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1. 发明授权

US07010957B2 Gas sensors with improved resistance to humidity interference 有权
标题翻译：气体传感器具有改善的耐湿度干扰能力
公开(公告)号：US07010957B2
公开(公告)日：2006-03-14
申请号：US10275887
申请日：2001-05-09
申请人： David Edward Williams , Keith Francis Edwin Pratt , Peter John Smith , Dirk Niemeyer
发明人： David Edward Williams , Keith Francis Edwin Pratt , Peter John Smith , Dirk Niemeyer
IPC分类号： G01N7/00
CPC分类号： G01N33/004 , G01N27/12 , G01N33/006 , Y10T436/184
摘要： Semiconductor gas-sensitive materials of the formula Cr2-xTixO3 where 0.05>x≧0.0001, and gas sensors formed therefrom.
摘要翻译：其中0.05> x> = 0.0001的式Cr 2 x x Ti 3 O 3的半导体气体敏感材料和由其形成的气体传感器。

2. 发明申请

US20090035876A1 Electrochemical Assay 审中-公开
标题翻译：电化学测定
公开(公告)号：US20090035876A1
公开(公告)日：2009-02-05
申请号：US11887393
申请日：2006-03-31
申请人： David Edward Williams , Phillip Lowe , Christopher John Slevin , Anne-Cecile Herve , Stephen John Carlisle , Alan Thomson
发明人： David Edward Williams , Phillip Lowe , Christopher John Slevin , Anne-Cecile Herve , Stephen John Carlisle , Alan Thomson
IPC分类号： G01N33/543
CPC分类号： G01N33/5438 , G01N33/532 , G01N33/58
摘要： A method of determining the presence or amount of analyte in a fluid sample, which comprises: contacting a fluid sample with a binding reagent that comprises a plurality of cleavable species and wherein said species, when cleaved, are detectable using electrochemical means; separating any binding reagent-analyte complex that forms from the unbound binding reagent; cleaving the cleavable species from the immobilized binding reagent-analyte complex; and detecting the cleaved species using electrochemical means.
摘要翻译：一种确定流体样品中分析物的存在或量的方法，其包括：使流体样品与包含多个可切割物质的结合试剂接触，并且其中当切割时所述物质可使用电化学方法检测; 分离从未结合试剂形成的任何结合试剂 - 分析物复合物; 从固定的结合试剂 - 分析物复合物切割可切割物种; 并使用电化学方法检测切割的物种。

3. 发明授权

US06481264B1 Materials for solid-state gas sensors 有权
标题翻译：固态气体传感器材料
公开(公告)号：US06481264B1
公开(公告)日：2002-11-19
申请号：US09830132
申请日：2001-04-24
申请人： David Edward Williams
发明人： David Edward Williams
IPC分类号： G01N700
CPC分类号： C01G37/00 , C01G37/006 , C01G45/125 , C01G49/0018 , C01G49/009 , C01P2002/34 , C01P2002/52 , C01P2002/54 , C01P2004/82 , G01N27/12 , G01N33/004
摘要： A sensor for detecting the presence of gas and methods for use. The sensor has a low sensitivity to relative humidity and high sensitivity to the presence of gases such as carbon monoxide. The sensor is comprised of ternary oxides of the formula Cr2−x(M1zM21−z)xO3 with M1=Fe or Mn, M2=Fe, Mn, or Al, 0.005≦x≦1.95, 0.005≦z≦0.995; ternary oxides of the formula Cr2−x(M1zM21−z)xO3 with M1=Fe or Mn, M2=Ti, 0.005≦x≦1.95, 0.005≦z≦0.45; or quaternary and quinternary oxides of the formula Cr2−x((M1aM2bM3c)zM41−z)xO3 with M1=Fe, M2=Mn, M3=Al, and M4=Ti, 0≦a,b,c≦1, 0.005≦x≦1.95, and 0.005≦z≦0.45.
摘要翻译：用于检测气体存在的传感器和使用方法。传感器对相对湿度的敏感性低，对一氧化碳等气体的敏感性高。传感器由M1 = Fe或Mn，M2 = Fe，Mn或Al的式Cr2-x（M1zM21-z）xO3的三元氧化物组成，0.005 <= x <= 1.95,0.005 <= z <= 0.995 ; M1 = Fe或Mn，M2 = Ti，0.005 <= x <= 1.95，0.005 <= z <= 0.45的式Cr2-x（M1zM21-z）xO3的三元氧化物; 或具有M1 = Fe，M2 = Mn，M3 = Al和M4 = Ti的式Cr2-x（（M1aM2bM3c）zM41-z）xO3的季铵和季铵氧化物，0 <= a，b，c < 0.005 <= x <= 1.95，0.005 <= z <= 0.45。

4. 发明申请

US20190062808A1 Methods and Apparatus for Amplifying Nucleic Acids 审中-公开
公开(公告)号：US20190062808A1
公开(公告)日：2019-02-28
申请号：US16189731
申请日：2018-11-13
申请人： Nihan Aydemir , Jadranka Travas-Sejdic , Clive William Evans , David Edward Williams
发明人： Nihan Aydemir , Jadranka Travas-Sejdic , Clive William Evans , David Edward Williams
IPC分类号： C12Q1/686 , G01N27/02
摘要： The present invention relates to methods and apparatuses for amplifying, detecting, and optionally quantifying, nucleic acids. In one aspect the method comprises (a) providing a reaction volume comprising (i) a first electrode comprising an electrochemically-active conducting polymer, a first single-stranded nucleic acid molecule capable of hybridizing to a target nucleic acid, wherein the first nucleic acid molecule is covalently attached to the electrochemically-active conducting polymer, and (ii) a second electrode, (b) providing a reaction mixture to the reaction volume, the reaction mixture comprising a target nucleic acid, a nucleic acid polymerase, a redox couple, and nucleic acid amplification reagents, (c) amplifying the nucleic acid, and (d) measuring the impedance of the first electrode at least once during the nucleic acid amplification reaction.

5. 发明授权

US10167501B2 Methods and apparatus for quantification of nucleic acid amplification by monitoring impedances 有权
公开(公告)号：US10167501B2
公开(公告)日：2019-01-01
申请号：US14738179
申请日：2015-06-12
申请人： Nihan Aydemir , Jadranka Travas-Sejdic , Clive William Evans , David Edward Williams
发明人： Nihan Aydemir , Jadranka Travas-Sejdic , Clive William Evans , David Edward Williams
IPC分类号： C12Q1/68 , G01N27/02 , C12Q1/686
摘要： The present invention relates to methods and apparatuses for amplifying, detecting, and optionally quantifying, nucleic acids. In one aspect the method comprises (a) providing a reaction volume comprising (i) a first electrode comprising an electrochemically-active conducting polymer, a first single-stranded nucleic acid molecule capable of hybridizing to a target nucleic acid, wherein the first nucleic acid molecule is covalently attached to the electrochemically-active conducting polymer, and (ii) a second electrode, (b) providing a reaction mixture to the reaction volume, the reaction mixture comprising a target nucleic acid, a nucleic acid polymerase, a redox couple, and nucleic acid amplification reagents, (c) amplifying the nucleic acid, and (d) measuring the impedance of the first electrode at least once during the nucleic acid amplification reaction.

6. 发明申请

US20080206849A1 Assay Device & Method 审中-公开
标题翻译：测定装置和方法
公开(公告)号：US20080206849A1
公开(公告)日：2008-08-28
申请号：US11573319
申请日：2005-07-27
申请人： Krzysztof Wojciech Zak , David Edward Williams
发明人： Krzysztof Wojciech Zak , David Edward Williams
IPC分类号： C12M1/00
CPC分类号： G01N33/558 , G01N33/56944 , G01N2400/00 , G01N2469/10
摘要： There is disclosed a lateral flow assay device and method of producing the same. The device, which is for identifying carbohydrate antigens in a biological sample comprises a substrate having, a) a sample receiving zone, b) an extraction zone for receiving the sample from said sample receiving zone and which extraction zone comprises immobilised or otherwise absorbed therein at least one or more reactants and reagents which when combined react to form an extraction reagent for a desired antigen in said sample, said sample to be added to said sample receiving zone optionally comprising the remaining reactant required to form said extraction reagent if not present in said extraction zone, c) optionally a neutralising agent capable of bringing the pH of the resulting sample to within the operational pH range of the assay and, d) a detection zone for a labelled specific binding or capture reagent for said antigen to be detected.
摘要翻译：公开了一种侧流测定装置及其制造方法。用于在生物样品中鉴定碳水化合物抗原的装置包括具有a）样品接收区的底物，b）用于从所述样品接收区接收样品的提取区，并且该提取区包含固定或以其他方式被其中吸收的提取区当组合反应以形成所述样品中所需抗原的提取试剂时，所述至少一种或多种反应物和试剂，待添加到所述样品接收区的所述样品，任选地包含形成所述提取试剂所需的剩余反应物，如果不存在于所述提取区，c）任选的能够使得到的样品的pH达到测定操作pH范围内的中和剂，和d）用于待检测的所述抗原的标记的特异性结合或捕获试剂的检测区。

7. 发明授权

US5814281A Resistive gas sensing 失效
标题翻译：电阻气体检测
公开(公告)号：US5814281A
公开(公告)日：1998-09-29
申请号：US732271
申请日：1996-10-28
申请人： David Edward Williams , Ruth Ridley , Eliot Sizeland
发明人： David Edward Williams , Ruth Ridley , Eliot Sizeland
IPC分类号： G01N27/12 , G01N30/64
CPC分类号： G01N27/12
摘要： A resistive gas sensor has a porous semiconducting oxide body in which the pore surfaces are decorated with a precious metal. The sensor operates at ambient temperatures for detection and measurement of target gases, especially carbon monoxide. The porous sensor body is formed of primary crystallites agglomerated together, the agglomerate size being less than 10 times the primary crystallite size, and the primary crystallite size having an average diameter of less than 5 micrometer. From 0.05 to 80% of the pore surfaces are covered by the metallic phase, the metallic phase consisting of particles having an average size of less than 50 nanometers. Presence of the target gas is indicated by a change in electrical resistance of the sensor.
摘要翻译： PCT No.PCT / GB95 / 00986 Sec。 371日期1996年10月28日第 102（e）日期1996年10月28日PCT提交1995年5月1日PCT公布。 WO95 / 30143 PCT出版物日期1995年11月9日电阻气体传感器具有多孔半导体氧化物体，其中孔表面用贵金属装饰。传感器在环境温度下工作，用于检测和测量目标气体，特别是一氧化碳。多孔传感器体由附聚在一起的初级微晶形成，团聚体尺寸小于初级微晶尺寸的10倍，并且初级微晶尺寸的平均直径小于5微米。 0.05至80％的孔表面被金属相覆盖，金属相由平均尺寸小于50纳米的颗粒组成。目标气体的存在由传感器的电阻变化表示。

8. 发明申请

US20090053741A1 ASSAY FOR MEASURING ASYMMETRIC METHYLARGININE IN A BIOLOGICAL SAMPLE 审中-公开
标题翻译：在生物样品中测量不对称甲基嘧啶的测定
公开(公告)号：US20090053741A1
公开(公告)日：2009-02-26
申请号：US11910107
申请日：2006-03-28
申请人： Patrick John Thompson Vallance , James Mitchell Leiper , David Edward Williams
发明人： Patrick John Thompson Vallance , James Mitchell Leiper , David Edward Williams
IPC分类号： G01N33/573 , C12M1/00
CPC分类号： G01N33/6812 , C12Q1/26 , G01N2333/90245
摘要： The invention relates to a method of determining the presence and/or amount of an asymmetric methylarginine in a sample, the method comprising: (a) contacting the sample with a nitric oxide synthase (NOS) polypeptide in the presence of a detectably labelled species under conditions which permit the asymmetric methylarginine and detectably labelled species to bind to the NOS polypeptide; and (b) determining the amount or presence of the detectably labelled species bound to the NOS polypeptide
摘要翻译：本发明涉及一种测定样品中不对称甲基精氨酸的存在和/或量的方法，所述方法包括：（a）在可检测标记的物种存在下使样品与一氧化氮合酶（NOS）多肽接触，允许不对称甲基精氨酸和可检测标记的物质结合NOS多肽的条件; 和（b）确定与NOS多肽结合的可检测标记的物质的量或存在

9. 发明授权

US5858739A Gas sensor 失效
标题翻译：气体传感器
公开(公告)号：US5858739A
公开(公告)日：1999-01-12
申请号：US884442
申请日：1997-06-27
申请人： David Edward Williams
发明人： David Edward Williams
IPC分类号： G01N27/12 , G01N33/00 , G01N27/04 , G01N27/416
CPC分类号： G01N33/007 , G01N27/12
摘要： A method for determining the presence of a first gas in a second gas uses a gas sensor made up of at least two pairs of electrodes, each pair of electrodes having different spacing between the electrodes. The electrodes of the gas sensor have surfaces that are reactive to the gases under investigation. The gas sensor is exposed to the gases, and the electrical resistances between the pairs of electrodes are measured over a period of time. `The results are compared with a calibration curve to determine if the first gas is present in the second, and to determine of the sensor is malfunctioning.
摘要翻译：用于确定第二气体中第一气体的存在的方法使用由至少两对电极构成的气体传感器，每对电极在电极之间具有不同的间隔。气体传感器的电极具有与被调查气体反应的表面。气体传感器暴露于气体，并且在一段时间内测量成对的电极之间的电阻。 “将结果与校准曲线进行比较，以确定第一个气体是否存在于第二个气体中，并确定传感器发生故障。

10. 发明授权

US6046054A Semiconducting oxide gas sensors 失效
标题翻译：半导体氧化物气体传感器
公开(公告)号：US6046054A
公开(公告)日：2000-04-04
申请号：US987539
申请日：1997-12-09
申请人： Peter McGeehin , Patrick Timothy Moseley , David Edward Williams , Geoffrey Stephen Henshaw , Darryl Hirst Dawson , Laura Jane Gellman
发明人： Peter McGeehin , Patrick Timothy Moseley , David Edward Williams , Geoffrey Stephen Henshaw , Darryl Hirst Dawson , Laura Jane Gellman
IPC分类号： G01N27/12 , G01N33/00
CPC分类号： G01N27/12 , Y10T436/184 , Y10T436/186 , Y10T436/20 , Y10T436/200833 , Y10T436/203332 , Y10T436/204165 , Y10T436/204998 , Y10T436/205831 , Y10T436/208339 , Y10T436/21 , Y10T436/212 , Y10T436/214 , Y10T436/216
摘要： The selectivity of response of resistive gas sensors to specific gases or vapors is improved by the selection of specified gas-sensitive materials which are not previously known for the applications described, which include detection of hydrocarbons in the presence of CO, H.sub.2 S, SO.sub.2, chlorine, NO.sub.2, CO.sub.2 (especially in low concentrations), CFC's, ammonia, free oxygen by determination of partial pressures, and numerous organic gases and vapors.
摘要翻译：电阻式气体传感器对特定气体或蒸气的响应选择性通过选择以前不为所述应用所了解的特定气体敏感材料而得到改进，包括在CO，H2S，SO2，氯气存在下检测烃，NO2，CO2（特别是低浓度），CFC，氨，通过测定分压的游离氧，以及许多有机气体和蒸气。

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