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1. 发明申请

US20100145361A1 Methods and Devices for Occlusion of an Atrial Appendage 审中-公开
标题翻译：用于闭塞心房附件的方法和装置
公开(公告)号：US20100145361A1
公开(公告)日：2010-06-10
申请号：US12572846
申请日：2009-10-02
申请人： David E. Francischelli , Roderick E. Briscoe , Leonard H. Leuer , Daniel C. Haeg , Tom P. Daigle , David Kim , Mark T. Stewart , Andrew L. Olson , Patrick J. Cloutier , Christopher W. Smith , Michael J. Hobday , Tessy Kanayinkal , Douglas H. Gubbin , Paul T. Rothstein , Joseph E. Cardinal , Jessica L. Foley , Christopher J. Plott
发明人： David E. Francischelli , Roderick E. Briscoe , Leonard H. Leuer , Daniel C. Haeg , Tom P. Daigle , David Kim , Mark T. Stewart , Andrew L. Olson , Patrick J. Cloutier , Christopher W. Smith , Michael J. Hobday , Tessy Kanayinkal , Douglas H. Gubbin , Paul T. Rothstein , Joseph E. Cardinal , Jessica L. Foley , Christopher J. Plott
IPC分类号： A61B17/12 , A61B17/122
CPC分类号： A61B17/12 , A61B17/12009 , A61B17/1285 , A61B2017/00243 , A61B2017/12018
摘要： A novel occluder application and clip device for treatment of embolic stroke caused by atrial fibrillation uses multiple sutures in a non directional handle to affix the occlusion device to the applicator and manipulate the occluder from an open and receiving position to a closed and occluding position. The occluder is retained in place by a clamping means related to locks retainers, resilient material or otherwise. An actuator mechanism is used to manipulate the occluder to a locked or occluding position. The applicator with the occluder attached has a low profile and remote manipulations to allow the occluder to be delivered to the clamping location within a patient through a small incision or delivery port such as a trocar cannula or the like.
摘要翻译：用于治疗由心房颤动引起的栓塞性中风的新型闭塞器应用和夹持装置在非方向性手柄中使用多个缝线以将闭塞装置固定到施用器上，并将闭塞器从打开和接收位置操纵到闭合和闭塞位置。封闭器通过与锁定件，弹性材料或其他方式相关的夹紧装置保持在适当的位置。致动器机构用于将闭塞器操纵到锁定或闭塞位置。具有闭塞器的施用器具有低轮廓和远程操作，以允许阻塞器通过诸如套管针插管等的小切口或输送口输送到患者体内的夹紧位置。

2. 发明授权

US08926635B2 Methods and devices for occlusion of an atrial appendage 有权
标题翻译：用于闭塞心房的方法和装置
公开(公告)号：US08926635B2
公开(公告)日：2015-01-06
申请号：US12572846
申请日：2009-10-02
申请人： David E. Francischelli , Roderick E. Briscoe , Leonard H. Leuer , Daniel C. Haeg , Tom P. Daigle , David Kim , Mark T. Stewart , Andrew L. Olson , Patrick J. Cloutier , Christopher W. Smith , Michael J. Hobday , Tessy Kanayinkal , Douglas H. Gubbin , Paul T. Rothstein , Joseph E. Cardinal , Jessica L. Foley , Christopher J. Plott
发明人： David E. Francischelli , Roderick E. Briscoe , Leonard H. Leuer , Daniel C. Haeg , Tom P. Daigle , David Kim , Mark T. Stewart , Andrew L. Olson , Patrick J. Cloutier , Christopher W. Smith , Michael J. Hobday , Tessy Kanayinkal , Douglas H. Gubbin , Paul T. Rothstein , Joseph E. Cardinal , Jessica L. Foley , Christopher J. Plott
IPC分类号： A61B17/12 , A61B17/128 , A61B17/00
CPC分类号： A61B17/12 , A61B17/12009 , A61B17/1285 , A61B2017/00243 , A61B2017/12018
摘要： A novel occluder application and clip device for treatment of embolic stroke caused by atrial fibrillation uses multiple sutures in a non directional handle to affix the occlusion device to the applicator and manipulate the occluder from an open and receiving position to a closed and occluding position. The occluder is retained in place by a clamping means related to locks retainers, resilient material or otherwise. An actuator mechanism is used to manipulate the occluder to a locked or occluding position. The applicator with the occluder attached has a low profile and remote manipulations to allow the occluder to be delivered to the clamping location within a patient through a small incision or delivery port such as a trocar cannula or the like.
摘要翻译：用于治疗由心房颤动引起的栓塞性中风的新型闭塞器应用和夹持装置在非方向性手柄中使用多个缝线以将闭塞装置固定到施用器上，并将闭塞器从打开和接收位置操纵到闭合和闭塞位置。封闭器通过与锁定件，弹性材料或其他方式相关的夹紧装置保持在适当的位置。致动器机构用于将闭塞器操纵到锁定或闭塞位置。具有闭塞器的施用器具有低轮廓和远程操作，以允许阻塞器通过诸如套管针插管等的小切口或输送口输送到患者体内的夹紧位置。

3. 发明授权

US08663245B2 Device for occlusion of a left atrial appendage 有权
标题翻译：用于闭塞左心耳的装置
公开(公告)号：US08663245B2
公开(公告)日：2014-03-04
申请号：US11788261
申请日：2007-04-19
申请人： David E. Francischelli , Roderick E. Briscoe , Leonard H. Leuer , Daniel C. Haeg , Tom P. Daigle , David Kim , Mark T. Stewart , Andrew L. Olson , Patrick J. Cloutier , Christopher W. Smith , Michael J. Hobday , Tessy Kanayinkal , Douglas H. Gubbin , Paul T. Rothstein , Joseph E. Cardinal , Jessica L. Foley , Christopher J. Plott
发明人： David E. Francischelli , Roderick E. Briscoe , Leonard H. Leuer , Daniel C. Haeg , Tom P. Daigle , David Kim , Mark T. Stewart , Andrew L. Olson , Patrick J. Cloutier , Christopher W. Smith , Michael J. Hobday , Tessy Kanayinkal , Douglas H. Gubbin , Paul T. Rothstein , Joseph E. Cardinal , Jessica L. Foley , Christopher J. Plott
IPC分类号： A61B17/04
CPC分类号： A61B17/12 , A61B17/0057 , A61B17/12009 , A61B17/12013 , A61B17/122 , A61B17/128 , A61B17/1285 , A61B90/39 , A61B2017/00243 , A61B2017/00575 , A61B2017/12018 , A61B2017/306
摘要： The invention provides a system for occluding a left atrial appendage of a patient. The system can include a ring occluder that can be positioned around the left atrial appendage and a ring applicator to position the ring occluder with respect to the left atrial appendage. The system can also provide a tissue-grasping tool that is separable from the ring applicator tool.
摘要翻译：本发明提供一种用于闭塞患者的左心耳的系统。该系统可以包括可以围绕左心耳定位的环形闭塞器和环形施放器，以相对于左心耳定位环形闭塞器。该系统还可以提供可与环施加工具分离的组织抓取工具。

4. 发明授权

US07510536B2 Ultrasound guided high intensity focused ultrasound treatment of nerves 有权
标题翻译：超声引导高强度聚焦超声治疗神经
公开(公告)号：US07510536B2
公开(公告)日：2009-03-31
申请号：US11016701
申请日：2004-12-16
申请人： Jessica L. Foley , Shahram Vaezy , James W. Little
发明人： Jessica L. Foley , Shahram Vaezy , James W. Little
IPC分类号： A61H1/00 , A61B8/00
CPC分类号： A61B8/06 , A61B8/0816 , A61B8/0833 , A61B8/12 , A61B8/4209 , A61B8/4254 , A61B8/4281 , A61B8/4444 , A61B8/481 , A61B8/483 , A61B2017/4216 , A61B2018/00434 , A61B2090/378 , A61N7/02
摘要： A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic affect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversible a block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.
摘要翻译：一种使用高强度聚焦超声（HIFU）治疗神经结构以达到理想的治疗效果的方法。根据施用的HIFU的剂量，它可以对神经结构具有可逆或不可逆的作用。例如，相对高剂量的HIFU可用于永久性阻断神经功能，提供切断神经以治疗严重痉挛状态的非侵入性替代方案。相对较低剂量的HIFU可用于逆转阻断神经功能，减轻疼痛，达到麻醉效果，或达到美容效果。如果感觉神经对于自愿功能不是必需的，而是涉及与肿瘤或骨癌相关的疼痛，HIFU可用于非侵入性地破坏这种感觉神经以缓解没有药物的疼痛。优选地，同步到HIFU治疗超声成像用于提供神经结构的实时超声图像引导HIFU疗法。

5. 发明申请

US20120316426A1 IMAGE GUIDED HIGH INTENSITY FOCUSED ULTRASOUND TREATMENT OF NERVES 审中-公开
标题翻译：图像指导高强度聚焦超声治疗神经
公开(公告)号：US20120316426A1
公开(公告)日：2012-12-13
申请号：US13590146
申请日：2012-08-20
申请人： Jessica L. Foley , Shahram Vaezy , James W. Little
发明人： Jessica L. Foley , Shahram Vaezy , James W. Little
IPC分类号： A61N7/02 , A61B5/055 , A61B8/12 , A61B8/13
CPC分类号： A61B8/13 , A61B5/0035 , A61B8/0808 , A61B8/4209 , A61B8/4254 , A61B8/4272 , A61B8/4281 , A61B2017/320069 , A61B2090/378 , A61N7/02
摘要： A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic effect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.
摘要翻译：一种使用高强度聚焦超声（HIFU）治疗神经结构以达到理想治疗效果的方法。根据施用的HIFU的剂量，它可以对神经结构具有可逆或不可逆的作用。例如，相对高剂量的HIFU可用于永久性阻断神经功能，提供切断神经以治疗严重痉挛状态的非侵入性替代方案。相对较低剂量的HIFU可用于可逆地阻断神经功能，减轻疼痛，达到麻醉效果，或达到美容效果。如果感觉神经对于自愿功能不是必需的，而是涉及与肿瘤或骨癌相关的疼痛，HIFU可用于非侵入性地破坏这种感觉神经以缓解没有药物的疼痛。优选地，与HIFU治疗同步的超声成像被用于提供神经结构的实时超声图像引导的HIFU治疗。

6. 发明授权

US08211017B2 Image guided high intensity focused ultrasound treatment of nerves 有权
标题翻译：图像引导高强度聚焦超声治疗神经
公开(公告)号：US08211017B2
公开(公告)日：2012-07-03
申请号：US12887178
申请日：2010-09-21
申请人： Jessica L. Foley , Shahram Vaezy , James W. Little
发明人： Jessica L. Foley , Shahram Vaezy , James W. Little
IPC分类号： A61B8/00 , A61H1/00
CPC分类号： A61B8/13 , A61B5/0035 , A61B8/0808 , A61B8/4209 , A61B8/4254 , A61B8/4272 , A61B8/4281 , A61B17/320068 , A61B2090/378 , A61N7/02
摘要： A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic effect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.
摘要翻译：一种使用高强度聚焦超声（HIFU）治疗神经结构以达到理想治疗效果的方法。根据施用的HIFU的剂量，它可以对神经结构具有可逆或不可逆的作用。例如，相对高剂量的HIFU可用于永久性阻断神经功能，提供切断神经以治疗严重痉挛状态的非侵入性替代方案。相对较低剂量的HIFU可用于可逆地阻断神经功能，减轻疼痛，达到麻醉效果，或达到美容效果。如果感觉神经对于自愿功能不是必需的，而是涉及与肿瘤或骨癌相关的疼痛，HIFU可用于非侵入性地破坏这种感觉神经以缓解没有药物的疼痛。优选地，与HIFU治疗同步的超声成像被用于提供神经结构的实时超声图像引导的HIFU治疗。

7. 发明授权

US08206299B2 Image guided high intensity focused ultrasound treatment of nerves 有权
公开(公告)号：US08206299B2
公开(公告)日：2012-06-26
申请号：US12887211
申请日：2010-09-21
申请人： Jessica L. Foley , Shahram Vaezy , James W. Little
发明人： Jessica L. Foley , Shahram Vaezy , James W. Little
IPC分类号： A61B8/00 , A61H1/00
CPC分类号： A61B8/13 , A61B5/0035 , A61B8/0808 , A61B8/4209 , A61B8/4254 , A61B8/4272 , A61B8/4281 , A61B17/320068 , A61B2090/378 , A61N7/02
摘要： A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic effect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.

8. 发明申请

US20100234728A1 ULTRASOUND GUIDED HIGH INTENSITY FOCUSED ULTRASOUND TREATMENT OF NERVES 有权
标题翻译：超声引导高强度聚焦超声治疗神经
公开(公告)号：US20100234728A1
公开(公告)日：2010-09-16
申请号：US12390975
申请日：2009-02-23
申请人： Jessica L. Foley , Shahram Vaezy , James W. Little
发明人： Jessica L. Foley , Shahram Vaezy , James W. Little
IPC分类号： A61N7/00 , A61B8/00
CPC分类号： A61B8/06 , A61B8/0816 , A61B8/0833 , A61B8/12 , A61B8/4209 , A61B8/4254 , A61B8/4281 , A61B8/4444 , A61B8/481 , A61B8/483 , A61B2017/4216 , A61B2018/00434 , A61B2090/378 , A61N7/02
摘要： A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic affect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.
摘要翻译：一种使用高强度聚焦超声（HIFU）治疗神经结构以达到理想的治疗效果的方法。根据施用的HIFU的剂量，它可以对神经结构具有可逆或不可逆的作用。例如，相对高剂量的HIFU可用于永久性阻断神经功能，提供切断神经以治疗严重痉挛状态的非侵入性替代方案。相对较低剂量的HIFU可用于可逆地阻断神经功能，减轻疼痛，达到麻醉效果或达到美容效果。如果感觉神经对于自愿功能不是必需的，而是涉及与肿瘤或骨癌相关的疼痛，HIFU可用于非侵入性地破坏这种感觉神经以缓解没有药物的疼痛。优选地，与HIFU治疗同步的超声成像被用于提供神经结构的实时超声图像引导的HIFU治疗。

9. 发明授权

US08197409B2 Ultrasound guided high intensity focused ultrasound treatment of nerves 有权
标题翻译：超声引导高强度聚焦超声治疗神经
公开(公告)号：US08197409B2
公开(公告)日：2012-06-12
申请号：US12390975
申请日：2009-02-23
申请人： Jessica L. Foley , Shahram Vaezy , James W. Little
发明人： Jessica L. Foley , Shahram Vaezy , James W. Little
IPC分类号： A61B8/00 , A61H1/00
CPC分类号： A61B8/06 , A61B8/0816 , A61B8/0833 , A61B8/12 , A61B8/4209 , A61B8/4254 , A61B8/4281 , A61B8/4444 , A61B8/481 , A61B8/483 , A61B2017/4216 , A61B2018/00434 , A61B2090/378 , A61N7/02
摘要： A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic effect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.
摘要翻译：一种使用高强度聚焦超声（HIFU）治疗神经结构以达到理想治疗效果的方法。根据施用的HIFU的剂量，它可以对神经结构具有可逆或不可逆的作用。例如，相对高剂量的HIFU可用于永久性阻断神经功能，提供切断神经以治疗严重痉挛状态的非侵入性替代方案。相对较低剂量的HIFU可用于可逆地阻断神经功能，减轻疼痛，达到麻醉效果，或达到美容效果。如果感觉神经对于自愿功能不是必需的，而是涉及与肿瘤或骨癌相关的疼痛，HIFU可用于非侵入性地破坏这种感觉神经以缓解没有药物的疼痛。优选地，与HIFU治疗同步的超声成像被用于提供神经结构的实时超声图像引导的HIFU治疗。

10. 发明申请

US20110040214A1 IMAGE GUIDED HIGH INTENSITY FOCUSED ULTRASOUND TREATMENT OF NERVES 有权
公开(公告)号：US20110040214A1
公开(公告)日：2011-02-17
申请号：US12887178
申请日：2010-09-21
申请人： Jessica L. Foley , Shahram Vaezy , James W. Little
发明人： Jessica L. Foley , Shahram Vaezy , James W. Little
IPC分类号： A61N7/00
CPC分类号： A61B8/13 , A61B5/0035 , A61B8/0808 , A61B8/4209 , A61B8/4254 , A61B8/4272 , A61B8/4281 , A61B17/320068 , A61B2090/378 , A61N7/02
摘要： A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic effect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.

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