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1. 发明授权

US07141045B2 Methods for enhancing fluid flow through an obstructed vascular site, and systems and kits for use in practicing the same 有权
标题翻译：通过阻塞血管部位增强流体流动的方法，以及用于实施血管部位的系统和试剂盒
公开(公告)号：US07141045B2
公开(公告)日：2006-11-28
申请号：US10265174
申请日：2002-10-04
申请人： Peter Johansson , David Delaney , Brent Constantz
发明人： Peter Johansson , David Delaney , Brent Constantz
IPC分类号： A61M31/00 , A61M29/00 , A61M5/00
CPC分类号： A61B17/22 , A61B5/14539 , A61B2017/22084 , A61K31/00 , A61K33/00 , A61K45/06 , A61M25/007 , A61M25/10 , A61M25/1011 , A61M2025/0004 , A61M2025/0034 , A61M2025/0175 , A61M2025/1015 , A61M2025/1052 , A61M2025/109 , A61K2300/00
摘要： Methods of enhancing fluid flow through a vascular site occupied by a vascular occlusion, as well as systems and kits for use in practicing the same, are provided. In practicing the subject methods, the vascular site is flushed simultaneously with a first dissolution fluid (e.g., an organic matter dissolution fluid and/or an inorganic matter dissolution fluid), and a second dissolution fluid attenuating fluid, where flushing is carried out in a manner such that only a surface of the vascular occlusion is contacted with the non-attenuated dissolution fluid. The subject methods, systems and kits for practicing the same find use in the treatment of a variety of different vascular diseases characterized by the presence of vascular occlusions, including both partial and total occlusions.
摘要翻译：提供了通过血管闭塞所占据的血管部位增强流体流动的方法以及用于实施血管闭塞的系统和试剂盒。在实施本发明的方法中，血管部位与第一溶解流体（例如，有机物溶解流体和/或无机物质溶解流体）同时冲洗，以及第二溶解流体衰减流体，其中冲洗在使得只有血管闭塞的表面与未减毒的溶解流体接触。用于实践相同的主题方法，系统和试剂盒可用于治疗多种不同血管疾病，其特征在于存在血管闭塞，包括部分和全部闭塞。

2. 发明申请

US20050106260A1 Calcium phosphate cements comprising an osteoclastogenic agent 有权
标题翻译：包含破骨细胞生成剂的磷酸钙胶结剂
公开(公告)号：US20050106260A1
公开(公告)日：2005-05-19
申请号：US10717171
申请日：2003-11-18
申请人： Brent Constantz , David Delaney
发明人： Brent Constantz , David Delaney
IPC分类号： A61L24/02 , A61K38/17 , A61K33/42
CPC分类号： A61L24/02
摘要： Methods and compositions are provided for producing flowable compositions, e.g. pastes, that set into calcium phosphate products that include an osteoclastogenic agent. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a setting fluid and an osteoclastogenic agent, e.g., RANKL or a mimetic thereof, and the combined reactants are mixed to produce the flowable composition. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including hard tissue repair applications.
摘要翻译：提供了用于生产可流动组合物的方法和组合物，例如。糊剂，其设置为包含破骨细胞生成剂的磷酸钙产品。在本发明方法中，将包含钙源和磷酸盐源的干燥反应物与凝固液和破骨细胞生成剂如RANKL或其模拟物组合，并将合并的反应物混合以产生可流动组合物。还提供了组合物本身以及用于制备它们的试剂盒。由此产生的主题方法和组合物可用于各种应用，包括硬组织修复应用。

3. 发明申请

US20050070914A1 Use of vibration with polymeric bone cements 有权
标题翻译：使用聚合物骨水泥的振动
公开(公告)号：US20050070914A1
公开(公告)日：2005-03-31
申请号：US10900019
申请日：2004-07-26
申请人： Brent Constantz , David Delaney , Duran Yetkinler
发明人： Brent Constantz , David Delaney , Duran Yetkinler
IPC分类号： A61B17/88 , A61F2/46 , A61K33/42 , A61B17/58
CPC分类号： A61K33/42 , A61B17/8822 , A61F2002/4602 , A61F2002/4683
摘要： Methods of employing bone defect filling, e.g., polymeric bone cements, are provided. A feature of the subject methods is that vibration is employed in conjunction with the use of the cement, e.g., in preparation of the cement, in preparation of the target site, in delivery of the cement to the target site, and/or following delivery of the cement to the target site. Also provided are devices, systems and kits that find use in practicing the subject methods. The subject methods, devices and systems find use in a variety of different applications.
摘要翻译：提供使用骨缺损填充的方法，例如聚合骨水泥。主题方法的一个特征是，与水泥的使用结合使用振动，例如在准备水泥时，在制备目标地点时，将水泥输送到目标地点和/或在运送之后的水泥到目标地点。还提供了用于实践主题方法的设备，系统和工具包。主题方法，设备和系统可用于各种不同的应用。

4. 发明申请

US20050023171A1 Calcium phosphate cements comprising a water-soluble contrast agent 有权
标题翻译：含有水溶性造影剂的磷酸钙水泥
公开(公告)号：US20050023171A1
公开(公告)日：2005-02-03
申请号：US10629321
申请日：2003-07-28
申请人： David Delaney , Brent Constantz
发明人： David Delaney , Brent Constantz
IPC分类号： A61F2/00 , A61F2/28 , A61L24/02 , A61L27/12 , A61B17/06 , A61B19/02 , A61L15/00 , B65D25/08
CPC分类号： A61L27/12 , A61F2/28 , A61F2310/00293 , A61L24/02
摘要： Methods are provided for producing flowable compositions, e.g. pastes, that set into calcium phosphate products and include a contrast agent. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with setting fluid and a water-soluble contrast agent, e.g., a water-soluble barium salt, and the combined reactants are mixed to produce the flowable composition. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g., bone defects.
摘要翻译：提供了用于生产可流动组合物的方法，例如。糊剂，其设置为磷酸钙产品并包括造影剂。在本发明方法中，将包含钙源和磷酸盐源的干燥反应物与凝固液和水溶性造影剂（例如水溶性钡盐）组合，并将混合的反应物混合以产生可流动组合物。还提供了组合物本身以及用于制备它们的试剂盒。由此产生的主题方法和组合物可用于各种应用，包括修复硬组织缺陷，例如骨缺损。

5. 发明授权

US06533767B2 Methods for enhancing fluid flow through an obstructed vascular site, and systems and kits for use in practicing the same 有权
标题翻译：通过阻塞血管部位增强流体流动的方法，以及用于实施血管部位的系统和试剂盒
公开(公告)号：US06533767B2
公开(公告)日：2003-03-18
申请号：US09774469
申请日：2001-01-30
申请人： Peter Johansson , David Delaney , Brent Constantz
发明人： Peter Johansson , David Delaney , Brent Constantz
IPC分类号： A61M3100
CPC分类号： A61B5/14539 , A61B17/22 , A61B2017/22084 , A61K31/00 , A61K33/00 , A61K45/06 , A61M25/007 , A61M25/10 , A61M25/1011 , A61M2025/0004 , A61M2025/0034 , A61M2025/0175 , A61M2025/1015 , A61M2025/105 , A61M2025/1052 , A61M2025/109 , A61K2300/00
摘要： Methods of enhancing fluid flow through a vascular site occupied by a vascular occlusion, as well as systems and kits for use in practicing the same, are provided. In practicing the subject methods, the vascular site is flushed simultaneously with a first dissolution fluid (e.g., an organic matter dissolution fluid and/or an inorganic matter dissolution fluid), and a second dissolution fluid attenuating fluid, where flushing is carried out in a manner such that only a surface of the vascular occlusion is contacted with the non-attenuated dissolution fluid. Examples of dissolution fluid/dissolution fluid attenuating fluid pairs include: (1) oxidizing agent fluid and fluid comprising oxidizable neutralizing agent; (2) surfactant fluid and phosphate buffered saline; (3) acidic solution and phosphate buffered saline; etc. Flushing is carried out in this manner for a period of time sufficient for fluid flow through the vascular site to be enhanced, e.g. increased or established. The subject methods, systems and kits for practicing the same find use in the treatment of a variety of different vascular diseases characterized by the presence of vascular occlusions, including both partial and total occlusions.
摘要翻译：提供了通过血管闭塞所占据的血管部位增强流体流动的方法以及用于实施血管闭塞的系统和试剂盒。在实施本发明的方法中，血管部位与第一溶解流体（例如，有机物溶解流体和/或无机物质溶解流体）同时冲洗，以及第二溶解流体衰减流体，其中冲洗在使得只有血管闭塞的表面与未减毒的溶解流体接触。溶解流体/溶解流体衰减流体对的实例包括：（1）氧化剂流体和包含可氧化中和剂的流体; （2）表面活性剂流体和磷酸盐缓冲盐水; （3）酸性溶液和磷酸缓冲盐水; 以这种方式进行冲洗一段时间，足以使液体流过血管部位以增强，例如，增加或建立用于实践相同的主题方法，系统和试剂盒可用于治疗各种不同血管疾病，其特征在于存在血管闭塞，包括部分和全部闭塞。

6. 发明申请

US20050058717A1 Methods and devices for delivering orthopedic cements to a target bone site 有权
标题翻译：将矫形水泥递送至目标骨骼部位的方法和装置
公开(公告)号：US20050058717A1
公开(公告)日：2005-03-17
申请号：US10661356
申请日：2003-09-11
申请人： Duran Yetkinler , David Delaney , Brent Constantz
发明人： Duran Yetkinler , David Delaney , Brent Constantz
IPC分类号： A61B17/00 , A61B17/88 , A61F2/46 , A61K33/42 , A61H1/02
CPC分类号： A61B17/8822 , A61F2002/4602 , A61F2002/4683 , A61K33/42
摘要： Methods and devices are provided for delivery an orthopedic, e.g., calcium phosphate cement to a target bone site. In practicing the subject methods, a flowable cement composition is delivered to a target bone site in conjunction with vibration. Also provided are the devices that deliver a flowable cement to a target bone site according to the subject methods. Introducing a flowable cement to a target bone site in conjunction with vibration in accordance with the subject methods provides for highly controlled penetration of the delivered cement throughout the target bone site without the use of substantial pressure. The subject devices and methods find use in a variety of different applications, and are particularly suited for use in applications where a calcium phosphate cement is to be delivered to cancellous tissue, e.g., as found in a vertebral body.
摘要翻译：提供方法和装置用于将矫形例如磷酸钙粘合剂递送至靶骨部位。在实施本发明方法时，将可流动的水泥组合物与振动一起递送至目标骨部位。还提供了根据主题方法将可流动的水泥递送到目标骨骼部位的装置。根据本发明的方法将可流动的水泥与振动结合引入目标骨骼部位提供了在不使用实质压力的情况下将所输送的水泥贯穿整个目标骨部位进行高度控制的渗透。本发明的装置和方法可用于各种不同的应用中，并且特别适用于将磷酸钙水泥输送到例如在椎体中发现的松质骨组织的应用中。

7. 发明申请

US20070173784A1 Methods for enhancing fluid flow through an obstructed vascular site, and systems and kits for use in practicing the same 审中-公开
标题翻译：通过阻塞血管部位增强流体流动的方法，以及用于实施血管部位的系统和试剂盒
公开(公告)号：US20070173784A1
公开(公告)日：2007-07-26
申请号：US11581222
申请日：2006-10-12
申请人： Peter Johansson , David Delaney , Brent Constantz
发明人： Peter Johansson , David Delaney , Brent Constantz
IPC分类号： A61M31/00
CPC分类号： A61B17/22 , A61B5/14539 , A61B2017/22084 , A61K31/00 , A61K33/00 , A61K45/06 , A61M25/007 , A61M25/10 , A61M25/1011 , A61M2025/0004 , A61M2025/0034 , A61M2025/0175 , A61M2025/1015 , A61M2025/1052 , A61M2025/109 , A61K2300/00
摘要： Methods of enhancing fluid flow through a vascular site occupied by a vascular occlusion, as well as systems and kits for use in practicing the same, are provided. In practicing the subject methods, the vascular site is flushed simultaneously with a first dissolution fluid (e.g., an organic matter dissolution fluid and/or an inorganic matter dissolution fluid), and a second dissolution fluid attenuating fluid, where flushing is carried out in a manner such that only a surface of the vascular occlusion is contacted with the non-attenuated dissolution fluid. Examples of dissolution fluid/dissolution fluid attenuating fluid pairs include: (1) oxidizing agent fluid and fluid comprising oxidizable neutralizing agent; (2) surfactant fluid and phosphate buffered saline; (3) acidic solution and phosphate buffered saline; etc. Flushing is carried out in this manner for a period of time sufficient for fluid flow through the vascular site to be enhanced, e.g. increased or established. The subject methods, systems and kits for practicing the same find use in the treatment of a variety of different vascular diseases characterized by the presence of vascular occlusions, including both partial and total occlusions.
摘要翻译：提供了通过血管闭塞所占据的血管部位增强流体流动的方法以及用于实施血管闭塞的系统和试剂盒。在实施本发明的方法中，血管部位与第一溶解流体（例如，有机物溶解流体和/或无机物质溶解流体）同时冲洗，以及第二溶解流体衰减流体，其中冲洗在使得只有血管闭塞的表面与未减毒的溶解流体接触。溶解流体/溶解流体衰减流体对的实例包括：（1）氧化剂流体和包含可氧化中和剂的流体; （2）表面活性剂流体和磷酸盐缓冲盐水; （3）酸性溶液和磷酸缓冲盐水; 以这种方式进行冲洗一段时间，足以使液体流过血管部位以增强，例如，增加或建立用于实践相同的主题方法，系统和试剂盒可用于治疗多种不同血管疾病，其特征在于存在血管闭塞，包括部分和全部闭塞。

8. 发明申请

US20060100636A1 Use of vibration in composite fixation 有权
标题翻译：复合固定中使用振动
公开(公告)号：US20060100636A1
公开(公告)日：2006-05-11
申请号：US11244435
申请日：2005-10-04
申请人： Duran Yetkinler , David Delaney , Brent Constantz
发明人： Duran Yetkinler , David Delaney , Brent Constantz
IPC分类号： A61F2/34
CPC分类号： A61K33/42 , A61B17/8822 , A61F2002/4602 , A61F2002/4683
摘要： Methods of employing bone defect filling, e.g., orthopedic cements, in conjunction with hard tissue securing devices, e.g., screws, plates or rods, are provided. A feature of the subject methods is that the cement is introduced to a target bone site through a passageway of the securing device while a vibratory force is applied to the securing device. Also provided are systems and kits that find use in practicing the subject methods. The subject methods, devices and systems find use in a variety of different applications.
摘要翻译：提供了使用骨缺损填充（例如矫形水泥）与硬组织固定装置（例如螺钉，板或杆）结合的方法。本发明方法的特征在于，当将固定装置施加振动力时，通过固定装置的通道将水泥引入目标骨骼部位。还提供了用于实践主题方法的系统和工具包。主题方法，设备和系统可用于各种不同的应用。

9. 发明申请

US20060018974A1 Calcium Phosphate cements and methods for using the same 有权
标题翻译：磷酸钙水泥及其使用方法
公开(公告)号：US20060018974A1
公开(公告)日：2006-01-26
申请号：US10900029
申请日：2004-07-26
申请人： Brent Constantz , David Delaney , Duran Yetkinler
发明人： Brent Constantz , David Delaney , Duran Yetkinler
IPC分类号： A61K33/42
CPC分类号： A61L27/12 , Y10S514/951 , Y10S514/955
摘要： Methods and compositions for producing flowable compositions, e.g. pastes, that set into calcium phosphate products are provided. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with setting fluid to produce the flowable composition. A feature of the subject methods is that the dry reactants include a particulate calcium and/or phosphate reactant having a mean particle size of less than about 8 μm and narrow size distribution. Also provided are the compositions themselves as well as kits for use in practicing the subject methods. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g., bone defects.
摘要翻译：用于生产可流动组合物的方法和组合物，例如提供了设置成磷酸钙产品的糊剂。在本发明方法中，包括钙源和磷酸盐源的干燥反应物与凝固流体组合以产生可流动组合物。本发明方法的特征在于干燥反应物包括平均粒径小于约8μm并具有窄尺寸分布的颗粒状钙和/或磷酸盐反应物。还提供了组合物本身以及用于实践本发明方法的试剂盒。由此产生的主题方法和组合物可用于各种应用，包括修复硬组织缺陷，例如骨缺损。

10. 发明申请

US20070299248A1 CALCIUM PHOSPHATE CEMENTS COMPRISING AN OSTEOCLASTOGENIC AGENT 审中-公开
标题翻译：包含OSTEOCL生物学剂的磷酸钙化合物
公开(公告)号：US20070299248A1
公开(公告)日：2007-12-27
申请号：US11771589
申请日：2007-06-29
申请人： Brent Constantz , David Delaney
发明人： Brent Constantz , David Delaney
IPC分类号： C01B25/00 , C07K14/00
CPC分类号： A61L24/02
摘要： Methods and compositions are provided for producing flowable compositions, e.g. pastes, that set into calcium phosphate products that include an osteoclastogenic agent. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a setting fluid and an osteoclastogenic agent, e.g., RANKL or a mimetic thereof, and the combined reactants are mixed to produce the flowable composition. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including hard tissue repair applications.
摘要翻译：提供了用于生产可流动组合物的方法和组合物，例如。糊剂，其设置为包含破骨细胞生成剂的磷酸钙产品。在本发明方法中，将包含钙源和磷酸盐源的干燥反应物与凝固液和破骨细胞生成剂如RANKL或其模拟物组合，并将合并的反应物混合以产生可流动组合物。还提供了组合物本身以及用于制备它们的试剂盒。由此产生的主题方法和组合物可用于各种应用，包括硬组织修复应用。

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