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1. 发明申请

US20050158249A1 Aerodynamically light particles for pulmonary drug delivery 审中-公开
公开(公告)号：US20050158249A1
公开(公告)日：2005-07-21
申请号：US11064065
申请日：2005-02-23
申请人： David Edwards , Giovanni Caponetti , Jeffrey Hrkach , Noah Lotan , Justin Hanes , Abdellaziz Ben-Jebria , Robert Langer
发明人： David Edwards , Giovanni Caponetti , Jeffrey Hrkach , Noah Lotan , Justin Hanes , Abdellaziz Ben-Jebria , Robert Langer
IPC分类号： A61K9/12 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/72 , A61K31/137 , A61K47/32 , A61K48/00 , A61K31/353 , A61K31/4439 , A61K31/56 , A61K31/573 , A61K38/09
CPC分类号： A61K9/0075 , A61K9/1647 , A61K31/137
摘要： Improved aerodynamically light particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of biodegradable material and have a tap density of less than 0.4 g/cm3 and a mass mean diameter between 5 μm and 30 μm. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear α-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 μm, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung. The aerodynamically light particles incorporating a therapeutic agent may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide variety of therapeutic agents.

2. 发明申请

US20050244341A1 Aerodynamically light particles for pulmonary drug delivery 审中-公开
标题翻译：用于肺部药物递送的空气动力学轻微颗粒
公开(公告)号：US20050244341A1
公开(公告)日：2005-11-03
申请号：US11177719
申请日：2005-07-08
申请人： David Edwards , Giovannia Caponetti , Jeffrey Hrkach , Noah Lotan , Justin Hanes , Abdell Ben-Jebria , Robert Langer
发明人： David Edwards , Giovannia Caponetti , Jeffrey Hrkach , Noah Lotan , Justin Hanes , Abdell Ben-Jebria , Robert Langer
IPC分类号： A61K9/00 , A61K9/14 , A61K9/16 , A61K31/57 , A61K38/28 , A61K47/34 , A61L9/04 , G06F7/00 , G06F17/30
CPC分类号： A61K31/57 , A61K9/0075 , A61K9/1647 , A61K9/1682 , A61K38/28 , A61K47/34 , G06F16/284
摘要： Improved aerodynamically light particles for delivery to the pulmonary system, and methods for their preparation and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a tap density less than 0.4 g/cm3 and a mass mean diameter between 5 μm and 30 μm. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear a-hydroxy-acid polyester backbone having at least one amino acid group incorporated herein and at least on poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 μm, can be used for enhanced delivery of a therapeutic or diagnostic agent to the alveolar region of the lung. The aerodynamically light particles optionally can incorporate a therapeutic or diagnostic agent, and may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of a wide variety of incorporated agents.
摘要翻译：提供用于递送至肺系统的改善的空气动力学轻微颗粒，以及其制备和给药方法。在优选的实施方案中，空气动力学轻微颗粒由可生物降解的材料制成，并且振实密度小于0.4g / cm 3，质量平均直径在5μm和30μm之间。颗粒可以由可生物降解的材料如可生物降解的聚合物形成。例如，颗粒可以由官能化的聚酯接枝共聚物形成，所述官能化聚酯接枝共聚物由具有至少一个引入本文的氨基酸基团和至少在从氨基酸延伸的聚（氨基酸）侧链上的直链α-羟基酸聚酯主链组成集团在聚酯骨干。在一个实施方案中，具有大平均直径（例如大于5μm）的空气动力学轻的颗粒可用于增强治疗或诊断剂递送至肺的肺泡区域。空气动力学轻微颗粒任选地可以掺入治疗剂或诊断剂，并且可以有效地雾化用于给予呼吸道以允许各种并入药剂的全身或局部递送。

3. 发明授权

US5855913A Particles incorporating surfactants for pulmonary drug delivery 失效
标题翻译：含有肺部药物递送表面活性剂的颗粒
公开(公告)号：US5855913A
公开(公告)日：1999-01-05
申请号：US784421
申请日：1997-01-16
申请人： Justin Hanes , David A. Edwards , Carmen Evora , Robert Langer
发明人： Justin Hanes , David A. Edwards , Carmen Evora , Robert Langer
IPC分类号： A61K9/00 , A61K9/12 , A61K9/14 , A61K9/16 , A61K31/135 , A61K31/137 , A61K38/28 , A61K38/38 , A61K47/48
CPC分类号： A61K9/0075 , A61K31/135 , A61K31/137 , A61K38/28 , A61K38/38 , A61K9/1617 , A61K9/1623 , A61K9/1641 , A61K9/1647 , A61K9/1658
摘要： Aerodynamically light particles incorporating a surfactant on the surface thereof for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a tap density less than 0.4 g/cm.sup.3 and a mass mean diameter between 5 .mu.m and 30 .mu.m. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of poly(lactic acid) or poly(glycolic acid) or copolymers thereof. Alternatively, the particles may be formed solely of the drug or diagnostic agent and a surfactant. Surfactants can be incorporated on the particle surface for example by coating the particle after particle formation, or by incorporating the surfactant in the material forming the particle prior to formation of the particle. Exemplary surfactants include phosphoglycerides such as L-.alpha.-phosphatidylcholine dipalmitoyl. The aerodynamically light particles incorporating a therapeutic or diagnostic agent and a surfactant may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide a variety of therapeutic agents.
摘要翻译：提供了在其表面上并入表面活性剂用于向肺系统输送药物的空气动力学轻微颗粒，以及用于其合成和给药的方法。在优选的实施方案中，空气动力学轻微颗粒由可生物降解的材料制成，并且具有小于0.4g / cm 3的振实密度和5μm-30μm之间的质量平均直径。颗粒可以由可生物降解的材料如可生物降解的聚合物形成。例如，颗粒可以由聚（乳酸）或聚（乙醇酸）或其共聚物形成。或者，颗粒可以仅由药物或诊断剂和表面活性剂形成。表面活性剂可以结合在颗粒表面上，例如通过在颗粒形成之后涂覆颗粒，或者通过在形成颗粒之前将表面活性剂并入形成颗粒的材料中。示例性的表面活性剂包括磷酸甘油酯如L-α-磷脂酰胆碱二棕榈酰基。包含治疗剂或诊断剂和表面活性剂的空气动力学轻微颗粒可以有效地雾化，用于给予呼吸道以允许全身或局部递送各种各样的治疗剂。

4. 再颁专利

USRE37053E1 Particles incorporating surfactants for pulmonary drug delivery 有权
标题翻译：含有肺部药物递送表面活性剂的颗粒
公开(公告)号：USRE37053E1
公开(公告)日：2001-02-13
申请号：US09351341
申请日：1999-07-12
申请人： Justin Hanes , David A. Edwards , Carmen Evora , Robert Langer
发明人： Justin Hanes , David A. Edwards , Carmen Evora , Robert Langer
IPC分类号： A61K914
CPC分类号： A61K31/135 , A61K9/0073 , A61K9/1617 , A61K9/1623 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K31/137 , A61K38/28 , A61K38/38
摘要： Improved aerodynamically light particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a tap density less than 0.4 g/cm3 and a mass mean diameter between 5 &mgr;m and 30 &mgr;m. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear &agr;-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 &mgr;m, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung. The aerodynamically light particles incorporating a therapeutic agent may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide variety of therapeutic agents.
摘要翻译：提供用于向肺系统输送药物的空气动力学轻微颗粒，以及用于其合成和给药的方法。在优选的实施方案中，空气动力学轻微颗粒由可生物降解的材料制成，并且振实密度小于0.4g / cm 3，质量平均直径在5μm和30μm之间。颗粒可以由可生物降解的材料如可生物降解的聚合物形成。例如，颗粒可以由官能化聚酯接枝共聚物形成，该聚酯接枝共聚物由具有至少一个氨基酸基团的直链α-羟基酸聚酯主链和至少一个从氨基酸延伸的聚（氨基酸）侧链组成集团在聚酯骨干。在一个实施方案中，具有大平均直径（例如大于5μm）的空气动力学轻微颗粒可用于增强治疗剂递送至肺的肺泡区域。掺入治疗剂的空气动力学轻微颗粒可以被有效地雾化，用于给予呼吸道以允许全身或局部递送多种治疗剂。

5. 发明申请

US20080253971A9 Particles for inhalation having sustained release properties 失效
公开(公告)号：US20080253971A9
公开(公告)日：2008-10-16
申请号：US10420071
申请日：2003-04-18
申请人： David Edwards , Robert Langer , Rita Vanbever , Jeffrey Mintzes , Jue Wang , Donghao Chen
发明人： David Edwards , Robert Langer , Rita Vanbever , Jeffrey Mintzes , Jue Wang , Donghao Chen
IPC分类号： A61K9/14 , A61L9/04 , A61K38/00
CPC分类号： A61K9/0073 , A61K9/0075 , A61K9/16 , A61K9/1617 , A61K9/1623 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K9/1694 , A61K31/135 , A61K31/137 , A61K31/566 , A61K38/28 , A61K38/38 , A61K47/12 , A61K47/183 , A61K47/24 , A61K47/6927
摘要： The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.

6. 发明申请

US20070014738A1 Particles for inhalation having sustained release properties 审中-公开
标题翻译：具有持续释放性质的吸入颗粒
公开(公告)号：US20070014738A1
公开(公告)日：2007-01-18
申请号：US11523914
申请日：2006-09-20
申请人： David Edwards , Robert Langer , Rita Vanbever , Jeffrey Mintzes , Jue Wang , Donghao Chen
发明人： David Edwards , Robert Langer , Rita Vanbever , Jeffrey Mintzes , Jue Wang , Donghao Chen
IPC分类号： A61K38/17 , A61K9/14 , A61L9/04
CPC分类号： A61K9/0073 , A61K9/0075 , A61K9/16 , A61K9/1617 , A61K9/1623 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K9/1694 , A61K31/135 , A61K31/137 , A61K31/566 , A61K38/28 , A61K38/38 , A61K47/12 , A61K47/183 , A61K47/24 , A61K47/6927
摘要： The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.
摘要翻译：本发明一般涉及将治疗性预防和诊断试剂肺部递送给患者，其中药剂以持续方式释放，以及适用于该方法的颗粒。特别地，本发明涉及用于肺部递送治疗性，预防性或诊断性药物的方法，其包括对需要治疗，预防或诊断的患者的呼吸道施用有效量的包含治疗性，预防性或诊断性的颗粒药剂或其任何组合与带电脂质相结合，其中带电脂质具有与药剂相关的与药剂相反的总净电荷。药剂从给药颗粒中的释放以持续的方式发生。

7. 发明授权

US09981068B2 Polymers which resist bacterial attachment 有权
公开(公告)号：US09981068B2
公开(公告)日：2018-05-29
申请号：US14115451
申请日：2012-05-04
申请人： Paul Williams , Morgan Russell Alexander , Martyn Christopher Davies , Robert Langer , Daniel Griffith Anderson
发明人： Paul Williams , Morgan Russell Alexander , Martyn Christopher Davies , Robert Langer , Daniel Griffith Anderson
IPC分类号： A61L29/16 , A01N37/12 , A01N37/20 , A61L29/08 , A61L31/14 , A61L31/10 , A61L27/50 , A61L27/34 , A61L29/14 , C08F220/56 , C08F220/24 , C08F220/18 , C08F220/22 , C08F222/10
CPC分类号： A61L29/16 , A01N37/12 , A01N37/20 , A61L27/34 , A61L27/50 , A61L29/085 , A61L29/14 , A61L31/10 , A61L31/14 , C08F220/18 , C08F220/22 , C08F220/24 , C08F220/56 , C08F222/1006 , C08L33/08 , C08L33/10 , C08L33/26 , A01N25/10 , A01N25/34
摘要： The invention provides a method for inhibiting bacterial attachment to a surface, the method comprising forming the surface from a polymer, or applying a polymer to the surface, wherein the polymer is a homopolymer formed from a (meth) acrylate or (meth) acrylamide monomer or a copolymer formed from one or more (meth) acrylate or (meth) acrylamide monomers, wherein the (meth) acrylate or (meth) acrylamide monomers are of formula (I) or (II): [H2C═CR′—C(═O)—O—]nR (I) [H2C═CR′—C(═O)—NH—]nR (II) wherein n is 1, 2 or 3, R′ is independently H or CH3, R is an organic group having a total of from 2 to 24 carbon atoms, wherein the organic group includes an aliphatic or aromatic hydrocarbon moiety and wherein the organic group does not include any hydroxyl groups.

8. 发明授权

US09412476B2 Systems, devices, methods, and compositions including fluidized x-ray shielding compositions 有权
公开(公告)号：US09412476B2
公开(公告)日：2016-08-09
申请号：US13373139
申请日：2011-11-03
申请人： Philip A. Eckhoff , William H. Gates, III , Peter L. Hagelstein , Roderick A. Hyde , Jordin T. Kare , Robert Langer , Erez Lieberman , Eric C. Leuthardt , Nathan P. Myhrvold , Michael Schnall-Levin , Clarence T. Tegreene , Lowell L. Wood, Jr.
发明人： Philip A. Eckhoff , William H. Gates, III , Peter L. Hagelstein , Roderick A. Hyde , Jordin T. Kare , Robert Langer , Erez Lieberman , Eric C. Leuthardt , Nathan P. Myhrvold , Michael Schnall-Levin , Clarence T. Tegreene , Lowell L. Wood, Jr.
IPC分类号： G21F1/00 , G21F1/06 , G21F1/08 , G21F1/10 , G21F1/02 , G21F3/00 , A61B6/10 , G21F3/02
CPC分类号： G21F1/06 , A61B6/10 , C09D5/32 , G21F1/02 , G21F1/08 , G21F1/10 , G21F3/00 , G21F3/02
摘要： Systems, devices, methods, and compositions are described for providing an x-ray shielding system including a flexible layer including a support structure having a plurality of interconnected interstitial spaces that provide a circulation network for an x-ray shielding fluid composition.

9. 发明授权

US09144488B2 Breast implant with analyte sensors responsive to external power source 有权
标题翻译：具有响应外部电源的分析物传感器的乳房植入物
公开(公告)号：US09144488B2
公开(公告)日：2015-09-29
申请号：US13495252
申请日：2012-06-13
申请人： Edward S. Boyden , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene
发明人： Edward S. Boyden , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene
IPC分类号： A61F2/12 , A61B5/07 , A61B5/00 , A61B5/145
CPC分类号： A61F2/12 , A61B5/0031 , A61B5/076 , A61B5/14546 , A61B5/4312 , A61B5/686 , A61B5/6867 , A61B2560/0219 , A61F2250/0085 , A61F2250/0096
摘要： Breast implants including sensor modules and related methods are described herein. Breast implants include those with: a shell configured to be substantially filled with a viscous material; and a plurality of sensor modules attached to the shell and positioned at a distance from each other, each of the plurality of sensor modules oriented to detect one or more analytes in a fluid adjacent to the shell, wherein each of the plurality of sensor modules includes a unique identifier and is configured to utilize energy transmitted from an external source.
摘要翻译：本文描述了包括传感器模块和相关方法的乳房植入物。乳房植入物包括具有：壳体被构造为基本上被粘性材料填充的植入物; 以及多个传感器模块，其附接到壳体并且彼此间隔一定距离，多个传感器模块中的每一个被定向成检测与壳体相邻的流体中的一种或多种分析物，其中多个传感器模块中的每一个包括唯一的标识符并被配置为利用从外部源发送的能量。

10. 发明授权

US09061075B2 Bone delivery device 有权
公开(公告)号：US09061075B2
公开(公告)日：2015-06-23
申请号：US11900776
申请日：2007-09-12
申请人： Ed Harlow , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
发明人： Ed Harlow , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
IPC分类号： C12N5/00 , C12N5/02 , C12N11/00 , C12N11/16 , A61K47/48 , A61K9/00 , C12N5/077 , A61K35/12
CPC分类号： A61K47/48776 , A61K9/0024 , A61K47/6901 , A61K2035/126 , B33Y80/00 , C12N5/0654 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.

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