计划，并记录其身体活动。专家系统算法基于预定义的标准，在预定义的程序里程碑上将预定义的身体活动程序分配给程序参与者。

9. 发明申请

US20060225647A1 Doctor blade holder 审中-公开
标题翻译：刮刀刀架
公开(公告)号：US20060225647A1
公开(公告)日：2006-10-12
申请号：US11101349
申请日：2005-04-07
申请人： Robert Reid
发明人： Robert Reid
IPC分类号： B05C1/08
CPC分类号： D21G3/005
摘要： A doctor blade holder has a top plate having a rear portion overlying a base structure and a front portion projecting forward from the base structure. Blade support members are carried by and cooperate with the front portion of the top plate to define forwardly open slots for receiving the doctor blade. A hinge is interposed between the rear portion of the doctor blade and the base structure. The hinge has a body portion defining a fulcrum about which the top plate pivots relative to the base structure, and has forwardly and rearwardly projecting integral flanges arranged respectively to underlie the top plate and overlie the base structure. The doctor blade holder has means for securing the forwardly projecting flanges to the top plate and for securing the rearwardly projecting flanges to the base structure.
摘要翻译：刮刀保持器具有顶板，该顶板具有覆盖基部结构的后部和从基部结构向前突出的前部。刀片支撑构件由顶板的前部承载并配合，以限定用于接收刮刀的向前开口的槽。铰链位于刮刀的后部与底座结构之间。铰链具有限定支点的主体部分，顶板相对于基座结构枢转，并且具有分别布置在顶板下方并且覆盖在基部结构上的向前和向后突出的整体凸缘。刮刀架具有用于将向前突出的凸缘固定到顶板并用于将向后突出的凸缘固定到基部结构的装置。

10. 发明授权

US4453215A Central processing apparatus for fault-tolerant computing 失效
标题翻译：用于容错计算的中央处理装置
公开(公告)号：US4453215A
公开(公告)日：1984-06-05
申请号：US307525
申请日：1981-10-01
申请人： Robert Reid
发明人： Robert Reid
IPC分类号： G06F11/18 , G06F11/00 , G06F11/10 , G06F11/16 , G06F11/20 , G06F13/00 , G06F13/374
CPC分类号： G06F11/1625 , G06F11/1641 , G06F11/2007 , G06F13/374 , G06F11/10 , G06F11/20
摘要： A fault-tolerant computer system provides information transfers between the units of a computing module, including a processor unit and a memory unit and one or more peripheral control units, on a bus structure common to all the units. Information-handling parts of the system, both in the bus structure and in each unit, can have a duplicate partner. Error detectors check the operation of the bus structure and of each system unit to provide information transfers only on fault-free bus conductors and between fault-free units. The computer system can operate in this manner essentially without interruption in the event of faults by using only fault-free conductors and functional units.Arbitration circuits of unusual speed and simplicity provide units of the computing module with access to the common bus structure according to the priority of each unit.The units of a module check incoming and outgoing signals for errors, signal other module units of a detected error, and disable the unit from sending potentially erroneous information onto the bus structure.
摘要翻译：容错计算机系统在计算模块的单元之间提供在所有单元共同的总线结构上的信息传输，包括处理器单元和存储器单元以及一个或多个外围控制单元。在总线结构和每个单元中，系统的信息处理部分可以具有重复的伙伴。错误检测器检查总线结构和每个系统单元的操作，仅在无故障总线导体和无故障单元之间提供信息传输。计算机系统可以通过仅使用无故障的导体和功能单元在基本上不发生故障的情况下以这种方式操作。具有异常速度和简单性的仲裁电路提供计算模块的单元根据每个单元的优先级访问公共总线结构。模块的单元检查输入和输出信号是否有错误，向其他模块单元发出检测到的错误信号，并禁止单元向总线结构发送潜在的错误信息。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式