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1. 发明授权

US06766799B2 Inhalation device 有权
标题翻译：吸入装置
公开(公告)号：US06766799B2
公开(公告)日：2004-07-27
申请号：US09835302
申请日：2001-04-16
申请人： David Edwards , Mark Delong , Craig Dunbar , Ernest E. Penachio , Kevin Stapleton , Mark Wolff
发明人： David Edwards , Mark Delong , Craig Dunbar , Ernest E. Penachio , Kevin Stapleton , Mark Wolff
IPC分类号： A61M1500
CPC分类号： A61M15/0028 , A61M11/003 , A61M15/0033 , A61M15/0035 , A61M15/0041 , A61M2202/064
摘要： Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber to achieve a higher reproducible emitted dose of medicament from the receptacle. The inhalation device also includes an improved implement for puncturing the receptacle, requiring less force and experiencing fewer failures.
摘要翻译：吸入装置和相关方法，用于便于患者容纳在容器中的粉末药物的吸入。吸入装置具有容纳容器的腔室。环周向耦合到腔室的内表面，以实现来自容器的较高可重复发射剂量的药物。吸入装置还包括用于刺穿容器的改进的工具，需要更少的力并且经历更少的故障。

2. 发明授权

US07146978B2 Inhalation device and method 有权
标题翻译：吸入装置及方法
公开(公告)号：US07146978B2
公开(公告)日：2006-12-12
申请号：US10771447
申请日：2004-02-05
申请人： David Edwards , Mark DeLong , Craig Dunbar , Ernest E. Penachio , Kevin Stapleton , Mark Wolff
发明人： David Edwards , Mark DeLong , Craig Dunbar , Ernest E. Penachio , Kevin Stapleton , Mark Wolff
IPC分类号： A61M16/00
CPC分类号： A61M15/0028 , A61M11/003 , A61M15/0033 , A61M15/0035 , A61M15/0041 , A61M2202/064
摘要： Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber to achieve a higher reproducible emitted dose of medicament from the receptacle. The inhalation device also includes an improved implement for puncturing the receptacle, requiring less force and experiencing fewer failures.
摘要翻译：吸入装置和相关方法，用于便于患者容纳在容器中的粉末药物的吸入。吸入装置具有容纳容器的腔室。环周向耦合到腔室的内表面，以实现来自容器的较高可重复发射剂量的药物。吸入装置还包括用于刺穿容器的改进的工具，需要更少的力并且经历更少的故障。

3. 发明申请

US20060283448A1 Inhalation device and method 审中-公开
公开(公告)号：US20060283448A1
公开(公告)日：2006-12-21
申请号：US11512197
申请日：2006-08-30
申请人： David Edwards , Mark DeLong , Craig Dunbar , Ernest Penachio , Kevin Stapleton , Mark Wolff
发明人： David Edwards , Mark DeLong , Craig Dunbar , Ernest Penachio , Kevin Stapleton , Mark Wolff
IPC分类号： A61M15/00 , A61M16/10
CPC分类号： A61M15/0028 , A61M11/003 , A61M15/0033 , A61M15/0035 , A61M15/0041 , A61M2202/064
摘要： Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber to achieve a higher reproducible emitted dose of medicament from the receptacle. The inhalation device also includes an improved implement for puncturing the receptacle, requiring less force and experiencing fewer failures.

4. 发明授权

US07278425B2 Inhalation device and method 有权
标题翻译：吸入装置及方法
公开(公告)号：US07278425B2
公开(公告)日：2007-10-09
申请号：US10771551
申请日：2004-02-05
申请人： David Edwards , Colleen Conlon , David L. Foshee , Jason R. Durkin , Tim Coker , Kevin Stapleton
发明人： David Edwards , Colleen Conlon , David L. Foshee , Jason R. Durkin , Tim Coker , Kevin Stapleton
IPC分类号： A61M15/00 , A61M16/00 , B05D7/14 , B65D83/06
CPC分类号： A61M15/0028 , A61M11/003 , A61M15/0033 , A61M15/0035 , A61M15/0041 , A61M2202/064
摘要： Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber to achieve a higher reproducible emitted dose of medicament from the receptacle. The inhalation device also includes an improved implement for puncturing the receptacle, requiring less force and experiencing fewer failures. The inhalation device also includes a means for indicating readiness.
摘要翻译：吸入装置和相关方法，用于便于患者容纳在容器中的粉末药物的吸入。吸入装置具有容纳容器的腔室。环周向耦合到腔室的内表面，以实现来自容器的较高可重复发射剂量的药物。吸入装置还包括用于刺穿容器的改进的工具，需要更少的力并且经历更少的故障。吸入装置还包括用于指示准备状态的装置。

5. 发明授权

US06732732B2 Inhalation device and method 有权
公开(公告)号：US06732732B2
公开(公告)日：2004-05-11
申请号：US10268059
申请日：2002-10-10
申请人： David Edwards , Colleen Conlon , Sarah Dreesen , Mark DeLong
发明人： David Edwards , Colleen Conlon , Sarah Dreesen , Mark DeLong
IPC分类号： A61M1500
CPC分类号： A61M15/0028 , A61M11/003 , A61M15/0033 , A61M15/0035 , A61M15/0041 , A61M2202/064
摘要： Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber to achieve a higher reproducible emitted dose of medicament from the receptacle. The inhalation device also includes an improved implement for puncturing the receptacle, requiring less force and experiencing fewer failures. The inhalation device also includes a means for indicating readiness.

6. 发明授权

US08641128B2 Vehicle floor assembly with insert 失效
标题翻译：车载地板总成与插入
公开(公告)号：US08641128B2
公开(公告)日：2014-02-04
申请号：US12537294
申请日：2009-08-07
申请人： David Edwards
发明人： David Edwards
IPC分类号： B62D27/02 , E04C5/16
CPC分类号： B62D25/2054
摘要： An insert that can be used support a vehicle floor if a cross member fails either mechanically or through corrosion. The insert may also be used to protect a fastener used in a vehicle floor assembly.
摘要翻译：如果交叉构件机械地或通过腐蚀失效，则可以使用的插入件支撑车辆底板。插入件也可用于保护用于车辆地板组件中的紧固件。

7. 发明授权

US08423280B2 Vehicle collision avoidance system 有权
标题翻译：车辆碰撞避免系统
公开(公告)号：US08423280B2
公开(公告)日：2013-04-16
申请号：US13572279
申请日：2012-08-10
申请人： David Edwards , David Robert Pavlik , Ramkumar Subramanian , Robert Martin Coats
发明人： David Edwards , David Robert Pavlik , Ramkumar Subramanian , Robert Martin Coats
IPC分类号： G06F17/10 , B60Q1/00 , G01S13/00
CPC分类号： G01S13/931 , G01S7/062 , G01S13/862 , G01S13/865 , G01S13/867 , G01S13/87 , G01S17/023 , G01S2013/9332 , G01S2013/9353 , G01S2013/9364 , G01S2013/9367 , G01S2013/9389 , G08G1/16 , G08G1/166 , G08G1/167
摘要： A method for collision avoidance for a machine is disclosed. The method includes detecting an obstacle with an obstacle detection system and generating a corresponding signal. The obstacle detection system includes an operator input device. The method also includes providing an obstacle detection warning in response to the signal. The method further includes determining with a controller whether the operator input device has been activated in response to the obstacle detection warning.
摘要翻译：公开了一种用于机器的防碰撞的方法。该方法包括利用障碍物检测系统检测障碍物并产生相应的信号。障碍物检测系统包括操作员输入装置。该方法还包括响应于该信号提供障碍物检测警告。该方法还包括利用控制器确定操作员输入装置是否已经响应于障碍物检测警告被激活。

8. 发明申请

US20080253971A9 Particles for inhalation having sustained release properties 失效
公开(公告)号：US20080253971A9
公开(公告)日：2008-10-16
申请号：US10420071
申请日：2003-04-18
申请人： David Edwards , Robert Langer , Rita Vanbever , Jeffrey Mintzes , Jue Wang , Donghao Chen
发明人： David Edwards , Robert Langer , Rita Vanbever , Jeffrey Mintzes , Jue Wang , Donghao Chen
IPC分类号： A61K9/14 , A61L9/04 , A61K38/00
CPC分类号： A61K9/0073 , A61K9/0075 , A61K9/16 , A61K9/1617 , A61K9/1623 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K9/1694 , A61K31/135 , A61K31/137 , A61K31/566 , A61K38/28 , A61K38/38 , A61K47/12 , A61K47/183 , A61K47/24 , A61K47/6927
摘要： The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.

9. 发明申请

US20080073239A1 Injection-Molded Water Soluble Container 审中-公开
标题翻译：注塑成型水溶性容器
公开(公告)号：US20080073239A1
公开(公告)日：2008-03-27
申请号：US11844493
申请日：2007-08-24
申请人： Paul Duffield , Geoffrey Hammond , David Edwards , William McCarthy , Arnold Beckett , Anthony Jackman
发明人： Paul Duffield , Geoffrey Hammond , David Edwards , William McCarthy , Arnold Beckett , Anthony Jackman
IPC分类号： B65D85/808
CPC分类号： C11D17/043 , A61G2205/00 , A61J3/07 , A61J3/071 , A61J3/072 , A61J3/08 , A61K9/4808 , A61K9/4816 , B29C45/0001 , B29C65/02 , B29C65/16 , B29C65/1612 , B29C65/1674 , B29C66/21 , B29C66/3452 , B29C66/54 , B29C2035/0822 , B29K2027/06 , B29K2029/04 , B29K2995/0062 , B29L2031/7174 , B65D1/24 , B65D1/30 , B65D25/04 , B65D51/28 , B65D65/46 , B65D81/32 , B65D81/3205 , B65D81/3283 , B65D81/3294 , C11D11/007 , C11D17/042 , C11D17/045 , Y02W90/12 , Y10T428/13 , Y10T428/1352 , Y10T428/1379 , Y10T428/1397
摘要： A rigid, water-soluble container is made of an injection molded poly(vinyl alcohol) and/or a cellulose ether, which container encases a fabric care, surface care or dishwashing composition; and a capsule container comprising at least two components made of one or more material(s) that can be molded and which are water soluble or water dispersible or in which a substantial part of the surface of these components is water soluble or water dispersible so as to leave perforations throughout the wall when the capsular container is placed in contact with an aqueous environment. The container has one to six compartments, preferably one, two or three, the content of the various compartments being accessible to the aqueous environment when the capsular container is exposed to such an aqueous environment. The accessibility time of the various compartments is the same or different from one compartment to another compartment, with the proviso that the content of the container is not a fabric care, surface care or dishwashing composition.
摘要翻译：刚性的水溶性容器由注射成型的聚（乙烯醇）和/或纤维素醚制成，该容器包含织物护理，表面护理或洗碗组合物; 以及胶囊容器，其包含至少两个由可以模制并且是水溶性或水分散性的一种或多种材料制成的部件，或者这些部件的大部分表面是水溶性或水分散性的，以便当胶囊容器与水性环境接触时，穿过整个墙壁穿孔。容器具有一至六个隔室，优选一个，二个或三个，当荚膜容器暴露于这种水性环境时，各种隔室的内容物可接触水溶液环境。各个隔室的可接近时间与一个隔室相同或不同，另一个隔间是条件，即容器的内容物不是织物护理，表面护理或餐具清洗组合物。

10. 发明申请

US20080038207A1 Method and device for decreasing contamination 有权
公开(公告)号：US20080038207A1
公开(公告)日：2008-02-14
申请号：US11827031
申请日：2007-07-10
申请人： David Edwards , Mark Gabrielson , Robert Clarke , Wesley Dehaan , Matthew Brande , Jonathan Man
发明人： David Edwards , Mark Gabrielson , Robert Clarke , Wesley Dehaan , Matthew Brande , Jonathan Man
IPC分类号： A61K31/70 , A01N37/18
CPC分类号： A61B5/097 , G01N33/497
摘要： Methods and devices to determine rate of particle production and the size range for the particles produced for an individual are described herein. The device (10) contains a mouthpiece (12), a filter (14), a low resistance one-way valve (16), a particle counter (20) and a computer (30). Optionally, the device also contains a gas flow meter (22). The data obtained using the device can be used to determine if a formulation for reducing particle exhalation should be administered to an individual. This device is particularly useful prior to and/or following entry in a cleanroom to ensure that the cleanroom standards are maintained. The device can also be used to identify animals and humans who have an enhanced propensity to exhale aerosols (referred to herein as “over producers”, “super-producers”, or “superspreaders”). Formulations to reduce particle production are also described herein. The formulation is administered in an amount sufficient to alter biophysical properties in the mucosal linings of the body. When applied to mucosal lining fluids, the formulation alters the physical properties such as the gel characteristics at the air/liquid interface, surface elasticity, surface viscosity, surface tension and bulk viscoelasticity of the mucosal lining. The formulation is administered in an effective amount to minimize ambient contamination due to particle formation during breathing, coughing, sneezing, or talking, which is particularly important in cleanroom applications. In one embodiment, the formulation for administration is a non-surfactant solution. In one embodiment, the formulations are conductive formulations containing conductive agents, such as salts, ionic surfactants, or other substances that are in an ionized state or easily ionized in an aqueous or organic solvent environment. Preferably the formulation is administered in the form of an aerosol.

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